Details for: ZNF606

Gene ID: 80095

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: ZNF606

Ensembl ID: ENSG00000166704

Description: zinc finger protein 606

Selected Context(s):  Overall

Cell Significance Landscape

Contexts:

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • secretory cell CL0000151
    CSI 4.67
    rCSI 4.87%
    PRS 96.83
  • B cell CL0000236
    CSI 4.33
    rCSI 5.79%
    PRS 95.41
  • interneuron CL0000099
    CSI 3.64
    rCSI 7.31%
    PRS 94.94
  • neural crest cell CL0011012
    CSI 3.38
    rCSI 2.67%
    PRS 95.09
  • multi-ciliated epithelial cell CL0005012
    CSI 3.25
    rCSI 3.24%
    PRS 94.45
  • stem cell CL0000034
    CSI 3.07
    rCSI 2.96%
    PRS 96.06
  • mature B cell CL0000785
    CSI 2.85
    rCSI 2.47%
    PRS 99.06
  • megakaryocyte-erythroid progenitor cell CL0000050
    CSI 2.84
    rCSI 2.56%
    PRS 97.09
  • choroid plexus epithelial cell CL0000706
    CSI 2.68
    rCSI 4.38%
    PRS 94.45
  • lung ciliated cell CL1000271
    CSI 2.62
    rCSI 3.02%
    PRS 94.6
  • pvalb GABAergic cortical interneuron CL4023018
    CSI 2.58
    rCSI 3.21%
    PRS 90.54
  • astrocyte of the cerebral cortex CL0002605
    CSI 2.55
    rCSI 5.71%
    PRS 92.22
  • ciliated epithelial cell CL0000067
    CSI 2.55
    rCSI 2.24%
    PRS 92.93
  • intestinal tuft cell CL0019032
    CSI 2.35
    rCSI 3.59%
    PRS 97.02
  • caudal ganglionic eminence derived cortical interneuron CL4023064
    CSI 2.16
    rCSI 3.81%
    PRS 91.84
  • ciliated cell CL0000064
    CSI 2.09
    rCSI 3.39%
    PRS 93.55
  • sst GABAergic cortical interneuron CL4023017
    CSI 1.94
    rCSI 2.5%
    PRS 92.51
  • peripheral nervous system neuron CL2000032
    CSI 1.94
    rCSI 2.64%
    PRS 94.4
  • retinal cone cell CL0000573
    CSI 1.66
    rCSI 2.67%
    PRS 93.07
  • L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040
    CSI 1.26
    rCSI 3.07%
    PRS 90.56
  • ciliated columnar cell of tracheobronchial tree CL0002145
    CSI 1.06
    rCSI 2.41%
    PRS 92.94

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Comma-separated if multiple.
Comma-separated if multiple.
Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [ZNF606](/details-gene/80095) is a protein-coding gene located on chromosome 19q13.43 that encodes Zinc finger protein 606. Functional annotations consistently identify [ZNF606](/details-gene/80095) as a DNA-binding transcription factor that localizes to the nucleus and is involved in the positive regulation of transcription by RNA polymerase II. Expression data indicates its significance across a diverse range of cell types, including [secretory cell](/details-cell/CL0000151), [B cell](/details-cell/CL0000236), and various neuronal subtypes such as [interneuron](/details-cell/CL0000099). This broad but distinct expression pattern suggests a fundamental role in regulating specific gene expression programs essential for the identity and function of multiple cellular lineages. Its initial identification from brain-derived cDNA clones underscores its relevance in the nervous system [Link](https://pubmed.ncbi.nlm.nih.gov/11347906/). ## Cellular Roles and Expression Landscape The **Overall** expression profile of [ZNF606](/details-gene/80095) highlights its importance in several distinct cellular contexts, suggesting it is a key transcriptional regulator in specific differentiated cell types and progenitor populations. A prominent role is indicated in epithelial and secretory lineages, with the gene showing the highest significance in [secretory cell](/details-cell/CL0000151) (CSI: 4.67). This is strongly supported by high significance in multiple ciliated cell types, including [multi-ciliated epithelial cell](/details-cell/CL0005012), [lung ciliated cell](/details-cell/CL1000271), and [ciliated epithelial cell](/details-cell/CL0000067), pointing towards a potential role in ciliogenesis or mucosal function. In the immune system, [ZNF606](/details-gene/80095) is a significant gene in the B-cell lineage, as evidenced by its high CSI in both general [B cell](/details-cell/CL0000236) populations and more specifically in [mature B cell](/details-cell/CL0000785). It is also significant in [megakaryocyte-erythroid progenitor cell](/details-cell/CL0000050), suggesting a role in hematopoietic differentiation. Furthermore, consistent with its initial characterization from brain tissue [Link](https://pubmed.ncbi.nlm.nih.gov/11347906/), [ZNF606](/details-gene/80095) shows high relevance in the central nervous system. It is a key gene in [interneuron](/details-cell/CL0000099), including specific subtypes like [pvalb GABAergic cortical interneuron](/details-cell/CL4023018) and [caudal ganglionic eminence derived cortical interneuron](/details-cell/CL4023064), as well as in glial cells like [astrocyte of the cerebral cortex](/details-cell/CL0002605). Its expression in progenitor populations like [neural crest cell](/details-cell/CL0011012) and [stem cell](/details-cell/CL0000034) suggests it may also be involved in developmental processes. ## Pathways and Molecular Function The molecular function of [ZNF606](/details-gene/80095) is centered on transcriptional regulation. Gene Ontology annotations confirm its localization to the [nucleus](/details-cell/GO:0005634) and specifically the [nucleoplasm](/details-cell/GO:0005654), which is consistent with its role as a transcription factor. Its molecular functions are defined as [metal ion binding](/details-cell/GO:0046872) (characteristic of zinc finger proteins), [Rna polymerase ii cis-regulatory region sequence-specific dna binding](/details-cell/GO:0000978), and [Dna-binding transcription activator activity, rna polymerase ii-specific](/details-cell/GO:0001228). At the process level, [ZNF606](/details-gene/80095) is involved in the [regulation of transcription by rna polymerase ii](/details-cell/GO:0006357) and, more specifically, the [positive regulation of transcription by rna polymerase ii](/details-cell/GO:0045944). This is reinforced by Reactome pathway data, which places it within the core machinery of [gene expression (transcription)](https://reactome.org/content/detail/R-HSA-74160), the [generic transcription pathway](https://reactome.org/content/detail/R-HSA-212436), and [rna polymerase ii transcription](https://reactome.org/content/detail/R-HSA-73857). Collectively, these annotations paint a clear picture of [ZNF606](/details-gene/80095) as a sequence-specific transcriptional activator that plays a direct role in controlling gene expression. ## Research Directions The diverse expression pattern of [ZNF606](/details-gene/80095) across epithelial, immune, and neural lineages, combined with its function as a transcriptional activator, opens several avenues for future investigation. **Proposed Hypotheses:** 1. Given its high significance in multiple ciliated cell types ([multi-ciliated epithelial cell](/details-cell/CL0005012), [lung ciliated cell](/details-cell/CL1000271)), [ZNF606](/details-gene/80095) may function as a master regulator of a transcriptional program essential for ciliogenesis or the maintenance of ciliary function. Its dysregulation could contribute to ciliopathies affecting respiratory or other organ systems. 2. The high CSI of [ZNF606](/details-gene/80095) in both progenitor cells ([megakaryocyte-erythroid progenitor cell](/details-cell/CL0000050)) and terminally differentiated cells ([mature B cell](/details-cell/CL0000785)) suggests it may regulate distinct sets of target genes during cell differentiation versus the maintenance of a mature cellular state. **Experimental Approach:** To test the hypothesis that [ZNF606](/details-gene/80095) is a key regulator of ciliogenesis (Hypothesis 1), a robust experimental model would be the differentiation of primary human bronchial epithelial cells in an air-liquid interface (ALI) culture system. Using CRISPR interference (CRISPRi) to specifically knockdown [ZNF606](/details-gene/80095) expression prior to initiating differentiation would be a precise method. The impact on ciliogenesis could be quantified by immunofluorescence microscopy staining for ciliary markers like acetylated tubulin and FOXJ1. Further, RNA-sequencing of the knockdown cells compared to controls would identify the downstream transcriptional targets of [ZNF606](/details-gene/80095) and reveal the specific pathways it regulates during this process. **Therapeutic Potential:** As an intracellular DNA-binding transcription factor, [ZNF606](/details-gene/80095) presents a challenging direct target for small molecule inhibitors. Its broad expression across several critical healthy cell types, including immune and neural cells, suggests that systemic inhibition could lead to significant off-target toxicity. Therefore, its therapeutic potential is likely limited. However, if future studies link its dysregulation to a specific disease context (e.g., a particular cancer subtype or a developmental disorder), it could serve as a valuable biomarker. In such a scenario, therapeutic strategies would more likely focus on modulating its downstream effector pathways rather than targeting [ZNF606](/details-gene/80095) itself.

Genular Protein ID: 2650597018

Symbol: ZN606_HUMAN

Name: Zinc finger protein 606

UniProtKB Accession Codes:

Q8WXB4 A8KAN2 Q8NE04 Q96JH5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 2 ExpressionAtlas 1 GO 6 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 5 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11347906

Title: Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 11347906

DOI: 10.1093/dnares/8.2.85

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15964554

Title: ZNF328, a novel human zinc-finger protein, suppresses transcriptional activities of SRE and AP-1.

PubMed ID: 15964554

DOI: 10.1016/j.bbrc.2005.05.192

Sequence Information:

  • Length: 792
  • Mass: 91812
  • Checksum: CC816EB8115443E4
  • Sequence:
    • MAAINPWASW GALTDQSWGM TAVDPWASWA LCPQYPAWHV EGSLEEGRRA TGLPAAQVQE 
PVTFKDVAVD FTQEEWGQLD LVQRTLYRDV MLETYGHLLS VGNQIAKPEV ISLLEQGEEP 
WSVEQACPQR TCPEWVRNLE SKALIPAQSI FEEEQSHGMK LERYIWDDPW FSRLEVLGCK 
DQLEMYHMNQ STAMRQMVFM QKQVLSQRSS EFCGLGAEFS QNLNFVPSQR VSQIEHFYKP 
DTHAQSWRCD SAIMYADKVT CENNDYDKTV YQSIQPIYPA RIQTGDNLFK CTDAVKSFNH 
IIHFGDHKGI HTGEKLYEYK ECHQIFNQSP SFNEHPRLHV GENQYNYKEY ENIFYFSSFM 
EHQKIGTVEK AYKYNEWEKV FGYDSFLTQH TSTYTAEKPY DYNECGTSFI WSSYLIQHKK 
THTGEKPYEC DKCGKVFRNR SALTKHERTH TGIKPYECNK CGKAFSWNSH LIVHKRIHTG 
EKPYVCNECG KSFNWNSHLI GHQRTHTGEK PFECTECGKS FSWSSHLIAH MRMHTGEKPF 
KCDECEKAFR DYSALSKHER THSGAKPYKC TECGKSFSWS SHLIAHQRTH TGEKPYNCQE 
CGKAFRERSA LTKHEIIHSG IKPYECNKCG KSCSQMAHLV RHQRTHTGEK PYECNKCGKS 
FSQSCHLVAH RRIHTGEKPY KCNQCERSFN CSSHLIAHRR THTGEKPYRC NECGKAFNES 
SSLIVHLRNH TGEKPYKCNH CEKAFCKNSS LIIHQRMHSG EKRFICSECG KAFSGHSALL 
QHQRNHSEEK LN

Genular Protein ID: 912193369

Symbol: B4DFC8_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DFC8

Database IDs:

ARBA 4 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 4 Gene3D 1 InterPro 4 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 5 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 RefSeq 2 SMART 1 SUPFAM 1

Sequence Information:

  • Length: 702
  • Mass: 81695
  • Checksum: D0086BDE6221E4B0
  • Sequence:
    • MLETYGHLLS VGNQIAKPEV ISLLEQGEEP WSVEQACPQR TCPEWVRNLE SKALIPAQSI 
FEEEQSHGMK LERYIWDDPW FSRLEVLGCK DQLEMYHMNQ STAMRQMVFM QKQVLSQRSS 
EFCGLGAEFS QNLNFVPSQR VSQIEHFYKP DTHAQSWRCD SAIMYADKVT CENNDYDKTV 
YQSIQPIYPA RIQAGDNLFK CTDAVKSFNH IIHFGDHKGI HTGEKLYEYK ECHQIFNQSP 
SFNEHPRLHV GENQYNYKEY ENIFYFSSFM EHQKIGTVEK AYKYNEWEKV FGYDSFLTQH 
TSTYTAEKPY DYNECGTSFI WSSYLIQHKK THTGEKPYEC DKCGKVFRNR SALTKHERTH 
TGIKPYECNK CGKAFSWNSH LIVHKRIHTG EKPYVCNECG KSFNWNSHLI GHQRTHTGEK 
PFECTECGKS FSWSSHLIAH MRMHTGEKPF KCDECEKAFR DYSALSKHER THSGAKPYKC 
TECGKSFSWS SHLIAHQRTH TGEKPYNCQE CGKAFRERSA LTKHEIIHSG IKPYECNKCG 
KSCSQMAHLV RHQRTHTGEK PYECNKCGKS FSQSCHLVAH RRIHTGEKPY KCNQCERSFN 
CSSHLIAHRR THTGEKPYRC NECGKAFNES SSLIVHLRNH TGEKPYKCNH CEKAFCKNSS 
LIIHQRMHSG EKRFICSECG KAFSGHSALL QHQRNHSEEK LN

Genular Protein ID: 2435640542

Symbol: Q9H7U2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9H7U2

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 2 Gene3D 1 IntAct 1 InterPro 2 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 RefSeq 5 SMART 1 SUPFAM 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 262
  • Mass: 30163
  • Checksum: 481093A80AE3389C
  • Sequence:
    • MRMHTGEKPF KCDECEKAFR DYSALSKHER THSGAKPYKC TECGKSFSWS SHLIAHQRTH 
TGEKPYNCQE CGKAFRERSA LTKHEIIHSG IKPYECNKCG KSCSQMAHLV RHQRTHTGEK 
PYECNKCGKS FSQSCHLVAH RRIHTGEKPY KCNQCERSFN CSSHLIAHRR THTGEKPYRC 
NECGKAFNES SSLIVHLRNH TGEKPYKCNH CEKAFCKNSS LIIHQRMHSG EKRFICSECG 
KAFSGHSALL QHQRNHSEEK LN