IGLC1 | ENSG00000211675 | NCBI 3537

Details for: IGLC1

Gene ID: 3537

Symbol: IGLC1

Ensembl ID: ENSG00000211675

Description: immunoglobulin lambda constant 1

Associated with

Adaptive immune response
(GO:0002250)
Antigen binding
(GO:0003823)
B cell receptor signaling pathway
(GO:0050853)
Blood microparticle
(GO:0072562)
Extracellular exosome
(GO:0070062)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Iga immunoglobulin complex
(GO:0071745)
Igd immunoglobulin complex
(GO:0071738)
Ige immunoglobulin complex
(GO:0071742)
Igg immunoglobulin complex
(GO:0071735)
Igm immunoglobulin complex
(GO:0071753)
Immune response
(GO:0006955)
Immunoglobulin mediated immune response
(GO:0016064)
Plasma membrane
(GO:0005886)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: oral mucosa squamous cell (CL1001576)
Fold Change: 2.3926
Cell Significance Index: 20.5600
Cell Name: common dendritic progenitor (CL0001029)
Fold Change: 1.4349
Cell Significance Index: 14.9300
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 0.0370
Cell Significance Index: 0.4200
Cell Name: keratinocyte (CL0000312)
Fold Change: 0.0172
Cell Significance Index: 0.4300
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: 0.0042
Cell Significance Index: 0.2100
Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.0071
Cell Significance Index: -0.2900
Cell Name: odontoblast (CL0000060)
Fold Change: -0.0111
Cell Significance Index: -1.4200
Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.0145
Cell Significance Index: -0.3500
Cell Name: ependymal cell (CL0000065)
Fold Change: -0.0254
Cell Significance Index: -0.3000
Cell Name: mesothelial cell (CL0000077)
Fold Change: -0.0308
Cell Significance Index: -0.3700
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0319
Cell Significance Index: -5.7500
Cell Name: neural progenitor cell (CL0011020)
Fold Change: -0.0336
Cell Significance Index: -0.3300
Cell Name: brain vascular cell (CL4023072)
Fold Change: -0.0359
Cell Significance Index: -0.4100
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0476
Cell Significance Index: -5.8500
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0599
Cell Significance Index: -12.0200
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0684
Cell Significance Index: -9.3900
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.1647
Cell Significance Index: -7.7400
Cell Name: transitional stage B cell (CL0000818)
Fold Change: -0.1759
Cell Significance Index: -1.5500
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.1768
Cell Significance Index: -9.9200
Cell Name: hematopoietic cell (CL0000988)
Fold Change: -0.1873
Cell Significance Index: -2.7400
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.2185
Cell Significance Index: -16.7700
Cell Name: leukocyte (CL0000738)
Fold Change: -0.2284
Cell Significance Index: -3.8800
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.2404
Cell Significance Index: -6.8900
Cell Name: peg cell (CL4033014)
Fold Change: -0.2428
Cell Significance Index: -5.6100
Cell Name: lymphocyte (CL0000542)
Fold Change: -0.2440
Cell Significance Index: -3.3200
Cell Name: erythrocyte (CL0000232)
Fold Change: -0.2504
Cell Significance Index: -6.3800
Cell Name: plasma cell (CL0000786)
Fold Change: -0.2524
Cell Significance Index: -2.8200
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.2613
Cell Significance Index: -6.3300
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.2686
Cell Significance Index: -7.3100
Cell Name: common lymphoid progenitor (CL0000051)
Fold Change: -0.2817
Cell Significance Index: -2.8600
Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: -0.3143
Cell Significance Index: -4.1100
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: -0.3166
Cell Significance Index: -6.1900
Cell Name: Schwann cell (CL0002573)
Fold Change: -0.3215
Cell Significance Index: -3.6000
Cell Name: B cell (CL0000236)
Fold Change: -0.3922
Cell Significance Index: -4.6400
Cell Name: small pre-B-II cell (CL0000954)
Fold Change: -0.4144
Cell Significance Index: -3.3300
Cell Name: precursor B cell (CL0000817)
Fold Change: -0.4297
Cell Significance Index: -5.5600
Cell Name: innate lymphoid cell (CL0001065)
Fold Change: -0.4312
Cell Significance Index: -5.5400
Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
Fold Change: -0.4333
Cell Significance Index: -5.2300
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: -0.4382
Cell Significance Index: -7.4900
Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
Fold Change: -0.4546
Cell Significance Index: -6.3800
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.4615
Cell Significance Index: -8.5300
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: -0.4616
Cell Significance Index: -6.3300
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: -0.4638
Cell Significance Index: -5.8800
Cell Name: immature B cell (CL0000816)
Fold Change: -0.4893
Cell Significance Index: -4.6300
Cell Name: proerythroblast (CL0000547)
Fold Change: -0.5108
Cell Significance Index: -7.3200
Cell Name: pro-B cell (CL0000826)
Fold Change: -0.5206
Cell Significance Index: -5.6000
Cell Name: megakaryocyte (CL0000556)
Fold Change: -0.5409
Cell Significance Index: -8.7600
Cell Name: erythroblast (CL0000765)
Fold Change: -0.5485
Cell Significance Index: -6.5400
Cell Name: cytotoxic T cell (CL0000910)
Fold Change: -0.5619
Cell Significance Index: -8.1900
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.5738
Cell Significance Index: -15.3200
Cell Name: naive B cell (CL0000788)
Fold Change: -0.5765
Cell Significance Index: -6.0700
Cell Name: adipocyte (CL0000136)
Fold Change: -0.5784
Cell Significance Index: -7.7100
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.5927
Cell Significance Index: -12.5800
Cell Name: promonocyte (CL0000559)
Fold Change: -0.5964
Cell Significance Index: -6.3700
Cell Name: plasmablast (CL0000980)
Fold Change: -0.6066
Cell Significance Index: -5.6300
Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.6147
Cell Significance Index: -12.3400
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: -0.6185
Cell Significance Index: -7.3100
Cell Name: granulocyte (CL0000094)
Fold Change: -0.6288
Cell Significance Index: -7.5900
Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.6313
Cell Significance Index: -9.3200
Cell Name: dendritic cell (CL0000451)
Fold Change: -0.6366
Cell Significance Index: -8.3100
Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: -0.6465
Cell Significance Index: -8.3300
Cell Name: lung ciliated cell (CL1000271)
Fold Change: -0.6480
Cell Significance Index: -6.3400
Cell Name: memory B cell (CL0000787)
Fold Change: -0.6599
Cell Significance Index: -7.0200
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: -0.6970
Cell Significance Index: -8.2000
Cell Name: mature B cell (CL0000785)
Fold Change: -0.6982
Cell Significance Index: -4.5500
Cell Name: T cell (CL0000084)
Fold Change: -0.7038
Cell Significance Index: -8.3100
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: -0.7131
Cell Significance Index: -7.9700
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: -0.7265
Cell Significance Index: -11.2400
Cell Name: promyelocyte (CL0000836)
Fold Change: -0.7274
Cell Significance Index: -7.1900
Cell Name: primitive red blood cell (CL0002355)
Fold Change: -0.7314
Cell Significance Index: -8.2800
Cell Name: IgG plasma cell (CL0000985)
Fold Change: -0.7338
Cell Significance Index: -6.7100
Cell Name: neutrophil (CL0000775)
Fold Change: -0.7341
Cell Significance Index: -9.1700
Cell Name: renal principal cell (CL0005009)
Fold Change: -0.7370
Cell Significance Index: -7.8000
Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
Fold Change: -0.7409
Cell Significance Index: -6.4800
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.7417
Cell Significance Index: -16.0200
Cell Name: serous secreting cell (CL0000313)
Fold Change: -0.7444
Cell Significance Index: -6.5500
Cell Name: capillary endothelial cell (CL0002144)
Fold Change: -0.7456
Cell Significance Index: -8.4700
Cell Name: natural killer cell (CL0000623)
Fold Change: -0.7512
Cell Significance Index: -8.3200
Cell Name: monocyte (CL0000576)
Fold Change: -0.7726
Cell Significance Index: -8.8900
Cell Name: double negative thymocyte (CL0002489)
Fold Change: -0.7733
Cell Significance Index: -9.1800
Cell Name: early lymphoid progenitor (CL0000936)
Fold Change: -0.7840
Cell Significance Index: -7.9600
Cell Name: retina horizontal cell (CL0000745)
Fold Change: -0.7874
Cell Significance Index: -9.8800
Cell Name: amacrine cell (CL0000561)
Fold Change: -0.7881
Cell Significance Index: -9.8700
Cell Name: retinal cone cell (CL0000573)
Fold Change: -0.7906
Cell Significance Index: -9.8700
Cell Name: helper T cell (CL0000912)
Fold Change: -0.7974
Cell Significance Index: -11.3300
Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: -0.8017
Cell Significance Index: -13.8200
Cell Name: parietal epithelial cell (CL1000452)
Fold Change: -0.8034
Cell Significance Index: -8.7800
Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: -0.8068
Cell Significance Index: -7.7700
Cell Name: osteoclast (CL0000092)
Fold Change: -0.8120
Cell Significance Index: -8.2900
Cell Name: glial cell (CL0000125)
Fold Change: -0.8132
Cell Significance Index: -8.9100
Cell Name: retinal bipolar neuron (CL0000748)
Fold Change: -0.8142
Cell Significance Index: -9.8700
Cell Name: plasmacytoid dendritic cell (CL0000784)
Fold Change: -0.8146
Cell Significance Index: -10.6900
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.8169
Cell Significance Index: -16.1500
Cell Name: myeloid cell (CL0000763)
Fold Change: -0.8195
Cell Significance Index: -10.8900
Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
Fold Change: -0.8231
Cell Significance Index: -7.7000
Cell Name: platelet (CL0000233)
Fold Change: -0.8243
Cell Significance Index: -8.4800
Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.8263
Cell Significance Index: -9.8500
Cell Name: renal beta-intercalated cell (CL0002201)
Fold Change: -0.8343
Cell Significance Index: -7.7200
Cell Name: classical monocyte (CL0000860)
Fold Change: -0.8345
Cell Significance Index: -7.7700
Cell Name: smooth muscle cell (CL0000192)
Fold Change: -0.8358
Cell Significance Index: -9.7100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Other Information

Description

**Key Characteristics:** IGLC1 is a lambda constant gene that is specifically expressed in B cells, a type of immune cell responsible for producing antibodies. The gene is characterized by its presence in various stages of B cell development, including transitional stage B cells, memory B cells, and plasma cells. IGLC1 is also found in T cells, particularly in alpha-beta memory T cells, highlighting its broader immunological significance. The gene's expression is tightly regulated, with elevated levels observed in activated B cells and plasmablasts, suggesting its involvement in the immune response. **Pathways and Functions:** IGLC1 is integral to the B cell receptor signaling pathway, which is critical for the activation and proliferation of B cells. The lambda constant is responsible for the proper assembly and maturation of the BCR complex, ensuring that the receptor is correctly folded and displayed on the plasma membrane. Upon antigen binding, the BCR complex triggers a cascade of signaling events that lead to the activation of downstream pathways, including the activation of NF-κB and the transcription of immunoglobulin genes. IGLC1 also plays a role in the regulation of B cell receptor signaling, influencing the efficiency and specificity of the immune response. **Clinical Significance:** IGLC1 has significant implications in the diagnosis and treatment of various immune-related disorders. Mutations in the IGLC1 gene have been linked to immunodeficiency disorders, such as selective IgA deficiency, highlighting the importance of this gene in the development of functional B cells. Additionally, alterations in IGLC1 expression have been observed in certain types of cancer, including lymphomas and leukemia, suggesting its potential as a biomarker for disease diagnosis and progression. Furthermore, IGLC1 has been implicated in the pathogenesis of autoimmune diseases, such as rheumatoid arthritis and lupus, where dysregulation of the B cell response contributes to disease progression. The gene's role in regulating B cell receptor signaling and immune response makes it an attractive target for therapeutic interventions aimed at modulating the immune system. In conclusion, IGLC1 is a critical component of the B cell receptor complex, playing a pivotal role in the adaptive immune response. Its regulation of B cell receptor signaling and its involvement in the development of functional B cells make it an essential gene for the proper functioning of the immune system. Further research into the role of IGLC1 in immune-related disorders and its potential as a therapeutic target will provide valuable insights into the complex mechanisms underlying the immune response.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.