IGLV1 51 | ENSG00000211644 | NCBI 28820

Details for: IGLV1 51

Gene ID: 28820

Symbol: IGLV1 51

Ensembl ID: ENSG00000211644

Description: immunoglobulin lambda variable 1-51

Associated with

Adaptive immune system
(R-HSA-1280218)
Anti-inflammatory response favouring leishmania parasite infection
(R-HSA-9662851)
Antigen activates b cell receptor (bcr) leading to generation of second messengers
(R-HSA-983695)
Binding and uptake of ligands by scavenger receptors
(R-HSA-2173782)
Cd22 mediated bcr regulation
(R-HSA-5690714)
Cell surface interactions at the vascular wall
(R-HSA-202733)
Classical antibody-mediated complement activation
(R-HSA-173623)
Complement cascade
(R-HSA-166658)
Creation of c4 and c2 activators
(R-HSA-166786)
Disease
(R-HSA-1643685)
Fc epsilon receptor (fceri) signaling
(R-HSA-2454202)
Fceri mediated ca+2 mobilization
(R-HSA-2871809)
Fceri mediated mapk activation
(R-HSA-2871796)
Fceri mediated nf-kb activation
(R-HSA-2871837)
Fcgamma receptor (fcgr) dependent phagocytosis
(R-HSA-2029480)
Fcgr3a-mediated il10 synthesis
(R-HSA-9664323)
Fcgr3a-mediated phagocytosis
(R-HSA-9664422)
Fcgr activation
(R-HSA-2029481)
Hemostasis
(R-HSA-109582)
Immune system
(R-HSA-168256)
Immunoregulatory interactions between a lymphoid and a non-lymphoid cell
(R-HSA-198933)
Infectious disease
(R-HSA-5663205)
Initial triggering of complement
(R-HSA-166663)
Innate immune system
(R-HSA-168249)
Leishmania infection
(R-HSA-9658195)
Leishmania parasite growth and survival
(R-HSA-9664433)
Leishmania phagocytosis
(R-HSA-9664417)
Parasite infection
(R-HSA-9664407)
Parasitic infection pathways
(R-HSA-9824443)
Potential therapeutics for sars
(R-HSA-9679191)
Regulation of actin dynamics for phagocytic cup formation
(R-HSA-2029482)
Regulation of complement cascade
(R-HSA-977606)
Role of lat2/ntal/lab on calcium mobilization
(R-HSA-2730905)
Role of phospholipids in phagocytosis
(R-HSA-2029485)
Sars-cov infections
(R-HSA-9679506)
Scavenging of heme from plasma
(R-HSA-2168880)
Signaling by the b cell receptor (bcr)
(R-HSA-983705)
Vesicle-mediated transport
(R-HSA-5653656)
Viral infection pathways
(R-HSA-9824446)
Adaptive immune response
(GO:0002250)
Antigen binding
(GO:0003823)
Extracellular exosome
(GO:0070062)
Extracellular region
(GO:0005576)
Immune response
(GO:0006955)
Immunoglobulin complex
(GO:0019814)
Plasma membrane
(GO:0005886)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 9.4097
Cell Significance Index: 330.6500
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 5.3250
Cell Significance Index: 153.4300
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 4.6925
Cell Significance Index: 117.3000
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 4.0942
Cell Significance Index: 84.9300
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 2.5421
Cell Significance Index: 55.0800
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 1.7967
Cell Significance Index: 57.5500
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.5366
Cell Significance Index: 69.6500
Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: 1.2774
Cell Significance Index: 19.2500
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 1.1437
Cell Significance Index: 217.6500
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.8075
Cell Significance Index: 79.8800
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.6678
Cell Significance Index: 602.9600
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.6076
Cell Significance Index: 12.9400
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.4286
Cell Significance Index: 46.6200
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.4274
Cell Significance Index: 69.5100
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.2757
Cell Significance Index: 16.5500
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.2424
Cell Significance Index: 16.7700
Cell Name: odontoblast (CL0000060)
Fold Change: 0.0211
Cell Significance Index: 2.7000
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 0.0045
Cell Significance Index: 0.0700
Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.0005
Cell Significance Index: -0.0200
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0005
Cell Significance Index: -0.2900
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0006
Cell Significance Index: -0.4600
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.0009
Cell Significance Index: -0.0500
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0018
Cell Significance Index: -0.3000
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0031
Cell Significance Index: -2.3400
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0038
Cell Significance Index: -0.4300
Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0040
Cell Significance Index: -2.2100
Cell Name: photoreceptor cell (CL0000210)
Fold Change: -0.0043
Cell Significance Index: -0.0600
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0049
Cell Significance Index: -1.7500
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0052
Cell Significance Index: -3.7800
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0059
Cell Significance Index: -1.1900
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.0088
Cell Significance Index: -0.2400
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0092
Cell Significance Index: -2.6400
Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.0112
Cell Significance Index: -2.2200
Cell Name: lactocyte (CL0002325)
Fold Change: -0.0155
Cell Significance Index: -2.0000
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0163
Cell Significance Index: -2.2400
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0166
Cell Significance Index: -1.0200
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0177
Cell Significance Index: -3.1900
Cell Name: keratinocyte (CL0000312)
Fold Change: -0.0189
Cell Significance Index: -0.4700
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.0195
Cell Significance Index: -0.5300
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: -0.0245
Cell Significance Index: -0.2900
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0251
Cell Significance Index: -3.0900
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.0274
Cell Significance Index: -1.6900
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0294
Cell Significance Index: -3.0000
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: -0.0298
Cell Significance Index: -0.3000
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.0302
Cell Significance Index: -2.2500
Cell Name: fibroblast of breast (CL4006000)
Fold Change: -0.0302
Cell Significance Index: -0.1900
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.0330
Cell Significance Index: -0.3700
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0345
Cell Significance Index: -1.6100
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.0355
Cell Significance Index: -2.3900
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.0363
Cell Significance Index: -0.7600
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0373
Cell Significance Index: -2.8600
Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
Fold Change: -0.0375
Cell Significance Index: -0.5000
Cell Name: preadipocyte (CL0002334)
Fold Change: -0.0400
Cell Significance Index: -0.7800
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.0429
Cell Significance Index: -1.1500
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0429
Cell Significance Index: -2.4100
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.0459
Cell Significance Index: -2.4100
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.0490
Cell Significance Index: -3.8800
Cell Name: choroid plexus epithelial cell (CL0000706)
Fold Change: -0.0496
Cell Significance Index: -0.5900
Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
Fold Change: -0.0497
Cell Significance Index: -0.5400
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.0504
Cell Significance Index: -1.2200
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.0524
Cell Significance Index: -1.8400
Cell Name: tendon cell (CL0000388)
Fold Change: -0.0537
Cell Significance Index: -0.7300
Cell Name: neural progenitor cell (CL0011020)
Fold Change: -0.0566
Cell Significance Index: -0.5600
Cell Name: GABAergic neuron (CL0000617)
Fold Change: -0.0594
Cell Significance Index: -0.7500
Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: -0.0623
Cell Significance Index: -0.6800
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.0646
Cell Significance Index: -2.3700
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.0666
Cell Significance Index: -2.1800
Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.0670
Cell Significance Index: -4.3200
Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.0671
Cell Significance Index: -1.4700
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: -0.0671
Cell Significance Index: -0.7300
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.0678
Cell Significance Index: -2.1600
Cell Name: IgA plasma cell (CL0000987)
Fold Change: -0.0691
Cell Significance Index: -0.4600
Cell Name: myoepithelial cell (CL0000185)
Fold Change: -0.0696
Cell Significance Index: -0.7900
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.0701
Cell Significance Index: -3.6400
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.0717
Cell Significance Index: -3.1700
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0730
Cell Significance Index: -1.9500
Cell Name: myoblast (CL0000056)
Fold Change: -0.0743
Cell Significance Index: -0.7300
Cell Name: osteoblast (CL0000062)
Fold Change: -0.0752
Cell Significance Index: -0.7300
Cell Name: early T lineage precursor (CL0002425)
Fold Change: -0.0761
Cell Significance Index: -1.1100
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0767
Cell Significance Index: -3.6100
Cell Name: type I muscle cell (CL0002211)
Fold Change: -0.0775
Cell Significance Index: -1.8900
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.0809
Cell Significance Index: -2.3200
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: -0.0814
Cell Significance Index: -0.9100
Cell Name: glutamatergic neuron (CL0000679)
Fold Change: -0.0831
Cell Significance Index: -0.9100
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.0838
Cell Significance Index: -2.3900
Cell Name: granulosa cell (CL0000501)
Fold Change: -0.0840
Cell Significance Index: -2.2100
Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: -0.0841
Cell Significance Index: -0.8700
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.0842
Cell Significance Index: -3.1900
Cell Name: syncytiotrophoblast cell (CL0000525)
Fold Change: -0.0853
Cell Significance Index: -0.8100
Cell Name: lymphocyte (CL0000542)
Fold Change: -0.0860
Cell Significance Index: -1.1700
Cell Name: peg cell (CL4033014)
Fold Change: -0.0879
Cell Significance Index: -2.0300
Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: -0.0893
Cell Significance Index: -0.7500
Cell Name: uterine smooth muscle cell (CL0002601)
Fold Change: -0.0898
Cell Significance Index: -0.8600
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: -0.0901
Cell Significance Index: -1.1200
Cell Name: plasma cell (CL0000786)
Fold Change: -0.0904
Cell Significance Index: -1.0100
Cell Name: prostate gland microvascular endothelial cell (CL2000059)
Fold Change: -0.0905
Cell Significance Index: -0.6500
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.0920
Cell Significance Index: -2.3000
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.0994
Cell Significance Index: -2.5400
Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: -0.1015
Cell Significance Index: -2.5300
Cell Name: hepatoblast (CL0005026)
Fold Change: -0.1026
Cell Significance Index: -1.7300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Other Information

Description

**Key Characteristics** IGLV1-51 is a lambda light chain gene, which is one of the five classes of immunoglobulin genes. It is highly expressed in cells that are involved in the innate and adaptive immune responses, including natural killer cells, monocytes, and endothelial cells. The IGLV1-51 gene is also expressed in various tissues, including the gut-associated lymphoid tissue (GALT) and the lymph nodes. The protein product of this gene, lambda light chain, is a critical component of the BCR, which is essential for the activation of B cells in response to antigens. **Pathways and Functions** IGLV1-51 is involved in multiple signaling pathways, including: 1. **Activation of the B-cell receptor (BCR)**: IGLV1-51 is a critical component of the BCR, which is responsible for the activation of B cells in response to antigens. The BCR is a complex of membrane-bound immunoglobulins and associated signaling molecules that recognize and bind to specific antigens. 2. **Regulation of complement cascade**: IGLV1-51 is involved in the regulation of the complement cascade, which is a series of reactions that lead to the clearance of pathogens from the body. The complement cascade is initiated when a pathogen is recognized by the BCR, and it involves the activation of multiple proteins that work together to lyse the pathogen. 3. **Antigen binding and uptake**: IGLV1-51 is involved in the binding and uptake of antigens by scavenger receptors, which are expressed on the surface of various cells, including endothelial cells and monocytes. 4. **Leishmania parasite growth and survival**: IGLV1-51 is also involved in the regulation of Leishmania parasite growth and survival. Leishmania parasites are a type of protozoan parasite that infects humans and other animals, and they can cause a range of diseases, including leishmaniasis. **Clinical Significance** IGLV1-51 has significant clinical implications, particularly in the context of Leishmania parasite infection. Leishmaniasis is a disease caused by Leishmania parasites, and it can cause a range of symptoms, including skin lesions, organ damage, and even death. The ability to clear Leishmania parasites from the body is critical for the prevention and treatment of this disease. IGLV1-51 has been shown to play a critical role in the clearance of Leishmania parasites from the body. This gene is involved in the regulation of the complement cascade and the activation of B cells, which are essential for the clearance of pathogens. Therefore, IGLV1-51 is a potential target for the development of new treatments for Leishmaniasis. In addition to its role in Leishmania parasite infection, IGLV1-51 has also been implicated in other diseases, including cancer and autoimmune diseases. The ability to modulate the immune response using IGLV1-51 may provide new therapeutic strategies for the treatment of these diseases. In conclusion, IGLV1-51 is a critical gene that plays a pivotal role in the immune response to Leishmania parasite infection. Its ability to regulate the complement cascade and activate B cells makes it an essential component of the adaptive immune response. The development of new treatments that target IGLV1-51 may provide new therapeutic strategies for the treatment of Leishmaniasis and other diseases.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.