Gene IGHG3 - ENSG00000211897 | NCBI Gene ID: 3502

Details for: IGHG3

Gene ID: 3502

Symbol: IGHG3

Ensembl ID: ENSG00000211897

Description: immunoglobulin heavy constant gamma 3 (G3m marker)

Associated with

Adaptive immune response
(GO:0002250)
Antibacterial humoral response
(GO:0019731)
Antigen binding
(GO:0003823)
B cell receptor signaling pathway
(GO:0050853)
Blood microparticle
(GO:0072562)
Complement activation, classical pathway
(GO:0006958)
Extracellular exosome
(GO:0070062)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Igg immunoglobulin complex
(GO:0071735)
Immunoglobulin complex, circulating
(GO:0042571)
Immunoglobulin receptor binding
(GO:0034987)
Plasma membrane
(GO:0005886)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: IgG plasmablast (CL0000982)
Fold Change: 3.86
Marker Score: 1064
Cell Name: IgG memory B cell (CL0000979)
Fold Change: 1.92
Marker Score: 1156
Cell Name: IgG plasma cell (CL0000985)
Fold Change: 1.85
Marker Score: 809
Cell Name: transitional stage B cell (CL0000818)
Fold Change: 1.74
Marker Score: 617
Cell Name: DN3 thymocyte (CL0000807)
Fold Change: 1.33
Marker Score: 664
Cell Name: DN1 thymic pro-T cell (CL0000894)
Fold Change: 1.24
Marker Score: 385
Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
Fold Change: 1.17
Marker Score: 3020
Cell Name: goblet cell (CL0000160)
Fold Change: 1.15
Marker Score: 7630
Cell Name: plasmablast (CL0000980)
Fold Change: 1.13
Marker Score: 1499
Cell Name: hematopoietic cell (CL0000988)
Fold Change: 1.03
Marker Score: 683
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 1.01
Marker Score: 775
Cell Name: respiratory basal cell (CL0002633)
Fold Change: 1
Marker Score: 1440
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 0.98
Marker Score: 624.5
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30404
Cell Name: IgA plasma cell (CL0000987)
Fold Change: 0.98
Marker Score: 835
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2412
Cell Name: memory B cell (CL0000787)
Fold Change: 0.94
Marker Score: 711
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.92
Marker Score: 5242
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2735
Cell Name: germinal center B cell (CL0000844)
Fold Change: 0.89
Marker Score: 543
Cell Name: bronchus fibroblast of lung (CL2000093)
Fold Change: 0.89
Marker Score: 1224
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5282
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1267
Cell Name: brush cell (CL0002204)
Fold Change: 0.76
Marker Score: 693
Cell Name: mature T cell (CL0002419)
Fold Change: 0.76
Marker Score: 7485
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.73
Marker Score: 481
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.68
Marker Score: 175
Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
Fold Change: 0.66
Marker Score: 482.5
Cell Name: neutrophil (CL0000775)
Fold Change: 0.65
Marker Score: 393
Cell Name: exhausted T cell (CL0011025)
Fold Change: 0.6
Marker Score: 348
Cell Name: myeloid cell (CL0000763)
Fold Change: 0.6
Marker Score: 963
Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
Fold Change: 0.58
Marker Score: 451
Cell Name: IgA plasmablast (CL0000984)
Fold Change: 0.57
Marker Score: 150
Cell Name: unswitched memory B cell (CL0000970)
Fold Change: 0.56
Marker Score: 331
Cell Name: intestinal crypt stem cell (CL0002250)
Fold Change: 0.56
Marker Score: 212
Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 0.56
Marker Score: 2929
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.56
Marker Score: 443
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.55
Marker Score: 146
Cell Name: plasma cell (CL0000786)
Fold Change: 0.55
Marker Score: 614
Cell Name: IgG-negative class switched memory B cell (CL0002117)
Fold Change: 0.55
Marker Score: 538
Cell Name: fibroblast of lung (CL0002553)
Fold Change: 0.52
Marker Score: 1370
Cell Name: type I NK T cell (CL0000921)
Fold Change: 0.52
Marker Score: 409
Cell Name: class switched memory B cell (CL0000972)
Fold Change: 0.51
Marker Score: 480
Cell Name: B cell (CL0000236)
Fold Change: 0.51
Marker Score: 483
Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
Fold Change: 0.51
Marker Score: 474
Cell Name: T cell (CL0000084)
Fold Change: 0.48
Marker Score: 834
Cell Name: naive B cell (CL0000788)
Fold Change: 0.48
Marker Score: 430
Cell Name: innate lymphoid cell (CL0001065)
Fold Change: 0.48
Marker Score: 173
Cell Name: pro-B cell (CL0000826)
Fold Change: 0.46
Marker Score: 441
Cell Name: ionocyte (CL0005006)
Fold Change: 0.45
Marker Score: 138
Cell Name: mast cell (CL0000097)
Fold Change: 0.42
Marker Score: 246
Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
Fold Change: 0.42
Marker Score: 356
Cell Name: alternatively activated macrophage (CL0000890)
Fold Change: 0.41
Marker Score: 169
Cell Name: megakaryocyte (CL0000556)
Fold Change: 0.4
Marker Score: 227
Cell Name: natural killer cell (CL0000623)
Fold Change: 0.39
Marker Score: 510
Cell Name: lymphocyte (CL0000542)
Fold Change: 0.39
Marker Score: 198
Cell Name: blood cell (CL0000081)
Fold Change: 0.38
Marker Score: 4379.5
Cell Name: mature B cell (CL0000785)
Fold Change: 0.38
Marker Score: 275
Cell Name: vein endothelial cell (CL0002543)
Fold Change: 0.37
Marker Score: 332
Cell Name: CD38-negative naive B cell (CL0002102)
Fold Change: 0.35
Marker Score: 728
Cell Name: pulmonary artery endothelial cell (CL1001568)
Fold Change: 0.34
Marker Score: 295
Cell Name: fibroblast (CL0000057)
Fold Change: 0.34
Marker Score: 328
Cell Name: platelet (CL0000233)
Fold Change: 0.33
Marker Score: 150
Cell Name: leukocyte (CL0000738)
Fold Change: 0.33
Marker Score: 188
Cell Name: smooth muscle cell (CL0000192)
Fold Change: 0.32
Marker Score: 212.5
Cell Name: malignant cell (CL0001064)
Fold Change: 0.32
Marker Score: 4330
Cell Name: multi-ciliated epithelial cell (CL0005012)
Fold Change: 0.32
Marker Score: 603
Cell Name: classical monocyte (CL0000860)
Fold Change: 0.31
Marker Score: 1287
Cell Name: common lymphoid progenitor (CL0000051)
Fold Change: 0.31
Marker Score: 208
Cell Name: mononuclear phagocyte (CL0000113)
Fold Change: 0.3
Marker Score: 302
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 0.3
Marker Score: 743
Cell Name: dendritic cell (CL0000451)
Fold Change: 0.3
Marker Score: 204
Cell Name: conventional dendritic cell (CL0000990)
Fold Change: 0.3
Marker Score: 204
Cell Name: follicular B cell (CL0000843)
Fold Change: 0.29
Marker Score: 315
Cell Name: peritubular capillary endothelial cell (CL1001033)
Fold Change: 0.28
Marker Score: 65
Cell Name: endothelial cell (CL0000115)
Fold Change: 0.27
Marker Score: 244
Cell Name: plasmacytoid dendritic cell (CL0000784)
Fold Change: 0.27
Marker Score: 146
Cell Name: neuroendocrine cell (CL0000165)
Fold Change: 0.27
Marker Score: 105
Cell Name: M cell of gut (CL0000682)
Fold Change: 0.26
Marker Score: 68
Cell Name: ILC1, human (CL0001077)
Fold Change: 0.25
Marker Score: 64
Cell Name: epithelial cell of glomerular capsule (CL1000450)
Fold Change: 0.25
Marker Score: 63
Cell Name: vascular associated smooth muscle cell (CL0000359)
Fold Change: 0.24
Marker Score: 112
Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
Fold Change: 0.23
Marker Score: 380
Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
Fold Change: 0.23
Marker Score: 525.5
Cell Name: plasmacytoid dendritic cell, human (CL0001058)
Fold Change: 0.23
Marker Score: 61
Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
Fold Change: 0.23
Marker Score: 61
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.23
Marker Score: 96
Cell Name: vasa recta descending limb cell (CL1001285)
Fold Change: 0.23
Marker Score: 62
Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
Fold Change: 0.22
Marker Score: 138
Cell Name: epithelial cell of uterus (CL0002149)
Fold Change: 0.22
Marker Score: 51
Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
Fold Change: 0.22
Marker Score: 59
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 0.22
Marker Score: 223
Cell Name: mesothelial cell (CL0000077)
Fold Change: 0.22
Marker Score: 88
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.22
Marker Score: 64
Cell Name: macrophage (CL0000235)
Fold Change: 0.22
Marker Score: 241
Cell Name: regulatory T cell (CL0000815)
Fold Change: 0.22
Marker Score: 239
Cell Name: type I pneumocyte (CL0002062)
Fold Change: 0.22
Marker Score: 259
Cell Name: B-1b B cell (CL0000821)
Fold Change: 0.21
Marker Score: 49
Cell Name: endothelial cell of lymphatic vessel (CL0002138)
Fold Change: 0.21
Marker Score: 132
Cell Name: megakaryocyte progenitor cell (CL0000553)
Fold Change: 0.21
Marker Score: 58

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Other Information

Description

**Key characteristics:** - IGHG3 is a single-exon gene with a calculated molecular weight of approximately 150 kDa. - It is located on chromosome 21q22. - IGHG3 is a member of the immunoglobulin heavy chain family, which is expressed in all lymphoid cells. - IGHG3 is a glycoprotein that is found in the plasma membrane of B cells and plasmablasts. - It is also found in the serum of patients with autoimmune disorders. **Pathways and functions:** - IGHG3 is primarily expressed in plasmablasts and memory B cells, which are responsible for humoral immune responses. - It is also expressed in transitional stage B cells, which are in the process of switching from immature to mature B cells. - IGHG3 is a key receptor for IgM antibodies, which are produced by plasmablasts and some B cells. - It is also a receptor for IgA antibodies, which are produced by plasmablasts. **Clinical significance:** - IGHG3 gene polymorphisms have been linked to an increased risk of autoimmune disorders, such as rheumatoid arthritis, lupus, and Crohn's disease. - Mutations in IGHG3 have also been linked to the development of some types of cancer. - IGHG3 is a promising target for the development of new therapies for autoimmune disorders.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.