Details for: TRNV

Gene ID: 4577

Symbol: TRNV

Ensembl ID: ENSG00000210077

Description: tRNA-Val

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 8.1261
    Cell Significance Index: 202.9600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 6.5372
    Cell Significance Index: 296.3100
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 5.9435
    Cell Significance Index: 76.5400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 4.9319
    Cell Significance Index: 73.9000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 3.9001
    Cell Significance Index: 112.3700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.8586
    Cell Significance Index: 50.5900
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 1.4920
    Cell Significance Index: 16.1700
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 1.3820
    Cell Significance Index: 13.3700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.1146
    Cell Significance Index: 51.9700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.9425
    Cell Significance Index: 27.7600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.8166
    Cell Significance Index: 234.9700
  • Cell Name: adipocyte (CL0000136)
    Fold Change: 0.7824
    Cell Significance Index: 10.4300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.7486
    Cell Significance Index: 38.8900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4237
    Cell Significance Index: 9.1800
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.3682
    Cell Significance Index: 3.8100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2422
    Cell Significance Index: 41.3500
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 0.1337
    Cell Significance Index: 1.5400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0419
    Cell Significance Index: 4.8000
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0023
    Cell Significance Index: -0.0200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0108
    Cell Significance Index: -19.9500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0114
    Cell Significance Index: -21.5300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0149
    Cell Significance Index: -22.9000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0182
    Cell Significance Index: -24.7700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0241
    Cell Significance Index: -15.2900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0268
    Cell Significance Index: -19.8300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0352
    Cell Significance Index: -19.8600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0524
    Cell Significance Index: -23.8000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0651
    Cell Significance Index: -4.1000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0931
    Cell Significance Index: -3.2700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1000
    Cell Significance Index: -20.0500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1159
    Cell Significance Index: -16.8500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2167
    Cell Significance Index: -22.5600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2549
    Cell Significance Index: -15.6300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2656
    Cell Significance Index: -5.5100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2780
    Cell Significance Index: -9.7400
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.3421
    Cell Significance Index: -4.4200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3457
    Cell Significance Index: -8.8900
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.3629
    Cell Significance Index: -4.5800
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.3837
    Cell Significance Index: -4.1800
  • Cell Name: muscle cell (CL0000187)
    Fold Change: -0.4171
    Cell Significance Index: -3.9900
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.4291
    Cell Significance Index: -4.4800
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.4573
    Cell Significance Index: -5.3800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.5336
    Cell Significance Index: -7.2800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5461
    Cell Significance Index: -17.4900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.6014
    Cell Significance Index: -19.6900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.6063
    Cell Significance Index: -19.3100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.6178
    Cell Significance Index: -15.4100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.6484
    Cell Significance Index: -13.8100
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.6618
    Cell Significance Index: -10.5000
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.6649
    Cell Significance Index: -16.9400
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.6719
    Cell Significance Index: -9.2900
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.6891
    Cell Significance Index: -6.9100
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.7073
    Cell Significance Index: -9.8100
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.7782
    Cell Significance Index: -9.1500
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.7947
    Cell Significance Index: -11.8900
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.7986
    Cell Significance Index: -9.5500
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.8054
    Cell Significance Index: -16.8100
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.8065
    Cell Significance Index: -16.4100
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: -0.8158
    Cell Significance Index: -8.6100
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.8536
    Cell Significance Index: -8.8500
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.8584
    Cell Significance Index: -11.9100
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.8662
    Cell Significance Index: -27.4000
  • Cell Name: salivary gland cell (CL0009005)
    Fold Change: -0.8867
    Cell Significance Index: -11.0100
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: -0.9035
    Cell Significance Index: -7.9500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.9252
    Cell Significance Index: -19.9900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.9419
    Cell Significance Index: -19.9900
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.9687
    Cell Significance Index: -13.7900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.9803
    Cell Significance Index: -19.6800
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.9821
    Cell Significance Index: -19.3300
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: -0.9940
    Cell Significance Index: -8.6900
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.9959
    Cell Significance Index: -19.8600
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.9983
    Cell Significance Index: -13.7100
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -1.0120
    Cell Significance Index: -20.0100
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -1.0134
    Cell Significance Index: -17.4700
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -1.0153
    Cell Significance Index: -10.7100
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -1.0357
    Cell Significance Index: -20.2500
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: -1.0425
    Cell Significance Index: -9.9100
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -1.0547
    Cell Significance Index: -26.3000
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -1.0577
    Cell Significance Index: -18.0800
  • Cell Name: mural cell (CL0008034)
    Fold Change: -1.0654
    Cell Significance Index: -12.9700
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -1.0719
    Cell Significance Index: -13.7700
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -1.0727
    Cell Significance Index: -10.9600
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: -1.0863
    Cell Significance Index: -13.6800
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: -1.0870
    Cell Significance Index: -11.9900
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: -1.0956
    Cell Significance Index: -6.8900
  • Cell Name: neuron (CL0000540)
    Fold Change: -1.1077
    Cell Significance Index: -10.5000
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -1.1136
    Cell Significance Index: -16.4400
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -1.1425
    Cell Significance Index: -6.7800
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -1.1550
    Cell Significance Index: -19.9700
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -1.1631
    Cell Significance Index: -14.5300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -1.1698
    Cell Significance Index: -13.9500
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -1.1903
    Cell Significance Index: -15.5400
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -1.2041
    Cell Significance Index: -14.8000
  • Cell Name: basal cell (CL0000646)
    Fold Change: -1.2151
    Cell Significance Index: -14.4600
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -1.2168
    Cell Significance Index: -14.7500
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -1.2340
    Cell Significance Index: -18.4600
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -1.2512
    Cell Significance Index: -8.1400
  • Cell Name: tracheobronchial serous cell (CL0019001)
    Fold Change: -1.2513
    Cell Significance Index: -9.4800
  • Cell Name: neuroplacodal cell (CL0000032)
    Fold Change: -1.2677
    Cell Significance Index: -15.6100
  • Cell Name: monocyte (CL0000576)
    Fold Change: -1.2740
    Cell Significance Index: -14.6600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Specific tRNA-Molecule**: tRNA-Val is a unique tRNA molecule that specifically charges with the amino acid valine, which is a fundamental component of proteins. 2. **Widespread Expression**: tRNA-Val is significantly expressed in various cell types, including enterocytes, Paneth cells, keratinocytes, and mesenchymal stem cells, suggesting its broad functional range. 3. **Cellular Specialization**: The expression of tRNA-Val in enterocytes, Paneth cells, and goblet cells suggests its involvement in intestinal immune regulation and mucosal barrier function. 4. **Heterogeneity**: The expression of tRNA-Val in different cell types and tissues highlights its potential role in diverse cellular processes, including immune response, stem cell maintenance, and cellular homeostasis. **Pathways and Functions:** 1. **Immune Response Modulation**: tRNA-Val may play a role in regulating immune responses by modulating the translation of specific mRNAs involved in immune cell function. 2. **Stem Cell Maintenance**: The expression of tRNA-Val in intestinal crypt stem cells and mesenchymal stem cells suggests its involvement in maintaining stem cell populations and promoting tissue homeostasis. 3. **Cellular Differentiation**: tRNA-Val may influence cellular differentiation processes, particularly in cells of the immune system, such as Paneth cells and innate lymphoid cells. 4. **Protein Synthesis Regulation**: The specific charging of valine by tRNA-Val may regulate protein synthesis in response to specific cellular stimuli, influencing cellular function and homeostasis. **Clinical Significance:** 1. **Intestinal Disorders**: Dysregulation of tRNA-Val expression may contribute to the pathogenesis of intestinal disorders, such as inflammatory bowel disease (IBD) and celiac disease. 2. **Immune System Dysregulation**: Alterations in tRNA-Val expression may also contribute to immune system dysregulation, leading to autoimmune diseases and other immune-related disorders. 3. **Cancer**: The expression of tRNA-Val in mesenchymal stem cells and other cell types may influence cancer development and progression, particularly in tissues with high stem cell activity. 4. **Regenerative Medicine**: Understanding the role of tRNA-Val in stem cell maintenance and cellular homeostasis may provide insights into the development of regenerative therapies for tissue repair and replacement. In conclusion, the tRNA-Val gene is a complex and multifaceted player in the regulation of immune responses and cellular homeostasis. Further research is needed to fully elucidate its role in various cellular processes and to explore its potential applications in the treatment of diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.