Details for: CCR10

Gene ID: 2826

Symbol: CCR10

Ensembl ID: ENSG00000184451

Description: C-C motif chemokine receptor 10

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 40.0527
    Cell Significance Index: -6.2300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 24.9957
    Cell Significance Index: -6.3400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 13.7105
    Cell Significance Index: -5.5700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 5.0935
    Cell Significance Index: -6.2800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 2.6877
    Cell Significance Index: -7.2000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 1.6250
    Cell Significance Index: -6.4100
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 1.0441
    Cell Significance Index: 8.7700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.6905
    Cell Significance Index: 131.4200
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.6433
    Cell Significance Index: 5.3200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.4031
    Cell Significance Index: 8.5900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4019
    Cell Significance Index: 39.7600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3389
    Cell Significance Index: 305.9600
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.3085
    Cell Significance Index: 4.9500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.2969
    Cell Significance Index: 8.5100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2528
    Cell Significance Index: 27.5000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2410
    Cell Significance Index: 14.4700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2218
    Cell Significance Index: 36.0700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1610
    Cell Significance Index: 32.2900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1296
    Cell Significance Index: 8.9600
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: 0.1083
    Cell Significance Index: 0.5000
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.0947
    Cell Significance Index: 0.7300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0810
    Cell Significance Index: 11.1300
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.0744
    Cell Significance Index: 1.1800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0672
    Cell Significance Index: 3.5300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0494
    Cell Significance Index: 17.7300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0220
    Cell Significance Index: 15.2000
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.0206
    Cell Significance Index: 0.2500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0205
    Cell Significance Index: 0.9300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0167
    Cell Significance Index: 1.9500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0142
    Cell Significance Index: 0.4100
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0123
    Cell Significance Index: 0.1900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0041
    Cell Significance Index: 2.2400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0037
    Cell Significance Index: 0.6700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0037
    Cell Significance Index: 0.0800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0028
    Cell Significance Index: 0.1000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0014
    Cell Significance Index: 0.1800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0009
    Cell Significance Index: 1.7600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0011
    Cell Significance Index: -0.4700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0012
    Cell Significance Index: -0.0300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0026
    Cell Significance Index: -3.5100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0027
    Cell Significance Index: -5.0200
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.0030
    Cell Significance Index: -0.0200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0039
    Cell Significance Index: -6.0300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0059
    Cell Significance Index: -4.3500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0073
    Cell Significance Index: -5.4400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0077
    Cell Significance Index: -4.9100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0079
    Cell Significance Index: -4.4300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0088
    Cell Significance Index: -6.6900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0089
    Cell Significance Index: -4.0400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0101
    Cell Significance Index: -2.9000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0193
    Cell Significance Index: -3.8400
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: -0.0215
    Cell Significance Index: -0.2300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0234
    Cell Significance Index: -2.8800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0246
    Cell Significance Index: -1.5500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0250
    Cell Significance Index: -1.5300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0261
    Cell Significance Index: -1.3600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0290
    Cell Significance Index: -0.9300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0299
    Cell Significance Index: -5.1000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0315
    Cell Significance Index: -4.5800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0325
    Cell Significance Index: -2.3000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0326
    Cell Significance Index: -6.8700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0333
    Cell Significance Index: -0.6900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0334
    Cell Significance Index: -3.4200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0358
    Cell Significance Index: -1.5900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0384
    Cell Significance Index: -0.5500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0428
    Cell Significance Index: -3.2800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0429
    Cell Significance Index: -1.2000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0468
    Cell Significance Index: -5.5200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0474
    Cell Significance Index: -6.1200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0483
    Cell Significance Index: -5.5300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0533
    Cell Significance Index: -2.0200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0590
    Cell Significance Index: -2.7500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0591
    Cell Significance Index: -6.1500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0594
    Cell Significance Index: -1.3000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0614
    Cell Significance Index: -4.1300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0685
    Cell Significance Index: -1.7600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0734
    Cell Significance Index: -2.5500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0746
    Cell Significance Index: -4.8100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0762
    Cell Significance Index: -5.6800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0776
    Cell Significance Index: -1.3300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0780
    Cell Significance Index: -6.1800
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.0842
    Cell Significance Index: -1.1800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0846
    Cell Significance Index: -5.2000
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0884
    Cell Significance Index: -1.2400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0891
    Cell Significance Index: -1.8900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0897
    Cell Significance Index: -2.5600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0904
    Cell Significance Index: -4.7100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0920
    Cell Significance Index: -1.5400
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0963
    Cell Significance Index: -1.2000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0992
    Cell Significance Index: -5.0100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1021
    Cell Significance Index: -4.8000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1035
    Cell Significance Index: -3.3000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1037
    Cell Significance Index: -2.1700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1067
    Cell Significance Index: -5.9900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1167
    Cell Significance Index: -3.8200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1187
    Cell Significance Index: -4.1600
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.1235
    Cell Significance Index: -1.0500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1326
    Cell Significance Index: -3.6100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1347
    Cell Significance Index: -1.5300
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.1356
    Cell Significance Index: -2.0600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CCR10 is a member of the C-C chemokine receptor family, which is characterized by its ability to bind to CC chemokines. The receptor is expressed on various cell types, including: * Immune cells: CCR10 is expressed on T cells, B cells, and dendritic cells, which are involved in the initiation and regulation of immune responses. * Epithelial cells: CCR10 is expressed on epithelial cells in the skin, mucosal surfaces, and the small intestine, where it plays a role in maintaining tissue homeostasis. * Neural cells: CCR10 is expressed on GABAergic interneurons in the cerebral cortex and on radial glial cells in the forebrain, where it may play a role in neural development and function. **Pathways and Functions:** The activation of CCR10 by its ligands, CC chemokines, triggers a signaling cascade that regulates various cellular processes, including: * Cell chemotaxis: CCR10 plays a role in the recruitment of immune cells to specific tissues, such as the skin and mucosal surfaces. * Calcium-mediated signaling: The activation of CCR10 leads to an increase in intracellular calcium concentrations, which is involved in the regulation of immune responses. * Cell surface signaling: CCR10 is involved in the regulation of cell surface signaling pathways, including the activation of protein kinases and the production of cytokines. * Immune response regulation: CCR10 regulates the production of cytokines and the activation of immune cells, which is involved in the regulation of immune responses. **Clinical Significance:** CCR10 has been implicated in various diseases, including: * Atopic dermatitis: CCR10 has been shown to play a role in the development and progression of atopic dermatitis, a chronic inflammatory skin disease. * Asthma: CCR10 has been implicated in the pathogenesis of asthma, a chronic inflammatory lung disease. * Cancer: CCR10 has been shown to be overexpressed in various types of cancer, including breast cancer and colon cancer, where it may play a role in tumor progression and metastasis. * Neurological disorders: CCR10 has been implicated in various neurological disorders, including multiple sclerosis and Alzheimer's disease, where it may play a role in the regulation of immune responses and inflammation. In conclusion, CCR10 plays a crucial role in immune regulation and tissue homeostasis. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the mechanisms of CCR10 and its role in human health.

Genular Protein ID: 391387355

Symbol: CCR10_HUMAN

Name: C-C chemokine receptor type 10

UniProtKB Accession Codes:

P46092 Q4V749 Q6T7X2 Q9NZG2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 1 ExpressionAtlas 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 3 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10725696

Title: Identification of the orphan receptor G-protein-coupled receptor 2 as CCR10, a specific receptor for the chemokine ESkine.

PubMed ID: 10725696

DOI: 10.4049/jimmunol.164.7.3460

PubMed ID: 10725697

Title: The orphan chemokine receptor G protein-coupled receptor-2 (GPR-2, CCR10) binds the skin-associated chemokine CCL27 (CTACK/ALP/ILC).

PubMed ID: 10725697

DOI: 10.4049/jimmunol.164.7.3465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7851889

Title: Cloning of human genes encoding novel G protein-coupled receptors.

PubMed ID: 7851889

DOI: 10.1006/geno.1994.1549

PubMed ID: 10781587

Title: Identification of a novel chemokine (CCL28), which binds CCR10 (GPR2).

PubMed ID: 10781587

DOI: 10.1074/jbc.m001461200

PubMed ID: 10975800

Title: A novel chemokine ligand for CCR10 and CCR3 expressed by epithelial cells in mucosal tissues.

PubMed ID: 10975800

DOI: 10.4049/jimmunol.165.6.2943

Sequence Information:

  • Length: 362
  • Mass: 38416
  • Checksum: 736EB9B639AEA99A
  • Sequence:
    • MGTEATEQVS WGHYSGDEED AYSAEPLPEL CYKADVQAFS RAFQPSVSLT VAALGLAGNG 
LVLATHLAAR RAARSPTSAH LLQLALADLL LALTLPFAAA GALQGWSLGS ATCRTISGLY 
SASFHAGFLF LACISADRYV AIARALPAGP RPSTPGRAHL VSVIVWLLSL LLALPALLFS 
QDGQREGQRR CRLIFPEGLT QTVKGASAVA QVALGFALPL GVMVACYALL GRTLLAARGP 
ERRRALRVVV ALVAAFVVLQ LPYSLALLLD TADLLAARER SCPASKRKDV ALLVTSGLAL 
ARCGLNPVLY AFLGLRFRQD LRRLLRGGSC PSGPQPRRGC PRRPRLSSCS APTETHSLSW 
DN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.