Details for: DELEC1

Gene ID: 50514

Symbol: DELEC1

Ensembl ID: ENSG00000173077

Description: deleted in esophageal cancer 1

Associated with

  • Negative regulation of cell population proliferation
    (GO:0008285)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 2.2678
    Cell Significance Index: 139.0400
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 1.0021
    Cell Significance Index: 24.9900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.9385
    Cell Significance Index: 35.5400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.9360
    Cell Significance Index: 41.4000
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 0.8367
    Cell Significance Index: 11.7000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.7379
    Cell Significance Index: 140.4300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5155
    Cell Significance Index: 51.0000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.5010
    Cell Significance Index: 771.2000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.4390
    Cell Significance Index: 9.3500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.3885
    Cell Significance Index: 8.0600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3778
    Cell Significance Index: 341.1400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.3060
    Cell Significance Index: 564.2500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2754
    Cell Significance Index: 29.9500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2622
    Cell Significance Index: 42.6400
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.2510
    Cell Significance Index: 7.9400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.2392
    Cell Significance Index: 4.1000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2327
    Cell Significance Index: 13.9700
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.2141
    Cell Significance Index: 3.1600
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.1977
    Cell Significance Index: 1.7100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1153
    Cell Significance Index: 7.9800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0850
    Cell Significance Index: 1.1600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0798
    Cell Significance Index: 16.0100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0644
    Cell Significance Index: 12.7900
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 0.0612
    Cell Significance Index: 0.8700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0529
    Cell Significance Index: 2.7500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0403
    Cell Significance Index: 54.8400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0398
    Cell Significance Index: 14.2600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0239
    Cell Significance Index: 0.8400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0155
    Cell Significance Index: 1.0400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0123
    Cell Significance Index: 1.5800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0104
    Cell Significance Index: 0.2900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0098
    Cell Significance Index: 2.8200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0074
    Cell Significance Index: 1.0700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0069
    Cell Significance Index: 0.8500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0068
    Cell Significance Index: 1.2300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0052
    Cell Significance Index: 9.7300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0003
    Cell Significance Index: 0.1400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0057
    Cell Significance Index: -3.5900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0097
    Cell Significance Index: -4.4200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0100
    Cell Significance Index: -7.5900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0101
    Cell Significance Index: -7.4800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0108
    Cell Significance Index: -0.2700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0123
    Cell Significance Index: -6.9500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0127
    Cell Significance Index: -7.9200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0129
    Cell Significance Index: -7.0500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0153
    Cell Significance Index: -0.4400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0170
    Cell Significance Index: -0.7700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0175
    Cell Significance Index: -0.3800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0225
    Cell Significance Index: -3.8500
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.0287
    Cell Significance Index: -0.1800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0293
    Cell Significance Index: -0.2700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0293
    Cell Significance Index: -0.4200
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0319
    Cell Significance Index: -0.3300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0372
    Cell Significance Index: -7.8300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0421
    Cell Significance Index: -1.9800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0467
    Cell Significance Index: -1.2700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0485
    Cell Significance Index: -6.6600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0500
    Cell Significance Index: -1.6000
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0552
    Cell Significance Index: -0.4500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0559
    Cell Significance Index: -7.2200
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0625
    Cell Significance Index: -1.5200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0646
    Cell Significance Index: -4.9600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0649
    Cell Significance Index: -7.4300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0669
    Cell Significance Index: -6.9700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0700
    Cell Significance Index: -7.1500
  • Cell Name: Langerhans cell (CL0000453)
    Fold Change: -0.0787
    Cell Significance Index: -0.7500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0825
    Cell Significance Index: -1.6100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0929
    Cell Significance Index: -2.6500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0961
    Cell Significance Index: -7.1600
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0994
    Cell Significance Index: -0.5900
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1052
    Cell Significance Index: -1.5900
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.1091
    Cell Significance Index: -1.3200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1096
    Cell Significance Index: -5.1100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1201
    Cell Significance Index: -6.7400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1333
    Cell Significance Index: -3.9300
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1378
    Cell Significance Index: -5.9900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1416
    Cell Significance Index: -3.6400
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -0.1429
    Cell Significance Index: -0.6600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1544
    Cell Significance Index: -7.8000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1597
    Cell Significance Index: -4.2800
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: -0.1623
    Cell Significance Index: -1.1800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1630
    Cell Significance Index: -3.5700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1827
    Cell Significance Index: -5.8200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1848
    Cell Significance Index: -6.0500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1870
    Cell Significance Index: -6.5500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1884
    Cell Significance Index: -5.0300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2035
    Cell Significance Index: -7.0700
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.2076
    Cell Significance Index: -3.5900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2098
    Cell Significance Index: -7.7000
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.2274
    Cell Significance Index: -5.6800
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.2304
    Cell Significance Index: -5.8700
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.2317
    Cell Significance Index: -1.5700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2370
    Cell Significance Index: -4.9600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.2439
    Cell Significance Index: -10.0000
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.2447
    Cell Significance Index: -2.3200
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.2451
    Cell Significance Index: -2.6700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2486
    Cell Significance Index: -7.3000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2498
    Cell Significance Index: -7.1600
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2514
    Cell Significance Index: -6.2700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2568
    Cell Significance Index: -5.4500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** DELEC1 is a non-coding gene that has been identified in the human genome (Ensembl ID: ENSG00000173077). Its primary function is to regulate the negative population proliferation of cells, which is essential for maintaining tissue homeostasis and preventing uncontrolled cell growth. DELEC1 expression has been observed in a diverse range of cell types, including intestinal tuft cells, obsolete epithelial cells of the alveolus of the lung, and enteroendocrine cells of the colon. These findings suggest that DELEC1 may play a broader role in regulating cell growth and development across various tissues. **Pathways and Functions:** The DELEC1 gene is involved in the regulation of cell population proliferation, which is a critical process that ensures the proper growth and maintenance of tissues. The negative regulation of cell population proliferation mediated by DELEC1 is thought to occur through the repression of cell cycle regulators, such as cyclin-dependent kinases (CDKs) and cyclin-dependent kinase inhibitors (CKIs). This repression prevents the uncontrolled proliferation of cells, which is a hallmark of cancer. DELEC1 may also interact with other signaling pathways, such as the Wnt/β-catenin pathway, to regulate cell growth and differentiation. **Clinical Significance:** The identification of DELEC1 as a tumor suppressor gene has significant implications for our understanding of cancer development and progression. Esophageal cancer, for example, is a type of cancer that is often associated with genetic alterations in tumor suppressor genes. The loss of DELEC1 expression has been observed in esophageal cancer tissues, suggesting that DELEC1 may play a role in the suppression of cancer development. Furthermore, the expression of DELEC1 in other tissues, such as the colon and lung, may indicate its role in maintaining tissue homeostasis and preventing cancer. In conclusion, the DELEC1 gene is a fascinating example of a non-coding gene that plays a critical role in regulating cell population proliferation and maintaining tissue homeostasis. Further research is needed to fully elucidate the mechanisms by which DELEC1 regulates cell growth and differentiation, as well as its role in cancer suppression. However, the current evidence suggests that DELEC1 is an important gene that warrants further investigation in the context of cancer research and tissue biology.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.