Details for: PTGER1

Gene ID: 5731

Symbol: PTGER1

Ensembl ID: ENSG00000160951

Description: prostaglandin E receptor 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 21.5263
    Cell Significance Index: -5.4600
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 2.8941
    Cell Significance Index: 17.9100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 1.2096
    Cell Significance Index: 74.1600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.1858
    Cell Significance Index: 31.7800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.7129
    Cell Significance Index: 15.4500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3865
    Cell Significance Index: 73.5500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3524
    Cell Significance Index: 34.8700
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.3365
    Cell Significance Index: 2.8600
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.2959
    Cell Significance Index: 3.4400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2245
    Cell Significance Index: 202.7100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1990
    Cell Significance Index: 10.3400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1674
    Cell Significance Index: 3.5700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1633
    Cell Significance Index: 26.5600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1321
    Cell Significance Index: 14.3700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0608
    Cell Significance Index: 3.6500
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.0577
    Cell Significance Index: 0.4900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0527
    Cell Significance Index: 2.3900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0398
    Cell Significance Index: 2.7500
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.0302
    Cell Significance Index: 0.3200
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.0176
    Cell Significance Index: 0.2800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0124
    Cell Significance Index: 0.5800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0105
    Cell Significance Index: 5.7600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0016
    Cell Significance Index: 0.1900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0027
    Cell Significance Index: -5.0500
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0027
    Cell Significance Index: -0.1200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0031
    Cell Significance Index: -0.8900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0035
    Cell Significance Index: -0.1000
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.0038
    Cell Significance Index: -0.0200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0042
    Cell Significance Index: -7.7200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0049
    Cell Significance Index: -7.5000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0052
    Cell Significance Index: -3.7800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0055
    Cell Significance Index: -7.5000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0067
    Cell Significance Index: -4.9800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0069
    Cell Significance Index: -5.2500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0077
    Cell Significance Index: -4.8600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0088
    Cell Significance Index: -1.5900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0094
    Cell Significance Index: -5.3200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0095
    Cell Significance Index: -0.3900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0102
    Cell Significance Index: -0.3600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0104
    Cell Significance Index: -0.2900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0111
    Cell Significance Index: -0.5600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0117
    Cell Significance Index: -0.2000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0120
    Cell Significance Index: -5.4400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0124
    Cell Significance Index: -0.3200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0127
    Cell Significance Index: -4.5500
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0142
    Cell Significance Index: -0.2200
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0164
    Cell Significance Index: -0.4100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0195
    Cell Significance Index: -0.4900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0195
    Cell Significance Index: -3.8600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0228
    Cell Significance Index: -4.5700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0255
    Cell Significance Index: -3.1400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0258
    Cell Significance Index: -0.3700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0275
    Cell Significance Index: -5.7900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0319
    Cell Significance Index: -5.4500
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0328
    Cell Significance Index: -0.3600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0333
    Cell Significance Index: -4.5700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0336
    Cell Significance Index: -4.8900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0343
    Cell Significance Index: -1.1000
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0344
    Cell Significance Index: -0.3400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0362
    Cell Significance Index: -0.7500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0366
    Cell Significance Index: -0.4200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0410
    Cell Significance Index: -4.7000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0455
    Cell Significance Index: -4.6500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0458
    Cell Significance Index: -5.9200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0528
    Cell Significance Index: -3.3300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0534
    Cell Significance Index: -5.5600
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.0560
    Cell Significance Index: -0.3800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0602
    Cell Significance Index: -1.2600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0614
    Cell Significance Index: -4.8600
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: -0.0669
    Cell Significance Index: -0.6100
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0726
    Cell Significance Index: -0.9500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0754
    Cell Significance Index: -3.9300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0773
    Cell Significance Index: -5.2000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0792
    Cell Significance Index: -5.1100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0804
    Cell Significance Index: -5.9900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0835
    Cell Significance Index: -6.4100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0853
    Cell Significance Index: -5.2400
  • Cell Name: myoepithelial cell (CL0000185)
    Fold Change: -0.0943
    Cell Significance Index: -1.0700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1004
    Cell Significance Index: -4.7200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1057
    Cell Significance Index: -5.9300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1158
    Cell Significance Index: -3.4100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1159
    Cell Significance Index: -1.2600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1202
    Cell Significance Index: -6.3100
  • Cell Name: osteoblast (CL0000062)
    Fold Change: -0.1242
    Cell Significance Index: -1.2100
  • Cell Name: retinal astrocyte (CL4033015)
    Fold Change: -0.1267
    Cell Significance Index: -1.2400
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.1271
    Cell Significance Index: -1.8500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1350
    Cell Significance Index: -4.6900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1433
    Cell Significance Index: -6.3400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1464
    Cell Significance Index: -5.1300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1532
    Cell Significance Index: -4.1700
  • Cell Name: Schwann cell precursor (CL0002375)
    Fold Change: -0.1548
    Cell Significance Index: -1.2300
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: -0.1557
    Cell Significance Index: -0.3500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1610
    Cell Significance Index: -5.2700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1621
    Cell Significance Index: -6.1400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1655
    Cell Significance Index: -5.2700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1663
    Cell Significance Index: -6.1100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1679
    Cell Significance Index: -4.4900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1734
    Cell Significance Index: -4.5600
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.1795
    Cell Significance Index: -2.4900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1811
    Cell Significance Index: -5.3200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **PGE2 Receptor:** PTGER1 is a specific receptor for PGE2, a potent pro-inflammatory mediator involved in various physiological and pathological processes. 2. **GPCR:** As a GPCR, PTGER1 activates G-proteins, leading to the activation of downstream signaling pathways. 3. **Signaling Pathways:** PTGER1 is involved in multiple signaling pathways, including adenylate cyclase-activating dopamine receptor signaling, adenylate cyclase-activating g protein-coupled receptor signaling, and G alpha (q) signaling events. 4. **Cellular Expression:** PTGER1 is expressed in a variety of cells, including immune cells, non-immune cells, and neural cells, highlighting its broad functional scope. **Pathways and Functions:** PTGER1's role in immune regulation and inflammation is well-established. PGE2 binding to PTGER1 triggers the activation of G-proteins, leading to the stimulation of adenylate cyclase, which increases intracellular cyclic AMP (cAMP) levels. This increase in cAMP activates protein kinase A (PKA), leading to the phosphorylation and activation of various downstream targets, including transcription factors and ion channels. These effects contribute to the pro-inflammatory and pro-survival signaling cascades. In addition to its role in inflammation, PTGER1 is also involved in other physiological processes, including: 1. **Immune Cell Regulation:** PTGER1 modulates the function of immune cells, such as granulocytes and monocytes, influencing their proliferation, differentiation, and survival. 2. **Neuroprotection:** PTGER1 has been shown to protect against neurodegeneration and neuroinflammation, suggesting a potential role in neuroprotection. 3. **Gastrointestinal Function:** PTGER1 is involved in regulating gastrointestinal function, including motility and secretion. **Clinical Significance:** Understanding the role of PTGER1 in various physiological and pathological processes has significant clinical implications: 1. **Inflammation and Immune Disorders:** PTGER1's pro-inflammatory effects make it a potential therapeutic target for treating inflammatory and immune disorders, such as rheumatoid arthritis, asthma, and inflammatory bowel disease. 2. **Neurological Disorders:** PTGER1's neuroprotective effects suggest a potential role in treating neurodegenerative diseases, such as Alzheimer's and Parkinson's. 3. **Gastrointestinal Diseases:** PTGER1's involvement in regulating gastrointestinal function highlights its potential as a therapeutic target for treating gastrointestinal disorders, such as irritable bowel syndrome and inflammatory bowel disease. In conclusion, PTGER1 is a multifunctional receptor with significant implications for our understanding of immune regulation, inflammation, and other physiological processes. Further research is necessary to fully elucidate the role of PTGER1 in these processes and to explore its potential as a therapeutic target for various clinical applications.

Genular Protein ID: 4125997533

Symbol: PE2R1_HUMAN

Name: Prostaglandin E2 receptor EP1 subtype

UniProtKB Accession Codes:

P34995 Q5U5U4 Q86UH3 Q86VB5 Q8NHB2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 11 DrugCentral 1 EMBL 5 Ensembl 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 3 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 8253813

Title: Cloning and expression of a cDNA for the human prostaglandin E receptor EP1 subtype.

PubMed ID: 8253813

DOI: 10.1016/s0021-9258(19)74379-8

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 402
  • Mass: 41801
  • Checksum: B925359ABD86880C
  • Sequence:
    • MSPCGPLNLS LAGEATTCAA PWVPNTSAVP PSGASPALPI FSMTLGAVSN LLALALLAQA 
AGRLRRRRSA ATFLLFVASL LATDLAGHVI PGALVLRLYT AGRAPAGGAC HFLGGCMVFF 
GLCPLLLGCG MAVERCVGVT RPLLHAARVS VARARLALAA VAAVALAVAL LPLARVGRYE 
LQYPGTWCFI GLGPPGGWRQ ALLAGLFASL GLVALLAALV CNTLSGLALL RARWRRRSRR 
PPPASGPDSR RRWGAHGPRS ASASSASSIA SASTFFGGSR SSGSARRARA HDVEMVGQLV 
GIMVVSCICW SPMLVLVALA VGGWSSTSLQ RPLFLAVRLA SWNQILDPWV YILLRQAVLR 
QLLRLLPPRA GAKGGPAGLG LTPSAWEASS LRSSRHSGLS HF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.