Details for: HSD17B8

Gene ID: 7923

Symbol: HSD17B8

Ensembl ID: ENSG00000204228

Description: hydroxysteroid 17-beta dehydrogenase 8

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 57.0895
    Cell Significance Index: -8.8800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 28.7609
    Cell Significance Index: -7.3000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 28.0364
    Cell Significance Index: -11.3900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 25.9149
    Cell Significance Index: -12.2400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 12.0870
    Cell Significance Index: -11.5400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 8.9460
    Cell Significance Index: -11.0300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 3.5724
    Cell Significance Index: -9.5700
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 3.3009
    Cell Significance Index: 82.3200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.9929
    Cell Significance Index: -11.8100
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 1.4046
    Cell Significance Index: 8.6900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.2953
    Cell Significance Index: 67.2900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.1306
    Cell Significance Index: 131.7600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.9580
    Cell Significance Index: 13.0700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 0.8727
    Cell Significance Index: -1.9100
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.8492
    Cell Significance Index: 19.6200
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.8467
    Cell Significance Index: 6.7600
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.8377
    Cell Significance Index: 8.9000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.7833
    Cell Significance Index: 21.3200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.7334
    Cell Significance Index: 50.7200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.7061
    Cell Significance Index: 32.9200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5675
    Cell Significance Index: 512.4000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.5308
    Cell Significance Index: 39.5600
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.5284
    Cell Significance Index: 4.3700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.5155
    Cell Significance Index: 66.6000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5083
    Cell Significance Index: 23.0400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.5010
    Cell Significance Index: 35.4300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4884
    Cell Significance Index: 215.9300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4699
    Cell Significance Index: 10.1800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4279
    Cell Significance Index: 52.6200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.4231
    Cell Significance Index: 72.2400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4170
    Cell Significance Index: 75.1700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3563
    Cell Significance Index: 10.2700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.3488
    Cell Significance Index: 11.1700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3219
    Cell Significance Index: 175.7900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3125
    Cell Significance Index: 50.8300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2709
    Cell Significance Index: 26.8000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2642
    Cell Significance Index: 16.6500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.2601
    Cell Significance Index: 2.4000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.2209
    Cell Significance Index: 3.3100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.2046
    Cell Significance Index: 5.3800
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.1907
    Cell Significance Index: 0.4300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1823
    Cell Significance Index: 8.5700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1716
    Cell Significance Index: 23.5700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.1517
    Cell Significance Index: 4.4600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.1470
    Cell Significance Index: 1.6700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1345
    Cell Significance Index: 3.7600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1218
    Cell Significance Index: 15.6100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.1104
    Cell Significance Index: 1.2000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1046
    Cell Significance Index: 19.9100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0990
    Cell Significance Index: 1.1800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0838
    Cell Significance Index: 9.8900
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 0.0601
    Cell Significance Index: 0.2300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0438
    Cell Significance Index: 2.3000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0421
    Cell Significance Index: 1.4800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0285
    Cell Significance Index: 21.6000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0283
    Cell Significance Index: 20.7200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0198
    Cell Significance Index: 3.9200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0075
    Cell Significance Index: 0.1300
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0008
    Cell Significance Index: -1.4900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0027
    Cell Significance Index: -5.0100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0053
    Cell Significance Index: -8.1100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0055
    Cell Significance Index: -0.1400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0093
    Cell Significance Index: -0.4700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0095
    Cell Significance Index: -12.8600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0108
    Cell Significance Index: -1.1000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0114
    Cell Significance Index: -8.4500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0120
    Cell Significance Index: -7.6000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0139
    Cell Significance Index: -7.8300
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: -0.0194
    Cell Significance Index: -0.2000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0196
    Cell Significance Index: -2.2500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0213
    Cell Significance Index: -13.3200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0216
    Cell Significance Index: -0.5400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0236
    Cell Significance Index: -10.7200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0312
    Cell Significance Index: -11.2000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0344
    Cell Significance Index: -1.7900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0391
    Cell Significance Index: -3.1000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0418
    Cell Significance Index: -8.3900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0429
    Cell Significance Index: -12.3400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0440
    Cell Significance Index: -1.8000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0543
    Cell Significance Index: -1.4500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0588
    Cell Significance Index: -12.3900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0629
    Cell Significance Index: -9.1500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0650
    Cell Significance Index: -2.2600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0721
    Cell Significance Index: -1.5100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0758
    Cell Significance Index: -4.8900
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0843
    Cell Significance Index: -1.2000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1100
    Cell Significance Index: -11.4500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1301
    Cell Significance Index: -7.3000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1360
    Cell Significance Index: -10.4400
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.1812
    Cell Significance Index: -2.3200
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.1863
    Cell Significance Index: -2.6700
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1942
    Cell Significance Index: -4.8500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1952
    Cell Significance Index: -11.9700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2074
    Cell Significance Index: -6.1100
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.2112
    Cell Significance Index: -1.9400
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.2229
    Cell Significance Index: -1.6200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2389
    Cell Significance Index: -6.1400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2405
    Cell Significance Index: -8.8300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2410
    Cell Significance Index: -2.5000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Enzyme Activity:** HSD17B8 exhibits (3R)-3-hydroxyacyl-CoA dehydrogenase activity, a crucial step in fatty acid biosynthesis and metabolism. 2. **Expression Profile:** This gene is highly expressed in cells involved in energy metabolism, including pulmonary interstitial fibroblasts, pancreatic acinar cells, and stem cells. 3. **Metabolic Pathways:** HSD17B8 is implicated in various metabolic pathways, including fatty acid biosynthesis, fatty acid metabolism, and lipid biosynthesis. 4. **Steroidogenesis:** This enzyme plays a significant role in the biosynthesis of steroids, including androgens and estrogens. **Pathways and Functions:** 1. **Fatty Acid Biosynthesis:** HSD17B8 catalyzes the conversion of 3-hydroxyacyl-CoA to 3-ketoacyl-CoA, a critical step in fatty acid biosynthesis. 2. **Fatty Acid Metabolism:** This enzyme is involved in the breakdown of fatty acids, regulating energy metabolism and lipid homeostasis. 3. **Lipid Biosynthesis:** HSD17B8 contributes to the biosynthesis of lipids, including phospholipids and triglycerides. 4. **Steroidogenesis:** This enzyme plays a crucial role in the biosynthesis of androgens and estrogens, influencing reproductive and hormonal processes. 5. **Mitochondrial Function:** HSD17B8 is localized to the mitochondrial matrix, where it regulates energy metabolism and fatty acid oxidation. **Clinical Significance:** 1. **Metabolic Disorders:** Dysregulation of HSD17B8 has been implicated in various metabolic disorders, including fatty liver disease, obesity, and insulin resistance. 2. **Cancer:** Altered expression of HSD17B8 has been observed in certain types of cancer, including breast and prostate cancer, where it may contribute to tumorigenesis and metastasis. 3. **Neurological Disorders:** HSD17B8 may play a role in the pathogenesis of neurological disorders, such as Alzheimer's disease and Parkinson's disease, where lipid metabolism and energy homeostasis are disrupted. 4. **Endocrine Disruption:** HSD17B8 has been implicated in the biosynthesis of endocrine-disrupting compounds, which can have adverse effects on reproductive and developmental processes. In conclusion, HSD17B8 is a multifunctional enzyme that plays a critical role in various metabolic and endocrine pathways. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding its mechanisms of action and potential therapeutic targets. Further research is necessary to elucidate the full extent of HSD17B8's involvement in human health and disease.

Genular Protein ID: 2482379870

Symbol: DHB8_HUMAN

Name: (3R)-3-hydroxyacyl-CoA dehydrogenase

UniProtKB Accession Codes:

Q92506 A6NLX7 Q5STP7 Q9UIQ1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 25 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EC 3 EMBL 12 Ensembl 6 EvolutionaryTrace 1 ExpressionAtlas 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 9 SABIO-RK 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniPathway 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8812499

Title: cDNA cloning of the human homologues of the mouse Ke4 and Ke6 genes at the centromeric end of the human MHC region.

PubMed ID: 8812499

DOI: 10.1006/geno.1996.0405

PubMed ID: 17978863

Title: Expression in E. coli and tissue distribution of the human homologue of the mouse Ke 6 gene, 17beta-hydroxysteroid dehydrogenase type 8.

PubMed ID: 17978863

DOI: 10.1007/s11010-007-9637-9

PubMed ID: 19571038

Title: 17beta-Hydroxysteroid dehydrogenase type 8 and carbonyl reductase type 4 assemble as a ketoacyl reductase of human mitochondrial FAS.

PubMed ID: 19571038

DOI: 10.1096/fj.09-133587

PubMed ID: 18852215

Title: Estradiol induces type 8 17beta-hydroxysteroid dehydrogenase expression: crosstalk between estrogen receptor alpha and C/EBPbeta.

PubMed ID: 18852215

DOI: 10.1677/joe-08-0134

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 30508570

Title: 17B-hydroxysteroid dehydrogenases as acyl thioester metabolizing enzymes.

PubMed ID: 30508570

DOI: 10.1016/j.mce.2018.11.012

PubMed ID: 25203508

Title: Insights into mitochondrial fatty acid synthesis from the structure of heterotetrameric 3-ketoacyl-ACP reductase/3R-hydroxyacyl-CoA dehydrogenase.

PubMed ID: 25203508

DOI: 10.1038/ncomms5805

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 261
  • Mass: 26974
  • Checksum: 8B8B2D7131714D71
  • Sequence:
    • MASQLQNRLR SALALVTGAG SGIGRAVSVR LAGEGATVAA CDLDRAAAQE TVRLLGGPGS 
KEGPPRGNHA AFQADVSEAR AARCLLEQVQ ACFSRPPSVV VSCAGITQDE FLLHMSEDDW 
DKVIAVNLKG TFLVTQAAAQ ALVSNGCRGS IINISSIVGK VGNVGQTNYA ASKAGVIGLT 
QTAARELGRH GIRCNSVLPG FIATPMTQKV PQKVVDKITE MIPMGHLGDP EDVADVVAFL 
ASEDSGYITG TSVEVTGGLF M

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.