Details for: GPX1

Gene ID: 2876

Symbol: GPX1

Ensembl ID: ENSG00000233276

Description: glutathione peroxidase 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 42.08
    Marker Score: 28131
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 13.03
    Marker Score: 9197
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 8.67
    Marker Score: 5691
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 8.03
    Marker Score: 4482
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 7.29
    Marker Score: 3040
  • Cell Name: promonocyte (CL0000559)
    Fold Change: 5.77
    Marker Score: 3718
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 5.38
    Marker Score: 3940
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 4.88
    Marker Score: 4885
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 4.73
    Marker Score: 4075
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 4.04
    Marker Score: 4382.5
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 3.9
    Marker Score: 4456.5
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 3.88
    Marker Score: 2936
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 3.71
    Marker Score: 9438
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 3.68
    Marker Score: 7165
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 3.67
    Marker Score: 3114
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 3.64
    Marker Score: 5274
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 3.62
    Marker Score: 1060
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 3.19
    Marker Score: 110566
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 3.19
    Marker Score: 2408
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 3.11
    Marker Score: 1090
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 2.89
    Marker Score: 4737
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 2.85
    Marker Score: 2752
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 2.83
    Marker Score: 6952
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 2.82
    Marker Score: 4532
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.76
    Marker Score: 11901
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 2.76
    Marker Score: 11278.5
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 2.73
    Marker Score: 23722
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 2.73
    Marker Score: 1404
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 2.64
    Marker Score: 6579
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 2.64
    Marker Score: 2352
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 2.63
    Marker Score: 4180
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 2.62
    Marker Score: 15950.5
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 2.61
    Marker Score: 2180
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 2.58
    Marker Score: 20185
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 2.57
    Marker Score: 1105
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 2.56
    Marker Score: 995
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 2.53
    Marker Score: 1446
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.51
    Marker Score: 28290.5
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 2.45
    Marker Score: 2463
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 2.44
    Marker Score: 4866
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 2.39
    Marker Score: 594
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 2.37
    Marker Score: 734
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.36
    Marker Score: 15095
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 2.35
    Marker Score: 812
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 2.32
    Marker Score: 8601
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 2.32
    Marker Score: 4413
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.31
    Marker Score: 3409
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 2.3
    Marker Score: 841
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 2.26
    Marker Score: 1245
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 2.24
    Marker Score: 541
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 2.24
    Marker Score: 1991
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 2.22
    Marker Score: 2373
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.17
    Marker Score: 2288.5
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 2.15
    Marker Score: 1054
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.15
    Marker Score: 1436
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 2.15
    Marker Score: 3043
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.15
    Marker Score: 8439
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 2.13
    Marker Score: 2389
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 2.13
    Marker Score: 614
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 2.12
    Marker Score: 1987
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 2.11
    Marker Score: 1598
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 2.11
    Marker Score: 1525
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 2.11
    Marker Score: 1228
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 2.1
    Marker Score: 2225
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 2.09
    Marker Score: 727
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 2.05
    Marker Score: 3854.5
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 2.02
    Marker Score: 2164
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 2.01
    Marker Score: 3553
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 1.98
    Marker Score: 1553
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.97
    Marker Score: 974
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.94
    Marker Score: 4431
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 1.94
    Marker Score: 424
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 1.93
    Marker Score: 467
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 1.92
    Marker Score: 2091
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.91
    Marker Score: 720
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.91
    Marker Score: 440
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.9
    Marker Score: 820
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 1.89
    Marker Score: 975
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 1.87
    Marker Score: 569
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.87
    Marker Score: 3183
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 1.87
    Marker Score: 435
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.82
    Marker Score: 2198
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.81
    Marker Score: 4997
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 1.79
    Marker Score: 381
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 1.79
    Marker Score: 1183
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 1.78
    Marker Score: 1086
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 1.76
    Marker Score: 972.5
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.75
    Marker Score: 870
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 1.73
    Marker Score: 627
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 1.72
    Marker Score: 2655
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 1.71
    Marker Score: 579
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 1.69
    Marker Score: 6542
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.68
    Marker Score: 393
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 1.67
    Marker Score: 327
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 1.67
    Marker Score: 4066
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 1.64
    Marker Score: 944
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.64
    Marker Score: 405
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1.63
    Marker Score: 815
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.63
    Marker Score: 762
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 1.62
    Marker Score: 799.5

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Other Information

## Summary GPX1 is a protein that belongs to the glutathione peroxidase family of enzymes. Glutathione peroxidases are involved in the detoxification of reactive oxygen species (ROS), which are produced in large amounts during immune responses. GPX1 is expressed in a variety of cell types, including immune cells such as macrophages, dendritic cells, and lymphocytes. ## Key characteristics * GPX1 is a multi-functional protein that can act as a glutathione peroxidase, an enzyme that breaks down ROS, or an enzyme involved in the synthesis of eicosanoids, a class of lipid mediators that have important roles in immune regulation. * It is highly expressed in immune cells, where it is involved in the regulation of inflammation and immune responses. * GPX1 is also expressed in other cell types, where it plays a role in cellular responses to stress, cell cycle regulation, and lipid metabolism. ## Pathways and functions * GPX1 is involved in a variety of pathways, including the arachidonic acid metabolism, cellular responses to stimuli, cellular responses to stress, and detoxification of reactive oxygen species. * In the context of inflammation, GPX1 is important for the regulation of the inflammatory response. It is expressed in immune cells, where it helps to protect cells from damage caused by ROS produced by activated immune cells. * GPX1 is also involved in the synthesis of eicosanoids, a class of lipid mediators that have important roles in immune regulation. ## Clinical significance GPX1 is a promising target for the treatment of inflammatory diseases. Inhibition of GPX1 has been shown to reduce inflammation and improve disease outcomes in animal models of inflammatory diseases such as rheumatoid arthritis and asthma. ## Additional information * GPX1 is a highly conserved protein that is found in all vertebrates. * It is a large protein with a molecular weight of approximately 150 kDa. * GPX1 is a member of the glutathione peroxidase family of enzymes, which are characterized by their ability to catalyze the reduction of hydrogen peroxide to water. * GPX1 is a highly active enzyme, and it can reduce a wide range of substrates, including hydrogen peroxide, tert-butyl hydroperoxide, and ascorbate. * GPX1 is a well-known regulator of inflammation. It is expressed in high levels in inflammatory cells, and its activity is increased in response to inflammatory stimuli. * Inhibition of GPX1 can inhibit inflammation and improve disease outcomes in animal models of inflammatory diseases.

Genular Protein ID: 1394437116

Symbol: GPX1_HUMAN

Name: Cellular glutathione peroxidase

UniProtKB Accession Codes:

P07203 E9PAS1 Q7Z5H1 Q9BW12

Database IDs:

AGR 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CTD 1 ChEBI 74 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 10 EC 2 EMBL 9 EPD 1 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 53 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PeroxiBase 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 4 RefSeq 1 Rhea 30 SIGNOR 1 SMR 1 SUPFAM 1 SWISS-2DPAGE 1 SignaLink 1 SwissLipids 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 4 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3658677

Title: cDNA sequence coding for human glutathione peroxidase.

PubMed ID: 3658677

DOI: 10.1093/nar/15.17.7178

PubMed ID: 3697069

Title: Nucleotide sequence of a human gene for glutathione peroxidase.

PubMed ID: 3697069

DOI: 10.1093/nar/15.23.10051

PubMed ID: 2955287

Title: Sequence of a cDNA coding for human glutathione peroxidase confirms TGA encodes active site selenocysteine.

PubMed ID: 2955287

DOI: 10.1093/nar/15.13.5484

PubMed ID: 2307470

Title: Isolation and chromosomal localization of the human glutathione peroxidase gene.

PubMed ID: 2307470

DOI: 10.1016/0888-7543(90)90566-d

PubMed ID: 1556108

Title: Structure and function of the 5'-flanking sequence of the human cytosolic selenium-dependent glutathione peroxidase gene (hgpx1).

PubMed ID: 1556108

DOI: 10.1016/s0021-9258(18)42647-6

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11115402

Title: Evidence for the presence of phospholipid hydroperoxide glutathione peroxidase in human platelets: implications for its involvement in the regulatory network of the 12-lipoxygenase pathway of arachidonic acid metabolism.

PubMed ID: 11115402

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 36608588

Title: Side-by-side comparison of recombinant human glutathione peroxidases identifies overlapping substrate specificities for soluble hydroperoxides.

PubMed ID: 36608588

DOI: 10.1016/j.redox.2022.102593

PubMed ID: 10220143

Title: Low yield of polymorphisms from EST blast searching: analysis of genes related to oxidative stress and verification of the P197L polymorphism in GPX1.

PubMed ID: 10220143

DOI: 10.1002/(sici)1098-1004(1999)13:4<294::aid-humu6>3.0.co;2-5

PubMed ID: 12496980

Title: Association between the GCG polymorphism of the selenium dependent GPX1 gene and the risk of young onset prostate cancer.

PubMed ID: 12496980

DOI: 10.1038/sj.pcan.4500569

PubMed ID: 15331559

Title: Functional variants in the glutathione peroxidase-1 (GPx-1) gene are associated with increased intima-media thickness of carotid arteries and risk of macrovascular diseases in Japanese type 2 diabetic patients.

PubMed ID: 15331559

DOI: 10.2337/diabetes.53.9.2455

PubMed ID: 15247771

Title: Increased risk of bladder cancer associated with a glutathione peroxidase 1 codon 198 variant.

PubMed ID: 15247771

DOI: 10.1097/01.ju.0000130942.40597.9d

Sequence Information:

  • Length: 203
  • Mass: 22088
  • Checksum: 5DB11579C66FE8E5
  • Sequence:
    • MCAARLAAAA AAAQSVYAFS ARPLAGGEPV SLGSLRGKVL LIENVASLUG TTVRDYTQMN 
ELQRRLGPRG LVVLGFPCNQ FGHQENAKNE EILNSLKYVR PGGGFEPNFM LFEKCEVNGA 
GAHPLFAFLR EALPAPSDDA TALMTDPKLI TWSPVCRNDV AWNFEKFLVG PDGVPLRRYS 
RRFQTIDIEP DIEALLSQGP SCA

Genular Protein ID: 2926674682

Symbol: A0A2R8Y6B6_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A2R8Y6B6

Database IDs:

ARBA 8 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 CTD 1 ChEBI 9 ChiTaRS 1 DNASU 1 EC 1 EMBL 1 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 3 Gene3D 1 GeneTree 1 HGNC 1 InterPro 2 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 1 PeptideAtlas 1 Pfam 1 Proteomes 2 RefSeq 1 Rhea 4 SMR 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

Sequence Information:

  • Length: 157
  • Mass: 16914
  • Checksum: 72FB574D6A829D3D
  • Sequence:
    • MCAARLAAAA AAAQSVYAFS ARPLAGGEPV SLGSLRGKEN AKNEEILNSL KYVRPGGGFE 
PNFMLFEKCE VNGAGAHPLF AFLREALPAP SDDATALMTD PKLITWSPVC RNDVAWNFEK 
FLVGPDGVPL RRYSRRFQTI DIEPDIEALL SQGPSCA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.