IGHV3 23 | ENSG00000211949 | NCBI 28442

Details for: IGHV3 23

Gene ID: 28442

Symbol: IGHV3 23

Ensembl ID: ENSG00000211949

Description: immunoglobulin heavy variable 3-23

Associated with

Adaptive immune system
(R-HSA-1280218)
Anti-inflammatory response favouring leishmania parasite infection
(R-HSA-9662851)
Antigen activates b cell receptor (bcr) leading to generation of second messengers
(R-HSA-983695)
Binding and uptake of ligands by scavenger receptors
(R-HSA-2173782)
Cd22 mediated bcr regulation
(R-HSA-5690714)
Cell surface interactions at the vascular wall
(R-HSA-202733)
Classical antibody-mediated complement activation
(R-HSA-173623)
Complement cascade
(R-HSA-166658)
Creation of c4 and c2 activators
(R-HSA-166786)
Disease
(R-HSA-1643685)
Fc epsilon receptor (fceri) signaling
(R-HSA-2454202)
Fceri mediated ca+2 mobilization
(R-HSA-2871809)
Fceri mediated mapk activation
(R-HSA-2871796)
Fceri mediated nf-kb activation
(R-HSA-2871837)
Fcgamma receptor (fcgr) dependent phagocytosis
(R-HSA-2029480)
Fcgr3a-mediated il10 synthesis
(R-HSA-9664323)
Fcgr3a-mediated phagocytosis
(R-HSA-9664422)
Fcgr activation
(R-HSA-2029481)
Hemostasis
(R-HSA-109582)
Immune system
(R-HSA-168256)
Immunoregulatory interactions between a lymphoid and a non-lymphoid cell
(R-HSA-198933)
Infectious disease
(R-HSA-5663205)
Initial triggering of complement
(R-HSA-166663)
Innate immune system
(R-HSA-168249)
Leishmania infection
(R-HSA-9658195)
Leishmania parasite growth and survival
(R-HSA-9664433)
Leishmania phagocytosis
(R-HSA-9664417)
Parasite infection
(R-HSA-9664407)
Parasitic infection pathways
(R-HSA-9824443)
Potential therapeutics for sars
(R-HSA-9679191)
Regulation of actin dynamics for phagocytic cup formation
(R-HSA-2029482)
Regulation of complement cascade
(R-HSA-977606)
Role of lat2/ntal/lab on calcium mobilization
(R-HSA-2730905)
Role of phospholipids in phagocytosis
(R-HSA-2029485)
Sars-cov infections
(R-HSA-9679506)
Scavenging of heme from plasma
(R-HSA-2168880)
Signaling by the b cell receptor (bcr)
(R-HSA-983705)
Vesicle-mediated transport
(R-HSA-5653656)
Viral infection pathways
(R-HSA-9824446)
Antigen binding
(GO:0003823)
Blood microparticle
(GO:0072562)
Extracellular exosome
(GO:0070062)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Immune response
(GO:0006955)
Immunoglobulin complex
(GO:0019814)
Immunoglobulin mediated immune response
(GO:0016064)
Plasma membrane
(GO:0005886)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 0.8530
Cell Significance Index: -2.6200
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.8400
Cell Significance Index: 12.2000
Cell Name: odontoblast (CL0000060)
Fold Change: 0.0307
Cell Significance Index: 3.9300
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0057
Cell Significance Index: -4.2800
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: -0.0116
Cell Significance Index: -0.1800
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0224
Cell Significance Index: -2.2900
Cell Name: lactocyte (CL0002325)
Fold Change: -0.0477
Cell Significance Index: -6.1600
Cell Name: glutamatergic neuron (CL0000679)
Fold Change: -0.0484
Cell Significance Index: -0.5300
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0519
Cell Significance Index: -2.4200
Cell Name: keratinocyte (CL0000312)
Fold Change: -0.0544
Cell Significance Index: -1.3600
Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
Fold Change: -0.0695
Cell Significance Index: -0.9300
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0756
Cell Significance Index: -5.8000
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0822
Cell Significance Index: -5.0400
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.0862
Cell Significance Index: -4.4800
Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.0890
Cell Significance Index: -5.7500
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.0915
Cell Significance Index: -6.8200
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.1174
Cell Significance Index: -5.3200
Cell Name: oligodendrocyte (CL0000128)
Fold Change: -0.1296
Cell Significance Index: -1.3900
Cell Name: granulosa cell (CL0000501)
Fold Change: -0.1529
Cell Significance Index: -4.0200
Cell Name: pulmonary capillary endothelial cell (CL4028001)
Fold Change: -0.1534
Cell Significance Index: -2.1000
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.1591
Cell Significance Index: -5.8400
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.1795
Cell Significance Index: -5.7500
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.1795
Cell Significance Index: -4.5900
Cell Name: IgA plasmablast (CL0000984)
Fold Change: -0.1804
Cell Significance Index: -1.4500
Cell Name: IgA plasma cell (CL0000987)
Fold Change: -0.1877
Cell Significance Index: -1.2500
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.1888
Cell Significance Index: -5.5600
Cell Name: plasma cell (CL0000786)
Fold Change: -0.1978
Cell Significance Index: -2.2100
Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: -0.1996
Cell Significance Index: -2.6100
Cell Name: leukocyte (CL0000738)
Fold Change: -0.2049
Cell Significance Index: -3.4800
Cell Name: lymphocyte (CL0000542)
Fold Change: -0.2095
Cell Significance Index: -2.8500
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: -0.2138
Cell Significance Index: -2.3900
Cell Name: erythrocyte (CL0000232)
Fold Change: -0.2178
Cell Significance Index: -5.5500
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.2180
Cell Significance Index: -5.2800
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: -0.2225
Cell Significance Index: -2.6300
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.2258
Cell Significance Index: -2.5600
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: -0.2264
Cell Significance Index: -2.8000
Cell Name: double negative thymocyte (CL0002489)
Fold Change: -0.2426
Cell Significance Index: -2.8800
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.2449
Cell Significance Index: -7.0200
Cell Name: megakaryocyte (CL0000556)
Fold Change: -0.2494
Cell Significance Index: -4.0400
Cell Name: naive B cell (CL0000788)
Fold Change: -0.2536
Cell Significance Index: -2.6700
Cell Name: T-helper 17 cell (CL0000899)
Fold Change: -0.2556
Cell Significance Index: -1.9500
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: -0.2618
Cell Significance Index: -3.0800
Cell Name: hematopoietic cell (CL0000988)
Fold Change: -0.2626
Cell Significance Index: -3.8400
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.2719
Cell Significance Index: -4.5500
Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
Fold Change: -0.2721
Cell Significance Index: -3.2900
Cell Name: thymocyte (CL0000893)
Fold Change: -0.2758
Cell Significance Index: -3.4900
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: -0.2762
Cell Significance Index: -5.4000
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.2770
Cell Significance Index: -5.1200
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: -0.2809
Cell Significance Index: -3.5600
Cell Name: plasmablast (CL0000980)
Fold Change: -0.2909
Cell Significance Index: -2.7000
Cell Name: precursor B cell (CL0000817)
Fold Change: -0.2921
Cell Significance Index: -3.7800
Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: -0.2948
Cell Significance Index: -3.8600
Cell Name: peg cell (CL4033014)
Fold Change: -0.2974
Cell Significance Index: -6.8700
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: -0.3156
Cell Significance Index: -5.4000
Cell Name: B cell (CL0000236)
Fold Change: -0.3207
Cell Significance Index: -3.7900
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -0.3241
Cell Significance Index: -5.4600
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: -0.3338
Cell Significance Index: -4.5800
Cell Name: seromucus secreting cell (CL0000159)
Fold Change: -0.3344
Cell Significance Index: -6.9800
Cell Name: memory B cell (CL0000787)
Fold Change: -0.3365
Cell Significance Index: -3.5800
Cell Name: stromal cell (CL0000499)
Fold Change: -0.3377
Cell Significance Index: -3.4500
Cell Name: monocyte (CL0000576)
Fold Change: -0.3468
Cell Significance Index: -3.9900
Cell Name: IgG plasma cell (CL0000985)
Fold Change: -0.3543
Cell Significance Index: -3.2400
Cell Name: blood cell (CL0000081)
Fold Change: -0.3555
Cell Significance Index: -3.0300
Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -0.3557
Cell Significance Index: -5.2500
Cell Name: IgG plasmablast (CL0000982)
Fold Change: -0.3610
Cell Significance Index: -2.9800
Cell Name: hepatocyte (CL0000182)
Fold Change: -0.3612
Cell Significance Index: -5.0100
Cell Name: transit amplifying cell (CL0009010)
Fold Change: -0.3730
Cell Significance Index: -3.5800
Cell Name: neutrophil (CL0000775)
Fold Change: -0.3786
Cell Significance Index: -4.7300
Cell Name: germinal center B cell (CL0000844)
Fold Change: -0.3807
Cell Significance Index: -2.6900
Cell Name: epithelial cell of lower respiratory tract (CL0002632)
Fold Change: -0.3866
Cell Significance Index: -4.3000
Cell Name: primitive red blood cell (CL0002355)
Fold Change: -0.3904
Cell Significance Index: -4.4200
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: -0.3964
Cell Significance Index: -7.0100
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: -0.4011
Cell Significance Index: -5.7600
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: -0.4015
Cell Significance Index: -5.7800
Cell Name: early lymphoid progenitor (CL0000936)
Fold Change: -0.4137
Cell Significance Index: -4.2000
Cell Name: class switched memory B cell (CL0000972)
Fold Change: -0.4148
Cell Significance Index: -3.7000
Cell Name: myelocyte (CL0002193)
Fold Change: -0.4183
Cell Significance Index: -4.4700
Cell Name: promonocyte (CL0000559)
Fold Change: -0.4195
Cell Significance Index: -4.4800
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: -0.4196
Cell Significance Index: -4.5900
Cell Name: duct epithelial cell (CL0000068)
Fold Change: -0.4224
Cell Significance Index: -5.8400
Cell Name: mast cell (CL0000097)
Fold Change: -0.4225
Cell Significance Index: -5.5600
Cell Name: osteoclast (CL0000092)
Fold Change: -0.4320
Cell Significance Index: -4.4100
Cell Name: common dendritic progenitor (CL0001029)
Fold Change: -0.4334
Cell Significance Index: -4.5100
Cell Name: pro-B cell (CL0000826)
Fold Change: -0.4390
Cell Significance Index: -4.7200
Cell Name: plasmacytoid dendritic cell (CL0000784)
Fold Change: -0.4397
Cell Significance Index: -5.7700
Cell Name: glial cell (CL0000125)
Fold Change: -0.4486
Cell Significance Index: -4.9200
Cell Name: promyelocyte (CL0000836)
Fold Change: -0.4487
Cell Significance Index: -4.4400
Cell Name: erythroblast (CL0000765)
Fold Change: -0.4487
Cell Significance Index: -5.3500
Cell Name: retinal pigment epithelial cell (CL0002586)
Fold Change: -0.4528
Cell Significance Index: -4.8700
Cell Name: mature B cell (CL0000785)
Fold Change: -0.4578
Cell Significance Index: -2.9800
Cell Name: Kupffer cell (CL0000091)
Fold Change: -0.4578
Cell Significance Index: -4.1900
Cell Name: cytotoxic T cell (CL0000910)
Fold Change: -0.4611
Cell Significance Index: -6.7200
Cell Name: lung ciliated cell (CL1000271)
Fold Change: -0.4615
Cell Significance Index: -4.5200
Cell Name: club cell (CL0000158)
Fold Change: -0.4626
Cell Significance Index: -5.0400
Cell Name: immature B cell (CL0000816)
Fold Change: -0.4640
Cell Significance Index: -4.3900
Cell Name: mesothelial cell (CL0000077)
Fold Change: -0.4656
Cell Significance Index: -5.6600
Cell Name: nasal mucosa goblet cell (CL0002480)
Fold Change: -0.4657
Cell Significance Index: -4.7500
Cell Name: conventional dendritic cell (CL0000990)
Fold Change: -0.4663
Cell Significance Index: -5.5100
Cell Name: osteoblast (CL0000062)
Fold Change: -0.4669
Cell Significance Index: -4.5300
Cell Name: respiratory basal cell (CL0002633)
Fold Change: -0.4673
Cell Significance Index: -4.6100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Other Information

Description

**Key Characteristics** The IGHV3-23 gene is characterized by its unique structure and expression patterns. It is part of the immunoglobulin heavy chain locus, which is a complex region of the genome that encodes the heavy chains of immunoglobulins. The IGHV3-23 gene is specifically expressed in B cells, which are a type of lymphocyte that plays a central role in the adaptive immune response. The IGHV3-23 gene is also notable for its involvement in the regulation of immune responses, particularly in the context of parasitic infections. Studies have shown that the IGHV3-23 gene is upregulated in response to Leishmania infection, suggesting that it plays a key role in the regulation of immune responses to this pathogen. **Pathways and Functions** The IGHV3-23 gene is involved in several key pathways and functions, including: 1. **Adaptive Immune Response**: The IGHV3-23 gene is essential for the adaptive immune response, which is a specific and targeted response to pathogens. The gene encodes the heavy chain of immunoglobulins, which recognizes and binds to specific antigens, triggering an immune response. 2. **Antigen Recognition**: The IGHV3-23 gene is involved in the recognition of antigens by B cells, which is a critical step in the adaptive immune response. The gene encodes the heavy chain of immunoglobulins, which binds to specific antigens, triggering an immune response. 3. **Complement Activation**: The IGHV3-23 gene is involved in the activation of the complement cascade, which is a series of chemical reactions that help to eliminate pathogens from the body. The gene encodes the heavy chain of immunoglobulins, which binds to specific antigens, triggering the activation of the complement cascade. 4. **Immune Response to Leishmania**: The IGHV3-23 gene is specifically upregulated in response to Leishmania infection, suggesting that it plays a key role in the regulation of immune responses to this pathogen. **Clinical Significance** The IGHV3-23 gene has significant clinical implications, particularly in the context of parasitic infections such as Leishmania. Studies have shown that the IGHV3-23 gene is upregulated in response to Leishmania infection, suggesting that it plays a key role in the regulation of immune responses to this pathogen. The IGHV3-23 gene also has implications for the development of new therapeutic strategies for parasitic infections. For example, the gene has been shown to be upregulated in response to Leishmania infection, suggesting that it may be a target for therapeutic intervention. In addition, the IGHV3-23 gene has implications for the understanding of immune responses to other pathogens. The gene's involvement in the regulation of immune responses to Leishmania infection suggests that it may play a similar role in the regulation of immune responses to other pathogens. In conclusion, the IGHV3-23 gene is a critical component of the adaptive immune system, and its unique structure and expression patterns make it an important target for research into the regulation of immune responses to parasitic infections. Further study of the IGHV3-23 gene is needed to fully understand its role in the regulation of immune responses and to develop new therapeutic strategies for parasitic infections.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.