IGKV1 39 | ENSG00000242371 | NCBI 28930

Details for: IGKV1 39

Gene ID: 28930

Symbol: IGKV1 39

Ensembl ID: ENSG00000242371

Description: immunoglobulin kappa variable 1-39

Associated with

Adaptive immune system
(R-HSA-1280218)
Anti-inflammatory response favouring leishmania parasite infection
(R-HSA-9662851)
Antigen activates b cell receptor (bcr) leading to generation of second messengers
(R-HSA-983695)
Binding and uptake of ligands by scavenger receptors
(R-HSA-2173782)
Cd22 mediated bcr regulation
(R-HSA-5690714)
Cell surface interactions at the vascular wall
(R-HSA-202733)
Classical antibody-mediated complement activation
(R-HSA-173623)
Complement cascade
(R-HSA-166658)
Creation of c4 and c2 activators
(R-HSA-166786)
Disease
(R-HSA-1643685)
Fc epsilon receptor (fceri) signaling
(R-HSA-2454202)
Fceri mediated ca+2 mobilization
(R-HSA-2871809)
Fceri mediated mapk activation
(R-HSA-2871796)
Fceri mediated nf-kb activation
(R-HSA-2871837)
Fcgamma receptor (fcgr) dependent phagocytosis
(R-HSA-2029480)
Fcgr3a-mediated il10 synthesis
(R-HSA-9664323)
Fcgr3a-mediated phagocytosis
(R-HSA-9664422)
Fcgr activation
(R-HSA-2029481)
Hemostasis
(R-HSA-109582)
Immune system
(R-HSA-168256)
Immunoregulatory interactions between a lymphoid and a non-lymphoid cell
(R-HSA-198933)
Infectious disease
(R-HSA-5663205)
Initial triggering of complement
(R-HSA-166663)
Innate immune system
(R-HSA-168249)
Leishmania infection
(R-HSA-9658195)
Leishmania parasite growth and survival
(R-HSA-9664433)
Leishmania phagocytosis
(R-HSA-9664417)
Parasite infection
(R-HSA-9664407)
Parasitic infection pathways
(R-HSA-9824443)
Potential therapeutics for sars
(R-HSA-9679191)
Regulation of actin dynamics for phagocytic cup formation
(R-HSA-2029482)
Regulation of complement cascade
(R-HSA-977606)
Role of lat2/ntal/lab on calcium mobilization
(R-HSA-2730905)
Role of phospholipids in phagocytosis
(R-HSA-2029485)
Sars-cov infections
(R-HSA-9679506)
Scavenging of heme from plasma
(R-HSA-2168880)
Signaling by the b cell receptor (bcr)
(R-HSA-983705)
Vesicle-mediated transport
(R-HSA-5653656)
Viral infection pathways
(R-HSA-9824446)
Adaptive immune response
(GO:0002250)
Antigen binding
(GO:0003823)
Blood microparticle
(GO:0072562)
Extracellular exosome
(GO:0070062)
Extracellular region
(GO:0005576)
Immune response
(GO:0006955)
Immunoglobulin complex
(GO:0019814)
Plasma membrane
(GO:0005886)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 1.4822
Cell Significance Index: 16.5700
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 0.5210
Cell Significance Index: 8.0600
Cell Name: cytotoxic T cell (CL0000910)
Fold Change: 0.0209
Cell Significance Index: 0.3100
Cell Name: odontoblast (CL0000060)
Fold Change: 0.0027
Cell Significance Index: 0.3400
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0076
Cell Significance Index: -5.7800
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0373
Cell Significance Index: -3.8100
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0828
Cell Significance Index: -14.1400
Cell Name: lactocyte (CL0002325)
Fold Change: -0.0905
Cell Significance Index: -11.6900
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0928
Cell Significance Index: -5.6900
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.1196
Cell Significance Index: -5.4200
Cell Name: early T lineage precursor (CL0002425)
Fold Change: -0.1316
Cell Significance Index: -1.9100
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1427
Cell Significance Index: -16.3500
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.1596
Cell Significance Index: -11.9000
Cell Name: keratinocyte (CL0000312)
Fold Change: -0.1640
Cell Significance Index: -4.1000
Cell Name: erythrocyte (CL0000232)
Fold Change: -0.1786
Cell Significance Index: -4.5500
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.1976
Cell Significance Index: -6.3300
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.2112
Cell Significance Index: -6.2200
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: -0.2118
Cell Significance Index: -2.6200
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.2215
Cell Significance Index: -8.1300
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.2216
Cell Significance Index: -6.0300
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.2310
Cell Significance Index: -5.6000
Cell Name: leukocyte (CL0000738)
Fold Change: -0.2396
Cell Significance Index: -4.0700
Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: -0.2422
Cell Significance Index: -6.0400
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.2471
Cell Significance Index: -11.5200
Cell Name: megakaryocyte (CL0000556)
Fold Change: -0.2476
Cell Significance Index: -4.0100
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: -0.2808
Cell Significance Index: -4.8000
Cell Name: IgG plasmablast (CL0000982)
Fold Change: -0.2871
Cell Significance Index: -2.3700
Cell Name: IgA plasma cell (CL0000987)
Fold Change: -0.2898
Cell Significance Index: -1.9300
Cell Name: plasma cell (CL0000786)
Fold Change: -0.2936
Cell Significance Index: -3.2800
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: -0.2975
Cell Significance Index: -4.0800
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: -0.3064
Cell Significance Index: -5.9900
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.3128
Cell Significance Index: -16.2500
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.3165
Cell Significance Index: -5.8500
Cell Name: lymphocyte (CL0000542)
Fold Change: -0.3514
Cell Significance Index: -4.7800
Cell Name: myoepithelial cell (CL0000185)
Fold Change: -0.3888
Cell Significance Index: -4.4100
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: -0.3901
Cell Significance Index: -4.5900
Cell Name: IgA plasmablast (CL0000984)
Fold Change: -0.4231
Cell Significance Index: -3.4000
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.4294
Cell Significance Index: -12.3100
Cell Name: Schwann cell (CL0002573)
Fold Change: -0.4319
Cell Significance Index: -4.8400
Cell Name: class switched memory B cell (CL0000972)
Fold Change: -0.4395
Cell Significance Index: -3.9200
Cell Name: precursor B cell (CL0000817)
Fold Change: -0.4475
Cell Significance Index: -5.7900
Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: -0.4481
Cell Significance Index: -5.8600
Cell Name: blood vessel smooth muscle cell (CL0019018)
Fold Change: -0.4512
Cell Significance Index: -4.2600
Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: -0.4643
Cell Significance Index: -3.9000
Cell Name: monocyte (CL0000576)
Fold Change: -0.4736
Cell Significance Index: -5.4500
Cell Name: glial cell (CL0000125)
Fold Change: -0.4783
Cell Significance Index: -5.2400
Cell Name: naive B cell (CL0000788)
Fold Change: -0.4787
Cell Significance Index: -5.0400
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: -0.4793
Cell Significance Index: -5.6700
Cell Name: memory B cell (CL0000787)
Fold Change: -0.4954
Cell Significance Index: -5.2700
Cell Name: stromal cell (CL0000499)
Fold Change: -0.4967
Cell Significance Index: -5.0800
Cell Name: granulocyte (CL0000094)
Fold Change: -0.4974
Cell Significance Index: -6.0000
Cell Name: neutrophil (CL0000775)
Fold Change: -0.5003
Cell Significance Index: -6.2500
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -0.5040
Cell Significance Index: -8.4900
Cell Name: B cell (CL0000236)
Fold Change: -0.5061
Cell Significance Index: -5.9800
Cell Name: peg cell (CL4033014)
Fold Change: -0.5069
Cell Significance Index: -11.7100
Cell Name: primitive red blood cell (CL0002355)
Fold Change: -0.5106
Cell Significance Index: -5.7800
Cell Name: plasmablast (CL0000980)
Fold Change: -0.5107
Cell Significance Index: -4.7400
Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: -0.5141
Cell Significance Index: -5.9700
Cell Name: conventional dendritic cell (CL0000990)
Fold Change: -0.5171
Cell Significance Index: -6.1100
Cell Name: hematopoietic cell (CL0000988)
Fold Change: -0.5190
Cell Significance Index: -7.5900
Cell Name: plasmacytoid dendritic cell (CL0000784)
Fold Change: -0.5212
Cell Significance Index: -6.8400
Cell Name: germinal center B cell (CL0000844)
Fold Change: -0.5349
Cell Significance Index: -3.7800
Cell Name: progenitor cell (CL0011026)
Fold Change: -0.5356
Cell Significance Index: -5.6900
Cell Name: innate lymphoid cell (CL0001065)
Fold Change: -0.5363
Cell Significance Index: -6.8900
Cell Name: non-classical monocyte (CL0000875)
Fold Change: -0.5419
Cell Significance Index: -6.0000
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.5511
Cell Significance Index: -25.9000
Cell Name: transit amplifying cell (CL0009010)
Fold Change: -0.5521
Cell Significance Index: -5.3000
Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: -0.5527
Cell Significance Index: -5.9600
Cell Name: paneth cell (CL0000510)
Fold Change: -0.5539
Cell Significance Index: -5.7300
Cell Name: promonocyte (CL0000559)
Fold Change: -0.5543
Cell Significance Index: -5.9200
Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
Fold Change: -0.5565
Cell Significance Index: -6.0000
Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
Fold Change: -0.5583
Cell Significance Index: -5.9400
Cell Name: platelet (CL0000233)
Fold Change: -0.5618
Cell Significance Index: -5.7800
Cell Name: blood cell (CL0000081)
Fold Change: -0.5620
Cell Significance Index: -4.7900
Cell Name: respiratory goblet cell (CL0002370)
Fold Change: -0.5652
Cell Significance Index: -5.8300
Cell Name: plasmacytoid dendritic cell, human (CL0001058)
Fold Change: -0.5677
Cell Significance Index: -5.6000
Cell Name: natural killer cell (CL0000623)
Fold Change: -0.5679
Cell Significance Index: -6.2900
Cell Name: ionocyte (CL0005006)
Fold Change: -0.5681
Cell Significance Index: -5.9400
Cell Name: erythroid lineage cell (CL0000764)
Fold Change: -0.5682
Cell Significance Index: -6.2700
Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -0.5711
Cell Significance Index: -8.4300
Cell Name: club cell (CL0000158)
Fold Change: -0.5718
Cell Significance Index: -6.2300
Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: -0.5739
Cell Significance Index: -6.0300
Cell Name: hepatocyte (CL0000182)
Fold Change: -0.5768
Cell Significance Index: -8.0000
Cell Name: mast cell (CL0000097)
Fold Change: -0.5783
Cell Significance Index: -7.6100
Cell Name: kidney interstitial alternatively activated macrophage (CL1000695)
Fold Change: -0.5830
Cell Significance Index: -5.9600
Cell Name: acinar cell (CL0000622)
Fold Change: -0.5844
Cell Significance Index: -7.3400
Cell Name: T follicular helper cell (CL0002038)
Fold Change: -0.5894
Cell Significance Index: -6.2500
Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
Fold Change: -0.5930
Cell Significance Index: -5.7900
Cell Name: mucosal invariant T cell (CL0000940)
Fold Change: -0.5935
Cell Significance Index: -6.8300
Cell Name: regulatory T cell (CL0000815)
Fold Change: -0.6009
Cell Significance Index: -6.9700
Cell Name: unswitched memory B cell (CL0000970)
Fold Change: -0.6056
Cell Significance Index: -5.4100
Cell Name: dendritic cell (CL0000451)
Fold Change: -0.6071
Cell Significance Index: -7.9300
Cell Name: immature B cell (CL0000816)
Fold Change: -0.6098
Cell Significance Index: -5.7700
Cell Name: serous secreting cell of bronchus submucosal gland (CL4033005)
Fold Change: -0.6106
Cell Significance Index: -6.1100
Cell Name: mature NK T cell (CL0000814)
Fold Change: -0.6119
Cell Significance Index: -6.9000
Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
Fold Change: -0.6124
Cell Significance Index: -6.1700
Cell Name: smooth muscle cell (CL0000192)
Fold Change: -0.6133
Cell Significance Index: -7.1300
Cell Name: lung ciliated cell (CL1000271)
Fold Change: -0.6143
Cell Significance Index: -6.0100
Cell Name: group 3 innate lymphoid cell (CL0001071)
Fold Change: -0.6151
Cell Significance Index: -6.0100
Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: -0.6158
Cell Significance Index: -5.9300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Other Information

Description

**Key Characteristics** IGKV1-39 is a member of the immunoglobulin kappa variable region family, which encodes the variable regions of kappa light chains in antibodies. This gene is characterized by its high expression levels in various cell types, including B cells, which are the primary cells responsible for antibody production. IGKV1-39 is also involved in several signaling pathways, including those related to antigen binding, complement activation, and phagocytosis. The gene is highly expressed in cells involved in the adaptive immune response, such as B cells, granulocytes, and macrophages. **Pathways and Functions** IGKV1-39 plays a critical role in various signaling pathways, including: 1. **Antigen binding**: IGKV1-39 is involved in the binding of antigens to the B cell receptor (BCR), leading to the activation of B cells and the generation of antibodies. 2. **Complement activation**: IGKV1-39 is involved in the classical pathway of complement activation, which leads to the formation of complement split products and the opsonization of pathogens. 3. **Phagocytosis**: IGKV1-39 is involved in the phagocytosis of pathogens by macrophages and other phagocytic cells, through its interaction with Fc receptors. 4. **Antigen presentation**: IGKV1-39 is involved in the presentation of antigens to T cells, through its interaction with MHC class II molecules. 5. **Immunoglobulin production**: IGKV1-39 is involved in the production of immunoglobulins, through its interaction with other immunoglobulin genes. **Clinical Significance** IGKV1-39 has significant clinical implications, particularly in the treatment of Leishmania infections. Leishmania parasites express IGKV1-39 on their surface, which can interact with the B cell receptor (BCR) on host cells, leading to the activation of B cells and the production of antibodies against the parasite. This interaction can be exploited to develop vaccines and therapies against Leishmania infections. Additionally, IGKV1-39 may play a role in the development of autoimmune diseases, such as rheumatoid arthritis, where the interaction between the B cell receptor (BCR) and IGKV1-39 can lead to the activation of autoreactive B cells. In conclusion, IGKV1-39 is a critical component of the B cell receptor (BCR) complex, involved in various signaling pathways, including antigen binding, complement activation, and phagocytosis. Its significant expression in various cell types and its clinical implications make it an important target for the development of vaccines and therapies against Leishmania infections and autoimmune diseases.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.