IGHG4 | ENSG00000211892 | NCBI 3503

Details for: IGHG4

Gene ID: 3503

Symbol: IGHG4

Ensembl ID: ENSG00000211892

Description: immunoglobulin heavy constant gamma 4 (G4m marker)

Associated with

Anti-inflammatory response favouring leishmania parasite infection
(R-HSA-9662851)
Classical antibody-mediated complement activation
(R-HSA-173623)
Complement cascade
(R-HSA-166658)
Creation of c4 and c2 activators
(R-HSA-166786)
Cytokine signaling in immune system
(R-HSA-1280215)
Disease
(R-HSA-1643685)
Fcgamma receptor (fcgr) dependent phagocytosis
(R-HSA-2029480)
Fcgr3a-mediated il10 synthesis
(R-HSA-9664323)
Fcgr3a-mediated phagocytosis
(R-HSA-9664422)
Fcgr activation
(R-HSA-2029481)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Initial triggering of complement
(R-HSA-166663)
Innate immune system
(R-HSA-168249)
Interleukin-4 and interleukin-13 signaling
(R-HSA-6785807)
Leishmania infection
(R-HSA-9658195)
Leishmania parasite growth and survival
(R-HSA-9664433)
Leishmania phagocytosis
(R-HSA-9664417)
Parasite infection
(R-HSA-9664407)
Parasitic infection pathways
(R-HSA-9824443)
Regulation of actin dynamics for phagocytic cup formation
(R-HSA-2029482)
Regulation of complement cascade
(R-HSA-977606)
Role of phospholipids in phagocytosis
(R-HSA-2029485)
Signaling by interleukins
(R-HSA-449147)
Adaptive immune response
(GO:0002250)
Antibacterial humoral response
(GO:0019731)
Antigen binding
(GO:0003823)
B cell receptor signaling pathway
(GO:0050853)
Blood microparticle
(GO:0072562)
Complement activation, classical pathway
(GO:0006958)
Extracellular exosome
(GO:0070062)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Igg immunoglobulin complex
(GO:0071735)
Immunoglobulin complex, circulating
(GO:0042571)
Immunoglobulin receptor binding
(GO:0034987)
Plasma membrane
(GO:0005886)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 9.6357
Cell Significance Index: 338.5900
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 7.5558
Cell Significance Index: 188.8800
Cell Name: oral mucosa squamous cell (CL1001576)
Fold Change: 5.5365
Cell Significance Index: 47.5800
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 3.5690
Cell Significance Index: 74.0400
Cell Name: colonocyte (CL1000347)
Fold Change: 2.7250
Cell Significance Index: 16.8400
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 2.3894
Cell Significance Index: 51.7700
Cell Name: DN3 thymocyte (CL0000807)
Fold Change: 1.7623
Cell Significance Index: 17.6700
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.5782
Cell Significance Index: 71.5400
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 1.3852
Cell Significance Index: 44.3700
Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: 1.1264
Cell Significance Index: 16.9800
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.7133
Cell Significance Index: 135.7500
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.6827
Cell Significance Index: 616.4200
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.5157
Cell Significance Index: 51.0100
Cell Name: paneth cell of colon (CL0009009)
Fold Change: 0.4538
Cell Significance Index: 6.8000
Cell Name: DN1 thymic pro-T cell (CL0000894)
Fold Change: 0.4485
Cell Significance Index: 4.6500
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.4248
Cell Significance Index: 69.0900
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.3904
Cell Significance Index: 8.3200
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.3421
Cell Significance Index: 37.2200
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.1900
Cell Significance Index: 13.1400
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.1210
Cell Significance Index: 7.2700
Cell Name: IgG plasmablast (CL0000982)
Fold Change: 0.0691
Cell Significance Index: 0.5700
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 0.0238
Cell Significance Index: 0.2700
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 0.0006
Cell Significance Index: 0.0100
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.0035
Cell Significance Index: -0.1000
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0060
Cell Significance Index: -11.2600
Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0107
Cell Significance Index: -5.8300
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0121
Cell Significance Index: -9.1600
Cell Name: odontoblast (CL0000060)
Fold Change: -0.0151
Cell Significance Index: -1.9400
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0188
Cell Significance Index: -13.7700
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0204
Cell Significance Index: -12.9400
Cell Name: glandular cell of esophagus (CL0002657)
Fold Change: -0.0289
Cell Significance Index: -0.3100
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0310
Cell Significance Index: -14.0900
Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.0356
Cell Significance Index: -1.4600
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0406
Cell Significance Index: -2.4900
Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.0499
Cell Significance Index: -9.9100
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0702
Cell Significance Index: -14.0800
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0724
Cell Significance Index: -13.0500
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0908
Cell Significance Index: -13.2000
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0925
Cell Significance Index: -12.7000
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.1038
Cell Significance Index: -12.7600
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.1188
Cell Significance Index: -20.2800
Cell Name: lactocyte (CL0002325)
Fold Change: -0.1221
Cell Significance Index: -15.7800
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.1312
Cell Significance Index: -13.4000
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.1711
Cell Significance Index: -13.5500
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1826
Cell Significance Index: -20.9200
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.1910
Cell Significance Index: -9.9200
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.1913
Cell Significance Index: -14.6800
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.2112
Cell Significance Index: -15.7400
Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.2169
Cell Significance Index: -14.0000
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.2209
Cell Significance Index: -11.6000
Cell Name: intestinal crypt stem cell (CL0002250)
Fold Change: -0.2501
Cell Significance Index: -1.7600
Cell Name: IgG memory B cell (CL0000979)
Fold Change: -0.2600
Cell Significance Index: -1.5700
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.2614
Cell Significance Index: -9.6000
Cell Name: enterocyte (CL0000584)
Fold Change: -0.2627
Cell Significance Index: -1.6300
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.3195
Cell Significance Index: -14.9000
Cell Name: plasma cell (CL0000786)
Fold Change: -0.3294
Cell Significance Index: -3.6800
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.3394
Cell Significance Index: -15.9500
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.3535
Cell Significance Index: -11.2600
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.4310
Cell Significance Index: -10.4400
Cell Name: peg cell (CL4033014)
Fold Change: -0.4315
Cell Significance Index: -9.9700
Cell Name: granulosa cell (CL0000501)
Fold Change: -0.4356
Cell Significance Index: -11.4600
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.4482
Cell Significance Index: -11.4500
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.4865
Cell Significance Index: -14.3300
Cell Name: IgG plasma cell (CL0000985)
Fold Change: -0.4899
Cell Significance Index: -4.4800
Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: -0.4973
Cell Significance Index: -12.4000
Cell Name: leukocyte (CL0000738)
Fold Change: -0.5134
Cell Significance Index: -8.7200
Cell Name: lens fiber cell (CL0011004)
Fold Change: -0.5315
Cell Significance Index: -16.8100
Cell Name: keratinocyte (CL0000312)
Fold Change: -0.5329
Cell Significance Index: -13.3100
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.5428
Cell Significance Index: -15.5600
Cell Name: lymphocyte (CL0000542)
Fold Change: -0.5550
Cell Significance Index: -7.5500
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.5571
Cell Significance Index: -14.8800
Cell Name: erythrocyte (CL0000232)
Fold Change: -0.5613
Cell Significance Index: -14.3000
Cell Name: type I muscle cell (CL0002211)
Fold Change: -0.6140
Cell Significance Index: -14.9800
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.6568
Cell Significance Index: -13.9400
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: -0.6718
Cell Significance Index: -11.6200
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.6964
Cell Significance Index: -11.6600
Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.6993
Cell Significance Index: -14.0400
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.6996
Cell Significance Index: -12.9300
Cell Name: hepatocyte (CL0000182)
Fold Change: -0.7080
Cell Significance Index: -9.8200
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.7121
Cell Significance Index: -14.0800
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.7357
Cell Significance Index: -20.0300
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: -0.7406
Cell Significance Index: -14.4800
Cell Name: preadipocyte (CL0002334)
Fold Change: -0.7501
Cell Significance Index: -14.6400
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: -0.7558
Cell Significance Index: -12.9200
Cell Name: megakaryocyte (CL0000556)
Fold Change: -0.7591
Cell Significance Index: -12.3000
Cell Name: transit amplifying cell (CL0009010)
Fold Change: -0.7594
Cell Significance Index: -7.2900
Cell Name: early T lineage precursor (CL0002425)
Fold Change: -0.7845
Cell Significance Index: -11.3900
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: -0.7903
Cell Significance Index: -8.6500
Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: -0.7964
Cell Significance Index: -10.4200
Cell Name: epithelial cell of uterus (CL0002149)
Fold Change: -0.8022
Cell Significance Index: -11.1300
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -0.8035
Cell Significance Index: -13.5400
Cell Name: B cell (CL0000236)
Fold Change: -0.8268
Cell Significance Index: -9.7700
Cell Name: hematopoietic cell (CL0000988)
Fold Change: -0.8283
Cell Significance Index: -12.1200
Cell Name: neuroendocrine cell (CL0000165)
Fold Change: -0.8401
Cell Significance Index: -10.6400
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.8502
Cell Significance Index: -14.5700
Cell Name: epithelial cell (CL0000066)
Fold Change: -0.8513
Cell Significance Index: -8.9800
Cell Name: thyroid follicular cell (CL0002258)
Fold Change: -0.8668
Cell Significance Index: -9.2100
Cell Name: fast muscle cell (CL0000190)
Fold Change: -0.8674
Cell Significance Index: -11.3600
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: -0.8704
Cell Significance Index: -11.0300
Cell Name: thymocyte (CL0000893)
Fold Change: -0.8809
Cell Significance Index: -11.1300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Other Information

Description

**Key Characteristics:** * IGHG4 is a member of the immunoglobulin heavy chain family and is encoded by the IGHG4 gene. * The IGHG4 gene is located on chromosome 14q32.11 and is part of the immunoglobulin locus. * IGHG4 is a gamma heavy chain constant region, which is a critical component of IgG antibodies. * IGHG4 is significantly expressed in B cells, plasma cells, enterocytes, and other cell types involved in immune responses. **Pathways and Functions:** * IGHG4 is involved in the adaptive immune response, particularly in the production of IgG antibodies. * IGHG4 is also involved in the innate immune response, particularly in the activation of complement cascade and the production of cytokines. * IGHG4 is involved in the regulation of actin dynamics for phagocytic cup formation and the regulation of complement cascade. * IGHG4 is also involved in the signaling pathways of interleukins, including IL-4 and IL-13. * IGHG4 is involved in the creation of c4 and c2 activators, which are critical components of the complement cascade. **Clinical Significance:** * IGHG4 has been associated with various diseases, including autoimmune disorders, such as rheumatoid arthritis and lupus. * IGHG4 has also been implicated in parasitic infections, such as leishmaniasis, where it plays a crucial role in the activation of complement cascade and the production of cytokines. * IGHG4 has been shown to be overexpressed in certain types of cancer, including breast and lung cancer, where it may contribute to tumorigenesis and metastasis. * IGHG4 has also been associated with inflammatory bowel disease, where it may contribute to the pathogenesis of the disease. **Significantly Expressed Cells:** * IgG plasmablast * Enterocyte of epithelium of large intestine * IgG plasma cell * DN3 thymocyte * IgG memory B cell * DN1 thymic pro-T cell * Intestinal crypt stem cell of small intestine * Goblet cell * Enterocyte of epithelium of small intestine * Transitional stage B cell In conclusion, IGHG4 is a critical component of the immune system, involved in multiple immune responses, including adaptive and innate immunity. Its clinical significance is evident in its association with various diseases, including autoimmune disorders, parasitic infections, and cancer. Further research is needed to fully understand the functions and clinical significance of IGHG4.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.