Gene IGHG4 - ENSG00000211892 | NCBI Gene ID: 3503

Details for: IGHG4

Gene ID: 3503

Symbol: IGHG4

Ensembl ID: ENSG00000211892

Description: immunoglobulin heavy constant gamma 4 (G4m marker)

Associated with

Anti-inflammatory response favouring leishmania parasite infection
(R-HSA-9662851)
Classical antibody-mediated complement activation
(R-HSA-173623)
Complement cascade
(R-HSA-166658)
Creation of c4 and c2 activators
(R-HSA-166786)
Cytokine signaling in immune system
(R-HSA-1280215)
Disease
(R-HSA-1643685)
Fcgamma receptor (fcgr) dependent phagocytosis
(R-HSA-2029480)
Fcgr3a-mediated il10 synthesis
(R-HSA-9664323)
Fcgr3a-mediated phagocytosis
(R-HSA-9664422)
Fcgr activation
(R-HSA-2029481)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Initial triggering of complement
(R-HSA-166663)
Innate immune system
(R-HSA-168249)
Interleukin-4 and interleukin-13 signaling
(R-HSA-6785807)
Leishmania infection
(R-HSA-9658195)
Leishmania parasite growth and survival
(R-HSA-9664433)
Leishmania phagocytosis
(R-HSA-9664417)
Parasite infection
(R-HSA-9664407)
Parasitic infection pathways
(R-HSA-9824443)
Regulation of actin dynamics for phagocytic cup formation
(R-HSA-2029482)
Regulation of complement cascade
(R-HSA-977606)
Role of phospholipids in phagocytosis
(R-HSA-2029485)
Signaling by interleukins
(R-HSA-449147)
Adaptive immune response
(GO:0002250)
Antibacterial humoral response
(GO:0019731)
Antigen binding
(GO:0003823)
B cell receptor signaling pathway
(GO:0050853)
Blood microparticle
(GO:0072562)
Complement activation, classical pathway
(GO:0006958)
Extracellular exosome
(GO:0070062)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Igg immunoglobulin complex
(GO:0071735)
Immunoglobulin complex, circulating
(GO:0042571)
Immunoglobulin receptor binding
(GO:0034987)
Plasma membrane
(GO:0005886)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: IgG plasmablast (CL0000982)
Fold Change: 3.88
Marker Score: 1069
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.98
Marker Score: 1976
Cell Name: IgG plasma cell (CL0000985)
Fold Change: 1.66
Marker Score: 724
Cell Name: DN3 thymocyte (CL0000807)
Fold Change: 1.42
Marker Score: 710
Cell Name: IgG memory B cell (CL0000979)
Fold Change: 1.37
Marker Score: 827
Cell Name: DN1 thymic pro-T cell (CL0000894)
Fold Change: 1.25
Marker Score: 386
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 1.24
Marker Score: 840
Cell Name: goblet cell (CL0000160)
Fold Change: 1.15
Marker Score: 7615
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.14
Marker Score: 4792
Cell Name: transitional stage B cell (CL0000818)
Fold Change: 1.09
Marker Score: 384
Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.07
Marker Score: 781
Cell Name: bronchus fibroblast of lung (CL2000093)
Fold Change: 1
Marker Score: 1374
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30406
Cell Name: plasmablast (CL0000980)
Fold Change: 0.98
Marker Score: 1299
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.96
Marker Score: 497
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.95
Marker Score: 450
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2411
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.93
Marker Score: 5281
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2738
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.91
Marker Score: 364
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.89
Marker Score: 370
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.88
Marker Score: 318
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5286
Cell Name: exhausted T cell (CL0011025)
Fold Change: 0.79
Marker Score: 457
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1269
Cell Name: brush cell (CL0002204)
Fold Change: 0.77
Marker Score: 699
Cell Name: IgA plasma cell (CL0000987)
Fold Change: 0.76
Marker Score: 650
Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 0.66
Marker Score: 3490
Cell Name: neutrophil (CL0000775)
Fold Change: 0.66
Marker Score: 402
Cell Name: germinal center B cell (CL0000844)
Fold Change: 0.63
Marker Score: 384
Cell Name: IgA plasmablast (CL0000984)
Fold Change: 0.63
Marker Score: 165
Cell Name: memory B cell (CL0000787)
Fold Change: 0.61
Marker Score: 461
Cell Name: myeloid cell (CL0000763)
Fold Change: 0.6
Marker Score: 964.5
Cell Name: intestinal crypt stem cell (CL0002250)
Fold Change: 0.6
Marker Score: 226
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.57
Marker Score: 364
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.56
Marker Score: 444
Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
Fold Change: 0.53
Marker Score: 1376
Cell Name: type I NK T cell (CL0000921)
Fold Change: 0.51
Marker Score: 399
Cell Name: hematopoietic cell (CL0000988)
Fold Change: 0.51
Marker Score: 336
Cell Name: neuroendocrine cell (CL0000165)
Fold Change: 0.5
Marker Score: 194
Cell Name: mast cell (CL0000097)
Fold Change: 0.5
Marker Score: 289
Cell Name: follicular B cell (CL0000843)
Fold Change: 0.48
Marker Score: 518
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.45
Marker Score: 207
Cell Name: alternatively activated macrophage (CL0000890)
Fold Change: 0.44
Marker Score: 183
Cell Name: platelet (CL0000233)
Fold Change: 0.42
Marker Score: 191
Cell Name: fibroblast of lung (CL0002553)
Fold Change: 0.42
Marker Score: 1089
Cell Name: innate lymphoid cell (CL0001065)
Fold Change: 0.42
Marker Score: 149.5
Cell Name: plasma cell (CL0000786)
Fold Change: 0.41
Marker Score: 456
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.41
Marker Score: 129
Cell Name: fibroblast (CL0000057)
Fold Change: 0.4
Marker Score: 384
Cell Name: classical monocyte (CL0000860)
Fold Change: 0.37
Marker Score: 1536
Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
Fold Change: 0.36
Marker Score: 302
Cell Name: mesothelial cell (CL0000077)
Fold Change: 0.34
Marker Score: 135
Cell Name: B cell (CL0000236)
Fold Change: 0.33
Marker Score: 314
Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
Fold Change: 0.33
Marker Score: 241
Cell Name: multi-ciliated epithelial cell (CL0005012)
Fold Change: 0.32
Marker Score: 611
Cell Name: malignant cell (CL0001064)
Fold Change: 0.31
Marker Score: 4203
Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: 0.31
Marker Score: 183
Cell Name: naive T cell (CL0000898)
Fold Change: 0.31
Marker Score: 200
Cell Name: T cell (CL0000084)
Fold Change: 0.31
Marker Score: 533
Cell Name: class switched memory B cell (CL0000972)
Fold Change: 0.3
Marker Score: 283
Cell Name: ionocyte (CL0005006)
Fold Change: 0.3
Marker Score: 90
Cell Name: plasmacytoid dendritic cell (CL0000784)
Fold Change: 0.29
Marker Score: 156
Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
Fold Change: 0.29
Marker Score: 178
Cell Name: dendritic cell (CL0000451)
Fold Change: 0.28
Marker Score: 195
Cell Name: conventional dendritic cell (CL0000990)
Fold Change: 0.28
Marker Score: 193
Cell Name: M cell of gut (CL0000682)
Fold Change: 0.27
Marker Score: 70
Cell Name: smooth muscle cell (CL0000192)
Fold Change: 0.26
Marker Score: 170
Cell Name: IgG-negative class switched memory B cell (CL0002117)
Fold Change: 0.25
Marker Score: 250
Cell Name: megakaryocyte (CL0000556)
Fold Change: 0.23
Marker Score: 133
Cell Name: leukocyte (CL0000738)
Fold Change: 0.23
Marker Score: 132
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.23
Marker Score: 559
Cell Name: endothelial cell (CL0000115)
Fold Change: 0.23
Marker Score: 203
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.22
Marker Score: 64
Cell Name: mesenchymal lymphangioblast (CL0005021)
Fold Change: 0.22
Marker Score: 50
Cell Name: paneth cell of colon (CL0009009)
Fold Change: 0.22
Marker Score: 63.5
Cell Name: mature T cell (CL0002419)
Fold Change: 0.22
Marker Score: 2170
Cell Name: blood cell (CL0000081)
Fold Change: 0.22
Marker Score: 2544
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.21
Marker Score: 141
Cell Name: kidney loop of Henle epithelial cell (CL1000909)
Fold Change: 0.21
Marker Score: 132
Cell Name: alveolar macrophage (CL0000583)
Fold Change: 0.21
Marker Score: 5301
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.21
Marker Score: 70
Cell Name: keratocyte (CL0002363)
Fold Change: 0.2
Marker Score: 47
Cell Name: ILC1, human (CL0001077)
Fold Change: 0.2
Marker Score: 51
Cell Name: late promyelocyte (CL0002151)
Fold Change: 0.2
Marker Score: 50
Cell Name: mesothelial cell of epicardium (CL0011019)
Fold Change: 0.2
Marker Score: 64
Cell Name: cardiac mesenchymal cell (CL0000569)
Fold Change: 0.2
Marker Score: 48
Cell Name: adventitial cell (CL0002503)
Fold Change: 0.19
Marker Score: 48
Cell Name: blood vessel smooth muscle cell (CL0019018)
Fold Change: 0.19
Marker Score: 51
Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
Fold Change: 0.19
Marker Score: 43
Cell Name: natural killer cell (CL0000623)
Fold Change: 0.19
Marker Score: 244
Cell Name: respiratory basal cell (CL0002633)
Fold Change: 0.19
Marker Score: 270
Cell Name: plasmacytoid dendritic cell, human (CL0001058)
Fold Change: 0.19
Marker Score: 49
Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
Fold Change: 0.19
Marker Score: 49
Cell Name: vasa recta ascending limb cell (CL1001131)
Fold Change: 0.19
Marker Score: 49
Cell Name: fibroblast of connective tissue of prostate (CL1000299)
Fold Change: 0.18
Marker Score: 46
Cell Name: endothelial cell of lymphatic vessel (CL0002138)
Fold Change: 0.18
Marker Score: 115
Cell Name: prostate stromal cell (CL0002622)
Fold Change: 0.18
Marker Score: 46
Cell Name: type II pneumocyte (CL0002063)
Fold Change: 0.18
Marker Score: 1191
Cell Name: megakaryocyte progenitor cell (CL0000553)
Fold Change: 0.18
Marker Score: 51

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Other Information

Description

**Key characteristics:** - IGHG4 is a glycoprotein, consisting of a heavy chain (IgH4) and a light chain (IgL4). - It is a member of the immunoglobulin heavy chain family, which is responsible for antibody-mediated immune responses. - IGHG4 is expressed in high levels in plasmablast and memory B cells, where it plays a crucial role in antibody production and activation. - It is also expressed in other immune cells, such as enterocytes and dendritic cells, where it may contribute to immune surveillance and pathogen recognition. **Pathways and functions:** - IGHG4 is involved in the classical antibody-mediated complement activation pathway, a part of the innate immune response. - It binds to complement proteins, particularly C1q, C2, and C3, and facilitates their interaction and activation. - This leads to the formation of the C4 and C2 complement complexes, which are central mediators of the inflammatory response. - IGHG4 also plays a role in the regulation of actin dynamics, which is essential for the formation and function of immune complexes. - It is involved in the regulation of the complement cascade, a complex network of protein interactions that is triggered by pathogens and inflammation. **Clinical significance:** - Mutations in the IGHG4 gene have been linked to several autoimmune disorders, including systemic sclerosis, rheumatoid arthritis, and inflammatory bowel disease. - In these disorders, IGHG4 is expressed in excess, leading to the formation of excessive complement complexes and tissue damage. - Targeting IGHG4 has emerged as a potential therapeutic strategy for these autoimmune diseases. **Additional notes:** - IGHG4 is a highly conserved protein, with a similar sequence in humans, mice, and rats. - It is a secreted protein, and its expression is regulated by various factors, including cytokines and hormones. - IGHG4 is a versatile protein with important roles in both innate and adaptive immune responses.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.