IGHA1 | ENSG00000211895 | NCBI 3493

Details for: IGHA1

Gene ID: 3493

Symbol: IGHA1

Ensembl ID: ENSG00000211895

Description: immunoglobulin heavy constant alpha 1

Associated with

Binding and uptake of ligands by scavenger receptors
(R-HSA-2173782)
Cell surface interactions at the vascular wall
(R-HSA-202733)
Hemostasis
(R-HSA-109582)
Scavenging of heme from plasma
(R-HSA-2168880)
Vesicle-mediated transport
(R-HSA-5653656)
Adaptive immune response
(GO:0002250)
Antibacterial humoral response
(GO:0019731)
Antigen binding
(GO:0003823)
B cell receptor signaling pathway
(GO:0050853)
Blood microparticle
(GO:0072562)
Complement activation, classical pathway
(GO:0006958)
Extracellular exosome
(GO:0070062)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Glomerular filtration
(GO:0003094)
Iga immunoglobulin complex
(GO:0071745)
Igg immunoglobulin complex
(GO:0071735)
Immune response
(GO:0006955)
Immunoglobulin complex, circulating
(GO:0042571)
Immunoglobulin receptor binding
(GO:0034987)
Monomeric iga immunoglobulin complex
(GO:0071748)
Plasma membrane
(GO:0005886)
Positive regulation of respiratory burst
(GO:0060267)
Secretory dimeric iga immunoglobulin complex
(GO:0071752)
Secretory iga immunoglobulin complex
(GO:0071751)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 60.8979
Cell Significance Index: -31.3300
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 50.2200
Cell Significance Index: -23.7100
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 37.2417
Cell Significance Index: -24.9900
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 11.3892
Cell Significance Index: -30.5100
Cell Name: retinal blood vessel endothelial cell (CL0002585)
Fold Change: 4.2222
Cell Significance Index: 54.5500
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 3.2558
Cell Significance Index: -10.0000
Cell Name: seromucus secreting cell (CL0000159)
Fold Change: 1.6653
Cell Significance Index: 34.7300
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.5230
Cell Significance Index: 43.8800
Cell Name: IgA plasmablast (CL0000984)
Fold Change: 1.4415
Cell Significance Index: 11.5900
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.9043
Cell Significance Index: 172.1000
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.8689
Cell Significance Index: 784.5100
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.7744
Cell Significance Index: 76.6100
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.6615
Cell Significance Index: 67.5700
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.6396
Cell Significance Index: 28.9900
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.5776
Cell Significance Index: 93.9400
Cell Name: DN3 thymocyte (CL0000807)
Fold Change: 0.4657
Cell Significance Index: 4.6700
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.3892
Cell Significance Index: 42.3400
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.2845
Cell Significance Index: 21.2000
Cell Name: lactocyte (CL0002325)
Fold Change: 0.1702
Cell Significance Index: 21.9900
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.1307
Cell Significance Index: 9.0400
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.1292
Cell Significance Index: 4.5400
Cell Name: serous secreting cell (CL0000313)
Fold Change: 0.0807
Cell Significance Index: 0.7100
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 0.0427
Cell Significance Index: 0.6600
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.0282
Cell Significance Index: 1.6900
Cell Name: odontoblast (CL0000060)
Fold Change: 0.0074
Cell Significance Index: 0.9500
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.0015
Cell Significance Index: 1.1100
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.0114
Cell Significance Index: -0.1300
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0128
Cell Significance Index: -24.1200
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0218
Cell Significance Index: -33.4900
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: -0.0279
Cell Significance Index: -12.3300
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.0281
Cell Significance Index: -1.4200
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0453
Cell Significance Index: -28.7800
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0558
Cell Significance Index: -2.6000
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0607
Cell Significance Index: -34.2500
Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.0635
Cell Significance Index: -2.6000
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0687
Cell Significance Index: -24.6300
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0722
Cell Significance Index: -32.7600
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: -0.0804
Cell Significance Index: -1.4200
Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.0935
Cell Significance Index: -18.5600
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0973
Cell Significance Index: -16.6100
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.1158
Cell Significance Index: -20.8800
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.1407
Cell Significance Index: -28.2200
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.1531
Cell Significance Index: -18.8200
Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.1856
Cell Significance Index: -13.1300
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1974
Cell Significance Index: -28.6900
Cell Name: IgA plasma cell (CL0000987)
Fold Change: -0.2057
Cell Significance Index: -1.3700
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.2059
Cell Significance Index: -28.2700
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.2183
Cell Significance Index: -4.7300
Cell Name: follicular B cell (CL0000843)
Fold Change: -0.2599
Cell Significance Index: -1.3000
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.2939
Cell Significance Index: -6.2600
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.3060
Cell Significance Index: -35.0600
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.3120
Cell Significance Index: -7.8000
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.3291
Cell Significance Index: -10.5400
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.3329
Cell Significance Index: -20.4100
Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.3673
Cell Significance Index: -5.5400
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.3679
Cell Significance Index: -29.1400
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.3798
Cell Significance Index: -29.1500
Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.3940
Cell Significance Index: -25.4200
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.4210
Cell Significance Index: -11.4600
Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.4406
Cell Significance Index: -19.1600
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.4726
Cell Significance Index: -22.2100
Cell Name: duct epithelial cell (CL0000068)
Fold Change: -0.4853
Cell Significance Index: -6.7100
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.4861
Cell Significance Index: -25.2500
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.5857
Cell Significance Index: -12.1500
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.6023
Cell Significance Index: -22.1100
Cell Name: peg cell (CL4033014)
Fold Change: -0.6267
Cell Significance Index: -14.4800
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.6275
Cell Significance Index: -39.5500
Cell Name: choroid plexus epithelial cell (CL0000706)
Fold Change: -0.6954
Cell Significance Index: -8.2800
Cell Name: enterocyte (CL0000584)
Fold Change: -0.7592
Cell Significance Index: -4.7100
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.7762
Cell Significance Index: -24.7200
Cell Name: monocyte-derived dendritic cell (CL0011031)
Fold Change: -0.7832
Cell Significance Index: -13.4600
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.8065
Cell Significance Index: -23.1200
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.8169
Cell Significance Index: -20.8700
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: -0.8260
Cell Significance Index: -8.3200
Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
Fold Change: -0.8526
Cell Significance Index: -11.3700
Cell Name: plasma cell (CL0000786)
Fold Change: -0.8629
Cell Significance Index: -9.6400
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.8895
Cell Significance Index: -23.7500
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.9153
Cell Significance Index: -24.4900
Cell Name: IgG memory B cell (CL0000979)
Fold Change: -0.9305
Cell Significance Index: -5.6200
Cell Name: DN1 thymic pro-T cell (CL0000894)
Fold Change: -0.9587
Cell Significance Index: -9.9400
Cell Name: stromal cell of endometrium (CL0002255)
Fold Change: -0.9877
Cell Significance Index: -14.0500
Cell Name: oral mucosa squamous cell (CL1001576)
Fold Change: -1.0139
Cell Significance Index: -8.7100
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -1.0206
Cell Significance Index: -30.0600
Cell Name: granulosa cell (CL0000501)
Fold Change: -1.0378
Cell Significance Index: -27.2900
Cell Name: lens fiber cell (CL0011004)
Fold Change: -1.0541
Cell Significance Index: -33.3400
Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: -1.0631
Cell Significance Index: -26.5100
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -1.1006
Cell Significance Index: -27.4600
Cell Name: paneth cell of colon (CL0009009)
Fold Change: -1.1379
Cell Significance Index: -17.0500
Cell Name: preadipocyte (CL0002334)
Fold Change: -1.1393
Cell Significance Index: -22.2400
Cell Name: erythrocyte (CL0000232)
Fold Change: -1.1420
Cell Significance Index: -29.1000
Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: -1.1996
Cell Significance Index: -20.6800
Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
Fold Change: -1.2173
Cell Significance Index: -8.5800
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -1.2181
Cell Significance Index: -29.5100
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: -1.2290
Cell Significance Index: -24.0300
Cell Name: keratinocyte (CL0000312)
Fold Change: -1.2388
Cell Significance Index: -30.9400
Cell Name: mesothelial cell of epicardium (CL0011019)
Fold Change: -1.2417
Cell Significance Index: -10.7400
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -1.2498
Cell Significance Index: -23.1000
Cell Name: leukocyte (CL0000738)
Fold Change: -1.2677
Cell Significance Index: -21.5300
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -1.2682
Cell Significance Index: -27.4000
Cell Name: lymphocyte (CL0000542)
Fold Change: -1.2746
Cell Significance Index: -17.3400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Other Information

Description

**Key Characteristics:** 1. **Gene Location and Structure:** The IGHA1 gene is located on chromosome 2q13.31 and consists of three exons that encode the heavy chain constant region of the IgA antibody. 2. **Protein Function:** IgHA1 is a monomeric protein that forms a secretory dimeric IgA complex with the light chain constant alpha 1 (IgA1) protein. This complex is crucial for mucosal immunity and defense against pathogens. 3. **Cellular Expression:** IGHA1 is highly expressed in IgA plasma cells, effector memory CD4-positive T cells, and hematopoietic cells, highlighting its importance in the adaptive immune response. 4. **Regulation:** IGHA1 expression is regulated by various transcription factors, including the nuclear factor kappa B (NF-κB) pathway, which plays a critical role in immune responses. **Pathways and Functions:** 1. **Adaptive Immune Response:** IGHA1 plays a crucial role in the adaptive immune response, particularly in mucosal immunity, where it helps to defend against pathogens. 2. **Antibacterial Humoral Response:** IGHA1 is involved in the production of secretory IgA, which is essential for neutralizing bacteria and other pathogens at mucosal surfaces. 3. **Antigen Binding:** IGHA1 has a specific binding site for antigens, allowing it to recognize and bind to pathogens, marking them for destruction. 4. **B Cell Receptor Signaling Pathway:** IGHA1 is involved in the signaling pathway of B cell receptors, which is essential for the activation and differentiation of B cells. **Clinical Significance:** 1. **Immunodeficiency Disorders:** Mutations in the IGHA1 gene have been associated with immunodeficiency disorders, such as IgA deficiency, which can increase the risk of infections. 2. **Autoimmune Diseases:** IGHA1 has been implicated in autoimmune diseases, such as rheumatoid arthritis and lupus, where it plays a role in the production of autoantibodies. 3. **Cancer:** IGHA1 has been identified as a potential biomarker for cancer, particularly in the context of mucosal-associated lymphoid tissue (MALT) lymphoma. 4. **Vaccine Development:** IGHA1 is an important target for vaccine development, particularly for mucosal vaccines, where it can provide long-term immunity against pathogens. In conclusion, the IGHA1 gene plays a critical role in the adaptive immune response, particularly in mucosal immunity and defense against pathogens. Its dysregulation has been implicated in various diseases, including immunodeficiency disorders, autoimmune diseases, and cancer. Further research into the IGHA1 gene is necessary to fully understand its role in human health and disease.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.