Details for: IGHV5 51

Gene ID: 28388

Symbol: IGHV5 51

Ensembl ID: ENSG00000211966

Description: immunoglobulin heavy variable 5-51

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 2.5588
    Cell Significance Index: 37.1500
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.8291
    Cell Significance Index: 10.2600
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.3891
    Cell Significance Index: 6.0200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.2901
    Cell Significance Index: 7.7600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0189
    Cell Significance Index: 2.4200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0047
    Cell Significance Index: -3.5600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0338
    Cell Significance Index: -3.4500
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: -0.0460
    Cell Significance Index: -0.3800
  • Cell Name: lymphocyte of B lineage (CL0000945)
    Fold Change: -0.0585
    Cell Significance Index: -0.4300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0651
    Cell Significance Index: -3.3800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0694
    Cell Significance Index: -4.4800
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.0787
    Cell Significance Index: -0.8800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0941
    Cell Significance Index: -16.0600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0955
    Cell Significance Index: -4.3300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0957
    Cell Significance Index: -12.3600
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.1128
    Cell Significance Index: -1.4300
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: -0.1389
    Cell Significance Index: -1.4100
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.1390
    Cell Significance Index: -2.3600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1433
    Cell Significance Index: -4.5900
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.1445
    Cell Significance Index: -1.7000
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.1516
    Cell Significance Index: -2.2100
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.1649
    Cell Significance Index: -2.6700
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.1661
    Cell Significance Index: -2.2600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1676
    Cell Significance Index: -12.4900
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -0.1704
    Cell Significance Index: -1.1400
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1724
    Cell Significance Index: -4.1800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1781
    Cell Significance Index: -2.9800
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.1794
    Cell Significance Index: -2.4600
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1884
    Cell Significance Index: -4.8000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1977
    Cell Significance Index: -9.2200
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.2013
    Cell Significance Index: -2.4300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2029
    Cell Significance Index: -7.4500
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.2039
    Cell Significance Index: -2.4100
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.2103
    Cell Significance Index: -2.3500
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.2210
    Cell Significance Index: -4.3200
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.2219
    Cell Significance Index: -3.2500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2235
    Cell Significance Index: -4.1300
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.2241
    Cell Significance Index: -2.9000
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.2333
    Cell Significance Index: -1.9600
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.2378
    Cell Significance Index: -3.1100
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.2417
    Cell Significance Index: -2.4700
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.2457
    Cell Significance Index: -4.2000
  • Cell Name: myoepithelial cell (CL0000185)
    Fold Change: -0.2546
    Cell Significance Index: -2.8900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.2652
    Cell Significance Index: -7.6400
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.2669
    Cell Significance Index: -2.8400
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.2731
    Cell Significance Index: -3.8300
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.2786
    Cell Significance Index: -3.5200
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.2851
    Cell Significance Index: -3.2800
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.2868
    Cell Significance Index: -3.0200
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.2910
    Cell Significance Index: -7.2700
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.2920
    Cell Significance Index: -3.4500
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.2990
    Cell Significance Index: -3.5500
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: -0.3032
    Cell Significance Index: -2.9100
  • Cell Name: promonocyte (CL0000559)
    Fold Change: -0.3090
    Cell Significance Index: -3.3000
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.3136
    Cell Significance Index: -3.5500
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: -0.3162
    Cell Significance Index: -2.8200
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.3273
    Cell Significance Index: -3.5800
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.3298
    Cell Significance Index: -4.1200
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.3350
    Cell Significance Index: -3.5800
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.3363
    Cell Significance Index: -4.3200
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: -0.3431
    Cell Significance Index: -3.5700
  • Cell Name: collagen secreting cell (CL0000667)
    Fold Change: -0.3442
    Cell Significance Index: -1.9200
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.3475
    Cell Significance Index: -4.8200
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.3482
    Cell Significance Index: -4.5700
  • Cell Name: osteoclast (CL0000092)
    Fold Change: -0.3526
    Cell Significance Index: -3.6000
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: -0.3542
    Cell Significance Index: -3.5000
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: -0.3561
    Cell Significance Index: -3.3900
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.3593
    Cell Significance Index: -4.3700
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: -0.3626
    Cell Significance Index: -3.8100
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.3644
    Cell Significance Index: -4.3700
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.3655
    Cell Significance Index: -4.4500
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.3663
    Cell Significance Index: -4.8200
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.3664
    Cell Significance Index: -4.3300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3733
    Cell Significance Index: -10.7000
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.3739
    Cell Significance Index: -4.0200
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.3750
    Cell Significance Index: -3.4800
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: -0.3753
    Cell Significance Index: -3.8100
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.3809
    Cell Significance Index: -4.1500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.3813
    Cell Significance Index: -7.9100
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.3867
    Cell Significance Index: -4.7100
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.3871
    Cell Significance Index: -4.4900
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: -0.3878
    Cell Significance Index: -3.8300
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.3884
    Cell Significance Index: -4.3000
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: -0.3912
    Cell Significance Index: -3.6300
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.3914
    Cell Significance Index: -4.2200
  • Cell Name: immature B cell (CL0000816)
    Fold Change: -0.3916
    Cell Significance Index: -3.7100
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.3922
    Cell Significance Index: -5.1200
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: -0.3923
    Cell Significance Index: -4.3300
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.3934
    Cell Significance Index: -4.5700
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.3943
    Cell Significance Index: -4.3200
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.3949
    Cell Significance Index: -4.2000
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: -0.3978
    Cell Significance Index: -3.6100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.3983
    Cell Significance Index: -8.6300
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.4000
    Cell Significance Index: -4.4300
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.4002
    Cell Significance Index: -4.5100
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.4023
    Cell Significance Index: -4.8900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.4068
    Cell Significance Index: -19.1200
  • Cell Name: eosinophil (CL0000771)
    Fold Change: -0.4075
    Cell Significance Index: -3.6100
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.4096
    Cell Significance Index: -4.3500
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: -0.4101
    Cell Significance Index: -3.7500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Immunoglobulin structure:** IGHV5-51 is a part of the immunoglobulin heavy chain variable region, which is responsible for antigen binding and recognition. 2. **Variable region:** The IGHV5-51 gene encodes for a unique variable region that is distinct from other immunoglobulin heavy chains. 3. **Expression patterns:** IGHV5-51 is significantly expressed in CD16-positive natural killer cells, CD56-dim natural killer cells, and other cell types, including granulocyte-monocyte progenitors, goblet cells, and epithelial cells. 4. **Ontology and pathways:** IGHV5-51 is involved in various biological processes, including antigen binding, extracellular region interactions, immunoglobulin complex formation, and immunoglobulin-mediated immune responses. **Pathways and Functions:** 1. **Antigen recognition:** The IGHV5-51 gene enables the recognition of antigens through binding to specific epitopes, triggering immune responses and initiating the elimination of pathogens. 2. **Immune surveillance:** IGHV5-51-expressing cells, such as natural killer cells, play a crucial role in surveillance and the elimination of tumor cells and virally infected cells. 3. **Tissue homeostasis:** The IGHV5-51 gene is also expressed in epithelial cells, where it contributes to the maintenance of tissue homeostasis and the regulation of immune responses. 4. **Immune response modulation:** IGHV5-51 may also modulate immune responses by influencing the activation, proliferation, and differentiation of immune cells. **Clinical Significance:** The IGHV5-51 gene has significant implications in various clinical contexts: 1. **Cancer immunotherapy:** The IGHV5-51 gene may serve as a target for cancer immunotherapy, as its expression is often associated with tumor cells. 2. **Infectious diseases:** IGHV5-51-expressing cells play a crucial role in the surveillance and elimination of pathogens, making it an important target for vaccine development and therapeutic interventions. 3. **Autoimmune diseases:** The IGHV5-51 gene may also contribute to the pathogenesis of autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis, where immune responses are dysregulated. 4. **Immunological disorders:** The IGHV5-51 gene may be involved in the pathogenesis of immunological disorders, such as immunodeficiency diseases and autoimmune disorders. In conclusion, the IGHV5-51 gene is a critical component of the human immune system, with significant implications in various clinical contexts. Further research is necessary to fully elucidate the functions and clinical significance of this gene, which may lead to the development of novel therapeutic strategies and a deeper understanding of immune biology.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.