H3C4 | ENSG00000197409 | NCBI 8351

Details for: H3C4

Gene ID: 8351

Symbol: H3C4

Ensembl ID: ENSG00000197409

Description: H3 clustered histone 4

Associated with

Activated pkn1 stimulates transcription of ar (androgen receptor) regulated genes klk2 and klk3
(R-HSA-5625886)
Activation of anterior hox genes in hindbrain development during early embryogenesis
(R-HSA-5617472)
Activation of hox genes during differentiation
(R-HSA-5619507)
Amyloid fiber formation
(R-HSA-977225)
Assembly of the orc complex at the origin of replication
(R-HSA-68616)
Assembly of the pre-replicative complex
(R-HSA-68867)
B-wich complex positively regulates rrna expression
(R-HSA-5250924)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular senescence
(R-HSA-2559583)
Chromatin modifications during the maternal to zygotic transition (mzt)
(R-HSA-9821002)
Chromatin modifying enzymes
(R-HSA-3247509)
Condensation of prophase chromosomes
(R-HSA-2299718)
Cytokine signaling in immune system
(R-HSA-1280215)
Defective pyroptosis
(R-HSA-9710421)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of programmed cell death
(R-HSA-9645723)
Dna methylation
(R-HSA-5334118)
Dna replication
(R-HSA-69306)
Dna replication pre-initiation
(R-HSA-69002)
Epigenetic regulation by wdr5-containing histone modifying complexes
(R-HSA-9917777)
Epigenetic regulation of adipogenesis genes by mll3 and mll4 complexes
(R-HSA-9851695)
Epigenetic regulation of gene expression
(R-HSA-212165)
Epigenetic regulation of gene expression by mll3 and mll4 complexes
(R-HSA-9818564)
Ercc6 (csb) and ehmt2 (g9a) positively regulate rrna expression
(R-HSA-427389)
Esr-mediated signaling
(R-HSA-8939211)
Estrogen-dependent gene expression
(R-HSA-9018519)
Factors involved in megakaryocyte development and platelet production
(R-HSA-983231)
Formation of the beta-catenin:tcf transactivating complex
(R-HSA-201722)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Gene silencing by rna
(R-HSA-211000)
Hats acetylate histones
(R-HSA-3214847)
Hcmv early events
(R-HSA-9609690)
Hcmv infection
(R-HSA-9609646)
Hcmv late events
(R-HSA-9610379)
Hdacs deacetylate histones
(R-HSA-3214815)
Hdms demethylate histones
(R-HSA-3214842)
Hemostasis
(R-HSA-109582)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Interleukin-7 signaling
(R-HSA-1266695)
Maternal to zygotic transition (mzt)
(R-HSA-9816359)
Meiosis
(R-HSA-1500620)
Meiotic recombination
(R-HSA-912446)
Metabolism of proteins
(R-HSA-392499)
Mitotic prophase
(R-HSA-68875)
Mll4 and mll3 complexes regulate expression of pparg target genes in adipogenesis and hepatic steatosis
(R-HSA-9841922)
M phase
(R-HSA-68886)
Negative epigenetic regulation of rrna expression
(R-HSA-5250941)
Norc negatively regulates rrna expression
(R-HSA-427413)
Oxidative stress induced senescence
(R-HSA-2559580)
Pkmts methylate histone lysines
(R-HSA-3214841)
Positive epigenetic regulation of rrna expression
(R-HSA-5250913)
Prc2 methylates histones and dna
(R-HSA-212300)
Pre-notch expression and processing
(R-HSA-1912422)
Pre-notch transcription and translation
(R-HSA-1912408)
Regulation of endogenous retroelements
(R-HSA-9842860)
Regulation of endogenous retroelements by krab-zfp proteins
(R-HSA-9843940)
Regulation of endogenous retroelements by piwi-interacting rnas (pirnas)
(R-HSA-9845323)
Regulation of endogenous retroelements by the human silencing hub (hush) complex
(R-HSA-9843970)
Reproduction
(R-HSA-1474165)
Rho gtpase effectors
(R-HSA-195258)
Rho gtpases activate pkns
(R-HSA-5625740)
Rmts methylate histone arginines
(R-HSA-3214858)
Rna polymerase ii transcription
(R-HSA-73857)
Rna polymerase i promoter clearance
(R-HSA-73854)
Rna polymerase i promoter escape
(R-HSA-73772)
Rna polymerase i promoter opening
(R-HSA-73728)
Rna polymerase i transcription
(R-HSA-73864)
Runx1 regulates genes involved in megakaryocyte differentiation and platelet function
(R-HSA-8936459)
Runx1 regulates transcription of genes involved in differentiation of hscs
(R-HSA-8939236)
Senescence-associated secretory phenotype (sasp)
(R-HSA-2559582)
Signaling by interleukins
(R-HSA-449147)
Signaling by notch
(R-HSA-157118)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signaling by wnt
(R-HSA-195721)
Signal transduction
(R-HSA-162582)
Sirt1 negatively regulates rrna expression
(R-HSA-427359)
Tcf dependent signaling in response to wnt
(R-HSA-201681)
Transcriptional regulation by runx1
(R-HSA-8878171)
Transcriptional regulation by small rnas
(R-HSA-5578749)
Transcriptional regulation of granulopoiesis
(R-HSA-9616222)
Viral infection pathways
(R-HSA-9824446)
Cadherin binding
(GO:0045296)
Chromatin organization
(GO:0006325)
Dna binding
(GO:0003677)
Gene expression
(GO:0010467)
Nucleosome assembly
(GO:0006334)
Protein binding
(GO:0005515)
Protein heterodimerization activity
(GO:0046982)
Structural constituent of chromatin
(GO:0030527)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 10.0192
Cell Significance Index: 320.9000
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 8.3147
Cell Significance Index: 172.4800
Cell Name: promonocyte (CL0000559)
Fold Change: 3.9984
Cell Significance Index: 42.7100
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 1.0149
Cell Significance Index: 12.0000
Cell Name: primitive red blood cell (CL0002355)
Fold Change: 0.9399
Cell Significance Index: 10.6400
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.9038
Cell Significance Index: 124.1200
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.6342
Cell Significance Index: 28.7500
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.5017
Cell Significance Index: 14.4600
Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
Fold Change: 0.4770
Cell Significance Index: 6.7000
Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
Fold Change: 0.4208
Cell Significance Index: 5.0800
Cell Name: common dendritic progenitor (CL0001029)
Fold Change: 0.3181
Cell Significance Index: 3.3100
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.2697
Cell Significance Index: 26.6800
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.2078
Cell Significance Index: 2.8500
Cell Name: thymocyte (CL0000893)
Fold Change: 0.1694
Cell Significance Index: 2.1400
Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: 0.1379
Cell Significance Index: 1.3300
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.1292
Cell Significance Index: 24.5900
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.1066
Cell Significance Index: 6.4000
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.0439
Cell Significance Index: 4.7700
Cell Name: odontoblast (CL0000060)
Fold Change: 0.0183
Cell Significance Index: 2.3500
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.0162
Cell Significance Index: 0.4400
Cell Name: keratinocyte (CL0000312)
Fold Change: 0.0100
Cell Significance Index: 0.2500
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0016
Cell Significance Index: 0.0500
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0021
Cell Significance Index: -0.3800
Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.0036
Cell Significance Index: -0.1500
Cell Name: helper T cell (CL0000912)
Fold Change: -0.0172
Cell Significance Index: -0.2500
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0252
Cell Significance Index: -9.0500
Cell Name: T-helper 17 cell (CL0000899)
Fold Change: -0.0328
Cell Significance Index: -0.2500
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0343
Cell Significance Index: -9.8700
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: -0.0360
Cell Significance Index: -5.8500
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: -0.0462
Cell Significance Index: -0.5900
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0507
Cell Significance Index: -10.1700
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0551
Cell Significance Index: -6.7700
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0583
Cell Significance Index: -5.9600
Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: -0.0657
Cell Significance Index: -0.6800
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0697
Cell Significance Index: -5.3500
Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: -0.0830
Cell Significance Index: -1.4300
Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: -0.0916
Cell Significance Index: -1.0000
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.1021
Cell Significance Index: -3.0000
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.1106
Cell Significance Index: -2.3600
Cell Name: preadipocyte (CL0002334)
Fold Change: -0.1253
Cell Significance Index: -2.4500
Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: -0.1341
Cell Significance Index: -0.8300
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.1386
Cell Significance Index: -7.7800
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.1393
Cell Significance Index: -3.0200
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.1452
Cell Significance Index: -3.6300
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -0.1543
Cell Significance Index: -10.6700
Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.1606
Cell Significance Index: -2.4200
Cell Name: smooth muscle cell of prostate (CL1000487)
Fold Change: -0.1728
Cell Significance Index: -2.0000
Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
Fold Change: -0.1738
Cell Significance Index: -1.9200
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.1906
Cell Significance Index: -8.9600
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.1950
Cell Significance Index: -2.2200
Cell Name: immature NK T cell (CL0000914)
Fold Change: -0.2000
Cell Significance Index: -2.5600
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: -0.2005
Cell Significance Index: -2.0200
Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: -0.2042
Cell Significance Index: -2.6700
Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
Fold Change: -0.2085
Cell Significance Index: -1.9300
Cell Name: prostate gland microvascular endothelial cell (CL2000059)
Fold Change: -0.2158
Cell Significance Index: -1.5500
Cell Name: Langerhans cell (CL0000453)
Fold Change: -0.2654
Cell Significance Index: -2.5300
Cell Name: proerythroblast (CL0000547)
Fold Change: -0.2694
Cell Significance Index: -3.8600
Cell Name: endothelial cell of vascular tree (CL0002139)
Fold Change: -0.2913
Cell Significance Index: -4.0000
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.3202
Cell Significance Index: -8.5500
Cell Name: melanocyte of skin (CL1000458)
Fold Change: -0.3268
Cell Significance Index: -4.5800
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.3425
Cell Significance Index: -12.0000
Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
Fold Change: -0.3761
Cell Significance Index: -1.9700
Cell Name: hematopoietic cell (CL0000988)
Fold Change: -0.3808
Cell Significance Index: -5.5700
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.3867
Cell Significance Index: -12.6600
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.3944
Cell Significance Index: -11.3100
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.4020
Cell Significance Index: -7.4300
Cell Name: urothelial cell (CL0000731)
Fold Change: -0.4058
Cell Significance Index: -2.8300
Cell Name: lymphocyte (CL0000542)
Fold Change: -0.4065
Cell Significance Index: -5.5300
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.4128
Cell Significance Index: -13.1500
Cell Name: regular atrial cardiac myocyte (CL0002129)
Fold Change: -0.4134
Cell Significance Index: -5.5800
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: -0.4199
Cell Significance Index: -6.0300
Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: -0.4214
Cell Significance Index: -4.3700
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: -0.4262
Cell Significance Index: -6.1300
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.4275
Cell Significance Index: -18.9100
Cell Name: erythrocyte (CL0000232)
Fold Change: -0.4416
Cell Significance Index: -11.2500
Cell Name: precursor B cell (CL0000817)
Fold Change: -0.4536
Cell Significance Index: -5.8700
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: -0.4562
Cell Significance Index: -8.9200
Cell Name: neural cell (CL0002319)
Fold Change: -0.4749
Cell Significance Index: -5.5400
Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
Fold Change: -0.4852
Cell Significance Index: -4.3200
Cell Name: basal cell of epidermis (CL0002187)
Fold Change: -0.4885
Cell Significance Index: -7.4200
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: -0.4956
Cell Significance Index: -6.1300
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.4966
Cell Significance Index: -12.0300
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.4994
Cell Significance Index: -18.9100
Cell Name: suprabasal keratinocyte (CL4033013)
Fold Change: -0.5000
Cell Significance Index: -8.0400
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.5022
Cell Significance Index: -8.4100
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.5192
Cell Significance Index: -12.9500
Cell Name: leukocyte (CL0000738)
Fold Change: -0.5205
Cell Significance Index: -8.8400
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: -0.5219
Cell Significance Index: -10.6200
Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: -0.5402
Cell Significance Index: -11.2800
Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.5478
Cell Significance Index: -7.8500
Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: -0.5498
Cell Significance Index: -13.7100
Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: -0.5587
Cell Significance Index: -6.2500
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.5693
Cell Significance Index: -12.3000
Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: -0.5732
Cell Significance Index: -7.3500
Cell Name: common lymphoid progenitor (CL0000051)
Fold Change: -0.5822
Cell Significance Index: -5.9100
Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
Fold Change: -0.5918
Cell Significance Index: -6.2300
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.6102
Cell Significance Index: -12.9500
Cell Name: neural progenitor cell (CL0011020)
Fold Change: -0.6145
Cell Significance Index: -6.0800
Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.6301
Cell Significance Index: -12.6500
Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
Fold Change: -0.6364
Cell Significance Index: -5.7900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Other Information

Description

**Key Characteristics** 1. **Histone variant**: H3C4 is a variant of histone H3, which is a core component of chromatin. 2. **Chromatin modifications**: H3C4 is involved in various chromatin modifications, including acetylation, methylation, and demethylation, which regulate gene expression and DNA replication. 3. **Transcriptional regulation**: H3C4 plays a role in transcriptional regulation, particularly in the activation of androgen receptor-regulated genes and the regulation of Hox genes in hindbrain development. 4. **Cellular expression**: H3C4 is expressed in various cell types, including immune cells, neurons, and epithelial cells, suggesting its involvement in multiple cellular processes. **Pathways and Functions** 1. **Transcriptional regulation**: H3C4 is involved in the activation of androgen receptor-regulated genes, such as KLK2 and KLK3, and the regulation of Hox genes in hindbrain development. 2. **Chromatin modifications**: H3C4 is involved in chromatin modifications, including acetylation, methylation, and demethylation, which regulate gene expression and DNA replication. 3. **DNA replication**: H3C4 is involved in DNA replication, particularly in the assembly of the pre-replicative complex. 4. **Cell cycle progression**: H3C4 is involved in cell cycle progression, particularly in the mitotic phase. 5. **Immune system**: H3C4 is expressed in immune cells, such as CD4-positive, alpha-beta memory T cells and CD16-positive, CD56-dim natural killer cells, suggesting its involvement in immune responses. 6. **Neurological development**: H3C4 is involved in the regulation of Hox genes in hindbrain development, which is essential for neurological development. 7. **Epigenetic regulation**: H3C4 is involved in epigenetic regulation, particularly in the regulation of RNA expression and the assembly of the Orc complex at the origin of replication. **Clinical Significance** 1. **Cancer**: Alterations in H3C4 expression have been associated with various cancers, including breast cancer and leukemia. 2. **Neurological disorders**: H3C4 has been implicated in neurological disorders, such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). 3. **Immunological disorders**: H3C4 has been implicated in immunological disorders, such as multiple sclerosis and rheumatoid arthritis. 4. **Reproductive disorders**: H3C4 has been implicated in reproductive disorders, such as infertility and miscarriage. 5. **Viral infections**: H3C4 has been implicated in viral infections, such as HIV and herpes simplex virus. In conclusion, H3C4 is a multifunctional gene that plays a crucial role in chromatin structure, transcriptional regulation, and cell cycle progression. Its involvement in various cellular processes and diseases highlights its importance in maintaining cellular homeostasis and responding to environmental cues. Further research is needed to fully understand the functions and clinical significance of H3C4.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.