Details for: RAB30

Gene ID: 27314

Symbol: RAB30

Ensembl ID: ENSG00000137502

Description: RAB30, member RAS oncogene family

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 192.9985
    Cell Significance Index: -30.0200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 119.2225
    Cell Significance Index: -30.2400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 61.9542
    Cell Significance Index: -29.2500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 61.0697
    Cell Significance Index: -24.8100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 24.3804
    Cell Significance Index: -30.0600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 10.7956
    Cell Significance Index: -28.9200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 10.4360
    Cell Significance Index: -22.8400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.6380
    Cell Significance Index: -30.1400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 6.8599
    Cell Significance Index: -21.0700
  • Cell Name: centroblast (CL0009112)
    Fold Change: 2.1088
    Cell Significance Index: 4.9200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 1.4661
    Cell Significance Index: 35.1600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.4466
    Cell Significance Index: 170.6000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.3412
    Cell Significance Index: 255.2400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.2819
    Cell Significance Index: 78.7900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.2327
    Cell Significance Index: 244.6300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.1795
    Cell Significance Index: 31.6100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.1670
    Cell Significance Index: 234.1000
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 1.0431
    Cell Significance Index: 25.4500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.9043
    Cell Significance Index: 324.3500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7483
    Cell Significance Index: 21.5600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7395
    Cell Significance Index: 667.6700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.6137
    Cell Significance Index: 424.4700
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.5726
    Cell Significance Index: 3.8800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.5149
    Cell Significance Index: 11.2800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.4870
    Cell Significance Index: 37.3800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.4328
    Cell Significance Index: 10.8200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4037
    Cell Significance Index: 65.6700
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 0.3948
    Cell Significance Index: 5.5200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3718
    Cell Significance Index: 10.3900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.3387
    Cell Significance Index: 6.6100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2899
    Cell Significance Index: 31.5400
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.2557
    Cell Significance Index: 5.4700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.2531
    Cell Significance Index: 14.2000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.2494
    Cell Significance Index: 12.6000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.2082
    Cell Significance Index: 14.0000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1739
    Cell Significance Index: 22.2900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1579
    Cell Significance Index: 15.6200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1484
    Cell Significance Index: 3.2200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1252
    Cell Significance Index: 55.3700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1081
    Cell Significance Index: 7.4800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0977
    Cell Significance Index: 6.1600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0693
    Cell Significance Index: 4.1600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0479
    Cell Significance Index: 21.7500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0464
    Cell Significance Index: 87.3000
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0026
    Cell Significance Index: 0.0400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0073
    Cell Significance Index: -0.3300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0088
    Cell Significance Index: -16.2600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0089
    Cell Significance Index: -4.8700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0105
    Cell Significance Index: -6.7000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0136
    Cell Significance Index: -2.4600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0136
    Cell Significance Index: -0.7100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0166
    Cell Significance Index: -0.5900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0177
    Cell Significance Index: -24.0300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0178
    Cell Significance Index: -27.4100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0186
    Cell Significance Index: -1.3900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0272
    Cell Significance Index: -0.7000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0342
    Cell Significance Index: -25.0800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0344
    Cell Significance Index: -25.4800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0392
    Cell Significance Index: -29.6500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0516
    Cell Significance Index: -29.1200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0534
    Cell Significance Index: -33.3300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0641
    Cell Significance Index: -1.8300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0667
    Cell Significance Index: -9.1600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0888
    Cell Significance Index: -25.5600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0934
    Cell Significance Index: -11.4900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1085
    Cell Significance Index: -12.6500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1121
    Cell Significance Index: -16.3000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1144
    Cell Significance Index: -19.5300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1599
    Cell Significance Index: -33.6800
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.1612
    Cell Significance Index: -2.0300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1707
    Cell Significance Index: -7.9600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1841
    Cell Significance Index: -23.7800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1972
    Cell Significance Index: -13.9500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2044
    Cell Significance Index: -20.8800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2377
    Cell Significance Index: -6.4700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2396
    Cell Significance Index: -14.6900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2460
    Cell Significance Index: -28.1800
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.2628
    Cell Significance Index: -4.1700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2722
    Cell Significance Index: -28.3400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2833
    Cell Significance Index: -12.5300
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.2894
    Cell Significance Index: -4.6700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3001
    Cell Significance Index: -11.3700
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.3208
    Cell Significance Index: -4.1600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3246
    Cell Significance Index: -16.8600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3383
    Cell Significance Index: -17.7600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3470
    Cell Significance Index: -27.4800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3670
    Cell Significance Index: -17.2500
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3678
    Cell Significance Index: -5.4300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.3746
    Cell Significance Index: -6.4200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.4068
    Cell Significance Index: -5.5500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.4120
    Cell Significance Index: -5.9000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.4149
    Cell Significance Index: -26.7700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.4175
    Cell Significance Index: -8.8600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4289
    Cell Significance Index: -14.0400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.4382
    Cell Significance Index: -8.6700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.4479
    Cell Significance Index: -9.5400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4481
    Cell Significance Index: -14.2700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.4488
    Cell Significance Index: -5.3500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.4682
    Cell Significance Index: -9.8000
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.4701
    Cell Significance Index: -7.1400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RAB30 is a small GTPase that belongs to the RAS superfamily, which is characterized by its ability to bind and hydrolyze GTP. The RAB30 protein is specifically localized to the Golgi apparatus and is involved in regulating membrane trafficking, protein modification, and signaling pathways. RAB30 is highly expressed in various tissues, including skeletal muscle, neurons, and immune cells, suggesting its importance in maintaining cellular homeostasis and function. **Pathways and Functions:** RAB30 is involved in several key pathways, including: 1. **Membrane Trafficking:** RAB30 regulates the transport of proteins and lipids between the Golgi apparatus and other cellular compartments, ensuring proper protein modification and secretion. 2. **Protein Modification:** RAB30 is involved in the regulation of protein folding, modification, and degradation, which are essential for maintaining protein homeostasis. 3. **Signaling Pathways:** RAB30 interacts with other signaling molecules, including Rab GTPases, to regulate various cellular processes, including cell growth, differentiation, and survival. 4. **GTPase Activity:** RAB30 exhibits GTPase activity, which allows it to hydrolyze GTP and regulate its own activity and interactions with other proteins. **Functions:** The functions of RAB30 include: 1. **Regulation of Golgi Apparatus Function:** RAB30 regulates the structure and function of the Golgi apparatus, ensuring proper protein modification and secretion. 2. **Cellular Homeostasis:** RAB30 maintains cellular homeostasis by regulating protein folding, modification, and degradation. 3. **Cell Signaling:** RAB30 interacts with other signaling molecules to regulate various cellular processes, including cell growth, differentiation, and survival. 4. **Immune Cell Function:** RAB30 is highly expressed in immune cells, suggesting its importance in regulating immune cell function and function. **Clinical Significance:** Dysregulation of RAB30 has been implicated in various disease states, including: 1. **Immune Disorders:** RAB30 has been linked to autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis, suggesting its importance in regulating immune cell function. 2. **Neurological Disorders:** RAB30 has been implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease, suggesting its role in regulating protein folding and modification. 3. **Cancer:** RAB30 has been linked to cancer, suggesting its role in regulating cell growth and differentiation. 4. **Metabolic Disorders:** RAB30 has been implicated in metabolic disorders, such as diabetes and obesity, suggesting its role in regulating protein metabolism and function. In conclusion, RAB30 is a multifunctional protein that plays a critical role in regulating various cellular processes, including membrane trafficking, protein modification, and signaling pathways. Dysregulation of RAB30 has been implicated in various disease states, highlighting its importance in maintaining cellular homeostasis and function. Further research is needed to fully understand the role of RAB30 in human disease and to identify potential therapeutic targets for the treatment of these disorders.

Genular Protein ID: 1657183157

Symbol: RAB30_HUMAN

Name: Ras-related protein Rab-30

UniProtKB Accession Codes:

Q15771 Q6FGK1 Q6MZH2 Q96CI8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 3 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 5 EvolutionaryTrace 1 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 4 SMART 4 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8863739

Title: Molecular cloning of two novel rab genes from human melanocytes.

PubMed ID: 8863739

DOI: 10.1016/0378-1119(96)00509-4

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22188167

Title: Rab30 is required for the morphological integrity of the Golgi apparatus.

PubMed ID: 22188167

DOI: 10.1111/boc.201100080

Sequence Information:

  • Length: 203
  • Mass: 23058
  • Checksum: 935E56DBD48DD7C2
  • Sequence:
    • MSMEDYDFLF KIVLIGNAGV GKTCLVRRFT QGLFPPGQGA TIGVDFMIKT VEINGEKVKL 
QIWDTAGQER FRSITQSYYR SANALILTYD ITCEESFRCL PEWLREIEQY ASNKVITVLV 
GNKIDLAERR EVSQQRAEEF SEAQDMYYLE TSAKESDNVE KLFLDLACRL ISEARQNTLV 
NNVSSPLPGE GKSISYLTCC NFN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.