Gene DLX5 - ENSG00000105880 | NCBI Gene ID: 1749

Details for: DLX5

Gene ID: 1749

Symbol: DLX5

Ensembl ID: ENSG00000105880

Description: distal-less homeobox 5

Associated with

Developmental biology
(R-HSA-1266738)
Gastrulation
(R-HSA-9758941)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Regulation of runx2 expression and activity
(R-HSA-8939902)
Rna polymerase ii transcription
(R-HSA-73857)
Specification of the neural plate border
(R-HSA-9834899)
Transcriptional regulation by runx2
(R-HSA-8878166)
Anatomical structure formation involved in morphogenesis
(GO:0048646)
Bmp signaling pathway
(GO:0030509)
Cell differentiation
(GO:0030154)
Cell population proliferation
(GO:0008283)
Chromatin
(GO:0000785)
Cytoplasm
(GO:0005737)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Embryo development
(GO:0009790)
Embryonic limb morphogenesis
(GO:0030326)
Endochondral ossification
(GO:0001958)
Epithelial cell differentiation
(GO:0030855)
Face morphogenesis
(GO:0060325)
Hmg box domain binding
(GO:0071837)
Inner ear morphogenesis
(GO:0042472)
Interneuron axon guidance
(GO:0097376)
Nervous system development
(GO:0007399)
Nucleus
(GO:0005634)
Olfactory bulb interneuron differentiation
(GO:0021889)
Olfactory pit development
(GO:0060166)
Osteoblast differentiation
(GO:0001649)
Positive regulation of canonical wnt signaling pathway
(GO:0090263)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of epithelial cell proliferation
(GO:0050679)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Roof of mouth development
(GO:0060021)
Sequence-specific double-stranded dna binding
(GO:1990837)
Skeletal system development
(GO:0001501)
Transcription cis-regulatory region binding
(GO:0000976)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
Fold Change: 17.65
Marker Score: 28720
Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
Fold Change: 16.43
Marker Score: 37000
Cell Name: natural killer cell (CL0000623)
Fold Change: 7.8
Marker Score: 10109
Cell Name: vein endothelial cell (CL0002543)
Fold Change: 7.75
Marker Score: 7004
Cell Name: regulatory T cell (CL0000815)
Fold Change: 7.23
Marker Score: 8001.5
Cell Name: classical monocyte (CL0000860)
Fold Change: 4.12
Marker Score: 17118.5
Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
Fold Change: 3.79
Marker Score: 9819
Cell Name: type II pneumocyte (CL0002063)
Fold Change: 3.77
Marker Score: 24568
Cell Name: endothelial cell of lymphatic vessel (CL0002138)
Fold Change: 3.2
Marker Score: 1999
Cell Name: plasmacytoid dendritic cell (CL0000784)
Fold Change: 3.05
Marker Score: 1641
Cell Name: pulmonary interstitial fibroblast (CL0002241)
Fold Change: 3.02
Marker Score: 2421
Cell Name: glandular epithelial cell (CL0000150)
Fold Change: 2.91
Marker Score: 7161
Cell Name: capillary endothelial cell (CL0002144)
Fold Change: 2.12
Marker Score: 2277
Cell Name: plasma cell (CL0000786)
Fold Change: 2
Marker Score: 2234
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 2
Marker Score: 1992.5
Cell Name: preosteoblast (CL0007010)
Fold Change: 1.99
Marker Score: 563
Cell Name: osteoblast (CL0000062)
Fold Change: 1.98
Marker Score: 1064
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 1.94
Marker Score: 7607
Cell Name: malignant cell (CL0001064)
Fold Change: 1.76
Marker Score: 23596
Cell Name: multi-ciliated epithelial cell (CL0005012)
Fold Change: 1.71
Marker Score: 3252
Cell Name: alveolar macrophage (CL0000583)
Fold Change: 1.69
Marker Score: 43340
Cell Name: fibroblast of lung (CL0002553)
Fold Change: 1.69
Marker Score: 4430
Cell Name: conventional dendritic cell (CL0000990)
Fold Change: 1.68
Marker Score: 1156.5
Cell Name: pulmonary artery endothelial cell (CL1001568)
Fold Change: 1.62
Marker Score: 1391
Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.61
Marker Score: 1170
Cell Name: cell in vitro (CL0001034)
Fold Change: 1.39
Marker Score: 48068
Cell Name: type I pneumocyte (CL0002062)
Fold Change: 1.31
Marker Score: 1575
Cell Name: B cell (CL0000236)
Fold Change: 1.27
Marker Score: 1209
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 1.26
Marker Score: 856
Cell Name: erythrocyte (CL0000232)
Fold Change: 1.24
Marker Score: 689
Cell Name: mast cell (CL0000097)
Fold Change: 1.23
Marker Score: 711
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 1.22
Marker Score: 774.5
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 1.18
Marker Score: 489
Cell Name: T cell (CL0000084)
Fold Change: 1.16
Marker Score: 1993
Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 1.15
Marker Score: 6035
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.15
Marker Score: 4806
Cell Name: goblet cell (CL0000160)
Fold Change: 1.11
Marker Score: 7381
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 1.1
Marker Score: 505
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 1.04
Marker Score: 251781
Cell Name: motor neuron (CL0000100)
Fold Change: 1.03
Marker Score: 610
Cell Name: peripheral nervous system neuron (CL2000032)
Fold Change: 1.01
Marker Score: 1136
Cell Name: non-classical monocyte (CL0000875)
Fold Change: 1
Marker Score: 2421
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71803
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48024
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.99
Marker Score: 511
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.98
Marker Score: 465
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30406
Cell Name: germ cell (CL0000586)
Fold Change: 0.97
Marker Score: 1697
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2412
Cell Name: eukaryotic cell (CL0000255)
Fold Change: 0.95
Marker Score: 488
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.94
Marker Score: 377
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.94
Marker Score: 717
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.94
Marker Score: 5345
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 0.94
Marker Score: 493
Cell Name: bronchus fibroblast of lung (CL2000093)
Fold Change: 0.93
Marker Score: 1280
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.91
Marker Score: 329
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2738
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5288
Cell Name: neural cell (CL0002319)
Fold Change: 0.82
Marker Score: 395.5
Cell Name: dendritic cell (CL0000451)
Fold Change: 0.81
Marker Score: 555
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1268
Cell Name: brush cell (CL0002204)
Fold Change: 0.78
Marker Score: 710
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.77
Marker Score: 399
Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
Fold Change: 0.76
Marker Score: 477.5
Cell Name: myeloid cell (CL0000763)
Fold Change: 0.74
Marker Score: 1193
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.74
Marker Score: 310.5
Cell Name: neural crest cell (CL0011012)
Fold Change: 0.74
Marker Score: 788
Cell Name: keratinocyte (CL0000312)
Fold Change: 0.73
Marker Score: 611
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.73
Marker Score: 464
Cell Name: extravillous trophoblast (CL0008036)
Fold Change: 0.72
Marker Score: 640
Cell Name: oogonial cell (CL0000024)
Fold Change: 0.71
Marker Score: 1027
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.71
Marker Score: 181
Cell Name: migratory enteric neural crest cell (CL0002607)
Fold Change: 0.71
Marker Score: 664
Cell Name: GABAergic neuron (CL0000617)
Fold Change: 0.67
Marker Score: 2785
Cell Name: adventitial cell (CL0002503)
Fold Change: 0.66
Marker Score: 163
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.66
Marker Score: 1248
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.62
Marker Score: 9743.5
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.61
Marker Score: 1249.5
Cell Name: megakaryocyte (CL0000556)
Fold Change: 0.61
Marker Score: 346
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 0.6
Marker Score: 981.5
Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 0.59
Marker Score: 629
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.58
Marker Score: 463
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.57
Marker Score: 151
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.56
Marker Score: 176
Cell Name: enteric neuron (CL0007011)
Fold Change: 0.55
Marker Score: 291
Cell Name: epithelial cell of uterus (CL0002149)
Fold Change: 0.54
Marker Score: 123
Cell Name: male germ cell (CL0000015)
Fold Change: 0.53
Marker Score: 152
Cell Name: serous secreting cell (CL0000313)
Fold Change: 0.51
Marker Score: 205
Cell Name: pro-B cell (CL0000826)
Fold Change: 0.5
Marker Score: 478
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.49
Marker Score: 327
Cell Name: precursor cell (CL0011115)
Fold Change: 0.49
Marker Score: 120
Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 0.49
Marker Score: 18711.5
Cell Name: inhibitory motor neuron (CL0008015)
Fold Change: 0.49
Marker Score: 230
Cell Name: vascular associated smooth muscle cell (CL0000359)
Fold Change: 0.47
Marker Score: 215
Cell Name: syncytiotrophoblast cell (CL0000525)
Fold Change: 0.45
Marker Score: 367
Cell Name: tracheal goblet cell (CL1000329)
Fold Change: 0.44
Marker Score: 1252
Cell Name: interneuron (CL0000099)
Fold Change: 0.44
Marker Score: 200.5
Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
Fold Change: 0.43
Marker Score: 889
Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 0.43
Marker Score: 1779
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.42
Marker Score: 251

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**Key characteristics**: - DLX5 is a homeobox gene, a group of transcription factors characterized by a homeobox DNA-binding domain. - It is expressed in a variety of cell types, including immune cells, endothelial cells, and neural cells. - DLX5 is a key regulator of endochondral ossification, where cartilage is formed from bone. - It is also involved in gastrulation, the process by which a blastocyst forms into an embryo. - It plays a crucial role in regulating the development of the nervous system, including the specification of the neural plate border and the differentiation of neural cells. **Pathways and functions**: - DLX5 is a key regulator of cell population proliferation by promoting the proliferation of specific cell types. - It is involved in the development of the vascular system, including the formation of blood vessels and the specification of the neural plate border. - It is also involved in the regulation of inflammation and tissue repair. **Clinical significance**: - Mutations in the DLX5 gene have been linked to various human diseases, including cancer, cardiovascular disease, and inflammatory disorders. - Dysregulation of DLX5 has been implicated in the pathogenesis of these diseases. - Therefore, understanding the role of DLX5 in health and disease could lead to the development of new therapeutic strategies for these conditions.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Homeobox protein DLX-5

Genular Protein ID: 901587050

Symbol: DLX5_HUMAN

Name: Homeobox protein DLX-5

UniProtKB Accession Codes:

P56178 B7Z4P3 Q9UPL1

Database IDs:

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7907794

Title: Cloning and characterization of two members of the vertebrate Dlx gene family.

PubMed ID: 7907794

DOI: 10.1073/pnas.91.6.2250

PubMed ID: 12145306

Title: Regulation of osteocalcin gene expression by a novel Ku antigen transcription factor complex.

PubMed ID: 12145306

DOI: 10.1074/jbc.m206482200

PubMed ID: 19497851

Title: DLX5 (distal-less homeobox 5) promotes tumor cell proliferation by transcriptionally regulating MYC.

PubMed ID: 19497851

DOI: 10.1074/jbc.m109.021477

PubMed ID: 22121204

Title: Identification of a novel DLX5 mutation in a family with autosomal recessive split hand and foot malformation.

PubMed ID: 22121204

DOI: 10.1136/jmedgenet-2011-100556

Sequence Information:

Length: 289
Mass: 31540
Checksum: 5BC9970B12E30554
Sequence:

MTGVFDRRVP SIRSGDFQAP FQTSAAMHHP SQESPTLPES SATDSDYYSP TGGAPHGYCS 
PTSASYGKAL NPYQYQYHGV NGSAGSYPAK AYADYSYASS YHQYGGAYNR VPSATNQPEK 
EVTEPEVRMV NGKPKKVRKP RTIYSSFQLA ALQRRFQKTQ YLALPERAEL AASLGLTQTQ 
VKIWFQNKRS KIKKIMKNGE MPPEHSPSSS DPMACNSPQS PAVWEPQGSS RSLSHHPHAH 
PPTSNQSPAS SYLENSASWY TSAASSINSH LPPPGSLQHP LALASGTLY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: DLX5

Associated with

Cells (max top 100)

Other Information

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence of human chromosome 7. PubMed ID: 12853948

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Cloning and characterization of two members of the vertebrate Dlx gene family. PubMed ID: 7907794

Regulation of osteocalcin gene expression by a novel Ku antigen transcription factor complex. PubMed ID: 12145306

DLX5 (distal-less homeobox 5) promotes tumor cell proliferation by transcriptionally regulating MYC. PubMed ID: 19497851

Identification of a novel DLX5 mutation in a family with autosomal recessive split hand and foot malformation. PubMed ID: 22121204