Details for: GPX1

Gene ID: 2876

Symbol: GPX1

Ensembl ID: ENSG00000233276

Description: glutathione peroxidase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 259.1834
    Cell Significance Index: -106.7700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 251.8625
    Cell Significance Index: -118.9100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 205.1575
    Cell Significance Index: -105.5300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 180.2623
    Cell Significance Index: -120.9600
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 32.1727
    Cell Significance Index: 244.9500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 31.4089
    Cell Significance Index: -84.1400
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 31.0136
    Cell Significance Index: 263.6000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 16.4450
    Cell Significance Index: -50.5100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 16.2833
    Cell Significance Index: -35.6400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 3.8998
    Cell Significance Index: 2129.8000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 3.0048
    Cell Significance Index: 350.1800
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 2.4651
    Cell Significance Index: 18.8100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.3416
    Cell Significance Index: 68.7700
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 1.5016
    Cell Significance Index: 9.3300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.1256
    Cell Significance Index: 323.8800
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 1.1166
    Cell Significance Index: 8.5800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.9261
    Cell Significance Index: 48.1100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.8210
    Cell Significance Index: 38.2800
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.7703
    Cell Significance Index: 19.2400
  • Cell Name: colonocyte (CL1000347)
    Fold Change: 0.6812
    Cell Significance Index: 4.2100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.5289
    Cell Significance Index: 400.3200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.3776
    Cell Significance Index: 13.1200
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.3544
    Cell Significance Index: 2.8300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3534
    Cell Significance Index: 48.5300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2301
    Cell Significance Index: 43.7800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.1790
    Cell Significance Index: 18.2800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1301
    Cell Significance Index: 3.5400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1129
    Cell Significance Index: 22.6400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0407
    Cell Significance Index: 6.9500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0066
    Cell Significance Index: -0.1100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0361
    Cell Significance Index: -67.9700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0447
    Cell Significance Index: -33.1100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0614
    Cell Significance Index: -1.6400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0654
    Cell Significance Index: -120.5500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0757
    Cell Significance Index: -15.9500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0781
    Cell Significance Index: -120.2700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0789
    Cell Significance Index: -44.4700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.0830
    Cell Significance Index: -8.2200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0900
    Cell Significance Index: -2.3000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0901
    Cell Significance Index: -122.5700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1028
    Cell Significance Index: -64.2100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.1373
    Cell Significance Index: -87.2200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.2168
    Cell Significance Index: -98.4000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.4508
    Cell Significance Index: -6.1500
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.4540
    Cell Significance Index: -4.0000
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: -0.4789
    Cell Significance Index: -2.5200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.6349
    Cell Significance Index: -92.2900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.6666
    Cell Significance Index: -76.3700
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.8535
    Cell Significance Index: -6.9600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.9419
    Cell Significance Index: -107.5100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.9642
    Cell Significance Index: -100.4000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -1.0590
    Cell Significance Index: -28.3800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.1580
    Cell Significance Index: -37.0900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -1.2742
    Cell Significance Index: -66.9000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -1.4014
    Cell Significance Index: -36.8500
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -1.4018
    Cell Significance Index: -9.1200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -1.4101
    Cell Significance Index: -108.2100
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -1.4392
    Cell Significance Index: -24.8100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -1.4457
    Cell Significance Index: -40.4000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -1.5716
    Cell Significance Index: -99.0500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.7894
    Cell Significance Index: -109.7100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -1.8423
    Cell Significance Index: -83.5100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -1.8911
    Cell Significance Index: -48.6100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -1.9169
    Cell Significance Index: -99.8500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.9725
    Cell Significance Index: -58.1000
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -2.1547
    Cell Significance Index: -32.7300
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -2.2282
    Cell Significance Index: -43.5700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -2.2637
    Cell Significance Index: -83.1000
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -2.3267
    Cell Significance Index: -19.6700
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -2.5834
    Cell Significance Index: -36.2100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -2.5894
    Cell Significance Index: -90.7100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -2.6501
    Cell Significance Index: -39.7100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -2.6939
    Cell Significance Index: -88.2000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -2.7285
    Cell Significance Index: -86.9000
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: -2.9498
    Cell Significance Index: -18.4700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -3.2148
    Cell Significance Index: -68.2300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -3.2434
    Cell Significance Index: -113.9700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -3.2750
    Cell Significance Index: -94.3600
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -3.5506
    Cell Significance Index: -112.3000
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -3.5940
    Cell Significance Index: -89.6500
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -3.7657
    Cell Significance Index: -74.4600
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -3.8100
    Cell Significance Index: -64.1800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -3.8694
    Cell Significance Index: -75.5200
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -3.8920
    Cell Significance Index: -99.1600
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -3.9116
    Cell Significance Index: -78.5300
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -3.9458
    Cell Significance Index: -85.2500
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -3.9905
    Cell Significance Index: -96.6600
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: -4.0114
    Cell Significance Index: -39.1700
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -4.0490
    Cell Significance Index: -51.1600
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -4.1937
    Cell Significance Index: -104.5800
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -4.2216
    Cell Significance Index: -85.9000
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -4.2392
    Cell Significance Index: -88.4800
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: -4.3675
    Cell Significance Index: -34.7500
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -4.3904
    Cell Significance Index: -56.5400
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -4.4151
    Cell Significance Index: -46.9100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -4.4436
    Cell Significance Index: -76.1500
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -4.5181
    Cell Significance Index: -90.1000
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -4.5377
    Cell Significance Index: -97.0000
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -4.5648
    Cell Significance Index: -64.9800
  • Cell Name: stem cell (CL0000034)
    Fold Change: -4.5652
    Cell Significance Index: -33.1800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** GPX1 is a member of the glutathione peroxidase family, which consists of four enzymes: GPX1, GPX2, GPX3, and GPX4. GPX1 is the most studied member of this family and is widely expressed in various tissues. This enzyme is a dimeric protein, consisting of two subunits, each containing a catalytic site. GPX1 has a high specificity for reducing hydrogen peroxide (H2O2) and other hydroperoxides, but it can also reduce other oxidants, such as lipid hydroperoxides and aldehydes. **Pathways and Functions** GPX1 is involved in various cellular processes, including: 1. **Cellular redox homeostasis**: GPX1 plays a crucial role in maintaining the balance between oxidative stress and antioxidant defenses, ensuring that cells do not accumulate excessive levels of ROS. 2. **Detoxification of reactive oxygen species**: GPX1 reduces ROS and hydroperoxides, preventing their potential damage to cellular components. 3. **Antioxidant defense**: GPX1 is part of the antioxidant defense system, which protects cells against oxidative damage. 4. **Cell signaling**: GPX1 is involved in cell signaling pathways, including the regulation of phosphatidylinositol 3-kinase/protein kinase B (PI3K/AKT) signaling. 5. **Apoptosis regulation**: GPX1 has been shown to regulate apoptosis (programmed cell death) by modulating the activity of pro-apoptotic and anti-apoptotic proteins. **Clinical Significance** GPX1 has been implicated in various diseases, including: 1. **Cancer**: GPX1 expression is often reduced in cancer cells, leading to increased oxidative stress and malignant transformation. 2. **Cardiovascular diseases**: GPX1 deficiency has been linked to cardiovascular diseases, including atherosclerosis and hypertension. 3. **Neurodegenerative disorders**: GPX1 has been implicated in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 4. **Inflammatory disorders**: GPX1 has anti-inflammatory properties, and its dysregulation has been linked to inflammatory diseases, such as rheumatoid arthritis. In conclusion, GPX1 is a vital enzyme that plays a crucial role in maintaining cellular redox homeostasis and protecting cells against oxidative stress. Its dysregulation has been implicated in various diseases, highlighting the importance of GPX1 in human health.

Genular Protein ID: 1394437116

Symbol: GPX1_HUMAN

Name: Cellular glutathione peroxidase

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 3658677

Title: cDNA sequence coding for human glutathione peroxidase.

PubMed ID: 3658677

DOI: 10.1093/nar/15.17.7178

PubMed ID: 3697069

Title: Nucleotide sequence of a human gene for glutathione peroxidase.

PubMed ID: 3697069

DOI: 10.1093/nar/15.23.10051

PubMed ID: 2955287

Title: Sequence of a cDNA coding for human glutathione peroxidase confirms TGA encodes active site selenocysteine.

PubMed ID: 2955287

DOI: 10.1093/nar/15.13.5484

PubMed ID: 2307470

Title: Isolation and chromosomal localization of the human glutathione peroxidase gene.

PubMed ID: 2307470

DOI: 10.1016/0888-7543(90)90566-d

PubMed ID: 1556108

Title: Structure and function of the 5'-flanking sequence of the human cytosolic selenium-dependent glutathione peroxidase gene (hgpx1).

PubMed ID: 1556108

DOI: 10.1016/s0021-9258(18)42647-6

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11115402

Title: Evidence for the presence of phospholipid hydroperoxide glutathione peroxidase in human platelets: implications for its involvement in the regulatory network of the 12-lipoxygenase pathway of arachidonic acid metabolism.

PubMed ID: 11115402

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 36608588

Title: Side-by-side comparison of recombinant human glutathione peroxidases identifies overlapping substrate specificities for soluble hydroperoxides.

PubMed ID: 36608588

DOI: 10.1016/j.redox.2022.102593

PubMed ID: 10220143

Title: Low yield of polymorphisms from EST blast searching: analysis of genes related to oxidative stress and verification of the P197L polymorphism in GPX1.

PubMed ID: 10220143

DOI: 10.1002/(sici)1098-1004(1999)13:4<294::aid-humu6>3.0.co;2-5

PubMed ID: 12496980

Title: Association between the GCG polymorphism of the selenium dependent GPX1 gene and the risk of young onset prostate cancer.

PubMed ID: 12496980

DOI: 10.1038/sj.pcan.4500569

PubMed ID: 15331559

Title: Functional variants in the glutathione peroxidase-1 (GPx-1) gene are associated with increased intima-media thickness of carotid arteries and risk of macrovascular diseases in Japanese type 2 diabetic patients.

PubMed ID: 15331559

DOI: 10.2337/diabetes.53.9.2455

PubMed ID: 15247771

Title: Increased risk of bladder cancer associated with a glutathione peroxidase 1 codon 198 variant.

PubMed ID: 15247771

DOI: 10.1097/01.ju.0000130942.40597.9d

Sequence Information:

  • Length: 203
  • Mass: 22088
  • Checksum: 5DB11579C66FE8E5
  • Sequence:
  • MCAARLAAAA AAAQSVYAFS ARPLAGGEPV SLGSLRGKVL LIENVASLUG TTVRDYTQMN 
    ELQRRLGPRG LVVLGFPCNQ FGHQENAKNE EILNSLKYVR PGGGFEPNFM LFEKCEVNGA 
    GAHPLFAFLR EALPAPSDDA TALMTDPKLI TWSPVCRNDV AWNFEKFLVG PDGVPLRRYS 
    RRFQTIDIEP DIEALLSQGP SCA

Genular Protein ID: 2926674682

Symbol: A0A2R8Y6B6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

Sequence Information:

  • Length: 157
  • Mass: 16914
  • Checksum: 72FB574D6A829D3D
  • Sequence:
  • MCAARLAAAA AAAQSVYAFS ARPLAGGEPV SLGSLRGKEN AKNEEILNSL KYVRPGGGFE 
    PNFMLFEKCE VNGAGAHPLF AFLREALPAP SDDATALMTD PKLITWSPVC RNDVAWNFEK 
    FLVGPDGVPL RRYSRRFQTI DIEPDIEALL SQGPSCA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.