Details for: GPX1
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: embryonic stem cell (CL0002322)
Fold Change: 259.1834
Cell Significance Index: -106.7700 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 251.8625
Cell Significance Index: -118.9100 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 205.1575
Cell Significance Index: -105.5300 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 180.2623
Cell Significance Index: -120.9600 - Cell Name: lung secretory cell (CL1000272)
Fold Change: 32.1727
Cell Significance Index: 244.9500 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 31.4089
Cell Significance Index: -84.1400 - Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 31.0136
Cell Significance Index: 263.6000 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 16.4450
Cell Significance Index: -50.5100 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 16.2833
Cell Significance Index: -35.6400 - Cell Name: cell in vitro (CL0001034)
Fold Change: 3.8998
Cell Significance Index: 2129.8000 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 3.0048
Cell Significance Index: 350.1800 - Cell Name: T-helper 17 cell (CL0000899)
Fold Change: 2.4651
Cell Significance Index: 18.8100 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 2.3416
Cell Significance Index: 68.7700 - Cell Name: extravillous trophoblast (CL0008036)
Fold Change: 1.5016
Cell Significance Index: 9.3300 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 1.1256
Cell Significance Index: 323.8800 - Cell Name: inflammatory macrophage (CL0000863)
Fold Change: 1.1166
Cell Significance Index: 8.5800 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.9261
Cell Significance Index: 48.1100 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.8210
Cell Significance Index: 38.2800 - Cell Name: keratinocyte (CL0000312)
Fold Change: 0.7703
Cell Significance Index: 19.2400 - Cell Name: colonocyte (CL1000347)
Fold Change: 0.6812
Cell Significance Index: 4.2100 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.5289
Cell Significance Index: 400.3200 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 0.3776
Cell Significance Index: 13.1200 - Cell Name: kidney cell (CL1000497)
Fold Change: 0.3544
Cell Significance Index: 2.8300 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.3534
Cell Significance Index: 48.5300 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.2301
Cell Significance Index: 43.7800 - Cell Name: abnormal cell (CL0001061)
Fold Change: 0.1790
Cell Significance Index: 18.2800 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.1301
Cell Significance Index: 3.5400 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.1129
Cell Significance Index: 22.6400 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.0407
Cell Significance Index: 6.9500 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0066
Cell Significance Index: -0.1100 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0361
Cell Significance Index: -67.9700 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0447
Cell Significance Index: -33.1100 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0614
Cell Significance Index: -1.6400 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0654
Cell Significance Index: -120.5500 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0757
Cell Significance Index: -15.9500 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0781
Cell Significance Index: -120.2700 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0789
Cell Significance Index: -44.4700 - Cell Name: colon goblet cell (CL0009039)
Fold Change: -0.0830
Cell Significance Index: -8.2200 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.0900
Cell Significance Index: -2.3000 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0901
Cell Significance Index: -122.5700 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.1028
Cell Significance Index: -64.2100 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.1373
Cell Significance Index: -87.2200 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.2168
Cell Significance Index: -98.4000 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.4508
Cell Significance Index: -6.1500 - Cell Name: alveolar macrophage (CL0000583)
Fold Change: -0.4540
Cell Significance Index: -4.0000 - Cell Name: enteric smooth muscle cell (CL0002504)
Fold Change: -0.4789
Cell Significance Index: -2.5200 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.6349
Cell Significance Index: -92.2900 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.6666
Cell Significance Index: -76.3700 - Cell Name: Hofbauer cell (CL3000001)
Fold Change: -0.8535
Cell Significance Index: -6.9600 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.9419
Cell Significance Index: -107.5100 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.9642
Cell Significance Index: -100.4000 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -1.0590
Cell Significance Index: -28.3800 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -1.1580
Cell Significance Index: -37.0900 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -1.2742
Cell Significance Index: -66.9000 - Cell Name: granulosa cell (CL0000501)
Fold Change: -1.4014
Cell Significance Index: -36.8500 - Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
Fold Change: -1.4018
Cell Significance Index: -9.1200 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -1.4101
Cell Significance Index: -108.2100 - Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: -1.4392
Cell Significance Index: -24.8100 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -1.4457
Cell Significance Index: -40.4000 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -1.5716
Cell Significance Index: -99.0500 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -1.7894
Cell Significance Index: -109.7100 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -1.8423
Cell Significance Index: -83.5100 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -1.8911
Cell Significance Index: -48.6100 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -1.9169
Cell Significance Index: -99.8500 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -1.9725
Cell Significance Index: -58.1000 - Cell Name: basal cell of epidermis (CL0002187)
Fold Change: -2.1547
Cell Significance Index: -32.7300 - Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: -2.2282
Cell Significance Index: -43.5700 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -2.2637
Cell Significance Index: -83.1000 - Cell Name: mononuclear phagocyte (CL0000113)
Fold Change: -2.3267
Cell Significance Index: -19.6700 - Cell Name: melanocyte of skin (CL1000458)
Fold Change: -2.5834
Cell Significance Index: -36.2100 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -2.5894
Cell Significance Index: -90.7100 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: -2.6501
Cell Significance Index: -39.7100 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -2.6939
Cell Significance Index: -88.2000 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -2.7285
Cell Significance Index: -86.9000 - Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: -2.9498
Cell Significance Index: -18.4700 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -3.2148
Cell Significance Index: -68.2300 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -3.2434
Cell Significance Index: -113.9700 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -3.2750
Cell Significance Index: -94.3600 - Cell Name: lens fiber cell (CL0011004)
Fold Change: -3.5506
Cell Significance Index: -112.3000 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -3.5940
Cell Significance Index: -89.6500 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -3.7657
Cell Significance Index: -74.4600 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -3.8100
Cell Significance Index: -64.1800 - Cell Name: preadipocyte (CL0002334)
Fold Change: -3.8694
Cell Significance Index: -75.5200 - Cell Name: erythrocyte (CL0000232)
Fold Change: -3.8920
Cell Significance Index: -99.1600 - Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -3.9116
Cell Significance Index: -78.5300 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -3.9458
Cell Significance Index: -85.2500 - Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -3.9905
Cell Significance Index: -96.6600 - Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
Fold Change: -4.0114
Cell Significance Index: -39.1700 - Cell Name: thymocyte (CL0000893)
Fold Change: -4.0490
Cell Significance Index: -51.1600 - Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: -4.1937
Cell Significance Index: -104.5800 - Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: -4.2216
Cell Significance Index: -85.9000 - Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: -4.2392
Cell Significance Index: -88.4800 - Cell Name: glandular epithelial cell (CL0000150)
Fold Change: -4.3675
Cell Significance Index: -34.7500 - Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: -4.3904
Cell Significance Index: -56.5400 - Cell Name: thyroid follicular cell (CL0002258)
Fold Change: -4.4151
Cell Significance Index: -46.9100 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -4.4436
Cell Significance Index: -76.1500 - Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
Fold Change: -4.5181
Cell Significance Index: -90.1000 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -4.5377
Cell Significance Index: -97.0000 - Cell Name: corneal epithelial cell (CL0000575)
Fold Change: -4.5648
Cell Significance Index: -64.9800 - Cell Name: stem cell (CL0000034)
Fold Change: -4.5652
Cell Significance Index: -33.1800
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 1394437116
Symbol: GPX1_HUMAN
Name: Cellular glutathione peroxidase
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 3658677
Title: cDNA sequence coding for human glutathione peroxidase.
PubMed ID: 3658677
PubMed ID: 3697069
Title: Nucleotide sequence of a human gene for glutathione peroxidase.
PubMed ID: 3697069
PubMed ID: 2955287
Title: Sequence of a cDNA coding for human glutathione peroxidase confirms TGA encodes active site selenocysteine.
PubMed ID: 2955287
PubMed ID: 2307470
Title: Isolation and chromosomal localization of the human glutathione peroxidase gene.
PubMed ID: 2307470
PubMed ID: 1556108
Title: Structure and function of the 5'-flanking sequence of the human cytosolic selenium-dependent glutathione peroxidase gene (hgpx1).
PubMed ID: 1556108
PubMed ID: 16641997
Title: The DNA sequence, annotation and analysis of human chromosome 3.
PubMed ID: 16641997
DOI: 10.1038/nature04728
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 11115402
Title: Evidence for the presence of phospholipid hydroperoxide glutathione peroxidase in human platelets: implications for its involvement in the regulatory network of the 12-lipoxygenase pathway of arachidonic acid metabolism.
PubMed ID: 11115402
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 36608588
Title: Side-by-side comparison of recombinant human glutathione peroxidases identifies overlapping substrate specificities for soluble hydroperoxides.
PubMed ID: 36608588
PubMed ID: 10220143
Title: Low yield of polymorphisms from EST blast searching: analysis of genes related to oxidative stress and verification of the P197L polymorphism in GPX1.
PubMed ID: 10220143
DOI: 10.1002/(sici)1098-1004(1999)13:4<294::aid-humu6>3.0.co;2-5
PubMed ID: 12496980
Title: Association between the GCG polymorphism of the selenium dependent GPX1 gene and the risk of young onset prostate cancer.
PubMed ID: 12496980
PubMed ID: 15331559
Title: Functional variants in the glutathione peroxidase-1 (GPx-1) gene are associated with increased intima-media thickness of carotid arteries and risk of macrovascular diseases in Japanese type 2 diabetic patients.
PubMed ID: 15331559
PubMed ID: 15247771
Title: Increased risk of bladder cancer associated with a glutathione peroxidase 1 codon 198 variant.
PubMed ID: 15247771
Sequence Information:
- Length: 203
- Mass: 22088
- Checksum: 5DB11579C66FE8E5
- Sequence:
MCAARLAAAA AAAQSVYAFS ARPLAGGEPV SLGSLRGKVL LIENVASLUG TTVRDYTQMN ELQRRLGPRG LVVLGFPCNQ FGHQENAKNE EILNSLKYVR PGGGFEPNFM LFEKCEVNGA GAHPLFAFLR EALPAPSDDA TALMTDPKLI TWSPVCRNDV AWNFEKFLVG PDGVPLRRYS RRFQTIDIEP DIEALLSQGP SCA
Genular Protein ID: 2926674682
Symbol: A0A2R8Y6B6_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11237011
Title: Initial sequencing and analysis of the human genome.
PubMed ID: 11237011
DOI: 10.1038/35057062
PubMed ID: 15496913
Title: Finishing the euchromatic sequence of the human genome.
PubMed ID: 15496913
DOI: 10.1038/nature03001
PubMed ID: 16641997
Title: The DNA sequence, annotation and analysis of human chromosome 3.
PubMed ID: 16641997
DOI: 10.1038/nature04728
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
Sequence Information:
- Length: 157
- Mass: 16914
- Checksum: 72FB574D6A829D3D
- Sequence:
MCAARLAAAA AAAQSVYAFS ARPLAGGEPV SLGSLRGKEN AKNEEILNSL KYVRPGGGFE PNFMLFEKCE VNGAGAHPLF AFLREALPAP SDDATALMTD PKLITWSPVC RNDVAWNFEK FLVGPDGVPL RRYSRRFQTI DIEPDIEALL SQGPSCA
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.