Details for: CCL18

Gene ID: 6362

Symbol: CCL18

Ensembl ID: ENSG00000275385

Description: C-C motif chemokine ligand 18

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.4430
    Cell Significance Index: 5.4800
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.3316
    Cell Significance Index: 1.3800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0663
    Cell Significance Index: 41.4000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0146
    Cell Significance Index: 11.0600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.0036
    Cell Significance Index: 2.0500
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0019
    Cell Significance Index: 0.0300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.0006
    Cell Significance Index: 0.4500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.0000
    Cell Significance Index: -0.0100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0006
    Cell Significance Index: -0.1100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0029
    Cell Significance Index: -5.4200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0043
    Cell Significance Index: -7.8700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0049
    Cell Significance Index: -7.5100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0055
    Cell Significance Index: -0.9400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0058
    Cell Significance Index: -7.8700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0063
    Cell Significance Index: -0.6400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0076
    Cell Significance Index: -0.8700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0082
    Cell Significance Index: -6.0100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0082
    Cell Significance Index: -0.9400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0093
    Cell Significance Index: -5.9000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0122
    Cell Significance Index: -0.6200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0141
    Cell Significance Index: -6.3900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0149
    Cell Significance Index: -1.9100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0263
    Cell Significance Index: -1.0800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0294
    Cell Significance Index: -5.9100
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.0300
    Cell Significance Index: -0.4200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0331
    Cell Significance Index: -5.9700
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0331
    Cell Significance Index: -0.2700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0379
    Cell Significance Index: -1.0600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0382
    Cell Significance Index: -5.5500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0398
    Cell Significance Index: -1.0200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0454
    Cell Significance Index: -0.7600
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0458
    Cell Significance Index: -1.1100
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0461
    Cell Significance Index: -1.1500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0462
    Cell Significance Index: -5.6800
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: -0.0487
    Cell Significance Index: -0.4400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0488
    Cell Significance Index: -6.7000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0494
    Cell Significance Index: -3.7900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0496
    Cell Significance Index: -6.4100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0537
    Cell Significance Index: -6.3300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0554
    Cell Significance Index: -5.7700
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0602
    Cell Significance Index: -0.8000
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: -0.0627
    Cell Significance Index: -0.7900
  • Cell Name: PP cell (CL0000696)
    Fold Change: -0.0826
    Cell Significance Index: -0.8400
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0851
    Cell Significance Index: -0.7500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0859
    Cell Significance Index: -6.4000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0899
    Cell Significance Index: -5.5100
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: -0.0934
    Cell Significance Index: -1.0200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0978
    Cell Significance Index: -2.6200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1023
    Cell Significance Index: -4.7700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1026
    Cell Significance Index: -5.3300
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: -0.1074
    Cell Significance Index: -0.8700
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.1083
    Cell Significance Index: -1.8400
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.1087
    Cell Significance Index: -1.5900
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1153
    Cell Significance Index: -2.8800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1169
    Cell Significance Index: -6.5600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1175
    Cell Significance Index: -6.1200
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: -0.1232
    Cell Significance Index: -0.9400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1257
    Cell Significance Index: -7.9200
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.1283
    Cell Significance Index: -1.3100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1285
    Cell Significance Index: -1.4600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1294
    Cell Significance Index: -6.0800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1428
    Cell Significance Index: -2.6400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1458
    Cell Significance Index: -6.4500
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.1495
    Cell Significance Index: -2.1700
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.1526
    Cell Significance Index: -1.2900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1553
    Cell Significance Index: -5.7000
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.1578
    Cell Significance Index: -1.0700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1602
    Cell Significance Index: -5.6300
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.1647
    Cell Significance Index: -1.4400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1648
    Cell Significance Index: -4.4000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1653
    Cell Significance Index: -5.7900
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: -0.1653
    Cell Significance Index: -2.8400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1703
    Cell Significance Index: -6.4500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1768
    Cell Significance Index: -5.7900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1770
    Cell Significance Index: -6.1500
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.1781
    Cell Significance Index: -1.9900
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.1811
    Cell Significance Index: -2.1400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1815
    Cell Significance Index: -5.7800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.1926
    Cell Significance Index: -5.5500
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.1975
    Cell Significance Index: -2.8100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2098
    Cell Significance Index: -6.1800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2201
    Cell Significance Index: -6.3100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.2401
    Cell Significance Index: -2.6100
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -0.2405
    Cell Significance Index: -3.0800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2477
    Cell Significance Index: -6.1800
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.2508
    Cell Significance Index: -6.3900
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: -0.2513
    Cell Significance Index: -1.3200
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: -0.2573
    Cell Significance Index: -0.5800
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.2624
    Cell Significance Index: -8.3000
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.2736
    Cell Significance Index: -3.5400
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.2779
    Cell Significance Index: -2.7500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2807
    Cell Significance Index: -6.0700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2818
    Cell Significance Index: -5.5000
  • Cell Name: osteoblast (CL0000062)
    Fold Change: -0.2819
    Cell Significance Index: -2.7400
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.2853
    Cell Significance Index: -5.6900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2869
    Cell Significance Index: -6.0900
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.2926
    Cell Significance Index: -5.7200
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.2937
    Cell Significance Index: -5.7800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.2956
    Cell Significance Index: -5.8500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.3018
    Cell Significance Index: -6.0600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CCL18 exhibits several key characteristics that distinguish it from other chemokines: 1. **Chemotactic activity:** CCL18 exhibits potent chemotactic activity towards eosinophils, neutrophils, and monocytes, facilitating their recruitment to sites of inflammation and immune responses. 2. **Receptor binding:** CCL18 binds specifically to the CCR1 receptor, triggering a signaling cascade that regulates immune cell activation, chemotaxis, and cytokine production. 3. **Tissue specificity:** CCL18 is expressed in various tissues, including the lungs, skin, and lymphoid organs, highlighting its role in localizing immune responses to specific anatomical sites. 4. **Diverse cell types:** CCL18 is expressed in multiple cell types, including endothelial cells, macrophages, and dendritic cells, underscoring its involvement in diverse immune and inflammatory processes. **Pathways and Functions:** CCL18's functions can be attributed to its interactions with the CCR1 receptor and other signaling pathways: 1. **Chemokine-mediated signaling:** CCL18 binds to CCR1, triggering a signaling cascade that regulates chemotaxis, cell activation, and cytokine production. 2. **Cell-cell signaling:** CCL18 interacts with other chemokines and cytokines to modulate immune responses, inflammation, and tissue repair. 3. **Cellular response to cytokines:** CCL18 modulates the response to cytokines, such as IL-1β and TNF-α, influencing the activation and function of immune cells. 4. **G protein-coupled receptor signaling:** CCL18 activates G protein-coupled receptor signaling pathways, regulating cell proliferation, differentiation, and survival. **Clinical Significance:** CCL18's dysregulation has been implicated in various diseases, including: 1. **Asthma and allergic inflammation:** CCL18's role in eosinophil recruitment and activation makes it a potential target for asthma and allergic inflammation therapies. 2. **Inflammatory bowel disease:** CCL18's involvement in chemotaxis and immune cell activation suggests its potential as a therapeutic target in IBD. 3. **Cancer:** CCL18's expression in tumor-associated macrophages and its role in tumor progression make it a potential biomarker and therapeutic target in cancer. 4. **Neuroinflammation:** CCL18's involvement in neuroinflammation and neurodegenerative diseases, such as Alzheimer's and Parkinson's, highlights its potential as a therapeutic target in these conditions. In conclusion, CCL18's multifaceted role in immune response, inflammation, and cellular communication underscores its importance in various diseases. Further research is necessary to fully elucidate the mechanisms underlying CCL18's functions and to explore its therapeutic potential in disease prevention and treatment.

Genular Protein ID: 4208303055

Symbol: CCL18_HUMAN

Name: C-C motif chemokine 18

UniProtKB Accession Codes:

P55774 B5BUM2 Q53X71

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 15 Ensembl 3 EvolutionaryTrace 1 GO 13 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 9233607

Title: A novel human CC chemokine PARC that is most homologous to macrophage-inflammatory protein-1 alpha/LD78 alpha and chemotactic for T lymphocytes, but not for monocytes.

PubMed ID: 9233607

PubMed ID: 9570561

Title: Alternative macrophage activation-associated CC-chemokine-1, a novel structural homologue of macrophage inflammatory protein-1 alpha with a Th2-associated expression pattern.

PubMed ID: 9570561

PubMed ID: 9192897

Title: A dendritic-cell-derived C-C chemokine that preferentially attracts naive T cells.

PubMed ID: 9192897

DOI: 10.1038/42716

PubMed ID: 10049593

Title: Chemokine PARC gene (SCYA18) generated by fusion of two MIP-1alpha/LD78alpha-like genes.

PubMed ID: 10049593

DOI: 10.1006/geno.1998.5670

PubMed ID: 10087196

Title: Genomic organization and biological characterization of the novel human CC chemokine DC-CK-1/PARC/MIP-4/SCYA18.

PubMed ID: 10087196

DOI: 10.1006/geno.1998.5635

PubMed ID: 19054851

Title: Human protein factory for converting the transcriptome into an in vitro-expressed proteome.

PubMed ID: 19054851

DOI: 10.1038/nmeth.1273

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9129202

Title: The chemokine information source: identification and characterization of novel chemokines using the WorldWideWeb and expressed sequence tag databases.

PubMed ID: 9129202

DOI: 10.1002/jlb.61.5.545

PubMed ID: 11745396

Title: Selective induction of CCL18/PARC by staphylococcal enterotoxins in mononuclear cells and enhanced levels in septic and rheumatoid arthritis.

PubMed ID: 11745396

DOI: 10.1002/1521-4141(200112)31:12<3755::aid-immu3755>3.0.co;2-o

PubMed ID: 11978786

Title: Identification of biologically active chemokine isoforms from ascitic fluid and elevated levels of CCL18/pulmonary and activation-regulated chemokine in ovarian carcinoma.

PubMed ID: 11978786

DOI: 10.1074/jbc.m112275200

PubMed ID: 23742785

Title: The disulfide bond between cysteine 10 and cysteine 34 is required for CCL18 activity.

PubMed ID: 23742785

DOI: 10.1016/j.cyto.2013.04.028

Sequence Information:

  • Length: 89
  • Mass: 9849
  • Checksum: C287B94B9C0518E4
  • Sequence:
    • MKGLAAALLV LVCTMALCSC AQVGTNKELC CLVYTSWQIP QKFIVDYSET SPQCPKPGVI 
LLTKRGRQIC ADPNKKWVQK YISDLKLNA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.