Details for: ST6GALNAC4

Gene ID: 27090

Symbol: ST6GALNAC4

Ensembl ID: ENSG00000136840

Description: ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 38.3018
    Cell Significance Index: -9.7200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 28.8241
    Cell Significance Index: -11.7100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 27.8741
    Cell Significance Index: -13.1600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 12.7155
    Cell Significance Index: -12.1400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 5.9410
    Cell Significance Index: -7.3300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 3.7889
    Cell Significance Index: -10.1500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.1703
    Cell Significance Index: -12.5100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 2.9139
    Cell Significance Index: -8.9500
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 1.2048
    Cell Significance Index: 10.1200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.7287
    Cell Significance Index: 47.0200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.6667
    Cell Significance Index: 77.7000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5597
    Cell Significance Index: 55.3700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5573
    Cell Significance Index: 33.4600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5077
    Cell Significance Index: 458.4300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4850
    Cell Significance Index: 66.6000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4521
    Cell Significance Index: 49.1800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3571
    Cell Significance Index: 67.9500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.3424
    Cell Significance Index: 3.8900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3393
    Cell Significance Index: 55.1900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.3251
    Cell Significance Index: 8.8500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.3124
    Cell Significance Index: 16.2800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3088
    Cell Significance Index: 6.6900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2977
    Cell Significance Index: 35.1100
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.2764
    Cell Significance Index: 3.5400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2430
    Cell Significance Index: 16.8100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2176
    Cell Significance Index: 118.8300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2144
    Cell Significance Index: 9.7200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.2006
    Cell Significance Index: 5.8900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1821
    Cell Significance Index: 22.3900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.1567
    Cell Significance Index: 3.2800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1517
    Cell Significance Index: 4.3700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1342
    Cell Significance Index: 24.2000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1189
    Cell Significance Index: 23.8600
  • Cell Name: basophilic erythroblast (CL0000549)
    Fold Change: 0.1098
    Cell Significance Index: 0.0500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1080
    Cell Significance Index: 13.8500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1024
    Cell Significance Index: 13.2300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0739
    Cell Significance Index: 32.6800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0669
    Cell Significance Index: 50.6300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0653
    Cell Significance Index: 3.3900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0583
    Cell Significance Index: 1.5600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0556
    Cell Significance Index: 9.5000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0463
    Cell Significance Index: 16.6200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0419
    Cell Significance Index: 1.9700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0361
    Cell Significance Index: 2.5500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0277
    Cell Significance Index: 3.1700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0247
    Cell Significance Index: 0.8600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0124
    Cell Significance Index: 2.4700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0113
    Cell Significance Index: 7.8500
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.0079
    Cell Significance Index: 0.1400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.0014
    Cell Significance Index: 0.0400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0006
    Cell Significance Index: 0.0200
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0009
    Cell Significance Index: -0.0100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0039
    Cell Significance Index: -7.2900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0065
    Cell Significance Index: -11.9200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0077
    Cell Significance Index: -11.7800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0095
    Cell Significance Index: -0.5000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0105
    Cell Significance Index: -14.2200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0125
    Cell Significance Index: -9.1400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0144
    Cell Significance Index: -10.6500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0145
    Cell Significance Index: -0.3800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0162
    Cell Significance Index: -10.3200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0163
    Cell Significance Index: -1.6700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0176
    Cell Significance Index: -0.3000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0191
    Cell Significance Index: -10.7700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0219
    Cell Significance Index: -9.9600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0220
    Cell Significance Index: -13.7500
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: -0.0251
    Cell Significance Index: -0.1500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0335
    Cell Significance Index: -9.6500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0404
    Cell Significance Index: -1.1300
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0441
    Cell Significance Index: -1.0200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0446
    Cell Significance Index: -1.1400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0451
    Cell Significance Index: -0.9600
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: -0.0452
    Cell Significance Index: -0.2200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0614
    Cell Significance Index: -8.9300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0642
    Cell Significance Index: -13.5200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0894
    Cell Significance Index: -6.8600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0916
    Cell Significance Index: -6.8300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0936
    Cell Significance Index: -5.7400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1010
    Cell Significance Index: -4.7100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1195
    Cell Significance Index: -12.4500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1209
    Cell Significance Index: -7.4300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1236
    Cell Significance Index: -3.9600
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.1241
    Cell Significance Index: -0.7500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1325
    Cell Significance Index: -6.7000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1423
    Cell Significance Index: -8.9700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1440
    Cell Significance Index: -9.6800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1500
    Cell Significance Index: -11.8800
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1522
    Cell Significance Index: -6.2400
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1889
    Cell Significance Index: -1.5400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1950
    Cell Significance Index: -2.6600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2056
    Cell Significance Index: -2.9500
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.2102
    Cell Significance Index: -2.3800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2199
    Cell Significance Index: -12.3400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2206
    Cell Significance Index: -5.9100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2268
    Cell Significance Index: -10.0300
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2568
    Cell Significance Index: -3.8700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2585
    Cell Significance Index: -9.7900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2609
    Cell Significance Index: -9.1400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2657
    Cell Significance Index: -5.6400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2715
    Cell Significance Index: -9.9700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Glycosylation Enzyme:** ST6GALNAC4 is a type II transmembrane glycosyltransferase that catalyzes the sialylation of glycoproteins, specifically N-acetylgalactosaminide to sialic acid. 2. **Substrate Specificity:** The enzyme has a high affinity for N-acetylgalactosaminide, a precursor molecule in glycosylation. 3. **Cellular Localization:** ST6GALNAC4 is primarily localized to the Golgi apparatus, where it interacts with other glycosylation enzymes to form a glycosylation complex. 4. **Regulation:** The expression and activity of ST6GALNAC4 are tightly regulated by post-translational modifications, including phosphorylation and glycosylation. **Pathways and Functions:** ST6GALNAC4 is involved in various cellular processes, including: 1. **Immune Response:** Sialylation of glycoproteins, such as IgA and complement proteins, is crucial for immune function and the elimination of pathogens. 2. **Cell Signaling:** ST6GALNAC4 regulates cell signaling pathways, including the Wnt/β-catenin and Notch signaling pathways, by modifying the sialylation of glycoproteins. 3. **Glycosylation of Proteins:** ST6GALNAC4 is essential for the sialylation of glycoproteins, which is necessary for protein stability, folding, and function. 4. **Glycolipid Biosynthesis:** The enzyme is involved in the biosynthesis of glycolipids, including gangliosides, which are essential for cellular recognition and signaling. **Clinical Significance:** Dysregulation of ST6GALNAC4 has been implicated in various diseases, including: 1. **Infectious Diseases:** Alterations in ST6GALNAC4 expression and function have been linked to the pathogenesis of infectious diseases, such as SARS-CoV-1 and SARS-CoV-2. 2. **Cancer:** ST6GALNAC4 has been identified as a tumor suppressor gene, and its dysregulation has been associated with cancer development and progression. 3. **Neurological Disorders:** The enzyme has been implicated in the pathogenesis of neurological disorders, including Alzheimer's disease and Parkinson's disease. In conclusion, ST6GALNAC4 is a critical enzyme involved in the regulation of glycosylation and immune response. Its dysregulation has been implicated in various diseases, highlighting the importance of this gene in maintaining cellular homeostasis and immune function. Further research is necessary to fully understand the complexities of ST6GALNAC4 and its role in human disease.

Genular Protein ID: 1162301195

Symbol: SIA7D_HUMAN

Name: Alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide alpha-2,6-sialyltransferase

UniProtKB Accession Codes:

Q9H4F1 Q5T9D0 Q9NWU6 Q9UKU1 Q9ULB9 Q9Y3G3 Q9Y3G4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CAZy 1 CCDS 1 CTD 1 ChEBI 25 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 9 Ensembl 1 ExpressionAtlas 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 5 RefSeq 2 Rhea 13 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11062056

Title: Cloning, expression and gene organization of a human Neu5Ac alpha 2-3Gal beta 1-3GalNAc alpha 2,6-sialyltransferase: hST6GalNAcIV.

PubMed ID: 11062056

DOI: 10.1042/bj3520037

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10369878

Title: Extensive gene order differences within regions of conserved synteny between the Fugu and human genomes: implications for chromosomal evolution and the cloning of disease genes.

PubMed ID: 10369878

DOI: 10.1093/hmg/8.7.1313

Sequence Information:

  • Length: 302
  • Mass: 34201
  • Checksum: 08A4CDC749A6D783
  • Sequence:
    • MKAPGRLVLI ILCSVVFSAV YILLCCWAGL PLCLATCLDH HFPTGSRPTV PGPLHFSGYS 
SVPDGKPLVR EPCRSCAVVS SSGQMLGSGL GAEIDSAECV FRMNQAPTVG FEADVGQRST 
LRVVSHTSVP LLLRNYSHYF QKARDTLYMV WGQGRHMDRV LGGRTYRTLL QLTRMYPGLQ 
VYTFTERMMA YCDQIFQDET GKNRRQSGSF LSTGWFTMIL ALELCEEIVV YGMVSDSYCR 
EKSHPSVPYH YFEKGRLDEC QMYLAHEQAP RSAHRFITEK AVFSRWAKKR PIVFAHPSWR 
TE

Genular Protein ID: 2426518945

Symbol: A8K7N4_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8K7N4

Database IDs:

ARBA 12 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChEBI 5 DNASU 1 DisGeNET 1 EMBL 4 GO 5 Gene3D 1 InterPro 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 1 PharmGKB 1 ProteomicsDB 1 RefSeq 1 Rhea 2 SMR 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

Sequence Information:

  • Length: 218
  • Mass: 25334
  • Checksum: 82DC232CA6D2FEBF
  • Sequence:
    • MLGSGLGAEI DSAECVFRMN QAPTVGFEAD VGQRSTLRVV SHTSVPLLLR NYSHYFQKAR 
DTLYMVWGQG RHMDRVLGGR TYRTLLQLTR MYPGLQVYTF TERMMAYCDQ IFQDETGKNR 
RQSGSFLSTG WFTMILALEL CEEIVVYGMV SDSYCREKSH PSVPYHYFEK GRLDECQMYL 
AHEQAPRSAH RFITEKAVFS RWAKKRPIVF AHPSWRTE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.