Details for: IGHG3

Gene ID: 3502

Symbol: IGHG3

Ensembl ID: ENSG00000211897

Description: immunoglobulin heavy constant gamma 3 (G3m marker)

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 31.7237
    Cell Significance Index: -14.9800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 3.9981
    Cell Significance Index: -12.2800
  • Cell Name: colonocyte (CL1000347)
    Fold Change: 3.9167
    Cell Significance Index: 24.2100
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 2.2799
    Cell Significance Index: 18.5800
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 1.0532
    Cell Significance Index: 9.0500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.7111
    Cell Significance Index: 91.1600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6836
    Cell Significance Index: 67.6200
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 0.5795
    Cell Significance Index: 3.5000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.4231
    Cell Significance Index: 6.3400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3671
    Cell Significance Index: 69.8600
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.3209
    Cell Significance Index: 3.2200
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 0.2181
    Cell Significance Index: 1.8000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0493
    Cell Significance Index: 5.0400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.0414
    Cell Significance Index: 0.4700
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0252
    Cell Significance Index: 0.3900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0056
    Cell Significance Index: -0.3600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0082
    Cell Significance Index: -15.4400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0100
    Cell Significance Index: -7.5900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0163
    Cell Significance Index: -0.6700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0198
    Cell Significance Index: -14.5200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0205
    Cell Significance Index: -1.0400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0217
    Cell Significance Index: -13.7600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0281
    Cell Significance Index: -15.3300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0463
    Cell Significance Index: -21.0100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0573
    Cell Significance Index: -11.3700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0756
    Cell Significance Index: -13.6300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0834
    Cell Significance Index: -16.7300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0981
    Cell Significance Index: -14.2600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1150
    Cell Significance Index: -15.7900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1197
    Cell Significance Index: -20.4500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1210
    Cell Significance Index: -14.8800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1643
    Cell Significance Index: -21.2200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1832
    Cell Significance Index: -14.5100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1899
    Cell Significance Index: -21.7600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2378
    Cell Significance Index: -14.5800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2555
    Cell Significance Index: -19.6100
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.2645
    Cell Significance Index: -11.5000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2786
    Cell Significance Index: -12.9900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2858
    Cell Significance Index: -21.3000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3167
    Cell Significance Index: -16.4500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3597
    Cell Significance Index: -22.6700
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.3615
    Cell Significance Index: -6.1400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3800
    Cell Significance Index: -17.8600
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: -0.3949
    Cell Significance Index: -4.0900
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.3992
    Cell Significance Index: -4.4600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4420
    Cell Significance Index: -16.2300
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: -0.4669
    Cell Significance Index: -4.2700
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.4731
    Cell Significance Index: -4.9100
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.4961
    Cell Significance Index: -6.4100
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.5072
    Cell Significance Index: -12.2900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.5361
    Cell Significance Index: -14.3400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.5400
    Cell Significance Index: -18.9800
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.5454
    Cell Significance Index: -12.6000
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.5700
    Cell Significance Index: -8.1000
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.5704
    Cell Significance Index: -6.0600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.5750
    Cell Significance Index: -14.6900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.5751
    Cell Significance Index: -16.9400
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.6017
    Cell Significance Index: -8.8000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.6379
    Cell Significance Index: -18.3800
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.6460
    Cell Significance Index: -16.4600
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.6480
    Cell Significance Index: -16.1600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.6749
    Cell Significance Index: -18.0200
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.6834
    Cell Significance Index: -17.0700
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.6976
    Cell Significance Index: -9.4900
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.7288
    Cell Significance Index: -14.4100
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.7373
    Cell Significance Index: -11.0300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.7542
    Cell Significance Index: -21.6200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.7833
    Cell Significance Index: -16.6300
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.7958
    Cell Significance Index: -13.4100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.7970
    Cell Significance Index: -14.7300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.8024
    Cell Significance Index: -21.8400
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.8064
    Cell Significance Index: -11.4700
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.8144
    Cell Significance Index: -12.0200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.8293
    Cell Significance Index: -16.6500
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: -0.8363
    Cell Significance Index: -5.8900
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.8516
    Cell Significance Index: -16.6500
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.8672
    Cell Significance Index: -21.1600
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.8817
    Cell Significance Index: -15.2500
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.8968
    Cell Significance Index: -15.3300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.9058
    Cell Significance Index: -18.7900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.9079
    Cell Significance Index: -17.7200
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.9122
    Cell Significance Index: -10.7800
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -0.9280
    Cell Significance Index: -6.1800
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.9366
    Cell Significance Index: -15.1700
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.9384
    Cell Significance Index: -13.0200
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.9691
    Cell Significance Index: -10.3100
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.9701
    Cell Significance Index: -13.4600
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.9710
    Cell Significance Index: -12.5700
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -1.0018
    Cell Significance Index: -14.5500
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -1.0042
    Cell Significance Index: -9.3200
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -1.0187
    Cell Significance Index: -6.3200
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: -1.0230
    Cell Significance Index: -9.8200
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -1.0262
    Cell Significance Index: -17.6900
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: -1.0346
    Cell Significance Index: -9.0900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -1.0385
    Cell Significance Index: -17.3800
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -1.0422
    Cell Significance Index: -21.7400
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -1.0690
    Cell Significance Index: -14.2500
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -1.0836
    Cell Significance Index: -14.8600
  • Cell Name: T cell (CL0000084)
    Fold Change: -1.0850
    Cell Significance Index: -12.8100
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -1.1122
    Cell Significance Index: -16.2100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Immunoglobulin Heavy Constant Gamma 3 (γ3)**: The IGHG3 gene encodes for the γ3 region of the immunoglobulin heavy chain, which is essential for the binding of antigens to the BCR. 2. **Significant Expression**: The IGHG3 gene is highly expressed in various cells of the immune system, including IgG plasmablasts, memory B cells, plasma cells, and transitional stage B cells. 3. **Adaptive Immune Response**: The IGHG3 gene is involved in the adaptive immune response, which is characterized by specific, targeted responses to antigens. 4. **Antigen Binding**: The γ3 region of the IGHG3 gene mediates antigen recognition and binding to the BCR, which is essential for the activation of B cells. **Pathways and Functions:** 1. **Adaptive Immune Response**: The IGHG3 gene is involved in the adaptive immune response, which is characterized by specific, targeted responses to antigens. 2. **Antigen Binding**: The γ3 region of the IGHG3 gene mediates antigen recognition and binding to the BCR, which is essential for the activation of B cells. 3. **B Cell Receptor Signaling Pathway**: The IGHG3 gene is involved in the signaling pathway of the BCR, which leads to the activation of B cells and the production of antibodies. 4. **Complement Activation**: The IGHG3 gene is involved in the complement activation pathway, which is a critical component of the innate immune response. **Clinical Significance:** 1. **Autoimmune Disorders**: Dysregulation of the IGHG3 gene has been implicated in various autoimmune disorders, including rheumatoid arthritis, lupus, and multiple sclerosis. 2. **Immunodeficiency Disorders**: The IGHG3 gene is also involved in immunodeficiency disorders, such as X-linked agammaglobulinemia (XLA), which is characterized by a deficiency in immunoglobulin production. 3. **Cancer**: The IGHG3 gene has been implicated in certain types of cancer, including lymphoma and leukemia, where it may contribute to the development and progression of the disease. 4. **Vaccine Development**: The IGHG3 gene is being explored as a target for vaccine development, where it may be used to enhance the immune response to specific antigens. In conclusion, the IGHG3 gene plays a critical role in the adaptive immune response, mediating antigen recognition, binding, and activation of B cells. Its dysregulation has been implicated in various autoimmune and immunodeficiency disorders, and it is being explored as a target for vaccine development. Further research is needed to fully understand the mechanisms by which the IGHG3 gene regulates the immune response and to explore its potential applications in the treatment of various diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.