Details for: IGHV5 78

Gene ID: 28387

Symbol: IGHV5 78

Ensembl ID: ENSG00000211978

Description: immunoglobulin heavy variable 5-78 (pseudogene)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 6.5175
    Cell Significance Index: 94.6300
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 2.2822
    Cell Significance Index: 28.2300
  • Cell Name: pre-B-I cell (CL0000956)
    Fold Change: 1.4838
    Cell Significance Index: 6.9700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.5826
    Cell Significance Index: 15.5900
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 0.1336
    Cell Significance Index: 0.6700
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.0410
    Cell Significance Index: 0.6000
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.0308
    Cell Significance Index: 0.3900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0043
    Cell Significance Index: -0.8500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0198
    Cell Significance Index: -3.5700
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0257
    Cell Significance Index: -0.3500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0295
    Cell Significance Index: -3.6300
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0313
    Cell Significance Index: -0.3700
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: -0.0398
    Cell Significance Index: -0.3200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0424
    Cell Significance Index: -2.6000
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: -0.0505
    Cell Significance Index: -0.5500
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0541
    Cell Significance Index: -1.3100
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0565
    Cell Significance Index: -0.6000
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.0573
    Cell Significance Index: -0.6400
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: -0.0594
    Cell Significance Index: -0.5500
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: -0.0621
    Cell Significance Index: -0.6300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0649
    Cell Significance Index: -4.1900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0674
    Cell Significance Index: -2.3700
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0680
    Cell Significance Index: -1.3300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0732
    Cell Significance Index: -2.1100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0740
    Cell Significance Index: -1.8500
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.0756
    Cell Significance Index: -0.8900
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0770
    Cell Significance Index: -1.0800
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0788
    Cell Significance Index: -1.0200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0829
    Cell Significance Index: -1.7200
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0837
    Cell Significance Index: -1.2200
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0838
    Cell Significance Index: -0.9900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0939
    Cell Significance Index: -4.8800
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: -0.0980
    Cell Significance Index: -0.8500
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.1000
    Cell Significance Index: -1.7100
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.1043
    Cell Significance Index: -1.1100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1070
    Cell Significance Index: -4.9900
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1136
    Cell Significance Index: -2.9000
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.1139
    Cell Significance Index: -1.4900
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.1159
    Cell Significance Index: -1.5900
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.1185
    Cell Significance Index: -1.5600
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.1215
    Cell Significance Index: -1.6900
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.1249
    Cell Significance Index: -1.5600
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.1293
    Cell Significance Index: -1.6700
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.1338
    Cell Significance Index: -1.5900
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.1352
    Cell Significance Index: -1.5300
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.1358
    Cell Significance Index: -1.7100
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.1426
    Cell Significance Index: -1.6200
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: -0.1430
    Cell Significance Index: -1.6000
  • Cell Name: promonocyte (CL0000559)
    Fold Change: -0.1433
    Cell Significance Index: -1.5300
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.1457
    Cell Significance Index: -1.5800
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.1464
    Cell Significance Index: -1.8000
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.1500
    Cell Significance Index: -2.4300
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: -0.1512
    Cell Significance Index: -1.3400
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.1524
    Cell Significance Index: -2.4500
  • Cell Name: mature B cell (CL0000785)
    Fold Change: -0.1552
    Cell Significance Index: -1.0100
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.1553
    Cell Significance Index: -1.6700
  • Cell Name: naive T cell (CL0000898)
    Fold Change: -0.1563
    Cell Significance Index: -1.4200
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: -0.1574
    Cell Significance Index: -1.7000
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: -0.1577
    Cell Significance Index: -1.7000
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.1578
    Cell Significance Index: -2.6600
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.1582
    Cell Significance Index: -1.6900
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: -0.1589
    Cell Significance Index: -1.7200
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: -0.1606
    Cell Significance Index: -1.7000
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.1613
    Cell Significance Index: -2.4500
  • Cell Name: osteoclast (CL0000092)
    Fold Change: -0.1616
    Cell Significance Index: -1.6500
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.1622
    Cell Significance Index: -2.3100
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: -0.1623
    Cell Significance Index: -1.7100
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.1667
    Cell Significance Index: -1.7000
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.1670
    Cell Significance Index: -1.7300
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: -0.1710
    Cell Significance Index: -1.6900
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: -0.1716
    Cell Significance Index: -1.6900
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.1716
    Cell Significance Index: -1.8700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1739
    Cell Significance Index: -2.9100
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.1743
    Cell Significance Index: -1.7200
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: -0.1745
    Cell Significance Index: -1.6800
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: -0.1755
    Cell Significance Index: -1.2400
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: -0.1756
    Cell Significance Index: -1.5300
  • Cell Name: osteoblast (CL0000062)
    Fold Change: -0.1763
    Cell Significance Index: -1.7100
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1767
    Cell Significance Index: -1.6800
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.1775
    Cell Significance Index: -1.6000
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: -0.1784
    Cell Significance Index: -1.8000
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: -0.1796
    Cell Significance Index: -1.7100
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: -0.1841
    Cell Significance Index: -1.6900
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: -0.1866
    Cell Significance Index: -1.3700
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.1873
    Cell Significance Index: -1.7200
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: -0.1876
    Cell Significance Index: -1.7100
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.1876
    Cell Significance Index: -1.6400
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.1881
    Cell Significance Index: -1.5900
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.1893
    Cell Significance Index: -2.1200
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.1924
    Cell Significance Index: -2.0300
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.1930
    Cell Significance Index: -2.3500
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.1952
    Cell Significance Index: -1.7200
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.1969
    Cell Significance Index: -2.5300
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.1974
    Cell Significance Index: -2.5900
  • Cell Name: immature B cell (CL0000816)
    Fold Change: -0.1992
    Cell Significance Index: -1.8900
  • Cell Name: B-1a B cell (CL0000820)
    Fold Change: -0.1995
    Cell Significance Index: -1.0600
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.2024
    Cell Significance Index: -2.7800
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.2051
    Cell Significance Index: -2.3600
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.2055
    Cell Significance Index: -2.4400
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.2055
    Cell Significance Index: -2.5000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Pseudogene status:** IGHV5-78 has undergone extensive mutations, rendering it non-functional in producing a functional antibody. 2. **Widespread expression:** IGHV5-78 is significantly expressed in various immune cells, including B cells, early T lineage precursors, and neutrophil progenitor cells. 3. **Unique expression profile:** IGHV5-78 is specifically expressed in B-1b B cells, which are a subset of B cells that play a crucial role in the innate immune response. 4. **Developmental significance:** IGHV5-78 is expressed in early stages of B cell development, suggesting its involvement in the developmental process of these cells. **Pathways and Functions:** 1. **B cell development:** IGHV5-78 is expressed during the early stages of B cell development, specifically in small pre-B-II cells and pre-B-I cells. This suggests that IGHV5-78 plays a role in the maturation process of B cells. 2. **Immune cell differentiation:** IGHV5-78 is also expressed in late pro-B cells, early T lineage precursors, and B-1b B cells, indicating its involvement in the differentiation of these immune cells. 3. **Gene regulation:** The expression of IGHV5-78 is tightly regulated, with its expression being significantly reduced or eliminated in mature B cells and T cells. This suggests that IGHV5-78 plays a role in the regulation of gene expression during immune cell development. **Clinical Significance:** 1. **Autoimmune diseases:** The expression of IGHV5-78 in B-1b B cells may contribute to the development of autoimmune diseases, such as rheumatoid arthritis and lupus, in which these cells play a key role. 2. **Cancer:** The expression of IGHV5-78 in neutrophil progenitor cells and early T lineage precursors may contribute to the development of certain types of cancer, such as acute myeloid leukemia (AML) and T-cell acute lymphoblastic leukemia (T-ALL). 3. **Immunodeficiency disorders:** The expression of IGHV5-78 in CD38-negative naive B cells may contribute to the development of immunodeficiency disorders, such as X-linked agammaglobulinemia (XLA). 4. **Gene therapy:** The study of IGHV5-78 may provide insights into the development of gene therapy for autoimmune diseases and immunodeficiency disorders, particularly those related to B cell development and function. In conclusion, the Immunoglobulin Heavy Variable Region 5-78 (IGHV5-78) gene is a pseudogene with significant expression in various immune cells. Its widespread expression suggests that IGHV5-78 plays a role in the development and function of these cells, and its dysregulation may contribute to the development of autoimmune diseases, cancer, and immunodeficiency disorders. Further study of IGHV5-78 may provide insights into the molecular mechanisms underlying immune cell development and function, and may lead to the development of novel therapeutic strategies for these diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.