Details for: DLX5

Gene ID: 1749

Symbol: DLX5

Ensembl ID: ENSG00000105880

Description: distal-less homeobox 5

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 6.7666
    Cell Significance Index: 237.7700
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 4.1169
    Cell Significance Index: 25.4700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 4.1160
    Cell Significance Index: 527.6500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 3.7943
    Cell Significance Index: 109.3200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 3.3368
    Cell Significance Index: 83.4100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 3.1401
    Cell Significance Index: 192.5200
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.5817
    Cell Significance Index: 14.3600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.4831
    Cell Significance Index: 32.1300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.1852
    Cell Significance Index: 24.5900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.0545
    Cell Significance Index: 575.8900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.9139
    Cell Significance Index: 29.2700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.8409
    Cell Significance Index: 160.0200
  • Cell Name: chondroblast (CL0000058)
    Fold Change: 0.7632
    Cell Significance Index: 4.4800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.6589
    Cell Significance Index: 40.5000
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.5818
    Cell Significance Index: 3.6200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.5813
    Cell Significance Index: 13.9400
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.5571
    Cell Significance Index: 7.7300
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.5388
    Cell Significance Index: 8.1200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5351
    Cell Significance Index: 52.9300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4922
    Cell Significance Index: 444.4500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.4071
    Cell Significance Index: 10.8700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2652
    Cell Significance Index: 43.1400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2585
    Cell Significance Index: 13.4300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1728
    Cell Significance Index: 18.8000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1210
    Cell Significance Index: 43.4000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1130
    Cell Significance Index: 78.1300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1029
    Cell Significance Index: 20.4200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0529
    Cell Significance Index: 3.6600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0164
    Cell Significance Index: 7.2600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0029
    Cell Significance Index: 0.5300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0123
    Cell Significance Index: -7.6500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0133
    Cell Significance Index: -1.8200
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0136
    Cell Significance Index: -0.2100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0185
    Cell Significance Index: -10.4400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0185
    Cell Significance Index: -13.7400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0228
    Cell Significance Index: -14.4500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0304
    Cell Significance Index: -3.7400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0326
    Cell Significance Index: -14.8000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0510
    Cell Significance Index: -14.6600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0553
    Cell Significance Index: -3.3200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0648
    Cell Significance Index: -2.9400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0669
    Cell Significance Index: -7.6700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0674
    Cell Significance Index: -13.5200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0682
    Cell Significance Index: -11.6500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0684
    Cell Significance Index: -14.4100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0960
    Cell Significance Index: -2.0500
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.0964
    Cell Significance Index: -0.8100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0976
    Cell Significance Index: -6.9000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0994
    Cell Significance Index: -14.4500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1144
    Cell Significance Index: -14.7800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1152
    Cell Significance Index: -13.4300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1241
    Cell Significance Index: -12.6800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.1347
    Cell Significance Index: -1.2400
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1510
    Cell Significance Index: -6.5600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2013
    Cell Significance Index: -15.0000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2131
    Cell Significance Index: -4.4600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2132
    Cell Significance Index: -9.4300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2142
    Cell Significance Index: -14.4100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2291
    Cell Significance Index: -17.5800
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: -0.2539
    Cell Significance Index: -2.0200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2620
    Cell Significance Index: -5.2600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2654
    Cell Significance Index: -10.0500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2734
    Cell Significance Index: -3.7300
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.2759
    Cell Significance Index: -6.8900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2785
    Cell Significance Index: -7.5800
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.2853
    Cell Significance Index: -2.7100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2924
    Cell Significance Index: -16.4100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3033
    Cell Significance Index: -14.2600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3180
    Cell Significance Index: -6.7500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.3221
    Cell Significance Index: -6.9600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.3247
    Cell Significance Index: -4.6500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3262
    Cell Significance Index: -15.2100
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.3550
    Cell Significance Index: -7.0200
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.3867
    Cell Significance Index: -8.0700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3895
    Cell Significance Index: -14.3000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3991
    Cell Significance Index: -13.9800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.4086
    Cell Significance Index: -11.4200
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.4135
    Cell Significance Index: -3.8500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4388
    Cell Significance Index: -14.3700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4528
    Cell Significance Index: -14.4200
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.4736
    Cell Significance Index: -5.4500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4901
    Cell Significance Index: -14.4400
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.4963
    Cell Significance Index: -5.7900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.5002
    Cell Significance Index: -14.3400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.5027
    Cell Significance Index: -14.3500
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.5050
    Cell Significance Index: -9.9400
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.5069
    Cell Significance Index: -6.3600
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.5119
    Cell Significance Index: -6.4600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.5206
    Cell Significance Index: -13.9300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.5225
    Cell Significance Index: -14.0000
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.5347
    Cell Significance Index: -13.3400
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.5404
    Cell Significance Index: -5.2100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.5495
    Cell Significance Index: -14.4500
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.5677
    Cell Significance Index: -11.3200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.5801
    Cell Significance Index: -14.4700
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.5840
    Cell Significance Index: -14.8800
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.5924
    Cell Significance Index: -6.4400
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.5990
    Cell Significance Index: -13.8400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.6026
    Cell Significance Index: -10.0900
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.6269
    Cell Significance Index: -8.4600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** DLX5 is a homeobox gene, which belongs to the distal-less (DLX) family of transcription factors. Homeobox genes are essential for the regulation of embryonic development and tissue patterning. DLX5 is specifically expressed in various cell types, including CD8-positive and CD4-positive alpha-beta T cells, natural killer cells, vein endothelial cells, and regulatory T cells. The protein product of the DLX5 gene, Homeobox protein DLX-5, exhibits a high degree of sequence similarity to other DLX family members and is characterized by the presence of a HMG box domain, which is essential for its transcriptional activity. **Pathways and Functions:** DLX5 is involved in multiple signaling pathways, including the BMP (Bone Morphogenetic Protein) signaling pathway, Wnt signaling pathway, and the Notch signaling pathway. These pathways play critical roles in the regulation of cell proliferation, differentiation, and survival. DLX5 also interacts with other transcription factors, such as RUNX2, to regulate the expression of target genes involved in the development of various tissues. In the context of immune cell development, DLX5 has been shown to regulate the expression of genes involved in T cell and dendritic cell differentiation, migration, and function. **Clinical Significance:** Dysregulation of DLX5 has been implicated in various immunological disorders, including autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. Altered expression of DLX5 has been observed in patients with these diseases, suggesting a potential role for DLX5 in the pathogenesis of these conditions. Additionally, DLX5 has been implicated in the development of certain types of cancer, including leukemia and lymphoma, where its expression is often downregulated. Furthermore, DLX5 has been shown to play a role in the regulation of epithelial cell differentiation and development, which is critical in the context of respiratory diseases, such as asthma and chronic obstructive pulmonary disease (COPD). In conclusion, DLX5 is a multifunctional transcription factor that plays a critical role in the regulation of developmental processes and immune cell development. Its dysregulation has been implicated in various immunological disorders, highlighting the importance of further research into the molecular mechanisms underlying DLX5 function and its potential therapeutic applications.

Genular Protein ID: 901587050

Symbol: DLX5_HUMAN

Name: Homeobox protein DLX-5

UniProtKB Accession Codes:

P56178 B7Z4P3 Q9UPL1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 31 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PRINTS 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7907794

Title: Cloning and characterization of two members of the vertebrate Dlx gene family.

PubMed ID: 7907794

DOI: 10.1073/pnas.91.6.2250

PubMed ID: 12145306

Title: Regulation of osteocalcin gene expression by a novel Ku antigen transcription factor complex.

PubMed ID: 12145306

DOI: 10.1074/jbc.m206482200

PubMed ID: 19497851

Title: DLX5 (distal-less homeobox 5) promotes tumor cell proliferation by transcriptionally regulating MYC.

PubMed ID: 19497851

DOI: 10.1074/jbc.m109.021477

PubMed ID: 22121204

Title: Identification of a novel DLX5 mutation in a family with autosomal recessive split hand and foot malformation.

PubMed ID: 22121204

DOI: 10.1136/jmedgenet-2011-100556

Sequence Information:

  • Length: 289
  • Mass: 31540
  • Checksum: 5BC9970B12E30554
  • Sequence:
    • MTGVFDRRVP SIRSGDFQAP FQTSAAMHHP SQESPTLPES SATDSDYYSP TGGAPHGYCS 
PTSASYGKAL NPYQYQYHGV NGSAGSYPAK AYADYSYASS YHQYGGAYNR VPSATNQPEK 
EVTEPEVRMV NGKPKKVRKP RTIYSSFQLA ALQRRFQKTQ YLALPERAEL AASLGLTQTQ 
VKIWFQNKRS KIKKIMKNGE MPPEHSPSSS DPMACNSPQS PAVWEPQGSS RSLSHHPHAH 
PPTSNQSPAS SYLENSASWY TSAASSINSH LPPPGSLQHP LALASGTLY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.