Details for: OGN

Gene ID: 4969

Symbol: OGN

Ensembl ID: ENSG00000106809

Description: osteoglycin

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 72.5428
    Cell Significance Index: -18.4000
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 46.5593
    Cell Significance Index: -19.1800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 35.0517
    Cell Significance Index: -14.2400
  • Cell Name: theca cell (CL0000503)
    Fold Change: 15.8212
    Cell Significance Index: 92.9500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 15.1873
    Cell Significance Index: -14.5000
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 8.9660
    Cell Significance Index: 55.4700
  • Cell Name: chondroblast (CL0000058)
    Fold Change: 6.1993
    Cell Significance Index: 36.3900
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 5.0036
    Cell Significance Index: 64.0800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 4.4189
    Cell Significance Index: 126.6700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.3126
    Cell Significance Index: -7.2500
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 3.2871
    Cell Significance Index: 52.1500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 2.3046
    Cell Significance Index: 44.9800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.8802
    Cell Significance Index: 39.3600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.6946
    Cell Significance Index: 232.7200
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.2588
    Cell Significance Index: 19.4800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.2069
    Cell Significance Index: 154.7200
  • Cell Name: articular chondrocyte (CL1001607)
    Fold Change: 0.9004
    Cell Significance Index: 4.8800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.7520
    Cell Significance Index: 19.3300
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.6765
    Cell Significance Index: 3.5600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.5050
    Cell Significance Index: 10.4800
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: 0.3020
    Cell Significance Index: 1.8500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2756
    Cell Significance Index: 54.6900
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 0.1676
    Cell Significance Index: 1.9300
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.1184
    Cell Significance Index: 1.7000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1155
    Cell Significance Index: 23.1700
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.1012
    Cell Significance Index: 1.1000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0609
    Cell Significance Index: 1.0200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0469
    Cell Significance Index: 32.4300
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.0436
    Cell Significance Index: 0.4200
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: 0.0334
    Cell Significance Index: 0.1600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0204
    Cell Significance Index: 27.7000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0202
    Cell Significance Index: 37.2700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0166
    Cell Significance Index: 25.5500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0041
    Cell Significance Index: 7.6300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0003
    Cell Significance Index: -0.1200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0093
    Cell Significance Index: -0.4700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0146
    Cell Significance Index: -9.3000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0196
    Cell Significance Index: -8.6600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0240
    Cell Significance Index: -18.1300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0263
    Cell Significance Index: -19.4800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0281
    Cell Significance Index: -15.8700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0289
    Cell Significance Index: -13.1000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0346
    Cell Significance Index: -18.8900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0352
    Cell Significance Index: -6.3500
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.0357
    Cell Significance Index: -0.3900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0361
    Cell Significance Index: -22.5700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0364
    Cell Significance Index: -2.0400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0390
    Cell Significance Index: -4.7900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0439
    Cell Significance Index: -12.6200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0747
    Cell Significance Index: -4.5900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0820
    Cell Significance Index: -11.9200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0825
    Cell Significance Index: -3.6500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0939
    Cell Significance Index: -19.7700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1043
    Cell Significance Index: -8.0100
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.1048
    Cell Significance Index: -0.7100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1092
    Cell Significance Index: -7.7200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1131
    Cell Significance Index: -13.1800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1227
    Cell Significance Index: -4.6500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1331
    Cell Significance Index: -17.1900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1353
    Cell Significance Index: -23.1000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1435
    Cell Significance Index: -14.6600
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1504
    Cell Significance Index: -3.2200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1621
    Cell Significance Index: -4.5300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1701
    Cell Significance Index: -17.7100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1726
    Cell Significance Index: -8.1100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1775
    Cell Significance Index: -20.9300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1871
    Cell Significance Index: -21.4400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.1891
    Cell Significance Index: -18.7100
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.1911
    Cell Significance Index: -1.6100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2139
    Cell Significance Index: -11.1400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2274
    Cell Significance Index: -16.9500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2762
    Cell Significance Index: -17.8200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3058
    Cell Significance Index: -18.7500
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.3264
    Cell Significance Index: -14.1900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3804
    Cell Significance Index: -19.7600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.3983
    Cell Significance Index: -14.0000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4030
    Cell Significance Index: -11.8700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.4085
    Cell Significance Index: -7.0000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4096
    Cell Significance Index: -14.3500
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.4231
    Cell Significance Index: -9.7800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.4312
    Cell Significance Index: -20.1100
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.4496
    Cell Significance Index: -4.3500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4542
    Cell Significance Index: -15.7900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4587
    Cell Significance Index: -16.8400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4631
    Cell Significance Index: -14.7500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4646
    Cell Significance Index: -15.2100
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.4749
    Cell Significance Index: -7.0100
  • Cell Name: retinal astrocyte (CL4033015)
    Fold Change: -0.4986
    Cell Significance Index: -4.8800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.5066
    Cell Significance Index: -12.1500
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.5321
    Cell Significance Index: -16.8300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.5454
    Cell Significance Index: -14.5900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.5506
    Cell Significance Index: -5.7000
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.5646
    Cell Significance Index: -14.0800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.5777
    Cell Significance Index: -15.4800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.5794
    Cell Significance Index: -15.4700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.5855
    Cell Significance Index: -23.9900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.6126
    Cell Significance Index: -15.2800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.6241
    Cell Significance Index: -18.3300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.6336
    Cell Significance Index: -16.6600
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: -0.6347
    Cell Significance Index: -5.8900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** OGN is a small leucine-rich proteoglycan with a molecular weight of approximately 30-40 kDa. It is composed of a core protein and a covalently attached glycosaminoglycan chain, primarily composed of keratan sulfate. OGN is expressed in various tissues, including the eye, bone, and connective tissue, and is highly regulated by post-translational modifications, such as glycosylation and proteolytic processing. **Pathways and Functions:** OGN plays a critical role in regulating the structure and function of the extracellular matrix through its interaction with growth factors, cell surface receptors, and other matrix components. Key pathways and functions of OGN include: 1. **Articular Cartilage Development:** OGN is essential for the formation and maintenance of articular cartilage, which is critical for joint health and function. 2. **Bone Development:** OGN regulates bone growth and development by modulating the activity of growth factors, such as bone morphogenetic protein-2 (BMP-2). 3. **Collagen-Containing Extracellular Matrix:** OGN interacts with collagen and other matrix components to regulate the structure and function of the extracellular matrix. 4. **Glycosaminoglycan Metabolism:** OGN is involved in the regulation of GAG metabolism, including the synthesis and degradation of keratan sulfate. 5. **Signal Transduction:** OGN interacts with cell surface receptors to regulate signal transduction pathways, including those involved in cell proliferation, differentiation, and survival. **Clinical Significance:** Dysregulation of OGN has been implicated in various diseases, including: 1. **Osteoarthritis:** OGN deficiency has been linked to osteoarthritis, a degenerative joint disease characterized by cartilage loss and joint pain. 2. **Bone Diseases:** OGN mutations have been associated with bone diseases, such as osteogenesis imperfecta and bone mineralization disorders. 3. **Eye Diseases:** OGN is involved in the development and maintenance of the eye, and its dysregulation has been linked to eye diseases, such as keratoconus and age-related macular degeneration. 4. **Cancer:** OGN has been implicated in cancer progression, including the regulation of cell proliferation, invasion, and metastasis. In conclusion, Osteoglycin (OGN) plays a crucial role in maintaining tissue homeostasis through its regulation of the extracellular matrix, growth factor activity, and glycosaminoglycan metabolism. Dysregulation of OGN has been implicated in various diseases, highlighting the importance of this protein in maintaining tissue health and function. Further research is needed to fully elucidate the mechanisms by which OGN regulates tissue homeostasis and to develop therapeutic strategies for the treatment of OGN-related diseases.

Genular Protein ID: 1297566582

Symbol: MIME_HUMAN

Name: Mimecan

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 2372374

Title: Molecular cloning of a novel bone-forming compound: osteoinductive factor.

PubMed ID: 2372374

DOI: 10.1089/dna.1990.9.303

PubMed ID: 10802664

Title: Mutations in KERA, encoding keratocan, cause cornea plana.

PubMed ID: 10802664

DOI: 10.1038/75664

PubMed ID: 10931946

Title: Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.

PubMed ID: 10931946

DOI: 10.1073/pnas.160270997

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10373482

Title: The bovine mimecan gene. Molecular cloning and characterization of two major RNA transcripts generated by alternative use of two splice acceptor sites in the third exon.

PubMed ID: 10373482

DOI: 10.1074/jbc.274.26.18693

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 19838169

Title: Enrichment of glycopeptides for glycan structure and attachment site identification.

PubMed ID: 19838169

DOI: 10.1038/nmeth.1392

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 298
  • Mass: 33922
  • Checksum: F4590785C3849F83
  • Sequence:
  • MKTLQSTLLL LLLVPLIKPA PPTQQDSRII YDYGTDNFEE SIFSQDYEDK YLDGKNIKEK 
    ETVIIPNEKS LQLQKDEAIT PLPPKKENDE MPTCLLCVCL SGSVYCEEVD IDAVPPLPKE 
    SAYLYARFNK IKKLTAKDFA DIPNLRRLDF TGNLIEDIED GTFSKLSLLE ELSLAENQLL 
    KLPVLPPKLT LFNAKYNKIK SRGIKANAFK KLNNLTFLYL DHNALESVPL NLPESLRVIH 
    LQFNNIASIT DDTFCKANDT SYIRDRIEEI RLEGNPIVLG KHPNSFICLK RLPIGSYF

Genular Protein ID: 2785924531

Symbol: B4DI63_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 356
  • Mass: 40553
  • Checksum: C8D8262AC2BE4DFF
  • Sequence:
  • MLAKISTTWK LFLKLLGPEI LLSSLKSRHS FSHSPSHLGL MHRHEHLLRK TTKNFKTATT 
    TLQSTLLLLL LVPLIKPAPP TQQDSRIIYD YGTDNFEESI FSQDYEDKYL DGKNIKEKET 
    VIIPNEKSLQ LQKDEAITPL PPKKENDEMP TCLLCVCLSG SVYCEEVDID AVPPLPKESA 
    YLYARFNKIK KLTAKDFADI PNLRRLDFTG NLIEDIEDGT FSKLSLLEEL SLAENQLLKL 
    PVLPPKLTLF NAKYNKIKSR GIKANAFKKL NNLTFLYLDH NALESVPLNL PESLRVIHLQ 
    FNNIASITDD TFCKANDTSY IRDRIEEIRL EGNPIVLGKH PNSFICLKRL PIGSYF

Genular Protein ID: 3881658251

Symbol: Q7Z532_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 298
  • Mass: 33922
  • Checksum: EFE31C24799F2583
  • Sequence:
  • MKTLQSTLLL LLLVPLIKPA PPTQQDSRII YDYGTDNFEE SIFSQDYEDK YLDGKNIKEK 
    ETVIIPNEKS LQLQKDEAIT PLPPKKENDE MPTCLLCVCL SGSVYCEEVD IDAVPPLPKE 
    SAYLYARFNK IKKLTAKDFA DIPNLRRLDF TGNLIEDIED GTFSKLSLLE ELSLAENQLL 
    KLPVLPPKLT LFNAKYNKIK SRGIKANAFQ KLNNLTFLYL DHNALESVPL NLPESLRVIH 
    LQFNNIASIT DDTFCKANDT SYIRDRIEEI RLEGNPIVLG KHPNSFICLK RLPIGSYF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.