Details for: LOXL2

Gene ID: 4017

Symbol: LOXL2

Ensembl ID: ENSG00000134013

Description: lysyl oxidase like 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 2.42
    Marker Score: 6935
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.81
    Marker Score: 566
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.71
    Marker Score: 11129
  • Cell Name: oocyte (CL0000023)
    Fold Change: 1.67
    Marker Score: 414
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 1.62
    Marker Score: 1953
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.6
    Marker Score: 21065
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.59
    Marker Score: 1159
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 1.49
    Marker Score: 843
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168981
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 1.4
    Marker Score: 512
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 1.39
    Marker Score: 1914
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.24
    Marker Score: 1560
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.23
    Marker Score: 347
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.22
    Marker Score: 1774
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.21
    Marker Score: 1136
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.14
    Marker Score: 4797
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.13
    Marker Score: 711.5
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.13
    Marker Score: 17604
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 1.12
    Marker Score: 252
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251786
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 1.01
    Marker Score: 6060
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71805
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48029
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 502
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.97
    Marker Score: 2288
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 456
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2411
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.92
    Marker Score: 369
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.92
    Marker Score: 2020
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.91
    Marker Score: 436
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2734
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.9
    Marker Score: 592
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.9
    Marker Score: 311
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 322
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.89
    Marker Score: 5097
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.89
    Marker Score: 1805
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.88
    Marker Score: 404
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5279
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.85
    Marker Score: 487
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.85
    Marker Score: 1993
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.83
    Marker Score: 1277
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.81
    Marker Score: 262
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.79
    Marker Score: 8911
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1251
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.76
    Marker Score: 25893
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.76
    Marker Score: 694
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.76
    Marker Score: 578.5
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 391
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 0.71
    Marker Score: 158
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.69
    Marker Score: 747
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 177
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.69
    Marker Score: 922
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.67
    Marker Score: 1291
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.67
    Marker Score: 322
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 0.67
    Marker Score: 252
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.66
    Marker Score: 759
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.66
    Marker Score: 434
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 0.64
    Marker Score: 150
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.64
    Marker Score: 371
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.63
    Marker Score: 198
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.63
    Marker Score: 773.5
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.61
    Marker Score: 366
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.6
    Marker Score: 337
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.6
    Marker Score: 538
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 0.59
    Marker Score: 143
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.58
    Marker Score: 623
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.58
    Marker Score: 612
  • Cell Name: centroblast (CL0009112)
    Fold Change: 0.57
    Marker Score: 283
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.57
    Marker Score: 240
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.57
    Marker Score: 1701
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.56
    Marker Score: 1119
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.56
    Marker Score: 145
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.55
    Marker Score: 230
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.54
    Marker Score: 322
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.51
    Marker Score: 136
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.5
    Marker Score: 4782
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.48
    Marker Score: 466
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.48
    Marker Score: 4115
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 0.47
    Marker Score: 212
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.47
    Marker Score: 208
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.46
    Marker Score: 111
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.45
    Marker Score: 407
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.44
    Marker Score: 438
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.44
    Marker Score: 676
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.44
    Marker Score: 106
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.44
    Marker Score: 234
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.44
    Marker Score: 276
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.43
    Marker Score: 541
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.43
    Marker Score: 521
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.43
    Marker Score: 136
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.42
    Marker Score: 794
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.42
    Marker Score: 300
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.41
    Marker Score: 107
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.41
    Marker Score: 434
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.4
    Marker Score: 1689
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.39
    Marker Score: 263
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.38
    Marker Score: 194
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.38
    Marker Score: 97

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Other Information

**Key characteristics:** * LOXL2 is a transmembrane protein with a molecular weight of approximately 120 kDa. * It is expressed in high levels in the retina, kidney, and oocyte. * It is a key regulator of endothelial cell proliferation and migration. * Mutations in LOXL2 have been linked to several human diseases, including age-related macular degeneration (AMD), diabetic retinopathy, and cardiovascular diseases. **Pathways and functions:** * LOXL2 is involved in the assembly of collagen fibrils and other multimeric structures. It is a key factor in the formation of the extracellular matrix (ECM), which provides structural support for cells and tissues. * It is also involved in the regulation of endothelial cell proliferation and migration. LOXL2 is expressed in high levels in endothelial cells, and its overexpression leads to the formation of new blood vessels and the growth of new tissues. * Mutations in LOXL2 have been linked to the development of several human diseases, including AMD and diabetic retinopathy. In AMD, LOXL2 mutations lead to the accumulation of lysyl residues in the collagenous matrix, which can damage the retina and lead to vision loss. In diabetic retinopathy, LOXL2 mutations lead to the formation of blood-brain barriers, which can lead to the development of brain tumors. **Clinical significance:** LOXL2 is a promising target for the treatment of several human diseases. By targeting LOXL2, it may be possible to inhibit the formation of blood-brain barriers and prevent the development of neurodegenerative diseases.

Genular Protein ID: 3852803537

Symbol: LOXL2_HUMAN

Name: Lysyl oxidase homolog 2

UniProtKB Accession Codes:

Q9Y4K0 B2R5Q0 Q53HV3 Q9BW70 Q9Y5Y8

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 17 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 6 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 27 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 1 PRINTS 2 PRO 1 PROSITE 3 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 Rhea 3 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9079631

Title: Regulation of a novel gene encoding a lysyl oxidase-related protein in cellular adhesion and senescence.

PubMed ID: 9079631

DOI: 10.1074/jbc.272.13.8157

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10212285

Title: The LOXL2 gene encodes a new lysyl oxidase-like protein and is expressed at high levels in reproductive tissues.

PubMed ID: 10212285

DOI: 10.1074/jbc.274.18.12939

PubMed ID: 16096638

Title: A molecular role for lysyl oxidase-like 2 enzyme in snail regulation and tumor progression.

PubMed ID: 16096638

DOI: 10.1038/sj.emboj.7600781

PubMed ID: 20026874

Title: The lysyl oxidases LOX and LOXL2 are necessary and sufficient to repress E-cadherin in hypoxia: insights into cellular transformation processes mediated by HIF-1.

PubMed ID: 20026874

DOI: 10.1074/jbc.m109.042424

PubMed ID: 20439985

Title: Modulation of lysyl oxidase-like 2 enzymatic activity by an allosteric antibody inhibitor.

PubMed ID: 20439985

DOI: 10.1074/jbc.m109.094136

PubMed ID: 20818376

Title: Allosteric inhibition of lysyl oxidase-like-2 impedes the development of a pathologic microenvironment.

PubMed ID: 20818376

DOI: 10.1038/nm.2208

PubMed ID: 21835952

Title: Lysyl oxidase-like protein-2 regulates sprouting angiogenesis and type IV collagen assembly in the endothelial basement membrane.

PubMed ID: 21835952

DOI: 10.1182/blood-2010-10-313296

PubMed ID: 21233336

Title: LOXL2-mediated matrix remodeling in metastasis and mammary gland involution.

PubMed ID: 21233336

DOI: 10.1158/0008-5472.can-10-2868

PubMed ID: 21732535

Title: Lysyl oxidase-like 2 (LOXL2), a new regulator of cell polarity required for metastatic dissemination of basal-like breast carcinomas.

PubMed ID: 21732535

DOI: 10.1002/emmm.201100156

PubMed ID: 20306300

Title: The human lysyl oxidase-like 2 protein functions as an amine oxidase toward collagen and elastin.

PubMed ID: 20306300

DOI: 10.1007/s11033-010-0088-0

PubMed ID: 22204712

Title: Reduced nuclear and ectopic cytoplasmic expression of lysyl oxidase-like 2 is associated with lymph node metastasis and poor prognosis in esophageal squamous cell carcinoma.

PubMed ID: 22204712

DOI: 10.1016/j.humpath.2011.07.027

PubMed ID: 22157764

Title: The enzymatic activity of lysyl oxidas-like-2 (LOXL2) is not required for LOXL2-induced inhibition of keratinocyte differentiation.

PubMed ID: 22157764

DOI: 10.1074/jbc.m111.261016

PubMed ID: 22483618

Title: Lysyl oxidase-like 2 deaminates lysine 4 in histone H3.

PubMed ID: 22483618

DOI: 10.1016/j.molcel.2012.03.002

PubMed ID: 27392148

Title:

PubMed ID: 27392148

DOI: 10.1016/j.molcel.2016.06.013

PubMed ID: 27339457

Title: Functional consequence of fibulin-4 missense mutations associated with vascular and skeletal abnormalities and cutis laxa.

PubMed ID: 27339457

DOI: 10.1016/j.matbio.2016.06.003

PubMed ID: 23319596

Title: Post-translational modifications of recombinant human lysyl oxidase-like 2 (rhLOXL2) secreted from Drosophila S2 cells.

PubMed ID: 23319596

DOI: 10.1074/jbc.c112.421768

PubMed ID: 24239292

Title: Regulation of heterochromatin transcription by Snail1/LOXL2 during epithelial-to-mesenchymal transition.

PubMed ID: 24239292

DOI: 10.1016/j.molcel.2013.10.015

PubMed ID: 24414204

Title: LOXL2 catalytically inactive mutants mediate epithelial-to-mesenchymal transition.

PubMed ID: 24414204

DOI: 10.1242/bio.20146841

PubMed ID: 25959397

Title: LOXL2 oxidizes methylated TAF10 and controls TFIID-dependent genes during neural progenitor differentiation.

PubMed ID: 25959397

DOI: 10.1016/j.molcel.2015.04.012

PubMed ID: 27735137

Title: Lysyl oxidase-like 2 (LOXL2) oxidizes trimethylated lysine 4 in histone H3.

PubMed ID: 27735137

DOI: 10.1111/febs.13922

PubMed ID: 28332555

Title: LOXL2 drives epithelial-mesenchymal transition via activation of IRE1-XBP1 signalling pathway.

PubMed ID: 28332555

DOI: 10.1038/srep44988

PubMed ID: 29581294

Title: Crystal structure of human lysyl oxidase-like 2 (hLOXL2) in a precursor state.

PubMed ID: 29581294

DOI: 10.1073/pnas.1720859115

Sequence Information:

  • Length: 774
  • Mass: 86725
  • Checksum: 9DF5D25D4824BCCD
  • Sequence:
    • MERPLCSHLC SCLAMLALLS PLSLAQYDSW PHYPEYFQQP APEYHQPQAP ANVAKIQLRL 
AGQKRKHSEG RVEVYYDGQW GTVCDDDFSI HAAHVVCREL GYVEAKSWTA SSSYGKGEGP 
IWLDNLHCTG NEATLAACTS NGWGVTDCKH TEDVGVVCSD KRIPGFKFDN SLINQIENLN 
IQVEDIRIRA ILSTYRKRTP VMEGYVEVKE GKTWKQICDK HWTAKNSRVV CGMFGFPGER 
TYNTKVYKMF ASRRKQRYWP FSMDCTGTEA HISSCKLGPQ VSLDPMKNVT CENGLPAVVS 
CVPGQVFSPD GPSRFRKAYK PEQPLVRLRG GAYIGEGRVE VLKNGEWGTV CDDKWDLVSA 
SVVCRELGFG SAKEAVTGSR LGQGIGPIHL NEIQCTGNEK SIIDCKFNAE SQGCNHEEDA 
GVRCNTPAMG LQKKLRLNGG RNPYEGRVEV LVERNGSLVW GMVCGQNWGI VEAMVVCRQL 
GLGFASNAFQ ETWYWHGDVN SNKVVMSGVK CSGTELSLAH CRHDGEDVAC PQGGVQYGAG 
VACSETAPDL VLNAEMVQQT TYLEDRPMFM LQCAMEENCL SASAAQTDPT TGYRRLLRFS 
SQIHNNGQSD FRPKNGRHAW IWHDCHRHYH SMEVFTHYDL LNLNGTKVAE GHKASFCLED 
TECEGDIQKN YECANFGDQG ITMGCWDMYR HDIDCQWVDI TDVPPGDYLF QVVINPNFEV 
AESDYSNNIM KCRSRYDGHR IWMYNCHIGG SFSEETEKKF EHFSGLLNNQ LSPQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.