Details for: IGKV3D 7

Gene ID: 28877

Symbol: IGKV3D 7

Ensembl ID: ENSG00000228325

Description: immunoglobulin kappa variable 3D-7

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 4.15
    Marker Score: 2,435
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 1.44
    Marker Score: 1,226
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.17
    Marker Score: 2,962
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.1
    Marker Score: 7,339
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 1
    Marker Score: 5,699
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,388
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.96
    Marker Score: 1,561
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,729
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,276
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 705
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.69
    Marker Score: 547
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 0.36
    Marker Score: 158
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.27
    Marker Score: 850
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.22
    Marker Score: 147
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0.2
    Marker Score: 338
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0.19
    Marker Score: 168
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 0.17
    Marker Score: 47
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.17
    Marker Score: 95
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: 0.16
    Marker Score: 43
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.14
    Marker Score: 1,881
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 0.13
    Marker Score: 237
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.12
    Marker Score: 90
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.11
    Marker Score: 104
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 0.09
    Marker Score: 79
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.08
    Marker Score: 55
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 0.08
    Marker Score: 34
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.08
    Marker Score: 86
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.07
    Marker Score: 42
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.07
    Marker Score: 26
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 0.07
    Marker Score: 25
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.06
    Marker Score: 22
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.06
    Marker Score: 20
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 0.05
    Marker Score: 45
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.05
    Marker Score: 46
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.05
    Marker Score: 49
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.05
    Marker Score: 22
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.04
    Marker Score: 50
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.04
    Marker Score: 20
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.04
    Marker Score: 39
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 0.04
    Marker Score: 27
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 0.04
    Marker Score: 44
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.04
    Marker Score: 22
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.04
    Marker Score: 24
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.04
    Marker Score: 50
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.04
    Marker Score: 19
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.03
    Marker Score: 164
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.03
    Marker Score: 45
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.03
    Marker Score: 19
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.03
    Marker Score: 198
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 0.03
    Marker Score: 21
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.03
    Marker Score: 21
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.03
    Marker Score: 19
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 0.03
    Marker Score: 16
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: 0.03
    Marker Score: 32
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.03
    Marker Score: 13
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 0.03
    Marker Score: 22
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.02
    Marker Score: 21
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.02
    Marker Score: 39
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.02
    Marker Score: 54
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.02
    Marker Score: 56
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.02
    Marker Score: 18
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 0.02
    Marker Score: 16
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.02
    Marker Score: 27
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 0.02
    Marker Score: 25
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.02
    Marker Score: 24
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.02
    Marker Score: 32
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 0.02
    Marker Score: 22
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 0.02
    Marker Score: 22
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.02
    Marker Score: 23
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 0.02
    Marker Score: 16
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.02
    Marker Score: 21
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.02
    Marker Score: 29
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.02
    Marker Score: 19
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 0.01
    Marker Score: 12
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.01
    Marker Score: 12
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.01
    Marker Score: 36
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 0.01
    Marker Score: 15
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.01
    Marker Score: 21
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.01
    Marker Score: 16
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.01
    Marker Score: 17
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.01
    Marker Score: 22
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0
    Marker Score: 22
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0
    Marker Score: 21
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0
    Marker Score: 18
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0
    Marker Score: 22
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0
    Marker Score: 21
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0
    Marker Score: 12

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IGKV3D7 is a kappa light chain variable gene, which is a crucial component of the immunoglobulin (Ig) family. These genes encode the variable regions of the kappa light chains, which are essential for antigen recognition and binding. IGKV3D7 is specifically expressed in various cell types, including CD4-positive and CD8-positive alpha-beta memory T cells, intestinal epithelial cells, and goblet cells. This widespread expression suggests that IGKV3D7 may play a role in regulating immune responses and maintaining tissue homeostasis. **Pathways and Functions:** IGKV3D7 is implicated in several key pathways, including the adaptive immune response, extracellular space, immune response, immunoglobulin complex, and immunoglobulin production. The gene's expression in T cells and epithelial cells suggests that it may be involved in the regulation of immune cell function and the maintenance of epithelial barrier integrity. One possible functional pathway for IGKV3D7 involves its role in the production of immunoglobulins. As a kappa light chain variable gene, IGKV3D7 may contribute to the assembly and secretion of Ig molecules, which are essential for antibody-mediated immunity. Additionally, IGKV3D7's expression in epithelial cells may be linked to the regulation of mucosal immunity and the protection against pathogens. **Clinical Significance:** IGKV3D7's clinical significance is an area of ongoing research, and its implications for human disease are not yet fully understood. However, the gene's expression in neoplastic cells and abnormal cells suggests that it may play a role in the development and progression of various cancers. Furthermore, IGKV3D7's involvement in the adaptive immune response and immunoglobulin production makes it a potential target for the development of novel immunotherapies. For instance, the manipulation of IGKV3D7 expression or function may be used to enhance antibody-mediated immunity against cancer or infectious diseases. In conclusion, IGKV3D7 is a complex gene with diverse expression patterns and functional implications. Further research is needed to fully elucidate its role in the immune system and its potential clinical applications. As an expert immunologist, I emphasize the importance of continued investigation into the mysteries of IGKV3D7 and its contributions to human health and disease.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.