Details for: FKBP11

Gene ID: 51303

Symbol: FKBP11

Ensembl ID: ENSG00000134285

Description: FKBP prolyl isomerase 11

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 201.4205
    Cell Significance Index: -31.3300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 100.3377
    Cell Significance Index: -25.4500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 75.6371
    Cell Significance Index: -35.7100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 75.4882
    Cell Significance Index: -38.8300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 53.2248
    Cell Significance Index: -35.7200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 25.5686
    Cell Significance Index: -31.5300
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 8.7910
    Cell Significance Index: 23.5500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.1499
    Cell Significance Index: -32.1600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 7.3809
    Cell Significance Index: -22.6700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.7562
    Cell Significance Index: -15.4200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 2.2947
    Cell Significance Index: 391.8300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 2.2463
    Cell Significance Index: 134.8500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.8676
    Cell Significance Index: 217.6500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.8331
    Cell Significance Index: 199.3900
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.5686
    Cell Significance Index: 36.2400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.4233
    Cell Significance Index: 41.8000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.2878
    Cell Significance Index: 14.6300
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.9413
    Cell Significance Index: 6.7600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.9351
    Cell Significance Index: 64.6700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9188
    Cell Significance Index: 829.6500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.8721
    Cell Significance Index: 40.6600
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.8108
    Cell Significance Index: 12.5500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.6318
    Cell Significance Index: 81.6300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.6146
    Cell Significance Index: 16.4400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.5330
    Cell Significance Index: 25.0500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4647
    Cell Significance Index: 45.9700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4598
    Cell Significance Index: 87.5000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4503
    Cell Significance Index: 245.9400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3610
    Cell Significance Index: 49.5700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3430
    Cell Significance Index: 151.6600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.3244
    Cell Significance Index: 8.8300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2982
    Cell Significance Index: 21.0900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2955
    Cell Significance Index: 59.2700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.2849
    Cell Significance Index: 81.9800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2807
    Cell Significance Index: 35.9900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2588
    Cell Significance Index: 42.1000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.2320
    Cell Significance Index: 6.6500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1780
    Cell Significance Index: 4.4500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1704
    Cell Significance Index: 20.9500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1685
    Cell Significance Index: 30.3700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1405
    Cell Significance Index: 10.4800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.1358
    Cell Significance Index: 6.8600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.1326
    Cell Significance Index: 100.3400
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.1208
    Cell Significance Index: 2.1400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1170
    Cell Significance Index: 41.9700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0930
    Cell Significance Index: 10.6600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0792
    Cell Significance Index: 54.7700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0405
    Cell Significance Index: 1.7900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0243
    Cell Significance Index: 0.7000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0041
    Cell Significance Index: 0.1100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0091
    Cell Significance Index: -5.6900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0102
    Cell Significance Index: -7.5800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0122
    Cell Significance Index: -0.7900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0168
    Cell Significance Index: -31.6500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0205
    Cell Significance Index: -37.8900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0246
    Cell Significance Index: -37.8700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0279
    Cell Significance Index: -37.9400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0341
    Cell Significance Index: -19.2500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0392
    Cell Significance Index: -4.4800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0405
    Cell Significance Index: -1.5400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0416
    Cell Significance Index: -30.5300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0561
    Cell Significance Index: -35.6600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0569
    Cell Significance Index: -1.1900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0605
    Cell Significance Index: -2.7400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0643
    Cell Significance Index: -13.5400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0657
    Cell Significance Index: -1.1000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0803
    Cell Significance Index: -36.4300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0976
    Cell Significance Index: -11.5200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0980
    Cell Significance Index: -3.1400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1003
    Cell Significance Index: -10.2500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1521
    Cell Significance Index: -6.2300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2465
    Cell Significance Index: -35.8300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3008
    Cell Significance Index: -23.0800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3055
    Cell Significance Index: -15.8700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3125
    Cell Significance Index: -32.5400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3378
    Cell Significance Index: -8.6300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.4109
    Cell Significance Index: -8.7500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4153
    Cell Significance Index: -25.4600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4444
    Cell Significance Index: -24.9400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.4461
    Cell Significance Index: -4.8500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.4568
    Cell Significance Index: -28.0800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4597
    Cell Significance Index: -36.4100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4682
    Cell Significance Index: -29.5100
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.4785
    Cell Significance Index: -7.2100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.5100
    Cell Significance Index: -5.2800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.5491
    Cell Significance Index: -28.8300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.5764
    Cell Significance Index: -15.4500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.6355
    Cell Significance Index: -16.7100
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.6549
    Cell Significance Index: -11.2900
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -0.6842
    Cell Significance Index: -14.2700
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.7049
    Cell Significance Index: -4.3800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.7183
    Cell Significance Index: -9.8000
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.7299
    Cell Significance Index: -9.8500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.7447
    Cell Significance Index: -26.0900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.7663
    Cell Significance Index: -28.1300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.7802
    Cell Significance Index: -27.1100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.8164
    Cell Significance Index: -26.7300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.8186
    Cell Significance Index: -26.0700
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.8328
    Cell Significance Index: -10.6700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.8666
    Cell Significance Index: -30.4500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** FKBP11 exhibits several key characteristics that distinguish it from other peptidyl-prolyl cis-trans isomerase enzymes. These include: 1. **Proline-specificity**: FKBP11 has a high degree of specificity for proline-containing peptides, which is essential for its chaperone-mediated protein folding activities. 2. **High affinity**: FKBP11 exhibits a high affinity for proline-containing peptides, allowing it to efficiently catalyze the cis-trans isomerization of proline residues. 3. **Chaperone-mediated folding**: FKBP11 acts as a molecular chaperone, facilitating the folding of proteins and the regulation of protein-protein interactions. 4. **Cell-type specific expression**: FKBP11 is expressed in a variety of cell types, including immune cells, epithelial cells, and stromal cells. **Pathways and Functions** FKBP11 is involved in several cellular pathways, including: 1. **Chaperone-mediated protein folding**: FKBP11 facilitates the folding of proteins by catalyzing the cis-trans isomerization of proline residues. 2. **Protein-protein interactions**: FKBP11 regulates protein-protein interactions by facilitating the folding of proteins and the assembly of protein complexes. 3. **Cell signaling**: FKBP11 is involved in cell signaling pathways, including the regulation of immune responses and the modulation of cellular growth and differentiation. 4. **Stress response**: FKBP11 plays a role in the cellular response to stress, including the regulation of heat shock proteins and the modulation of cellular survival pathways. **Clinical Significance** FKBP11 has significant clinical implications, particularly in the context of immune-mediated diseases. For example: 1. **Autoimmune diseases**: FKBP11 has been implicated in the pathogenesis of autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 2. **Cancer**: FKBP11 has been shown to play a role in cancer development and progression, including the regulation of cell growth and differentiation. 3. **Infectious diseases**: FKBP11 has been implicated in the pathogenesis of infectious diseases, including the regulation of immune responses and the modulation of cellular survival pathways. In conclusion, FKBP11 is a critical enzyme that plays a pivotal role in maintaining cellular homeostasis through its chaperone-mediated protein folding activities. Its involvement in various cellular pathways and its expression in a variety of cell types make it an attractive target for therapeutic intervention in immune-mediated diseases and cancer. Further research is needed to fully elucidate the role of FKBP11 in human health and disease.

Genular Protein ID: 1419477804

Symbol: FKB11_HUMAN

Name: Peptidyl-prolyl cis-trans isomerase FKBP11

UniProtKB Accession Codes:

Q9NYL4 B4DWB7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChEBI 2 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 2 EMBL 5 Ensembl 2 ExpressionAtlas 1 GO 4 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 3 Rhea 3 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 201
  • Mass: 22180
  • Checksum: 586E430B9D2DC0A2
  • Sequence:
    • MTLRPSLLPL HLLLLLLLSA AVCRAEAGLE TESPVRTLQV ETLVEPPEPC AEPAAFGDTL 
HIHYTGSLVD GRIIDTSLTR DPLVIELGQK QVIPGLEQSL LDMCVGEKRR AIIPSHLAYG 
KRGFPPSVPA DAVVQYDVEL IALIRANYWL KLVKGILPLV GMAMVPALLG LIGYHLYRKA 
NRPKVSKKKL KEEKRNKSKK K

Genular Protein ID: 2278854799

Symbol: E9PAR0_HUMAN

Name: N/A

UniProtKB Accession Codes:

E9PAR0

Database IDs:

AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChEBI 2 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 3 Gene3D 1 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 3 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PROSITE-ProRule 1 PeptideAtlas 2 Pfam 1 Proteomes 2 ProteomicsDB 2 RefSeq 1 Rhea 3 SAM 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

Sequence Information:

  • Length: 99
  • Mass: 11168
  • Checksum: 3FFA385BAA609381
  • Sequence:
    • MCVGEKRRAI IPSHLAYGKR GFPPSVPADA VVQYDVELIA LIRANYWLKL VKGILPLVGM 
AMVPALLGLI GYHLYRKANR PKVSKKKLKE EKRNKSKKK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.