IGHG2 | ENSG00000211893 | NCBI 3501

Details for: IGHG2

Gene ID: 3501

Symbol: IGHG2

Ensembl ID: ENSG00000211893

Description: immunoglobulin heavy constant gamma 2 (G2m marker)

Associated with

Anti-inflammatory response favouring leishmania parasite infection
(R-HSA-9662851)
Classical antibody-mediated complement activation
(R-HSA-173623)
Complement cascade
(R-HSA-166658)
Creation of c4 and c2 activators
(R-HSA-166786)
Disease
(R-HSA-1643685)
Fcgamma receptor (fcgr) dependent phagocytosis
(R-HSA-2029480)
Fcgr3a-mediated il10 synthesis
(R-HSA-9664323)
Fcgr3a-mediated phagocytosis
(R-HSA-9664422)
Fcgr activation
(R-HSA-2029481)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Initial triggering of complement
(R-HSA-166663)
Innate immune system
(R-HSA-168249)
Leishmania infection
(R-HSA-9658195)
Leishmania parasite growth and survival
(R-HSA-9664433)
Leishmania phagocytosis
(R-HSA-9664417)
Parasite infection
(R-HSA-9664407)
Parasitic infection pathways
(R-HSA-9824443)
Regulation of actin dynamics for phagocytic cup formation
(R-HSA-2029482)
Regulation of complement cascade
(R-HSA-977606)
Role of phospholipids in phagocytosis
(R-HSA-2029485)
Adaptive immune response
(GO:0002250)
Antibacterial humoral response
(GO:0019731)
Antigen binding
(GO:0003823)
B cell receptor signaling pathway
(GO:0050853)
Blood microparticle
(GO:0072562)
Complement activation, classical pathway
(GO:0006958)
Extracellular exosome
(GO:0070062)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Igg immunoglobulin complex
(GO:0071735)
Immunoglobulin complex, circulating
(GO:0042571)
Immunoglobulin receptor binding
(GO:0034987)
Plasma membrane
(GO:0005886)
Protein binding
(GO:0005515)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 8.4078
Cell Significance Index: 269.2900
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 3.6252
Cell Significance Index: 164.3200
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 3.3698
Cell Significance Index: 73.0100
Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: 3.3664
Cell Significance Index: 50.7300
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 2.4991
Cell Significance Index: 62.4700
Cell Name: odontoblast (CL0000060)
Fold Change: 0.9381
Cell Significance Index: 120.2600
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.7469
Cell Significance Index: 73.8900
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.7326
Cell Significance Index: 43.9800
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.7297
Cell Significance Index: 15.5400
Cell Name: IgG plasmablast (CL0000982)
Fold Change: 0.6796
Cell Significance Index: 5.6100
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.5150
Cell Significance Index: 98.0100
Cell Name: IgG memory B cell (CL0000979)
Fold Change: 0.4421
Cell Significance Index: 2.6700
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 0.3388
Cell Significance Index: 3.8500
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.3088
Cell Significance Index: 33.5900
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.1582
Cell Significance Index: 10.9400
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 0.0065
Cell Significance Index: 0.1000
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.0035
Cell Significance Index: 0.1000
Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.0021
Cell Significance Index: -0.0900
Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.0035
Cell Significance Index: -0.1500
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0036
Cell Significance Index: -6.8300
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: -0.0046
Cell Significance Index: -0.7500
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0077
Cell Significance Index: -0.2700
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0083
Cell Significance Index: -6.2800
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.0089
Cell Significance Index: -0.4500
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0114
Cell Significance Index: -8.3500
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0126
Cell Significance Index: -8.0000
Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0130
Cell Significance Index: -7.0800
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0228
Cell Significance Index: -10.3700
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0324
Cell Significance Index: -6.4900
Cell Name: exhausted T cell (CL0011025)
Fold Change: -0.0325
Cell Significance Index: -0.2600
Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.0330
Cell Significance Index: -6.5400
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0427
Cell Significance Index: -7.7000
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0510
Cell Significance Index: -7.0100
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0554
Cell Significance Index: -8.0600
Cell Name: peg cell (CL4033014)
Fold Change: -0.0623
Cell Significance Index: -1.4400
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0634
Cell Significance Index: -3.8900
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0669
Cell Significance Index: -8.2200
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0675
Cell Significance Index: -6.9000
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.0836
Cell Significance Index: -1.7400
Cell Name: lactocyte (CL0002325)
Fold Change: -0.0960
Cell Significance Index: -12.4000
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.1071
Cell Significance Index: -8.4800
Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.1269
Cell Significance Index: -8.1900
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.1363
Cell Significance Index: -10.4600
Cell Name: DN3 thymocyte (CL0000807)
Fold Change: -0.1396
Cell Significance Index: -1.4000
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1512
Cell Significance Index: -17.3200
Cell Name: IgG plasma cell (CL0000985)
Fold Change: -0.1531
Cell Significance Index: -1.4000
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.1571
Cell Significance Index: -11.7100
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.1616
Cell Significance Index: -7.1500
Cell Name: plasma cell (CL0000786)
Fold Change: -0.1826
Cell Significance Index: -2.0400
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.1970
Cell Significance Index: -6.4500
Cell Name: leukocyte (CL0000738)
Fold Change: -0.2031
Cell Significance Index: -3.4500
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.2144
Cell Significance Index: -7.8700
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.2421
Cell Significance Index: -5.8700
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.2434
Cell Significance Index: -11.3500
Cell Name: hematopoietic cell (CL0000988)
Fold Change: -0.2489
Cell Significance Index: -3.6400
Cell Name: granulosa cell (CL0000501)
Fold Change: -0.2586
Cell Significance Index: -6.8000
Cell Name: lymphocyte (CL0000542)
Fold Change: -0.2602
Cell Significance Index: -3.5400
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.2650
Cell Significance Index: -6.7700
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.2697
Cell Significance Index: -17.0000
Cell Name: enterocyte (CL0000584)
Fold Change: -0.2756
Cell Significance Index: -1.7100
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.3345
Cell Significance Index: -15.7200
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.3434
Cell Significance Index: -9.1700
Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: -0.3517
Cell Significance Index: -8.7700
Cell Name: erythrocyte (CL0000232)
Fold Change: -0.3764
Cell Significance Index: -9.5900
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.4111
Cell Significance Index: -6.8800
Cell Name: thyroid follicular cell (CL0002258)
Fold Change: -0.4264
Cell Significance Index: -4.5300
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.4376
Cell Significance Index: -12.5500
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.4404
Cell Significance Index: -8.1400
Cell Name: memory B cell (CL0000787)
Fold Change: -0.4408
Cell Significance Index: -4.6900
Cell Name: B cell (CL0000236)
Fold Change: -0.4477
Cell Significance Index: -5.2900
Cell Name: transitional stage B cell (CL0000818)
Fold Change: -0.4496
Cell Significance Index: -3.9500
Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: -0.4519
Cell Significance Index: -5.9100
Cell Name: precursor B cell (CL0000817)
Fold Change: -0.4529
Cell Significance Index: -5.8600
Cell Name: plasmablast (CL0000980)
Fold Change: -0.4547
Cell Significance Index: -4.2200
Cell Name: type I muscle cell (CL0002211)
Fold Change: -0.4590
Cell Significance Index: -11.2000
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: -0.4603
Cell Significance Index: -9.0000
Cell Name: keratinocyte (CL0000312)
Fold Change: -0.4608
Cell Significance Index: -11.5100
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: -0.4680
Cell Significance Index: -8.0000
Cell Name: neuroendocrine cell (CL0000165)
Fold Change: -0.4785
Cell Significance Index: -6.0600
Cell Name: intestinal crypt stem cell (CL0002250)
Fold Change: -0.4846
Cell Significance Index: -3.4100
Cell Name: Sertoli cell (CL0000216)
Fold Change: -0.4848
Cell Significance Index: -6.8000
Cell Name: IgA plasma cell (CL0000987)
Fold Change: -0.4895
Cell Significance Index: -3.2600
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: -0.4946
Cell Significance Index: -5.4100
Cell Name: megakaryocyte (CL0000556)
Fold Change: -0.4949
Cell Significance Index: -8.0200
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: -0.5049
Cell Significance Index: -8.7300
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -0.5058
Cell Significance Index: -8.5200
Cell Name: thymocyte (CL0000893)
Fold Change: -0.5271
Cell Significance Index: -6.6600
Cell Name: DN1 thymic pro-T cell (CL0000894)
Fold Change: -0.5276
Cell Significance Index: -5.4700
Cell Name: monocyte (CL0000576)
Fold Change: -0.5284
Cell Significance Index: -6.0800
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: -0.5310
Cell Significance Index: -6.8000
Cell Name: seromucus secreting cell (CL0000159)
Fold Change: -0.5418
Cell Significance Index: -11.3000
Cell Name: acinar cell (CL0000622)
Fold Change: -0.5485
Cell Significance Index: -6.8900
Cell Name: hepatocyte (CL0000182)
Fold Change: -0.5527
Cell Significance Index: -7.6700
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: -0.5559
Cell Significance Index: -6.5400
Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: -0.5586
Cell Significance Index: -9.6300
Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.5595
Cell Significance Index: -6.6700
Cell Name: cytotoxic T cell (CL0000910)
Fold Change: -0.5962
Cell Significance Index: -8.6900
Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -0.6006
Cell Significance Index: -8.8700
Cell Name: progenitor cell (CL0011026)
Fold Change: -0.6100
Cell Significance Index: -6.4800
Cell Name: naive T cell (CL0000898)
Fold Change: -0.6231
Cell Significance Index: -5.6600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Other Information

Description

**Key Characteristics** 1. **Gene Function**: IGHG2 encodes the gamma heavy chain of IgG antibodies, which is essential for the recognition and binding of antigens by B cells. 2. **Cell Type Expression**: IGHG2 is expressed in a variety of cell types, including IgG plasmablasts, plasma cells, enterocytes, intestinal crypt stem cells, and goblet cells. 3. **Signaling Pathways**: IGHG2 is involved in multiple signaling pathways, including B cell receptor signaling, complement activation, and phagocytosis. 4. **Disease Association**: IGHG2 has been associated with various diseases, including infectious diseases, autoimmune disorders, and cancer. **Pathways and Functions** IGHG2 plays a crucial role in the adaptive immune response, particularly in the humoral immunity mediated by B cells. The gene is involved in the following pathways: 1. **B Cell Receptor Signaling**: IGHG2 is essential for the recognition and binding of antigens by B cells, leading to the activation of B cell receptor signaling. 2. **Complement Activation**: IGHG2 is involved in the classical pathway of complement activation, which plays a crucial role in the clearance of pathogens and foreign substances. 3. **Phagocytosis**: IGHG2 is involved in phagocytosis, particularly through the Fcγ receptor (Fcgr) dependent phagocytosis pathway. 4. **Antibacterial Humoral Response**: IGHG2 is involved in the antibacterial humoral response, particularly through the production of IgG antibodies. **Clinical Significance** IGHG2 has significant clinical implications, particularly in the context of infectious diseases and autoimmune disorders. The gene's involvement in the adaptive immune response and complement activation pathways makes it an important target for the development of novel therapeutic strategies. Additionally, IGHG2's association with various diseases highlights its potential role as a biomarker for disease diagnosis and monitoring. In the context of Leishmania parasite infection, IGHG2's involvement in the anti-inflammatory response and phagocytosis pathways makes it an important player in the host's defense against this parasitic infection. Understanding the role of IGHG2 in Leishmania infection and other diseases can provide valuable insights into the development of novel therapeutic strategies and the prevention of disease. In summary, IGHG2 is a critical gene involved in the adaptive immune response, particularly in the humoral immunity mediated by B cells. Its involvement in multiple signaling pathways, including B cell receptor signaling, complement activation, and phagocytosis, highlights its importance in immune system function and disease.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.