Details for: OGN

Gene ID: 4969

Symbol: OGN

Ensembl ID: ENSG00000106809

Description: osteoglycin

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 5.55
    Marker Score: 16176.5
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 4.92
    Marker Score: 14589
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 3.95
    Marker Score: 11350
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 3.42
    Marker Score: 9746
  • Cell Name: theca cell (CL0000503)
    Fold Change: 2.54
    Marker Score: 1821
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 2.46
    Marker Score: 32434
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.24
    Marker Score: 76191
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 2.01
    Marker Score: 3095
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.99
    Marker Score: 458
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 1.98
    Marker Score: 1685
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.95
    Marker Score: 12676
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.75
    Marker Score: 4580
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.6
    Marker Score: 1163
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.55
    Marker Score: 6685
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 1.53
    Marker Score: 1842
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.52
    Marker Score: 752
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 169137
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 1.42
    Marker Score: 1747
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.39
    Marker Score: 15655
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.27
    Marker Score: 313
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 1.16
    Marker Score: 401
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 1.12
    Marker Score: 450
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.09
    Marker Score: 694.5
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.02
    Marker Score: 328
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71816
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48041
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 504
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 457
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 0.93
    Marker Score: 389
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5312
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 0.93
    Marker Score: 228
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 371
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2737
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 0.9
    Marker Score: 225
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 323
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 0.9
    Marker Score: 225
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.88
    Marker Score: 852
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5283
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.86
    Marker Score: 1042
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.83
    Marker Score: 637
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.83
    Marker Score: 1148.5
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1266
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 706
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 394
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.71
    Marker Score: 2980
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.71
    Marker Score: 813
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 177
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.63
    Marker Score: 367
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 0.61
    Marker Score: 464
  • Cell Name: adipose microvascular endothelial cell (CL2000072)
    Fold Change: 0.61
    Marker Score: 181
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.57
    Marker Score: 276
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 0.56
    Marker Score: 254
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.55
    Marker Score: 156
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.54
    Marker Score: 172
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 0.53
    Marker Score: 119
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.51
    Marker Score: 289
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 0.49
    Marker Score: 677
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.49
    Marker Score: 913
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.47
    Marker Score: 2818
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.45
    Marker Score: 118
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.45
    Marker Score: 447
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.43
    Marker Score: 285
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.43
    Marker Score: 663
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.43
    Marker Score: 283
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.42
    Marker Score: 571
  • Cell Name: tendon cell (CL0000388)
    Fold Change: 0.41
    Marker Score: 102
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.41
    Marker Score: 836
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.41
    Marker Score: 169
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.41
    Marker Score: 267
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.39
    Marker Score: 124
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.38
    Marker Score: 463
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.38
    Marker Score: 953
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.38
    Marker Score: 240
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.38
    Marker Score: 5052
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.38
    Marker Score: 159
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.36
    Marker Score: 427
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.36
    Marker Score: 166
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 0.35
    Marker Score: 133
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.35
    Marker Score: 91
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 0.35
    Marker Score: 126.5
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.35
    Marker Score: 98
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.34
    Marker Score: 799
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.32
    Marker Score: 342
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 0.32
    Marker Score: 136
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.3
    Marker Score: 136
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.3
    Marker Score: 79
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.3
    Marker Score: 185
  • Cell Name: smooth muscle cell of small intestine (CL1000275)
    Fold Change: 0.29
    Marker Score: 76
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.27
    Marker Score: 74
  • Cell Name: ventricular cardiac muscle cell (CL2000046)
    Fold Change: 0.27
    Marker Score: 111
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.26
    Marker Score: 509
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.26
    Marker Score: 293
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.26
    Marker Score: 232
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.26
    Marker Score: 175
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.25
    Marker Score: 99
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.25
    Marker Score: 476
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.25
    Marker Score: 160

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Other Information

## Summary The OGN gene encodes for osteoglycan, a protein that plays a crucial role in the development, maintenance, and function of cartilage. It is involved in various cellular processes, including cell migration, tissue repair, and differentiation. ## Key characteristics * OGN is a large protein with a molecular weight of approximately 180 kDa. * It is a glycoprotein with a unique structure that allows it to interact with both collagen and proteoglycans. * OGN is highly expressed in articular cartilage, where it is essential for the integrity of the extracellular matrix. * Mutations in the OGN gene have been linked to several diseases, including rheumatoid arthritis, osteoarthritis, and osteoporosis. ## Pathways and functions * OGN is involved in several cellular processes, including cell migration, tissue repair, and differentiation. * It is a key regulator of the development of the embryonic joint. * It is also involved in the regulation of cartilage metabolism and remodeling. * Mutations in the OGN gene have been linked to the development of cartilage defects and joint diseases. ## Clinical significance * OGN is a potential therapeutic target for cartilage diseases. * Inhibition of OGN has been shown to be effective in preventing the progression of cartilage defects in animal models. * Therefore, OGN is a promising target for the treatment of cartilage diseases. ## Other important points * OGN is a highly conserved protein, with a similar gene found in other mammals. * Mutations in the OGN gene have been linked to a wide range of human diseases, including rheumatoid arthritis, osteoarthritis, and osteoporosis. * The exact mechanisms by which OGN mutations contribute to disease are still being investigated.

Genular Protein ID: 1297566582

Symbol: MIME_HUMAN

Name: Mimecan

UniProtKB Accession Codes:

P20774 Q6FIB0 Q9UF90 Q9UNK5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 15 Ensembl 4 ExpressionAtlas 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 5 RefSeq 3 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2372374

Title: Molecular cloning of a novel bone-forming compound: osteoinductive factor.

PubMed ID: 2372374

DOI: 10.1089/dna.1990.9.303

PubMed ID: 10802664

Title: Mutations in KERA, encoding keratocan, cause cornea plana.

PubMed ID: 10802664

DOI: 10.1038/75664

PubMed ID: 10931946

Title: Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.

PubMed ID: 10931946

DOI: 10.1073/pnas.160270997

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10373482

Title: The bovine mimecan gene. Molecular cloning and characterization of two major RNA transcripts generated by alternative use of two splice acceptor sites in the third exon.

PubMed ID: 10373482

DOI: 10.1074/jbc.274.26.18693

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 19838169

Title: Enrichment of glycopeptides for glycan structure and attachment site identification.

PubMed ID: 19838169

DOI: 10.1038/nmeth.1392

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 298
  • Mass: 33922
  • Checksum: F4590785C3849F83
  • Sequence:
    • MKTLQSTLLL LLLVPLIKPA PPTQQDSRII YDYGTDNFEE SIFSQDYEDK YLDGKNIKEK 
ETVIIPNEKS LQLQKDEAIT PLPPKKENDE MPTCLLCVCL SGSVYCEEVD IDAVPPLPKE 
SAYLYARFNK IKKLTAKDFA DIPNLRRLDF TGNLIEDIED GTFSKLSLLE ELSLAENQLL 
KLPVLPPKLT LFNAKYNKIK SRGIKANAFK KLNNLTFLYL DHNALESVPL NLPESLRVIH 
LQFNNIASIT DDTFCKANDT SYIRDRIEEI RLEGNPIVLG KHPNSFICLK RLPIGSYF

Genular Protein ID: 2785924531

Symbol: B4DI63_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DI63

Database IDs:

ARBA 8 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 2 GO 1 Gene3D 1 GenomeRNAi 1 InterPro 4 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 1 PeptideAtlas 1 Pfam 1 RefSeq 3 SMART 1 SUPFAM 1

Sequence Information:

  • Length: 356
  • Mass: 40553
  • Checksum: C8D8262AC2BE4DFF
  • Sequence:
    • MLAKISTTWK LFLKLLGPEI LLSSLKSRHS FSHSPSHLGL MHRHEHLLRK TTKNFKTATT 
TLQSTLLLLL LVPLIKPAPP TQQDSRIIYD YGTDNFEESI FSQDYEDKYL DGKNIKEKET 
VIIPNEKSLQ LQKDEAITPL PPKKENDEMP TCLLCVCLSG SVYCEEVDID AVPPLPKESA 
YLYARFNKIK KLTAKDFADI PNLRRLDFTG NLIEDIEDGT FSKLSLLEEL SLAENQLLKL 
PVLPPKLTLF NAKYNKIKSR GIKANAFKKL NNLTFLYLDH NALESVPLNL PESLRVIHLQ 
FNNIASITDD TFCKANDTSY IRDRIEEIRL EGNPIVLGKH PNSFICLKRL PIGSYF

Genular Protein ID: 3881658251

Symbol: Q7Z532_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q7Z532

Database IDs:

ARBA 8 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 2 Gene3D 1 Genevisible 1 GenomeRNAi 1 InterPro 4 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 2 SAM 1 SMART 1 SUPFAM 1

Sequence Information:

  • Length: 298
  • Mass: 33922
  • Checksum: EFE31C24799F2583
  • Sequence:
    • MKTLQSTLLL LLLVPLIKPA PPTQQDSRII YDYGTDNFEE SIFSQDYEDK YLDGKNIKEK 
ETVIIPNEKS LQLQKDEAIT PLPPKKENDE MPTCLLCVCL SGSVYCEEVD IDAVPPLPKE 
SAYLYARFNK IKKLTAKDFA DIPNLRRLDF TGNLIEDIED GTFSKLSLLE ELSLAENQLL 
KLPVLPPKLT LFNAKYNKIK SRGIKANAFQ KLNNLTFLYL DHNALESVPL NLPESLRVIH 
LQFNNIASIT DDTFCKANDT SYIRDRIEEI RLEGNPIVLG KHPNSFICLK RLPIGSYF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.