Gene CCR10 - ENSG00000184451 | NCBI Gene ID: 2826

Details for: CCR10

Gene ID: 2826

Symbol: CCR10

Ensembl ID: ENSG00000184451

Description: C-C motif chemokine receptor 10

Associated with

Chemokine receptors bind chemokines
(R-HSA-380108)
Class a/1 (rhodopsin-like receptors)
(R-HSA-373076)
G alpha (i) signalling events
(R-HSA-418594)
Gpcr downstream signalling
(R-HSA-388396)
Gpcr ligand binding
(R-HSA-500792)
Peptide ligand-binding receptors
(R-HSA-375276)
Signaling by gpcr
(R-HSA-372790)
Signal transduction
(R-HSA-162582)
C-c chemokine binding
(GO:0019957)
C-c chemokine receptor activity
(GO:0016493)
Calcium-mediated signaling
(GO:0019722)
Cell chemotaxis
(GO:0060326)
Cell surface
(GO:0009986)
Chemokine-mediated signaling pathway
(GO:0070098)
Endoplasmic reticulum
(GO:0005783)
External side of plasma membrane
(GO:0009897)
G protein-coupled receptor activity
(GO:0004930)
G protein-coupled receptor signaling pathway
(GO:0007186)
Immune response
(GO:0006955)
Plasma membrane
(GO:0005886)
Positive regulation of cytosolic calcium ion concentration
(GO:0007204)
Protein binding
(GO:0005515)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.6
Marker Score: 1164
Cell Name: IgA plasma cell (CL0000987)
Fold Change: 1.54
Marker Score: 1315
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.15
Marker Score: 4808
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 1.03
Marker Score: 789.5
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71820
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48045
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30408
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.98
Marker Score: 503
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.97
Marker Score: 457
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.96
Marker Score: 15010
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2412
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.94
Marker Score: 636
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.93
Marker Score: 5320
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.93
Marker Score: 1760
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.92
Marker Score: 369
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2737
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.9
Marker Score: 374
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.89
Marker Score: 321
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5284
Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 0.85
Marker Score: 3143
Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
Fold Change: 0.85
Marker Score: 1749
Cell Name: plasmablast (CL0000980)
Fold Change: 0.83
Marker Score: 1097.5
Cell Name: IgM plasma cell (CL0000986)
Fold Change: 0.82
Marker Score: 287
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.78
Marker Score: 1577
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.77
Marker Score: 1258
Cell Name: brush cell (CL0002204)
Fold Change: 0.77
Marker Score: 704
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.76
Marker Score: 392
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.68
Marker Score: 174
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 0.63
Marker Score: 969
Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 0.6
Marker Score: 1211
Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.59
Marker Score: 283
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.56
Marker Score: 357
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.55
Marker Score: 441
Cell Name: renal beta-intercalated cell (CL0002201)
Fold Change: 0.45
Marker Score: 141
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.44
Marker Score: 14879
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.43
Marker Score: 261
Cell Name: supporting cell (CL0000630)
Fold Change: 0.43
Marker Score: 803
Cell Name: pancreatic A cell (CL0000171)
Fold Change: 0.4
Marker Score: 390
Cell Name: neuronal receptor cell (CL0000006)
Fold Change: 0.37
Marker Score: 165
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: 0.36
Marker Score: 358
Cell Name: IgG plasma cell (CL0000985)
Fold Change: 0.36
Marker Score: 156
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 0.35
Marker Score: 3664.5
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 0.35
Marker Score: 2986
Cell Name: connective tissue cell (CL0002320)
Fold Change: 0.34
Marker Score: 88
Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.33
Marker Score: 107
Cell Name: plasma cell (CL0000786)
Fold Change: 0.33
Marker Score: 369
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.32
Marker Score: 19902
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.31
Marker Score: 98
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.31
Marker Score: 141
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.3
Marker Score: 95
Cell Name: pericyte (CL0000669)
Fold Change: 0.3
Marker Score: 177
Cell Name: pancreatic D cell (CL0000173)
Fold Change: 0.29
Marker Score: 125.5
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 0.29
Marker Score: 10602
Cell Name: neuron (CL0000540)
Fold Change: 0.28
Marker Score: 1152
Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
Fold Change: 0.28
Marker Score: 94
Cell Name: kidney interstitial cell (CL1000500)
Fold Change: 0.28
Marker Score: 196
Cell Name: T-helper 22 cell (CL0001042)
Fold Change: 0.26
Marker Score: 1133
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.25
Marker Score: 67
Cell Name: pancreatic stellate cell (CL0002410)
Fold Change: 0.25
Marker Score: 157
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.24
Marker Score: 161
Cell Name: plasmacytoid dendritic cell, human (CL0001058)
Fold Change: 0.24
Marker Score: 64
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 0.24
Marker Score: 2284
Cell Name: renal interstitial pericyte (CL1001318)
Fold Change: 0.23
Marker Score: 221
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 0.23
Marker Score: 2201
Cell Name: OFF retinal ganglion cell (CL4023033)
Fold Change: 0.23
Marker Score: 96
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.22
Marker Score: 1328
Cell Name: glycinergic amacrine cell (CL4030028)
Fold Change: 0.22
Marker Score: 208.5
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.22
Marker Score: 63
Cell Name: fibroblast (CL0000057)
Fold Change: 0.22
Marker Score: 210
Cell Name: fibroblast of breast (CL4006000)
Fold Change: 0.22
Marker Score: 124
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 0.22
Marker Score: 355
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.22
Marker Score: 260
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.21
Marker Score: 72
Cell Name: blood cell (CL0000081)
Fold Change: 0.21
Marker Score: 2470
Cell Name: thymocyte (CL0000893)
Fold Change: 0.21
Marker Score: 222
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.21
Marker Score: 483
Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: 0.2
Marker Score: 104
Cell Name: retinal pigment epithelial cell (CL0002586)
Fold Change: 0.19
Marker Score: 57
Cell Name: T follicular helper cell (CL0002038)
Fold Change: 0.19
Marker Score: 159
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.19
Marker Score: 114
Cell Name: pro-B cell (CL0000826)
Fold Change: 0.19
Marker Score: 180
Cell Name: leukocyte (CL0000738)
Fold Change: 0.18
Marker Score: 106
Cell Name: smooth muscle cell (CL0000192)
Fold Change: 0.18
Marker Score: 121
Cell Name: mesothelial cell of epicardium (CL0011019)
Fold Change: 0.18
Marker Score: 58
Cell Name: epithelial cell of glomerular capsule (CL1000450)
Fold Change: 0.18
Marker Score: 45
Cell Name: ON retinal ganglion cell (CL4023032)
Fold Change: 0.18
Marker Score: 48
Cell Name: vascular associated smooth muscle cell (CL0000359)
Fold Change: 0.17
Marker Score: 80
Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
Fold Change: 0.17
Marker Score: 125
Cell Name: fibroblast of lung (CL0002553)
Fold Change: 0.17
Marker Score: 445
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.17
Marker Score: 42
Cell Name: melanocyte (CL0000148)
Fold Change: 0.17
Marker Score: 68
Cell Name: peripheral nervous system neuron (CL2000032)
Fold Change: 0.17
Marker Score: 186
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.16
Marker Score: 1853
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 0.16
Marker Score: 1058
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 0.16
Marker Score: 3155
Cell Name: PP cell (CL0000696)
Fold Change: 0.16
Marker Score: 35
Cell Name: ciliated epithelial cell (CL0000067)
Fold Change: 0.15
Marker Score: 70
Cell Name: Leydig cell (CL0000178)
Fold Change: 0.15
Marker Score: 165
Cell Name: rod bipolar cell (CL0000751)
Fold Change: 0.15
Marker Score: 78
Cell Name: B-1 B cell (CL0000819)
Fold Change: 0.15
Marker Score: 256

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**Key characteristics:** * It is a cell surface receptor that belongs to the C-C chemokine receptor family. * It is expressed in high levels in epithelial cells in the gut, where it is involved in the regulation of mucosal immunity. * It is also expressed in immune cells, including dendritic cells and macrophages. * It is a key regulator of inflammation in the gut, where it is expressed on epithelial cells and immune cells. **Pathways and functions:** * CCR10 binds to C-C chemokines, which are a family of chemotactic molecules that are produced by immune cells. * Upon binding to a C-C chemokine, CCR10 recruits the G protein-coupled receptor (GPCR) GPCR2 to the cell surface. * This binding activates the GPCR, which in turn activates the downstream signaling pathway. * The downstream signaling pathway includes the activation of mitogen-activated protein kinase (MAPK), which is a major signaling pathway involved in inflammation. **Clinical significance:** * Mutations in the CCR10 gene have been linked to several autoimmune diseases, including inflammatory bowel disease (IBD), ulcerative colitis, and rheumatoid arthritis. * CCR10 is also involved in the regulation of inflammation in the heart, where it is expressed on cardiac muscle cells. * Targeting CCR10 with antibodies or small molecules has shown promise in preclinical models of inflammatory diseases, suggesting that it could be a potential therapeutic target. **Additional notes:** * CCR10 is a highly conserved protein, with similar sequences found in mammals, birds, and fish. * It is a key player in the regulation of mucosal immunity in the gut. * It is also involved in the regulation of inflammation in other tissues, including the heart and lungs.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

C-C chemokine receptor type 10

Genular Protein ID: 391387355

Symbol: CCR10_HUMAN

Name: C-C chemokine receptor type 10

UniProtKB Accession Codes:

P46092 Q4V749 Q6T7X2 Q9NZG2

Database IDs:

Citations:

PubMed ID: 10725696

Title: Identification of the orphan receptor G-protein-coupled receptor 2 as CCR10, a specific receptor for the chemokine ESkine.

PubMed ID: 10725696

DOI: 10.4049/jimmunol.164.7.3460

PubMed ID: 10725697

Title: The orphan chemokine receptor G protein-coupled receptor-2 (GPR-2, CCR10) binds the skin-associated chemokine CCL27 (CTACK/ALP/ILC).

PubMed ID: 10725697

DOI: 10.4049/jimmunol.164.7.3465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7851889

Title: Cloning of human genes encoding novel G protein-coupled receptors.

PubMed ID: 7851889

DOI: 10.1006/geno.1994.1549

PubMed ID: 10781587

Title: Identification of a novel chemokine (CCL28), which binds CCR10 (GPR2).

PubMed ID: 10781587

DOI: 10.1074/jbc.m001461200

PubMed ID: 10975800

Title: A novel chemokine ligand for CCR10 and CCR3 expressed by epithelial cells in mucosal tissues.

PubMed ID: 10975800

DOI: 10.4049/jimmunol.165.6.2943

Sequence Information:

Length: 362
Mass: 38416
Checksum: 736EB9B639AEA99A
Sequence:

MGTEATEQVS WGHYSGDEED AYSAEPLPEL CYKADVQAFS RAFQPSVSLT VAALGLAGNG 
LVLATHLAAR RAARSPTSAH LLQLALADLL LALTLPFAAA GALQGWSLGS ATCRTISGLY 
SASFHAGFLF LACISADRYV AIARALPAGP RPSTPGRAHL VSVIVWLLSL LLALPALLFS 
QDGQREGQRR CRLIFPEGLT QTVKGASAVA QVALGFALPL GVMVACYALL GRTLLAARGP 
ERRRALRVVV ALVAAFVVLQ LPYSLALLLD TADLLAARER SCPASKRKDV ALLVTSGLAL 
ARCGLNPVLY AFLGLRFRQD LRRLLRGGSC PSGPQPRRGC PRRPRLSSCS APTETHSLSW 
DN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: CCR10

Associated with

Cells (max top 100)

Other Information

Identification of the orphan receptor G-protein-coupled receptor 2 as CCR10, a specific receptor for the chemokine ESkine. PubMed ID: 10725696

The orphan chemokine receptor G protein-coupled receptor-2 (GPR-2, CCR10) binds the skin-associated chemokine CCL27 (CTACK/ALP/ILC). PubMed ID: 10725697

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Cloning of human genes encoding novel G protein-coupled receptors. PubMed ID: 7851889

Identification of a novel chemokine (CCL28), which binds CCR10 (GPR2). PubMed ID: 10781587