Gene IGHA1 - ENSG00000211895 | NCBI Gene ID: 3493

Details for: IGHA1

Gene ID: 3493

Symbol: IGHA1

Ensembl ID: ENSG00000211895

Description: immunoglobulin heavy constant alpha 1

Associated with

Binding and uptake of ligands by scavenger receptors
(R-HSA-2173782)
Cell surface interactions at the vascular wall
(R-HSA-202733)
Hemostasis
(R-HSA-109582)
Scavenging of heme from plasma
(R-HSA-2168880)
Vesicle-mediated transport
(R-HSA-5653656)
Adaptive immune response
(GO:0002250)
Antibacterial humoral response
(GO:0019731)
Antigen binding
(GO:0003823)
B cell receptor signaling pathway
(GO:0050853)
Blood microparticle
(GO:0072562)
Complement activation, classical pathway
(GO:0006958)
Extracellular exosome
(GO:0070062)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Glomerular filtration
(GO:0003094)
Iga immunoglobulin complex
(GO:0071745)
Igg immunoglobulin complex
(GO:0071735)
Immune response
(GO:0006955)
Immunoglobulin complex, circulating
(GO:0042571)
Immunoglobulin receptor binding
(GO:0034987)
Monomeric iga immunoglobulin complex
(GO:0071748)
Plasma membrane
(GO:0005886)
Positive regulation of respiratory burst
(GO:0060267)
Secretory dimeric iga immunoglobulin complex
(GO:0071752)
Secretory iga immunoglobulin complex
(GO:0071751)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: IgA plasma cell (CL0000987)
Fold Change: 5.92
Marker Score: 5039
Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
Fold Change: 4.08
Marker Score: 2986.5
Cell Name: IgA plasmablast (CL0000984)
Fold Change: 3.38
Marker Score: 889
Cell Name: hematopoietic cell (CL0000988)
Fold Change: 3.19
Marker Score: 2123
Cell Name: respiratory basal cell (CL0002633)
Fold Change: 2.98
Marker Score: 4283
Cell Name: DN3 thymocyte (CL0000807)
Fold Change: 2.81
Marker Score: 1403
Cell Name: memory T cell (CL0000813)
Fold Change: 2.63
Marker Score: 1130
Cell Name: type G enteroendocrine cell (CL0000508)
Fold Change: 2.46
Marker Score: 848
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 2.43
Marker Score: 15518
Cell Name: DN1 thymic pro-T cell (CL0000894)
Fold Change: 2.39
Marker Score: 742
Cell Name: mucous neck cell (CL0000651)
Fold Change: 2.17
Marker Score: 4921.5
Cell Name: intestinal crypt stem cell (CL0002250)
Fold Change: 2.15
Marker Score: 808
Cell Name: natural T-regulatory cell (CL0000903)
Fold Change: 2.09
Marker Score: 1072
Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
Fold Change: 2.02
Marker Score: 1469
Cell Name: duct epithelial cell (CL0000068)
Fold Change: 2.01
Marker Score: 939
Cell Name: T-helper 1 cell (CL0000545)
Fold Change: 2
Marker Score: 780
Cell Name: enteroendocrine cell (CL0000164)
Fold Change: 1.87
Marker Score: 971
Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
Fold Change: 1.86
Marker Score: 801
Cell Name: germinal center B cell (CL0000844)
Fold Change: 1.85
Marker Score: 1124
Cell Name: IgG memory B cell (CL0000979)
Fold Change: 1.81
Marker Score: 1093
Cell Name: IgG plasma cell (CL0000985)
Fold Change: 1.79
Marker Score: 782
Cell Name: class switched memory B cell (CL0000972)
Fold Change: 1.78
Marker Score: 1670
Cell Name: glandular cell of esophagus (CL0002657)
Fold Change: 1.77
Marker Score: 562
Cell Name: peptic cell (CL0000155)
Fold Change: 1.7
Marker Score: 711
Cell Name: plasmablast (CL0000980)
Fold Change: 1.68
Marker Score: 2230
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 1.59
Marker Score: 3964
Cell Name: megakaryocyte (CL0000556)
Fold Change: 1.55
Marker Score: 880
Cell Name: innate lymphoid cell (CL0001065)
Fold Change: 1.49
Marker Score: 534
Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
Fold Change: 1.47
Marker Score: 1134
Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
Fold Change: 1.46
Marker Score: 332
Cell Name: follicular B cell (CL0000843)
Fold Change: 1.44
Marker Score: 1563
Cell Name: memory B cell (CL0000787)
Fold Change: 1.42
Marker Score: 1073
Cell Name: mononuclear phagocyte (CL0000113)
Fold Change: 1.36
Marker Score: 1368
Cell Name: IgM plasma cell (CL0000986)
Fold Change: 1.36
Marker Score: 474
Cell Name: exhausted T cell (CL0011025)
Fold Change: 1.33
Marker Score: 764
Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
Fold Change: 1.29
Marker Score: 374
Cell Name: classical monocyte (CL0000860)
Fold Change: 1.29
Marker Score: 5340
Cell Name: ionocyte (CL0005006)
Fold Change: 1.28
Marker Score: 390
Cell Name: transitional stage B cell (CL0000818)
Fold Change: 1.24
Marker Score: 439
Cell Name: gamma-delta T cell (CL0000798)
Fold Change: 1.23
Marker Score: 824
Cell Name: keratocyte (CL0002363)
Fold Change: 1.19
Marker Score: 273
Cell Name: epithelial fate stem cell (CL0000036)
Fold Change: 1.17
Marker Score: 336
Cell Name: enterocyte (CL0000584)
Fold Change: 1.17
Marker Score: 5611
Cell Name: unswitched memory B cell (CL0000970)
Fold Change: 1.16
Marker Score: 677
Cell Name: T-helper 17 cell (CL0000899)
Fold Change: 1.15
Marker Score: 753
Cell Name: bronchus fibroblast of lung (CL2000093)
Fold Change: 1.14
Marker Score: 1573
Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
Fold Change: 1.13
Marker Score: 301
Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
Fold Change: 1.12
Marker Score: 947
Cell Name: P/D1 enteroendocrine cell (CL0002268)
Fold Change: 1.1
Marker Score: 411
Cell Name: goblet cell (CL0000160)
Fold Change: 1.08
Marker Score: 7208
Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
Fold Change: 1.08
Marker Score: 2803.5
Cell Name: fibroblast (CL0000057)
Fold Change: 1.05
Marker Score: 1010
Cell Name: type I NK T cell (CL0000921)
Fold Change: 1.03
Marker Score: 811
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.03
Marker Score: 1029
Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: 1.03
Marker Score: 2876
Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 1.02
Marker Score: 5384
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 1
Marker Score: 767
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30398
Cell Name: vein endothelial cell (CL0002543)
Fold Change: 0.97
Marker Score: 880
Cell Name: neutrophil (CL0000775)
Fold Change: 0.97
Marker Score: 590
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.97
Marker Score: 497.5
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.96
Marker Score: 453
Cell Name: enterocyte of colon (CL1000347)
Fold Change: 0.95
Marker Score: 1463
Cell Name: blood cell (CL0000081)
Fold Change: 0.95
Marker Score: 11030
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.94
Marker Score: 2401
Cell Name: fibroblast of lung (CL0002553)
Fold Change: 0.94
Marker Score: 2472
Cell Name: alternatively activated macrophage (CL0000890)
Fold Change: 0.94
Marker Score: 391
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 0.92
Marker Score: 1564
Cell Name: plasma cell (CL0000786)
Fold Change: 0.92
Marker Score: 1032
Cell Name: T cell (CL0000084)
Fold Change: 0.92
Marker Score: 1585
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.91
Marker Score: 5208
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2726
Cell Name: B cell (CL0000236)
Fold Change: 0.91
Marker Score: 864
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.9
Marker Score: 324
Cell Name: retinal blood vessel endothelial cell (CL0002585)
Fold Change: 0.9
Marker Score: 216
Cell Name: platelet (CL0000233)
Fold Change: 0.89
Marker Score: 403
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.89
Marker Score: 2025
Cell Name: papillary tips cell (CL1000597)
Fold Change: 0.89
Marker Score: 179
Cell Name: endothelial cell of artery (CL1000413)
Fold Change: 0.88
Marker Score: 365
Cell Name: naive B cell (CL0000788)
Fold Change: 0.87
Marker Score: 776
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5268
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.86
Marker Score: 397
Cell Name: stem cell (CL0000034)
Fold Change: 0.85
Marker Score: 2025
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.84
Marker Score: 337
Cell Name: mast cell (CL0000097)
Fold Change: 0.83
Marker Score: 479
Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
Fold Change: 0.82
Marker Score: 268
Cell Name: mature NK T cell (CL0000814)
Fold Change: 0.81
Marker Score: 377
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 0.8
Marker Score: 505
Cell Name: epithelial cell of uterus (CL0002149)
Fold Change: 0.78
Marker Score: 179
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1264
Cell Name: B-1b B cell (CL0000821)
Fold Change: 0.77
Marker Score: 178
Cell Name: intestine goblet cell (CL0019031)
Fold Change: 0.77
Marker Score: 739
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.76
Marker Score: 549.5
Cell Name: brush cell (CL0002204)
Fold Change: 0.75
Marker Score: 687
Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
Fold Change: 0.75
Marker Score: 169
Cell Name: myeloid cell (CL0000763)
Fold Change: 0.75
Marker Score: 1200
Cell Name: smooth muscle cell (CL0000192)
Fold Change: 0.73
Marker Score: 483
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.73
Marker Score: 495
Cell Name: leukocyte (CL0000738)
Fold Change: 0.72
Marker Score: 416
Cell Name: pulmonary artery endothelial cell (CL1001568)
Fold Change: 0.72
Marker Score: 623

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Other Information

Description

**Key characteristics:** - It is a member of the immunoglobulin heavy chain superfamily. - It is expressed in high levels in mucosal tissues and during inflammation. - It is a homotrimer, meaning it consists of four identical subunits. - It is a negative regulator of the adaptive immune response. **Pathways and functions:** - IGHA1 is a ligand for CD80 and CD86 molecules expressed on activated T cells. - It is also a ligand for complement component 3 (C3). - It is involved in the regulation of inflammation and cell death. - It is a key regulator of mucosal inflammation and immune responses to pathogens. **Clinical significance:** - Mutations in IGHA1 have been linked to a number of human diseases, including asthma, rheumatoid arthritis, and inflammatory bowel disease. - Targeting IGHA1 has been investigated as a therapeutic strategy for these diseases. - IGHA1 is a promising target for the development of new treatments for inflammatory diseases. **Additional information:** - It is a highly conserved gene, with a similar sequence found in mammals, birds, and fish. - It is expressed in high levels in mucosal tissues, including the stomach, lung, and gut. - It is also expressed in some cell types, including dendritic cells and macrophages. - It is a key regulator of the adaptive immune response and plays a role in the regulation of inflammation and cell death.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.