Details for: SDC1

Gene ID: 6382

Symbol: SDC1

Ensembl ID: ENSG00000115884

Description: syndecan 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 120.2866
    Cell Significance Index: -18.7100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 73.8833
    Cell Significance Index: -18.7400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 45.9684
    Cell Significance Index: -18.6800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 41.3664
    Cell Significance Index: -19.5300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 19.5969
    Cell Significance Index: -18.7100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 15.1506
    Cell Significance Index: -18.6800
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 12.5794
    Cell Significance Index: 28.3600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 8.4346
    Cell Significance Index: -22.6000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 7.5153
    Cell Significance Index: 390.4000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 5.3987
    Cell Significance Index: 49.7200
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 5.0983
    Cell Significance Index: 43.8100
  • Cell Name: sebaceous gland cell (CL2000021)
    Fold Change: 4.7457
    Cell Significance Index: 6.1400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.7186
    Cell Significance Index: -18.6200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 3.9450
    Cell Significance Index: 459.7500
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 3.5447
    Cell Significance Index: 50.4600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 3.2305
    Cell Significance Index: 582.3600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.7442
    Cell Significance Index: 74.7000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.7060
    Cell Significance Index: 332.7300
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 2.6533
    Cell Significance Index: 16.3700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 2.1419
    Cell Significance Index: 128.5900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.9419
    Cell Significance Index: 211.2200
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.7518
    Cell Significance Index: 15.5500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.6121
    Cell Significance Index: 1455.6100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.4793
    Cell Significance Index: 41.3400
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.3897
    Cell Significance Index: 23.4100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.3510
    Cell Significance Index: 95.5500
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 1.2718
    Cell Significance Index: 4.7900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.2450
    Cell Significance Index: 550.4300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.2294
    Cell Significance Index: 26.9200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.1159
    Cell Significance Index: 77.1700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.8630
    Cell Significance Index: 171.2700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.6349
    Cell Significance Index: 13.2900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.6091
    Cell Significance Index: 27.6100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5975
    Cell Significance Index: 17.2200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.5425
    Cell Significance Index: 69.5400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5419
    Cell Significance Index: 11.7400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.4602
    Cell Significance Index: 59.4600
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.4238
    Cell Significance Index: 6.3500
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.4096
    Cell Significance Index: 2.5400
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.4069
    Cell Significance Index: 1.2100
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.3895
    Cell Significance Index: 2.4200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3535
    Cell Significance Index: 34.9700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2680
    Cell Significance Index: 6.7000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2592
    Cell Significance Index: 141.5300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.2285
    Cell Significance Index: 7.3200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2186
    Cell Significance Index: 41.6100
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.2053
    Cell Significance Index: 3.0300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1831
    Cell Significance Index: 8.6100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1639
    Cell Significance Index: 3.4900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.1595
    Cell Significance Index: 2.6700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1514
    Cell Significance Index: 11.2900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.1212
    Cell Significance Index: 13.8900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.1078
    Cell Significance Index: 81.6200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0852
    Cell Significance Index: 62.4800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0694
    Cell Significance Index: 2.4400
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.0382
    Cell Significance Index: 0.2200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.0336
    Cell Significance Index: 3.8300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0293
    Cell Significance Index: 4.7700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0049
    Cell Significance Index: 0.1300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0029
    Cell Significance Index: -0.4900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0076
    Cell Significance Index: -5.6300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0087
    Cell Significance Index: -16.4200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0095
    Cell Significance Index: -5.9600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0114
    Cell Significance Index: -3.2900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0117
    Cell Significance Index: -0.1600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0129
    Cell Significance Index: -23.8100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0136
    Cell Significance Index: -7.6800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0151
    Cell Significance Index: -23.3100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0175
    Cell Significance Index: -23.8100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0324
    Cell Significance Index: -20.5700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0396
    Cell Significance Index: -14.2100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0397
    Cell Significance Index: -8.3600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0460
    Cell Significance Index: -4.7000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0466
    Cell Significance Index: -21.1400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0512
    Cell Significance Index: -7.0400
  • Cell Name: trophoblast giant cell (CL0002488)
    Fold Change: -0.0514
    Cell Significance Index: -0.3700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0888
    Cell Significance Index: -17.8200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1118
    Cell Significance Index: -4.5800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1395
    Cell Significance Index: -20.2800
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.1403
    Cell Significance Index: -2.1700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1426
    Cell Significance Index: -7.2100
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.1491
    Cell Significance Index: -2.2300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1655
    Cell Significance Index: -1.8800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1821
    Cell Significance Index: -18.9700
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.1871
    Cell Significance Index: -1.4300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1871
    Cell Significance Index: -22.0600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2088
    Cell Significance Index: -16.5400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2122
    Cell Significance Index: -11.1400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2165
    Cell Significance Index: -11.2800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2531
    Cell Significance Index: -2.6200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2633
    Cell Significance Index: -9.1500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2780
    Cell Significance Index: -18.6900
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.2817
    Cell Significance Index: -7.0400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2844
    Cell Significance Index: -5.9000
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.2848
    Cell Significance Index: -4.7900
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: -0.2850
    Cell Significance Index: -2.9400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2956
    Cell Significance Index: -13.7800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3097
    Cell Significance Index: -17.3800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3103
    Cell Significance Index: -9.1400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3391
    Cell Significance Index: -20.8400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** SDC1 is a transmembrane protein composed of three extracellular domains (ECDs) and a cytoplasmic tail. Its extracellular domain is characterized by a tetrasaccharide linker sequence, which is essential for its function. SDC1 contains binding sites for laminin, collagen, and other extracellular matrix proteins, as well as for growth factors and cytokines. Its cytoplasmic tail is rich in tyrosine phosphorylation sites, which are involved in signaling pathways. **Pathways and Functions** SDC1 is involved in various signaling pathways, including: 1. **Wnt signaling pathway**: SDC1 interacts with Wnt proteins and modulates their activity, influencing cell proliferation, differentiation, and survival. 2. **Cell migration and attachment**: SDC1 is involved in the regulation of cell migration, attachment, and spreading, which is essential for tissue development, wound healing, and cancer metastasis. 3. **Immune responses**: SDC1 interacts with immune cells, such as T cells and dendritic cells, and regulates their activation, proliferation, and differentiation. 4. **Exosome and endosome trafficking**: SDC1 is involved in the regulation of exosome and endosome trafficking, which is essential for the transport of proteins and lipids between cells. 5. **Glycosaminoglycan metabolism**: SDC1 regulates the production and degradation of glycosaminoglycans (GAGs), which are essential for the maintenance of tissue integrity and inflammation. **Clinical Significance** SDC1 has been implicated in various diseases, including: 1. **Cancer**: SDC1 is overexpressed in several types of cancer, including breast, lung, and colon cancer, and is involved in tumor progression and metastasis. 2. **Cardiovascular disease**: SDC1 is involved in the regulation of vascular cell migration and proliferation, and its dysregulation is associated with atherosclerosis and cardiovascular disease. 3. **Neurodegenerative disorders**: SDC1 is involved in the regulation of neuronal migration and differentiation, and its dysregulation is associated with neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease. 4. **Infectious diseases**: SDC1 is involved in the regulation of immune responses to viral infections, such as respiratory syncytial virus (RSV) and SARS-CoV-2. In conclusion, SDC1 is a multifunctional protein that plays a crucial role in various cellular processes, including cell migration, attachment, and signaling, as well as in the regulation of immune responses and the maintenance of tissue integrity. Its dysregulation is associated with various diseases, including cancer, cardiovascular disease, and neurodegenerative disorders. Further studies are needed to fully understand the role of SDC1 in human disease and to develop therapeutic strategies to target its dysregulation.

Genular Protein ID: 3314233766

Symbol: SDC1_HUMAN

Name: N/A

UniProtKB Accession Codes:

P18827 D6W523 Q53QV0 Q546D3 Q96HB7

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 10 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 23 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 15 RefSeq 2 SASBDB 1 SMART 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1339431

Title: Differential expression of cell surface heparan sulfate proteoglycans in human mammary epithelial cells and lung fibroblasts.

PubMed ID: 1339431

DOI: 10.1016/s0021-9258(18)48404-9

PubMed ID: 2324102

Title: Sequence of human syndecan indicates a novel gene family of integral membrane proteoglycans.

PubMed ID: 2324102

DOI: 10.1016/s0021-9258(19)39232-4

PubMed ID: 15177497

Title: Shift of syndecan-1 expression from epithelial to stromal cells during progression of solid tumours.

PubMed ID: 15177497

DOI: 10.1016/j.ejca.2004.01.038

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9050911

Title: The mapping and visual ordering of the human syndecan-1 and N-myc genes near the telomeric region of chromosome 2p.

PubMed ID: 9050911

DOI: 10.1007/s004390050360

PubMed ID: 9169435

Title: Regulated shedding of syndecan-1 and -4 ectodomains by thrombin and growth factor receptor activation.

PubMed ID: 9169435

DOI: 10.1074/jbc.272.23.14713

PubMed ID: 16007225

Title: Adhesion signaling by a novel mitotic substrate of src kinases.

PubMed ID: 16007225

DOI: 10.1038/sj.onc.1208582

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22660413

Title: Syndecan-syntenin-ALIX regulates the biogenesis of exosomes.

PubMed ID: 22660413

DOI: 10.1038/ncb2502

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 32337544

Title: An affinity chromatography and glycoproteomics workflow to profile the chondroitin sulfate proteoglycans that interact with malarial VAR2CSA in the placenta and in cancer.

PubMed ID: 32337544

DOI: 10.1093/glycob/cwaa039

PubMed ID: 36213313

Title: Mass spectrometric analysis of chondroitin sulfate-linked peptides.

PubMed ID: 36213313

DOI: 10.1007/s42485-022-00092-3

PubMed ID: 23395182

Title: The structure of the Tiam1 PDZ domain/ phospho-syndecan1 complex reveals a ligand conformation that modulates protein dynamics.

PubMed ID: 23395182

DOI: 10.1016/j.str.2013.01.004

Sequence Information:

  • Length: 310
  • Mass: 32462
  • Checksum: 8E9EF4A57F5FDBD0
  • Sequence:
    • MRRAALWLWL CALALSLQPA LPQIVATNLP PEDQDGSGDD SDNFSGSGAG ALQDITLSQQ 
TPSTWKDTQL LTAIPTSPEP TGLEATAAST STLPAGEGPK EGEAVVLPEV EPGLTAREQE 
ATPRPRETTQ LPTTHLASTT TATTAQEPAT SHPHRDMQPG HHETSTPAGP SQADLHTPHT 
EDGGPSATER AAEDGASSQL PAAEGSGEQD FTFETSGENT AVVAVEPDRR NQSPVDQGAT 
GASQGLLDRK EVLGGVIAGG LVGLIFAVCL VGFMLYRMKK KDEGSYSLEE PKQANGGAYQ 
KPTKQEEFYA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.