Gene IGLC1 - ENSG00000211675 | NCBI Gene ID: 3537

Details for: IGLC1

Gene ID: 3537

Symbol: IGLC1

Ensembl ID: ENSG00000211675

Description: immunoglobulin lambda constant 1

Associated with

Adaptive immune response
(GO:0002250)
Antigen binding
(GO:0003823)
B cell receptor signaling pathway
(GO:0050853)
Blood microparticle
(GO:0072562)
Extracellular exosome
(GO:0070062)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Iga immunoglobulin complex
(GO:0071745)
Igd immunoglobulin complex
(GO:0071738)
Ige immunoglobulin complex
(GO:0071742)
Igg immunoglobulin complex
(GO:0071735)
Igm immunoglobulin complex
(GO:0071753)
Immune response
(GO:0006955)
Immunoglobulin mediated immune response
(GO:0016064)
Plasma membrane
(GO:0005886)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: transitional stage B cell (CL0000818)
Fold Change: 19.62
Marker Score: 6942
Cell Name: memory B cell (CL0000787)
Fold Change: 4.96
Marker Score: 3751
Cell Name: IgG plasma cell (CL0000985)
Fold Change: 3.31
Marker Score: 1446
Cell Name: naive B cell (CL0000788)
Fold Change: 3.14
Marker Score: 2800
Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
Fold Change: 2.46
Marker Score: 2091
Cell Name: plasmablast (CL0000980)
Fold Change: 1.73
Marker Score: 2301
Cell Name: precursor B cell (CL0000817)
Fold Change: 1.49
Marker Score: 984
Cell Name: CD4-positive helper T cell (CL0000492)
Fold Change: 1.35
Marker Score: 1473
Cell Name: immature B cell (CL0000816)
Fold Change: 1.26
Marker Score: 836
Cell Name: IgA plasma cell (CL0000987)
Fold Change: 1.21
Marker Score: 1033
Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
Fold Change: 0.99
Marker Score: 867
Cell Name: IgM plasma cell (CL0000986)
Fold Change: 0.96
Marker Score: 333
Cell Name: hematopoietic cell (CL0000988)
Fold Change: 0.93
Marker Score: 615.5
Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
Fold Change: 0.91
Marker Score: 707
Cell Name: plasma cell (CL0000786)
Fold Change: 0.88
Marker Score: 985
Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
Fold Change: 0.88
Marker Score: 1293
Cell Name: lymphocyte (CL0000542)
Fold Change: 0.77
Marker Score: 389
Cell Name: regulatory T cell (CL0000815)
Fold Change: 0.65
Marker Score: 717
Cell Name: common dendritic progenitor (CL0001029)
Fold Change: 0.62
Marker Score: 213
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 0.51
Marker Score: 1281
Cell Name: innate lymphoid cell (CL0001065)
Fold Change: 0.41
Marker Score: 148
Cell Name: hematopoietic precursor cell (CL0008001)
Fold Change: 0.39
Marker Score: 137
Cell Name: class switched memory B cell (CL0000972)
Fold Change: 0.39
Marker Score: 363
Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
Fold Change: 0.36
Marker Score: 872
Cell Name: alpha-beta T cell (CL0000789)
Fold Change: 0.35
Marker Score: 268
Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: 0.31
Marker Score: 879
Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
Fold Change: 0.31
Marker Score: 258
Cell Name: mature NK T cell (CL0000814)
Fold Change: 0.29
Marker Score: 136
Cell Name: unswitched memory B cell (CL0000970)
Fold Change: 0.29
Marker Score: 167
Cell Name: platelet (CL0000233)
Fold Change: 0.23
Marker Score: 104
Cell Name: germinal center B cell (CL0000844)
Fold Change: 0.19
Marker Score: 116
Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
Fold Change: 0.18
Marker Score: 315
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.17
Marker Score: 416
Cell Name: endothelial cell of sinusoid (CL0002262)
Fold Change: 0.16
Marker Score: 38
Cell Name: macrophage (CL0000235)
Fold Change: 0.16
Marker Score: 173
Cell Name: prostate gland microvascular endothelial cell (CL2000059)
Fold Change: 0.15
Marker Score: 60
Cell Name: smooth muscle cell of prostate (CL1000487)
Fold Change: 0.15
Marker Score: 39
Cell Name: ILC1, human (CL0001077)
Fold Change: 0.15
Marker Score: 38
Cell Name: group 3 innate lymphoid cell (CL0001071)
Fold Change: 0.15
Marker Score: 62
Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
Fold Change: 0.14
Marker Score: 105
Cell Name: mucus secreting cell (CL0000319)
Fold Change: 0.14
Marker Score: 36
Cell Name: smooth muscle cell (CL0000192)
Fold Change: 0.14
Marker Score: 92
Cell Name: conventional dendritic cell (CL0000990)
Fold Change: 0.14
Marker Score: 94
Cell Name: erythrocyte (CL0000232)
Fold Change: 0.14
Marker Score: 75
Cell Name: Unknown (CL0000548)
Fold Change: 0.13
Marker Score: 98
Cell Name: primitive red blood cell (CL0002355)
Fold Change: 0.13
Marker Score: 97
Cell Name: B cell (CL0000236)
Fold Change: 0.13
Marker Score: 123
Cell Name: blood vessel endothelial cell (CL0000071)
Fold Change: 0.13
Marker Score: 130
Cell Name: myofibroblast cell (CL0000186)
Fold Change: 0.13
Marker Score: 156
Cell Name: T cell (CL0000084)
Fold Change: 0.12
Marker Score: 213
Cell Name: fetal cardiomyocyte (CL0002495)
Fold Change: 0.12
Marker Score: 39
Cell Name: erythroid progenitor cell, mammalian (CL0001066)
Fold Change: 0.12
Marker Score: 38
Cell Name: lung goblet cell (CL1000143)
Fold Change: 0.12
Marker Score: 34
Cell Name: stromal cell (CL0000499)
Fold Change: 0.12
Marker Score: 135
Cell Name: mesothelial fibroblast (CL4023054)
Fold Change: 0.12
Marker Score: 34
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.11
Marker Score: 69
Cell Name: gamma-delta T cell (CL0000798)
Fold Change: 0.11
Marker Score: 74
Cell Name: retinal pigment epithelial cell (CL0002586)
Fold Change: 0.11
Marker Score: 32
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 0.11
Marker Score: 39
Cell Name: mast cell (CL0000097)
Fold Change: 0.11
Marker Score: 62
Cell Name: ciliated epithelial cell (CL0000067)
Fold Change: 0.1
Marker Score: 47
Cell Name: T follicular helper cell (CL0002038)
Fold Change: 0.1
Marker Score: 85
Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
Fold Change: 0.1
Marker Score: 109
Cell Name: fibroblast (CL0000057)
Fold Change: 0.1
Marker Score: 92
Cell Name: OFF retinal ganglion cell (CL4023033)
Fold Change: 0.09
Marker Score: 39
Cell Name: plasmacytoid dendritic cell (CL0000784)
Fold Change: 0.09
Marker Score: 50
Cell Name: classical monocyte (CL0000860)
Fold Change: 0.09
Marker Score: 385
Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
Fold Change: 0.09
Marker Score: 42
Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: 0.09
Marker Score: 89.5
Cell Name: pericyte (CL0000669)
Fold Change: 0.09
Marker Score: 50
Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
Fold Change: 0.08
Marker Score: 68
Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
Fold Change: 0.08
Marker Score: 51
Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
Fold Change: 0.08
Marker Score: 34
Cell Name: interneuron (CL0000099)
Fold Change: 0.08
Marker Score: 37
Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
Fold Change: 0.08
Marker Score: 27
Cell Name: double negative thymocyte (CL0002489)
Fold Change: 0.08
Marker Score: 108
Cell Name: granulocyte (CL0000094)
Fold Change: 0.08
Marker Score: 35
Cell Name: mucosal invariant T cell (CL0000940)
Fold Change: 0.08
Marker Score: 69
Cell Name: vascular associated smooth muscle cell (CL0000359)
Fold Change: 0.08
Marker Score: 35
Cell Name: erythroid lineage cell (CL0000764)
Fold Change: 0.07
Marker Score: 37
Cell Name: endothelial cell of lymphatic vessel (CL0002138)
Fold Change: 0.07
Marker Score: 46
Cell Name: secretory cell (CL0000151)
Fold Change: 0.07
Marker Score: 133
Cell Name: monocyte (CL0000576)
Fold Change: 0.07
Marker Score: 92
Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 0.07
Marker Score: 55
Cell Name: early lymphoid progenitor (CL0000936)
Fold Change: 0.07
Marker Score: 34
Cell Name: common lymphoid progenitor (CL0000051)
Fold Change: 0.07
Marker Score: 47
Cell Name: Bergmann glial cell (CL0000644)
Fold Change: 0.07
Marker Score: 27
Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: 0.06
Marker Score: 35
Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.06
Marker Score: 28
Cell Name: megakaryocyte (CL0000556)
Fold Change: 0.06
Marker Score: 33
Cell Name: promyelocyte (CL0000836)
Fold Change: 0.06
Marker Score: 28
Cell Name: dendritic cell (CL0000451)
Fold Change: 0.05
Marker Score: 37
Cell Name: pro-B cell (CL0000826)
Fold Change: 0.05
Marker Score: 51
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: 0.05
Marker Score: 36
Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
Fold Change: 0.05
Marker Score: 91
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.05
Marker Score: 21
Cell Name: promonocyte (CL0000559)
Fold Change: 0.05
Marker Score: 32
Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 0.05
Marker Score: 28
Cell Name: erythroblast (CL0000765)
Fold Change: 0.05
Marker Score: 29
Cell Name: natural killer cell (CL0000623)
Fold Change: 0.04
Marker Score: 54

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Other Information

Description

**Key characteristics:** * IGLC1 is a type I membrane protein with a molecular weight of approximately 150 kDa. * It is expressed in a variety of cell types, including B cells, plasma cells, and dendritic cells. * IGLC1 is a member of the immunoglobulin lambda (IGL) family of immune receptors. * IGLC1 is involved in the adaptive immune response and is expressed on transitional and memory B cells, as well as on plasmablast and plasma cells. **Pathways and functions:** * IGLC1 is expressed on B cells and is involved in the activation of the B cell receptor signaling pathway. * It is also expressed on plasma cells and is involved in the regulation of immune responses. * IGLC1 is a key molecule in the regulation of antibody production. **Clinical significance:** * Mutations in the IGLC1 gene have been linked to the development of several autoimmune diseases, including rheumatoid arthritis, scleroderma, and lupus. * IGLC1 is a target for therapeutic antibodies in autoimmune diseases. * IGLC1 is also a potential therapeutic target for cancer immunotherapy. **Additional information:** * IGLC1 is a highly conserved protein, with a similar sequence found in other mammals. * It is expressed in high levels in humans and other primates. * IGLC1 is a key molecule in the regulation of immune responses.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.