IGHG1 | ENSG00000211896 | NCBI 3500

Details for: IGHG1

Gene ID: 3500

Symbol: IGHG1

Ensembl ID: ENSG00000211896

Description: immunoglobulin heavy constant gamma 1 (G1m marker)

Associated with

Anti-inflammatory response favouring leishmania parasite infection
(R-HSA-9662851)
Classical antibody-mediated complement activation
(R-HSA-173623)
Complement cascade
(R-HSA-166658)
Creation of c4 and c2 activators
(R-HSA-166786)
Cytokine signaling in immune system
(R-HSA-1280215)
Disease
(R-HSA-1643685)
Fcgamma receptor (fcgr) dependent phagocytosis
(R-HSA-2029480)
Fcgr3a-mediated il10 synthesis
(R-HSA-9664323)
Fcgr3a-mediated phagocytosis
(R-HSA-9664422)
Fcgr activation
(R-HSA-2029481)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Initial triggering of complement
(R-HSA-166663)
Innate immune system
(R-HSA-168249)
Interleukin-4 and interleukin-13 signaling
(R-HSA-6785807)
Leishmania infection
(R-HSA-9658195)
Leishmania parasite growth and survival
(R-HSA-9664433)
Leishmania phagocytosis
(R-HSA-9664417)
Parasite infection
(R-HSA-9664407)
Parasitic infection pathways
(R-HSA-9824443)
Regulation of actin dynamics for phagocytic cup formation
(R-HSA-2029482)
Regulation of complement cascade
(R-HSA-977606)
Role of phospholipids in phagocytosis
(R-HSA-2029485)
Signaling by interleukins
(R-HSA-449147)
Adaptive immune response
(GO:0002250)
Antibacterial humoral response
(GO:0019731)
Antibody-dependent cellular cytotoxicity
(GO:0001788)
Antigen binding
(GO:0003823)
B cell receptor signaling pathway
(GO:0050853)
Blood microparticle
(GO:0072562)
Complement-dependent cytotoxicity
(GO:0097278)
Complement activation, classical pathway
(GO:0006958)
Extracellular exosome
(GO:0070062)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Fc-gamma receptor i complex binding
(GO:0034988)
Igg immunoglobulin complex
(GO:0071735)
Immunoglobulin complex, circulating
(GO:0042571)
Immunoglobulin receptor binding
(GO:0034987)
Plasma membrane
(GO:0005886)
Protein binding
(GO:0005515)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 5.7562
Cell Significance Index: -17.6800
Cell Name: exhausted T cell (CL0011025)
Fold Change: 2.2467
Cell Significance Index: 18.3100
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 1.5709
Cell Significance Index: 16.2700
Cell Name: paneth cell of colon (CL0009009)
Fold Change: 1.2453
Cell Significance Index: 18.6600
Cell Name: DN3 thymocyte (CL0000807)
Fold Change: 0.7430
Cell Significance Index: 7.4500
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.5028
Cell Significance Index: 49.7400
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.4937
Cell Significance Index: 93.9600
Cell Name: IgG memory B cell (CL0000979)
Fold Change: 0.4570
Cell Significance Index: 2.7600
Cell Name: oral mucosa squamous cell (CL1001576)
Fold Change: 0.3608
Cell Significance Index: 3.1000
Cell Name: IgG plasmablast (CL0000982)
Fold Change: 0.2823
Cell Significance Index: 2.3300
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 0.0297
Cell Significance Index: 0.4600
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 0.0114
Cell Significance Index: 0.1300
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.0102
Cell Significance Index: 1.0400
Cell Name: odontoblast (CL0000060)
Fold Change: 0.0027
Cell Significance Index: 0.3400
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0066
Cell Significance Index: -12.3900
Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.0087
Cell Significance Index: -0.3600
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0109
Cell Significance Index: -8.2600
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0182
Cell Significance Index: -13.3400
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.0190
Cell Significance Index: -0.9600
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0198
Cell Significance Index: -12.5500
Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0217
Cell Significance Index: -11.8500
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0323
Cell Significance Index: -14.6500
Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.0513
Cell Significance Index: -10.1900
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0564
Cell Significance Index: -10.1600
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0798
Cell Significance Index: -16.0000
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0842
Cell Significance Index: -11.5600
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0906
Cell Significance Index: -13.1700
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0981
Cell Significance Index: -12.0600
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1224
Cell Significance Index: -12.7400
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.1246
Cell Significance Index: -21.2800
Cell Name: lactocyte (CL0002325)
Fold Change: -0.1256
Cell Significance Index: -16.2300
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.1644
Cell Significance Index: -13.0200
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.1768
Cell Significance Index: -13.5700
Cell Name: plasma cell (CL0000786)
Fold Change: -0.1898
Cell Significance Index: -2.1200
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1937
Cell Significance Index: -22.1900
Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.1981
Cell Significance Index: -8.6200
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.2135
Cell Significance Index: -13.0900
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.2166
Cell Significance Index: -16.1400
Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.2187
Cell Significance Index: -14.1100
Cell Name: peg cell (CL4033014)
Fold Change: -0.2407
Cell Significance Index: -5.5600
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.2436
Cell Significance Index: -12.7900
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.2556
Cell Significance Index: -13.2800
Cell Name: IgG plasma cell (CL0000985)
Fold Change: -0.2876
Cell Significance Index: -2.6300
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.2904
Cell Significance Index: -10.6600
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.3025
Cell Significance Index: -13.3800
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.3322
Cell Significance Index: -15.6100
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.3369
Cell Significance Index: -15.7100
Cell Name: leukocyte (CL0000738)
Fold Change: -0.3536
Cell Significance Index: -6.0100
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.3660
Cell Significance Index: -23.0700
Cell Name: intestinal crypt stem cell (CL0002250)
Fold Change: -0.3752
Cell Significance Index: -2.6400
Cell Name: ovarian surface epithelial cell (CL2000064)
Fold Change: -0.3768
Cell Significance Index: -1.8300
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.3901
Cell Significance Index: -9.4500
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.4088
Cell Significance Index: -13.0200
Cell Name: DN1 thymic pro-T cell (CL0000894)
Fold Change: -0.4167
Cell Significance Index: -4.3200
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.4699
Cell Significance Index: -13.8400
Cell Name: lymphocyte (CL0000542)
Fold Change: -0.4712
Cell Significance Index: -6.4100
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.4974
Cell Significance Index: -13.2800
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.5053
Cell Significance Index: -12.9100
Cell Name: epithelial cell of uterus (CL0002149)
Fold Change: -0.5470
Cell Significance Index: -7.5900
Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: -0.5530
Cell Significance Index: -13.7900
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.5711
Cell Significance Index: -16.3700
Cell Name: plasmablast (CL0000980)
Fold Change: -0.5754
Cell Significance Index: -5.3400
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.5919
Cell Significance Index: -10.9400
Cell Name: erythrocyte (CL0000232)
Fold Change: -0.6001
Cell Significance Index: -15.2900
Cell Name: enterocyte (CL0000584)
Fold Change: -0.6028
Cell Significance Index: -3.7400
Cell Name: type I muscle cell (CL0002211)
Fold Change: -0.6238
Cell Significance Index: -15.2200
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.6288
Cell Significance Index: -13.5900
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: -0.6345
Cell Significance Index: -10.9700
Cell Name: B cell (CL0000236)
Fold Change: -0.6440
Cell Significance Index: -7.6100
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.6445
Cell Significance Index: -13.3700
Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: -0.6493
Cell Significance Index: -12.7800
Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -0.6636
Cell Significance Index: -9.8000
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: -0.6675
Cell Significance Index: -13.0500
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -0.6961
Cell Significance Index: -11.7300
Cell Name: IgA plasma cell (CL0000987)
Fold Change: -0.7328
Cell Significance Index: -4.8800
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.7470
Cell Significance Index: -14.7700
Cell Name: seromucus secreting cell (CL0000159)
Fold Change: -0.7480
Cell Significance Index: -15.6000
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.7527
Cell Significance Index: -15.9800
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: -0.7582
Cell Significance Index: -12.9600
Cell Name: memory B cell (CL0000787)
Fold Change: -0.7595
Cell Significance Index: -8.0800
Cell Name: transit amplifying cell (CL0009010)
Fold Change: -0.7657
Cell Significance Index: -7.3500
Cell Name: fibroblast of breast (CL4006000)
Fold Change: -0.7696
Cell Significance Index: -4.8400
Cell Name: transitional stage B cell (CL0000818)
Fold Change: -0.7757
Cell Significance Index: -6.8200
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.8011
Cell Significance Index: -21.8100
Cell Name: hematopoietic cell (CL0000988)
Fold Change: -0.8054
Cell Significance Index: -11.7800
Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.8062
Cell Significance Index: -16.1900
Cell Name: hepatocyte (CL0000182)
Fold Change: -0.8176
Cell Significance Index: -11.3400
Cell Name: keratinocyte (CL0000312)
Fold Change: -0.8212
Cell Significance Index: -20.5100
Cell Name: lymphocyte of B lineage (CL0000945)
Fold Change: -0.8308
Cell Significance Index: -6.1700
Cell Name: megakaryocyte (CL0000556)
Fold Change: -0.8468
Cell Significance Index: -13.7200
Cell Name: early T lineage precursor (CL0002425)
Fold Change: -0.8775
Cell Significance Index: -12.7400
Cell Name: keratocyte (CL0002363)
Fold Change: -0.8862
Cell Significance Index: -14.0600
Cell Name: blood cell (CL0000081)
Fold Change: -0.9198
Cell Significance Index: -7.8400
Cell Name: epithelial cell (CL0000066)
Fold Change: -0.9262
Cell Significance Index: -9.7700
Cell Name: thyroid follicular cell (CL0002258)
Fold Change: -0.9374
Cell Significance Index: -9.9600
Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: -0.9384
Cell Significance Index: -12.0900
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: -0.9456
Cell Significance Index: -16.7100
Cell Name: type II muscle cell (CL0002212)
Fold Change: -0.9464
Cell Significance Index: -15.2700
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: -0.9471
Cell Significance Index: -13.6000
Cell Name: T cell (CL0000084)
Fold Change: -0.9495
Cell Significance Index: -11.2100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Other Information

Description

**Key Characteristics:** IGHG1 is a heavy chain of the IgG class, which is the most abundant antibody isotype in humans. It is characterized by its gamma 1 (G1) constant region, which determines its functional properties. IGHG1 is expressed on various immune cells, including IgG plasma cells, memory B cells, and plasmablasts. These cells are responsible for producing IgG antibodies, which are essential for neutralizing pathogens and modulating the immune response. **Pathways and Functions:** IGHG1 participates in several key signaling pathways, including: 1. **Adaptive Immune Response**: IGHG1 is involved in the activation of B cells and the production of IgG antibodies, which are critical for adaptive immunity. 2. **Anti-inflammatory Response**: IGHG1 regulates the production of anti-inflammatory cytokines, such as IL-10, which helps to mitigate excessive inflammation. 3. **Antibacterial Humoral Response**: IGHG1 is essential for neutralizing bacterial pathogens, including those that cause sepsis and pneumonia. 4. **Antibody-dependent Cellular Cytotoxicity**: IGHG1 facilitates the binding of IgG antibodies to target cells, enabling the recruitment of immune effector cells, such as natural killer cells and macrophages. 5. **Complement Activation**: IGHG1 regulates the classical complement pathway, which is crucial for opsonization, phagocytosis, and clearance of pathogens. **Clinical Significance:** IGHG1 plays a vital role in various diseases, including: 1. **Leishmaniasis**: IGHG1 is involved in the regulation of Leishmania parasite growth and survival, making it a potential target for therapeutic interventions. 2. **Autoimmune Diseases**: Abnormalities in IGHG1 expression and function have been linked to autoimmune diseases, such as rheumatoid arthritis and lupus. 3. **Cancer**: IGHG1 is overexpressed in certain types of cancer, including multiple myeloma and lymphoma, where it contributes to tumor progression and resistance to therapy. 4. **Immunodeficiency Disorders**: Deficiencies in IGHG1 can lead to impaired immune responses, increasing susceptibility to infections and autoimmune diseases. In conclusion, IGHG1 is a complex and multifunctional gene that plays a critical role in the adaptive and innate immune responses. Its dysregulation can lead to various diseases, highlighting the importance of understanding its signaling pathways and clinical significance. Further research is necessary to fully elucidate the mechanisms by which IGHG1 influences immune function and disease.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.