Details for: IGKV3D 7

Gene ID: 28877

Symbol: IGKV3D 7

Ensembl ID: ENSG00000228325

Description: immunoglobulin kappa variable 3D-7

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.0112
    Cell Significance Index: 0.0600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0036
    Cell Significance Index: -0.7200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0051
    Cell Significance Index: -0.7000
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0118
    Cell Significance Index: -0.1600
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.0129
    Cell Significance Index: -0.0800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0133
    Cell Significance Index: -0.3900
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0152
    Cell Significance Index: -0.1700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0172
    Cell Significance Index: -0.4600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0203
    Cell Significance Index: -0.9000
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: -0.0208
    Cell Significance Index: -0.1800
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0213
    Cell Significance Index: -0.2000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0217
    Cell Significance Index: -0.6900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0259
    Cell Significance Index: -0.9800
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0268
    Cell Significance Index: -0.3300
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0318
    Cell Significance Index: -0.5400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0335
    Cell Significance Index: -0.7100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0359
    Cell Significance Index: -0.7200
  • Cell Name: goblet cell (CL0000160)
    Fold Change: -0.0365
    Cell Significance Index: -0.3300
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0370
    Cell Significance Index: -0.3900
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.0451
    Cell Significance Index: -0.6000
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.0470
    Cell Significance Index: -0.5200
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0471
    Cell Significance Index: -1.2000
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0480
    Cell Significance Index: -0.2900
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: -0.0499
    Cell Significance Index: -0.4200
  • Cell Name: precursor cell (CL0011115)
    Fold Change: -0.0514
    Cell Significance Index: -0.3900
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0521
    Cell Significance Index: -0.6000
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.0523
    Cell Significance Index: -0.3800
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0541
    Cell Significance Index: -0.5200
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0547
    Cell Significance Index: -1.3700
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0562
    Cell Significance Index: -0.7400
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0567
    Cell Significance Index: -0.7400
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0586
    Cell Significance Index: -0.7900
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.0592
    Cell Significance Index: -0.7500
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0601
    Cell Significance Index: -0.6100
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -0.0606
    Cell Significance Index: -0.2800
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.0638
    Cell Significance Index: -0.7000
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: -0.0649
    Cell Significance Index: -0.6800
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: -0.0659
    Cell Significance Index: -0.5300
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0694
    Cell Significance Index: -0.8900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0711
    Cell Significance Index: -1.0500
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.0745
    Cell Significance Index: -0.7900
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.0771
    Cell Significance Index: -0.9900
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: -0.0776
    Cell Significance Index: -0.7300
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.0792
    Cell Significance Index: -1.0000
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0795
    Cell Significance Index: -1.5600
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0795
    Cell Significance Index: -1.0900
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0802
    Cell Significance Index: -1.0000
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0804
    Cell Significance Index: -1.0500
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0806
    Cell Significance Index: -1.0000
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0817
    Cell Significance Index: -0.9500
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: -0.0818
    Cell Significance Index: -0.7100
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0838
    Cell Significance Index: -0.5000
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0846
    Cell Significance Index: -1.0000
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0858
    Cell Significance Index: -0.7400
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0862
    Cell Significance Index: -1.0000
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0876
    Cell Significance Index: -1.1500
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: -0.0877
    Cell Significance Index: -0.7000
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0900
    Cell Significance Index: -0.9200
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0902
    Cell Significance Index: -1.0700
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0904
    Cell Significance Index: -1.0400
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0909
    Cell Significance Index: -1.0900
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0912
    Cell Significance Index: -1.1800
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0926
    Cell Significance Index: -1.2300
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.0927
    Cell Significance Index: -0.9600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0937
    Cell Significance Index: -1.5700
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -0.0946
    Cell Significance Index: -0.6300
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0949
    Cell Significance Index: -1.0100
  • Cell Name: brush cell (CL0002204)
    Fold Change: -0.0971
    Cell Significance Index: -0.8900
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.0971
    Cell Significance Index: -1.1400
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: -0.0995
    Cell Significance Index: -1.0500
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0999
    Cell Significance Index: -1.0200
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.1010
    Cell Significance Index: -0.8900
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: -0.1028
    Cell Significance Index: -0.9500
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.1029
    Cell Significance Index: -1.4100
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: -0.1034
    Cell Significance Index: -0.9300
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.1035
    Cell Significance Index: -1.0900
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.1049
    Cell Significance Index: -1.0300
  • Cell Name: paneth cell (CL0000510)
    Fold Change: -0.1054
    Cell Significance Index: -1.0900
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.1057
    Cell Significance Index: -1.1700
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: -0.1063
    Cell Significance Index: -0.7800
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.1065
    Cell Significance Index: -1.1800
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.1092
    Cell Significance Index: -1.1000
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.1092
    Cell Significance Index: -1.0900
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1097
    Cell Significance Index: -1.0400
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: -0.1108
    Cell Significance Index: -0.8900
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.1112
    Cell Significance Index: -1.3200
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.1126
    Cell Significance Index: -1.3300
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.1155
    Cell Significance Index: -1.0800
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.1160
    Cell Significance Index: -1.1000
  • Cell Name: mature B cell (CL0000785)
    Fold Change: -0.1168
    Cell Significance Index: -0.7600
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: -0.1170
    Cell Significance Index: -1.0200
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: -0.1173
    Cell Significance Index: -1.0400
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.1194
    Cell Significance Index: -1.4100
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1205
    Cell Significance Index: -1.3100
  • Cell Name: naive T cell (CL0000898)
    Fold Change: -0.1211
    Cell Significance Index: -1.1000
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: -0.1236
    Cell Significance Index: -1.0200
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: -0.1239
    Cell Significance Index: -1.0100
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: -0.1258
    Cell Significance Index: -1.1500
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.1268
    Cell Significance Index: -1.5300
  • Cell Name: platelet (CL0000233)
    Fold Change: -0.1283
    Cell Significance Index: -1.3200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IGKV3D7 is a kappa light chain variable gene, which is a crucial component of the immunoglobulin (Ig) family. These genes encode the variable regions of the kappa light chains, which are essential for antigen recognition and binding. IGKV3D7 is specifically expressed in various cell types, including CD4-positive and CD8-positive alpha-beta memory T cells, intestinal epithelial cells, and goblet cells. This widespread expression suggests that IGKV3D7 may play a role in regulating immune responses and maintaining tissue homeostasis. **Pathways and Functions:** IGKV3D7 is implicated in several key pathways, including the adaptive immune response, extracellular space, immune response, immunoglobulin complex, and immunoglobulin production. The gene's expression in T cells and epithelial cells suggests that it may be involved in the regulation of immune cell function and the maintenance of epithelial barrier integrity. One possible functional pathway for IGKV3D7 involves its role in the production of immunoglobulins. As a kappa light chain variable gene, IGKV3D7 may contribute to the assembly and secretion of Ig molecules, which are essential for antibody-mediated immunity. Additionally, IGKV3D7's expression in epithelial cells may be linked to the regulation of mucosal immunity and the protection against pathogens. **Clinical Significance:** IGKV3D7's clinical significance is an area of ongoing research, and its implications for human disease are not yet fully understood. However, the gene's expression in neoplastic cells and abnormal cells suggests that it may play a role in the development and progression of various cancers. Furthermore, IGKV3D7's involvement in the adaptive immune response and immunoglobulin production makes it a potential target for the development of novel immunotherapies. For instance, the manipulation of IGKV3D7 expression or function may be used to enhance antibody-mediated immunity against cancer or infectious diseases. In conclusion, IGKV3D7 is a complex gene with diverse expression patterns and functional implications. Further research is needed to fully elucidate its role in the immune system and its potential clinical applications. As an expert immunologist, I emphasize the importance of continued investigation into the mysteries of IGKV3D7 and its contributions to human health and disease.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.