Gene IGHG2 - ENSG00000211893 | NCBI Gene ID: 3501

Details for: IGHG2

Gene ID: 3501

Symbol: IGHG2

Ensembl ID: ENSG00000211893

Description: immunoglobulin heavy constant gamma 2 (G2m marker)

Associated with

Anti-inflammatory response favouring leishmania parasite infection
(R-HSA-9662851)
Classical antibody-mediated complement activation
(R-HSA-173623)
Complement cascade
(R-HSA-166658)
Creation of c4 and c2 activators
(R-HSA-166786)
Disease
(R-HSA-1643685)
Fcgamma receptor (fcgr) dependent phagocytosis
(R-HSA-2029480)
Fcgr3a-mediated il10 synthesis
(R-HSA-9664323)
Fcgr3a-mediated phagocytosis
(R-HSA-9664422)
Fcgr activation
(R-HSA-2029481)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Initial triggering of complement
(R-HSA-166663)
Innate immune system
(R-HSA-168249)
Leishmania infection
(R-HSA-9658195)
Leishmania parasite growth and survival
(R-HSA-9664433)
Leishmania phagocytosis
(R-HSA-9664417)
Parasite infection
(R-HSA-9664407)
Parasitic infection pathways
(R-HSA-9824443)
Regulation of actin dynamics for phagocytic cup formation
(R-HSA-2029482)
Regulation of complement cascade
(R-HSA-977606)
Role of phospholipids in phagocytosis
(R-HSA-2029485)
Adaptive immune response
(GO:0002250)
Antibacterial humoral response
(GO:0019731)
Antigen binding
(GO:0003823)
B cell receptor signaling pathway
(GO:0050853)
Blood microparticle
(GO:0072562)
Complement activation, classical pathway
(GO:0006958)
Extracellular exosome
(GO:0070062)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Igg immunoglobulin complex
(GO:0071735)
Immunoglobulin complex, circulating
(GO:0042571)
Immunoglobulin receptor binding
(GO:0034987)
Plasma membrane
(GO:0005886)
Protein binding
(GO:0005515)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: IgG plasmablast (CL0000982)
Fold Change: 3.91
Marker Score: 1079
Cell Name: IgG plasma cell (CL0000985)
Fold Change: 1.43
Marker Score: 624
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.34
Marker Score: 1331
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 1.25
Marker Score: 848
Cell Name: IgG memory B cell (CL0000979)
Fold Change: 1.24
Marker Score: 749
Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.17
Marker Score: 850
Cell Name: goblet cell (CL0000160)
Fold Change: 1.15
Marker Score: 7647
Cell Name: transitional stage B cell (CL0000818)
Fold Change: 1.04
Marker Score: 368
Cell Name: class switched memory B cell (CL0000972)
Fold Change: 0.98
Marker Score: 923
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30407
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.98
Marker Score: 504
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.97
Marker Score: 458
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2411
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.94
Marker Score: 391
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.93
Marker Score: 5291
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.92
Marker Score: 370
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2737
Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
Fold Change: 0.91
Marker Score: 706
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.9
Marker Score: 322
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.89
Marker Score: 407
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5286
Cell Name: plasmablast (CL0000980)
Fold Change: 0.81
Marker Score: 1080.5
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1269
Cell Name: brush cell (CL0002204)
Fold Change: 0.77
Marker Score: 703
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.68
Marker Score: 2858
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.68
Marker Score: 450
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.59
Marker Score: 380
Cell Name: IgA plasmablast (CL0000984)
Fold Change: 0.59
Marker Score: 156
Cell Name: hematopoietic cell (CL0000988)
Fold Change: 0.59
Marker Score: 390
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.56
Marker Score: 444
Cell Name: unswitched memory B cell (CL0000970)
Fold Change: 0.55
Marker Score: 320
Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
Fold Change: 0.49
Marker Score: 359.5
Cell Name: mast cell (CL0000097)
Fold Change: 0.48
Marker Score: 276
Cell Name: memory B cell (CL0000787)
Fold Change: 0.45
Marker Score: 343
Cell Name: megakaryocyte (CL0000556)
Fold Change: 0.41
Marker Score: 235
Cell Name: plasma cell (CL0000786)
Fold Change: 0.41
Marker Score: 462
Cell Name: natural killer cell (CL0000623)
Fold Change: 0.41
Marker Score: 527.5
Cell Name: DN3 thymocyte (CL0000807)
Fold Change: 0.38
Marker Score: 191
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.37
Marker Score: 116
Cell Name: neutrophil (CL0000775)
Fold Change: 0.36
Marker Score: 219
Cell Name: blood cell (CL0000081)
Fold Change: 0.36
Marker Score: 4138
Cell Name: germinal center B cell (CL0000844)
Fold Change: 0.35
Marker Score: 213
Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
Fold Change: 0.33
Marker Score: 858.5
Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
Fold Change: 0.33
Marker Score: 291
Cell Name: naive T cell (CL0000898)
Fold Change: 0.32
Marker Score: 206
Cell Name: classical monocyte (CL0000860)
Fold Change: 0.31
Marker Score: 1284
Cell Name: T cell (CL0000084)
Fold Change: 0.31
Marker Score: 531
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 0.31
Marker Score: 761
Cell Name: IgA plasma cell (CL0000987)
Fold Change: 0.3
Marker Score: 259
Cell Name: vein endothelial cell (CL0002543)
Fold Change: 0.3
Marker Score: 267
Cell Name: B cell (CL0000236)
Fold Change: 0.28
Marker Score: 267
Cell Name: professional antigen presenting cell (CL0000145)
Fold Change: 0.28
Marker Score: 143
Cell Name: naive B cell (CL0000788)
Fold Change: 0.28
Marker Score: 247
Cell Name: B-1a B cell (CL0000820)
Fold Change: 0.27
Marker Score: 65
Cell Name: bronchus fibroblast of lung (CL2000093)
Fold Change: 0.27
Marker Score: 366
Cell Name: B-1 B cell (CL0000819)
Fold Change: 0.26
Marker Score: 451
Cell Name: myeloid cell (CL0000763)
Fold Change: 0.23
Marker Score: 367
Cell Name: fibroblast (CL0000057)
Fold Change: 0.23
Marker Score: 220
Cell Name: intestinal crypt stem cell (CL0002250)
Fold Change: 0.23
Marker Score: 85
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.22
Marker Score: 64
Cell Name: plasmacytoid dendritic cell (CL0000784)
Fold Change: 0.22
Marker Score: 116
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.22
Marker Score: 73
Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
Fold Change: 0.21
Marker Score: 182
Cell Name: follicular B cell (CL0000843)
Fold Change: 0.21
Marker Score: 230
Cell Name: vascular associated smooth muscle cell (CL0000359)
Fold Change: 0.21
Marker Score: 95
Cell Name: IgG-negative class switched memory B cell (CL0002117)
Fold Change: 0.2
Marker Score: 198
Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
Fold Change: 0.2
Marker Score: 452.5
Cell Name: CD38-negative naive B cell (CL0002102)
Fold Change: 0.2
Marker Score: 410
Cell Name: respiratory basal cell (CL0002633)
Fold Change: 0.19
Marker Score: 277
Cell Name: alternatively activated macrophage (CL0000890)
Fold Change: 0.19
Marker Score: 80
Cell Name: DN1 thymic pro-T cell (CL0000894)
Fold Change: 0.19
Marker Score: 58
Cell Name: exhausted T cell (CL0011025)
Fold Change: 0.19
Marker Score: 107
Cell Name: mononuclear phagocyte (CL0000113)
Fold Change: 0.18
Marker Score: 181
Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
Fold Change: 0.18
Marker Score: 40
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.17
Marker Score: 43
Cell Name: regulatory T cell (CL0000815)
Fold Change: 0.17
Marker Score: 186
Cell Name: ionocyte (CL0005006)
Fold Change: 0.17
Marker Score: 51
Cell Name: capillary endothelial cell (CL0002144)
Fold Change: 0.16
Marker Score: 171
Cell Name: endothelial cell (CL0000115)
Fold Change: 0.16
Marker Score: 142
Cell Name: innate lymphoid cell (CL0001065)
Fold Change: 0.15
Marker Score: 55
Cell Name: plasmacytoid dendritic cell, human (CL0001058)
Fold Change: 0.15
Marker Score: 40
Cell Name: megakaryocyte progenitor cell (CL0000553)
Fold Change: 0.15
Marker Score: 41
Cell Name: dendritic cell (CL0000451)
Fold Change: 0.15
Marker Score: 99.5
Cell Name: epithelial fate stem cell (CL0000036)
Fold Change: 0.14
Marker Score: 41
Cell Name: lung goblet cell (CL1000143)
Fold Change: 0.14
Marker Score: 41
Cell Name: mature B cell (CL0000785)
Fold Change: 0.14
Marker Score: 104
Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
Fold Change: 0.14
Marker Score: 39
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.14
Marker Score: 41
Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
Fold Change: 0.14
Marker Score: 41
Cell Name: neuroendocrine cell (CL0000165)
Fold Change: 0.13
Marker Score: 52
Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
Fold Change: 0.13
Marker Score: 213
Cell Name: colon macrophage (CL0009038)
Fold Change: 0.13
Marker Score: 36
Cell Name: platelet (CL0000233)
Fold Change: 0.13
Marker Score: 59
Cell Name: T follicular helper cell (CL0002038)
Fold Change: 0.13
Marker Score: 108
Cell Name: mature NK T cell (CL0000814)
Fold Change: 0.13
Marker Score: 60
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 0.13
Marker Score: 41
Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
Fold Change: 0.13
Marker Score: 37
Cell Name: erythroid progenitor cell, mammalian (CL0001066)
Fold Change: 0.13
Marker Score: 41
Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
Fold Change: 0.13
Marker Score: 29
Cell Name: mesothelial cell of epicardium (CL0011019)
Fold Change: 0.13
Marker Score: 41

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Other Information

Description

**Key characteristics:** * IGHG2 is a glycoprotein with a molecular weight of approximately 180 kDa. * It is a member of the immunoglobulin heavy chain family. * It is expressed in high levels in mucosal tissues and during immune responses. **Pathways and functions:** * IGHG2 is a key regulator of the inflammatory response to infection. * It is involved in the initial triggering of complement activation through the classical pathway. * It also contributes to the regulation of the complement cascade and the formation of the Fc receptor (fcgr) complex. * IGHG2 is important for the phagocytosis of parasites by immune cells. * It is expressed in high levels in mucosal tissues infected with leishmania parasites. * IGHG2 plays a role in the regulation of actin dynamics for phagocytic cup formation. **Clinical significance:** * Mutations in the IGHG2 gene have been linked to inflammatory diseases, including rheumatoid arthritis, Crohn's disease, and lupus. * IGHG2 is a potential therapeutic target for inflammatory diseases. **Additional notes:** * IGHG2 is a highly conserved protein, with similar sequences found in mammals, birds, and fish. * It is expressed in high levels in mucosal tissues, including the gut, skin, and lungs. * IGHG2 is a key regulator of the immune response to infection.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.