Gene IGHG1 - ENSG00000211896 | NCBI Gene ID: 3500

Details for: IGHG1

Gene ID: 3500

Symbol: IGHG1

Ensembl ID: ENSG00000211896

Description: immunoglobulin heavy constant gamma 1 (G1m marker)

Associated with

Anti-inflammatory response favouring leishmania parasite infection
(R-HSA-9662851)
Classical antibody-mediated complement activation
(R-HSA-173623)
Complement cascade
(R-HSA-166658)
Creation of c4 and c2 activators
(R-HSA-166786)
Cytokine signaling in immune system
(R-HSA-1280215)
Disease
(R-HSA-1643685)
Fcgamma receptor (fcgr) dependent phagocytosis
(R-HSA-2029480)
Fcgr3a-mediated il10 synthesis
(R-HSA-9664323)
Fcgr3a-mediated phagocytosis
(R-HSA-9664422)
Fcgr activation
(R-HSA-2029481)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Initial triggering of complement
(R-HSA-166663)
Innate immune system
(R-HSA-168249)
Interleukin-4 and interleukin-13 signaling
(R-HSA-6785807)
Leishmania infection
(R-HSA-9658195)
Leishmania parasite growth and survival
(R-HSA-9664433)
Leishmania phagocytosis
(R-HSA-9664417)
Parasite infection
(R-HSA-9664407)
Parasitic infection pathways
(R-HSA-9824443)
Regulation of actin dynamics for phagocytic cup formation
(R-HSA-2029482)
Regulation of complement cascade
(R-HSA-977606)
Role of phospholipids in phagocytosis
(R-HSA-2029485)
Signaling by interleukins
(R-HSA-449147)
Adaptive immune response
(GO:0002250)
Antibacterial humoral response
(GO:0019731)
Antibody-dependent cellular cytotoxicity
(GO:0001788)
Antigen binding
(GO:0003823)
B cell receptor signaling pathway
(GO:0050853)
Blood microparticle
(GO:0072562)
Complement-dependent cytotoxicity
(GO:0097278)
Complement activation, classical pathway
(GO:0006958)
Extracellular exosome
(GO:0070062)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Fc-gamma receptor i complex binding
(GO:0034988)
Igg immunoglobulin complex
(GO:0071735)
Immunoglobulin complex, circulating
(GO:0042571)
Immunoglobulin receptor binding
(GO:0034987)
Plasma membrane
(GO:0005886)
Protein binding
(GO:0005515)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: IgG plasmablast (CL0000982)
Fold Change: 3.87
Marker Score: 1068
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 2.08
Marker Score: 5188
Cell Name: IgG plasma cell (CL0000985)
Fold Change: 1.85
Marker Score: 808
Cell Name: IgG memory B cell (CL0000979)
Fold Change: 1.83
Marker Score: 1101
Cell Name: plasmablast (CL0000980)
Fold Change: 1.8
Marker Score: 2399
Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
Fold Change: 1.73
Marker Score: 1338.5
Cell Name: DN3 thymocyte (CL0000807)
Fold Change: 1.67
Marker Score: 836
Cell Name: transitional stage B cell (CL0000818)
Fold Change: 1.63
Marker Score: 577
Cell Name: megakaryocyte (CL0000556)
Fold Change: 1.4
Marker Score: 797.5
Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
Fold Change: 1.39
Marker Score: 1014.5
Cell Name: respiratory basal cell (CL0002633)
Fold Change: 1.37
Marker Score: 1970
Cell Name: DN1 thymic pro-T cell (CL0000894)
Fold Change: 1.23
Marker Score: 380
Cell Name: hematopoietic cell (CL0000988)
Fold Change: 1.17
Marker Score: 778
Cell Name: class switched memory B cell (CL0000972)
Fold Change: 1.14
Marker Score: 1076
Cell Name: goblet cell (CL0000160)
Fold Change: 1.13
Marker Score: 7485
Cell Name: germinal center B cell (CL0000844)
Fold Change: 1.12
Marker Score: 679
Cell Name: classical monocyte (CL0000860)
Fold Change: 1.1
Marker Score: 4556
Cell Name: IgA plasma cell (CL0000987)
Fold Change: 1.08
Marker Score: 921
Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
Fold Change: 1.01
Marker Score: 2620
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71781.5
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48007
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30404
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2413
Cell Name: memory B cell (CL0000787)
Fold Change: 0.93
Marker Score: 704
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.92
Marker Score: 5248
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2736
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5281
Cell Name: bronchus fibroblast of lung (CL2000093)
Fold Change: 0.85
Marker Score: 1164
Cell Name: neutrophil (CL0000775)
Fold Change: 0.81
Marker Score: 491
Cell Name: IgA plasmablast (CL0000984)
Fold Change: 0.8
Marker Score: 211
Cell Name: exhausted T cell (CL0011025)
Fold Change: 0.78
Marker Score: 450
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1268
Cell Name: blood cell (CL0000081)
Fold Change: 0.78
Marker Score: 9009
Cell Name: brush cell (CL0002204)
Fold Change: 0.76
Marker Score: 694
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.75
Marker Score: 387
Cell Name: ionocyte (CL0005006)
Fold Change: 0.68
Marker Score: 205
Cell Name: unswitched memory B cell (CL0000970)
Fold Change: 0.64
Marker Score: 377
Cell Name: plasma cell (CL0000786)
Fold Change: 0.64
Marker Score: 718
Cell Name: myeloid cell (CL0000763)
Fold Change: 0.62
Marker Score: 989
Cell Name: intestinal crypt stem cell (CL0002250)
Fold Change: 0.6
Marker Score: 224
Cell Name: microglial cell (CL0000129)
Fold Change: 0.58
Marker Score: 1056.5
Cell Name: alternatively activated macrophage (CL0000890)
Fold Change: 0.58
Marker Score: 241
Cell Name: B cell (CL0000236)
Fold Change: 0.57
Marker Score: 547
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.56
Marker Score: 444
Cell Name: fibroblast of lung (CL0002553)
Fold Change: 0.5
Marker Score: 1304
Cell Name: IgM plasma cell (CL0000986)
Fold Change: 0.49
Marker Score: 172
Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 0.48
Marker Score: 2513
Cell Name: mast cell (CL0000097)
Fold Change: 0.47
Marker Score: 271
Cell Name: professional antigen presenting cell (CL0000145)
Fold Change: 0.46
Marker Score: 236
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.45
Marker Score: 271
Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
Fold Change: 0.44
Marker Score: 374
Cell Name: fibroblast (CL0000057)
Fold Change: 0.44
Marker Score: 423
Cell Name: dendritic cell (CL0000451)
Fold Change: 0.43
Marker Score: 296
Cell Name: T cell (CL0000084)
Fold Change: 0.42
Marker Score: 728
Cell Name: platelet (CL0000233)
Fold Change: 0.41
Marker Score: 184
Cell Name: lymphocyte (CL0000542)
Fold Change: 0.4
Marker Score: 204
Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
Fold Change: 0.4
Marker Score: 105
Cell Name: naive T cell (CL0000898)
Fold Change: 0.39
Marker Score: 250
Cell Name: vein endothelial cell (CL0002543)
Fold Change: 0.38
Marker Score: 345
Cell Name: mononuclear phagocyte (CL0000113)
Fold Change: 0.38
Marker Score: 382.5
Cell Name: naive B cell (CL0000788)
Fold Change: 0.38
Marker Score: 336
Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: 0.38
Marker Score: 1052
Cell Name: smooth muscle cell (CL0000192)
Fold Change: 0.37
Marker Score: 242
Cell Name: follicular B cell (CL0000843)
Fold Change: 0.35
Marker Score: 383
Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
Fold Change: 0.35
Marker Score: 77
Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
Fold Change: 0.35
Marker Score: 790
Cell Name: double negative T regulatory cell (CL0011024)
Fold Change: 0.34
Marker Score: 329
Cell Name: IgG-negative class switched memory B cell (CL0002117)
Fold Change: 0.34
Marker Score: 334
Cell Name: mature T cell (CL0002419)
Fold Change: 0.34
Marker Score: 3334
Cell Name: plasmacytoid dendritic cell (CL0000784)
Fold Change: 0.33
Marker Score: 180
Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
Fold Change: 0.33
Marker Score: 106
Cell Name: conventional dendritic cell (CL0000990)
Fold Change: 0.32
Marker Score: 218
Cell Name: mature B cell (CL0000785)
Fold Change: 0.32
Marker Score: 231
Cell Name: endothelial cell (CL0000115)
Fold Change: 0.31
Marker Score: 276
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 0.31
Marker Score: 162
Cell Name: B-1b B cell (CL0000821)
Fold Change: 0.3
Marker Score: 70
Cell Name: peritubular capillary endothelial cell (CL1001033)
Fold Change: 0.3
Marker Score: 70
Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
Fold Change: 0.29
Marker Score: 479.5
Cell Name: multi-ciliated epithelial cell (CL0005012)
Fold Change: 0.29
Marker Score: 553
Cell Name: immature B cell (CL0000816)
Fold Change: 0.29
Marker Score: 192
Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
Fold Change: 0.29
Marker Score: 567
Cell Name: mucosal invariant T cell (CL0000940)
Fold Change: 0.29
Marker Score: 256
Cell Name: pulmonary artery endothelial cell (CL1001568)
Fold Change: 0.29
Marker Score: 246
Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
Fold Change: 0.28
Marker Score: 64
Cell Name: leukocyte (CL0000738)
Fold Change: 0.28
Marker Score: 162
Cell Name: kidney loop of Henle epithelial cell (CL1000909)
Fold Change: 0.28
Marker Score: 173
Cell Name: late promyelocyte (CL0002151)
Fold Change: 0.27
Marker Score: 68
Cell Name: natural killer cell (CL0000623)
Fold Change: 0.27
Marker Score: 351
Cell Name: mucus secreting cell (CL0000319)
Fold Change: 0.27
Marker Score: 68
Cell Name: mature NK T cell (CL0000814)
Fold Change: 0.26
Marker Score: 122
Cell Name: epithelial cell of glomerular capsule (CL1000450)
Fold Change: 0.26
Marker Score: 67
Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
Fold Change: 0.26
Marker Score: 68
Cell Name: T follicular helper cell (CL0002038)
Fold Change: 0.26
Marker Score: 213
Cell Name: regulatory T cell (CL0000815)
Fold Change: 0.25
Marker Score: 282
Cell Name: inflammatory macrophage (CL0000863)
Fold Change: 0.25
Marker Score: 78
Cell Name: retinal blood vessel endothelial cell (CL0002585)
Fold Change: 0.25
Marker Score: 60
Cell Name: mesothelial cell (CL0000077)
Fold Change: 0.25
Marker Score: 100
Cell Name: vasa recta descending limb cell (CL1001285)
Fold Change: 0.24
Marker Score: 67
Cell Name: endothelial cell of lymphatic vessel (CL0002138)
Fold Change: 0.24
Marker Score: 152
Cell Name: smooth muscle cell of prostate (CL1000487)
Fold Change: 0.24
Marker Score: 62

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Other Information

Description

**Key characteristics:** - IGHG1 is a glycoprotein with a molecular weight of approximately 180 kDa. - It is produced by plasma cells and is found in association with immune complexes. - IGHG1 is a member of the immunoglobulin heavy chain family. **Pathways and functions:** - IGHG1 is involved in the classical antibody-mediated complement activation pathway. - It is a key regulator of the complement cascade, which is a complex network of proteins involved in the innate immune response. - IGHG1 is also involved in the regulation of inflammation and immune responses. **Clinical significance:** - Mutations in the IGHG1 gene have been linked to the development of some autoimmune diseases, such as systemic sclerosis and rheumatoid arthritis. - IGHG1 is also involved in the regulation of parasitic infections, with studies suggesting that it may play a role in the development and progression of leishmaniasis. **Additional information:** - IGHG1 is expressed in high levels in plasma and serum. - It is a highly effective activator of the classical complement pathway. - IGHG1 is also involved in the regulation of actin dynamics for phagocytic cup formation.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.