Details for: WT1 AS

Gene ID: 51352

Symbol: WT1 AS

Ensembl ID: ENSG00000183242

Description: WT1 antisense RNA

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 15.7421
    Cell Significance Index: 133.8000
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 4.1892
    Cell Significance Index: 67.2100
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 3.8388
    Cell Significance Index: 30.6500
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 1.9691
    Cell Significance Index: 13.6600
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.0230
    Cell Significance Index: 12.0900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.9934
    Cell Significance Index: 34.5200
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.9713
    Cell Significance Index: 22.4400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.7557
    Cell Significance Index: 103.7900
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.7085
    Cell Significance Index: 10.1900
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.6827
    Cell Significance Index: 9.9500
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.6560
    Cell Significance Index: 15.8900
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 0.4932
    Cell Significance Index: 5.6800
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.3083
    Cell Significance Index: 3.1300
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.3031
    Cell Significance Index: 4.6900
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.2191
    Cell Significance Index: 2.1700
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.2178
    Cell Significance Index: 2.1000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.1947
    Cell Significance Index: 3.8000
  • Cell Name: tendon cell (CL0000388)
    Fold Change: 0.1581
    Cell Significance Index: 2.1500
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.1575
    Cell Significance Index: 1.7200
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.1511
    Cell Significance Index: 2.1700
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.1087
    Cell Significance Index: 0.9400
  • Cell Name: theca cell (CL0000503)
    Fold Change: 0.0919
    Cell Significance Index: 0.5400
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.0801
    Cell Significance Index: 2.0000
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: 0.0747
    Cell Significance Index: 0.6000
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.0585
    Cell Significance Index: 0.2700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0210
    Cell Significance Index: 0.3600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0099
    Cell Significance Index: 0.4500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0089
    Cell Significance Index: 2.5700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0070
    Cell Significance Index: 1.4000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0003
    Cell Significance Index: -0.0100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0007
    Cell Significance Index: -1.2900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0010
    Cell Significance Index: -1.9500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0012
    Cell Significance Index: -1.7900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0014
    Cell Significance Index: -0.4900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0017
    Cell Significance Index: -2.3600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0048
    Cell Significance Index: -3.0400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0058
    Cell Significance Index: -4.3700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0059
    Cell Significance Index: -4.3900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0065
    Cell Significance Index: -2.9700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0078
    Cell Significance Index: -4.4100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0080
    Cell Significance Index: -4.3600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0127
    Cell Significance Index: -0.5900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0151
    Cell Significance Index: -2.7300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0184
    Cell Significance Index: -3.1500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0185
    Cell Significance Index: -2.6900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0196
    Cell Significance Index: -1.0200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0212
    Cell Significance Index: -4.4600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0264
    Cell Significance Index: -3.0300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0283
    Cell Significance Index: -3.4800
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: -0.0315
    Cell Significance Index: -0.3300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0327
    Cell Significance Index: -3.3400
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.0352
    Cell Significance Index: -0.5000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0404
    Cell Significance Index: -1.1900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0427
    Cell Significance Index: -4.4500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0468
    Cell Significance Index: -1.2300
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: -0.0470
    Cell Significance Index: -0.4500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0476
    Cell Significance Index: -3.6500
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: -0.0556
    Cell Significance Index: -0.6500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0558
    Cell Significance Index: -3.4300
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: -0.0606
    Cell Significance Index: -0.5000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0630
    Cell Significance Index: -0.8600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0660
    Cell Significance Index: -1.1100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0696
    Cell Significance Index: -3.2700
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0718
    Cell Significance Index: -0.7100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0718
    Cell Significance Index: -2.3000
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0746
    Cell Significance Index: -2.3600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0765
    Cell Significance Index: -4.3000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0775
    Cell Significance Index: -2.5400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0779
    Cell Significance Index: -2.7300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0817
    Cell Significance Index: -2.6000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0838
    Cell Significance Index: -2.2800
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0857
    Cell Significance Index: -1.2200
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0858
    Cell Significance Index: -1.1900
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0895
    Cell Significance Index: -2.2800
  • Cell Name: podocyte (CL0000653)
    Fold Change: -0.0942
    Cell Significance Index: -1.0800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0943
    Cell Significance Index: -4.1700
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.0945
    Cell Significance Index: -1.5000
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.0948
    Cell Significance Index: -1.3300
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0973
    Cell Significance Index: -1.0600
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1058
    Cell Significance Index: -2.6400
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.1072
    Cell Significance Index: -1.4700
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.1078
    Cell Significance Index: -1.4900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1097
    Cell Significance Index: -5.5400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1146
    Cell Significance Index: -4.3400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1187
    Cell Significance Index: -3.1700
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: -0.1203
    Cell Significance Index: -1.1000
  • Cell Name: myoepithelial cell (CL0000185)
    Fold Change: -0.1208
    Cell Significance Index: -1.3700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1229
    Cell Significance Index: -2.6600
  • Cell Name: neuroplacodal cell (CL0000032)
    Fold Change: -0.1234
    Cell Significance Index: -1.5200
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: -0.1237
    Cell Significance Index: -1.2800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1246
    Cell Significance Index: -4.3800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.1284
    Cell Significance Index: -3.7000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1287
    Cell Significance Index: -3.6900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1300
    Cell Significance Index: -2.7600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1382
    Cell Significance Index: -3.5300
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1385
    Cell Significance Index: -2.8900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1407
    Cell Significance Index: -3.7700
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.1430
    Cell Significance Index: -1.8500
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1444
    Cell Significance Index: -2.8600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1466
    Cell Significance Index: -3.2100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The WT1 AS gene is a long non-coding RNA (lncRNA) that is approximately 7.4 kilobases in length. It is antisense to the WT1 gene, which is a tumor suppressor gene involved in the development and maintenance of the kidney, gonads, and immune system. The WT1 AS gene is highly expressed in cells of the nephron, decidual cells, and immune cells, but its expression is significantly reduced in cancerous cells. This suggests that the WT1 AS gene plays a role in suppressing tumorigenesis and promoting cellular homeostasis. **Pathways and Functions:** The WT1 AS gene is involved in regulating multiple biological pathways, including: 1. **Cellular differentiation**: The WT1 AS gene is required for the proper differentiation of cells in the kidney, gonads, and immune system. Its dysregulation can lead to abnormal cell development and function. 2. **Cell proliferation**: The WT1 AS gene is involved in regulating cell proliferation and apoptosis, which are critical processes in maintaining tissue homeostasis. 3. **Immune response**: The WT1 AS gene is expressed in immune cells, including cytotoxic T cells, and plays a role in regulating the immune response. 4. **Reproductive development**: The WT1 AS gene is required for the proper development of the gonads and reproductive system. **Clinical Significance:** The WT1 AS gene has been implicated in various diseases, including: 1. **Wilms' tumor**: The WT1 AS gene is required for the suppression of tumorigenesis in the kidney. Its dysregulation has been linked to the development of Wilms' tumor, a childhood cancer. 2. **Autoimmune disorders**: The WT1 AS gene is involved in regulating the immune response and its dysregulation has been implicated in autoimmune disorders, such as type 1 diabetes and rheumatoid arthritis. 3. **Reproductive abnormalities**: The WT1 AS gene is required for the proper development of the gonads and reproductive system. Its dysregulation has been linked to reproductive abnormalities, such as ovarian cancer and infertility. 4. **Cancer**: The WT1 AS gene is involved in regulating cellular homeostasis and its dysregulation has been implicated in various types of cancer, including breast, lung, and colon cancer. In conclusion, the WT1 AS gene is a critical non-coding RNA that plays a vital role in regulating gene expression and maintaining cellular homeostasis. Its dysregulation has been implicated in various diseases, including cancer, autoimmune disorders, and reproductive abnormalities. Further research is needed to fully understand the role of the WT1 AS gene in human health and disease.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.