Details for: CLEC17A

Gene ID: 388512

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: CLEC17A

Ensembl ID: ENSG00000187912

Description: C-type lectin domain containing 17A

Selected Context(s):  Overall

Cell Significance Landscape

Contexts:

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • immature B cell CL0000816
    CSI 3.6
    rCSI 2.68%
    PRS 99.6
  • mature B cell CL0000785
    CSI 3.44
    rCSI 2.99%
    PRS 99.72
  • B cell CL0000236
    CSI 3.31
    rCSI 4.43%
    PRS 97.66

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

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  • Node Color (Target Cell CSI, relative to current network):
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    • High
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    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [CLEC17A](/details-gene/388512), also known as Prolectin, is a C-type lectin domain-containing protein that functions as a cell surface receptor. Functional annotations indicate its role as a pattern recognition receptor involved in the [immune response](/details-go/GO:0006955), with binding specificities for glycans such as D-mannose and fucose. Expression data reveals that [CLEC17A](/details-gene/388512) is a highly specific marker for the B-cell lineage, with significant expression in [immature B cell](/details-cell/CL0000816), [mature B cell](/details-cell/CL0000785), and general [B cell](/details-cell/CL0000236) populations. This is consistent with research identifying it as a glycan-binding receptor on dividing B cells within germinal centers, suggesting a role in B cell activation and differentiation [Link](https://doi.org/10.1074/jbc.m109.012807). ## Cellular Roles and Expression Landscape The expression profile of [CLEC17A](/details-gene/388512) demonstrates a highly restricted and specialized role within the hematopoietic system, specifically within the B lymphocyte lineage. **Overall**, the gene shows its most significant expression in cells central to the adaptive humoral immune response. It is a top marker in [immature B cell](/details-cell/CL0000816) (CSI: 3.60), [mature B cell](/details-cell/CL0000785) (CSI: 3.44), and the broader [B cell](/details-cell/CL0000236) population (CSI: 3.31). This specific expression pattern across B cell development stages suggests a continuous role from maturation to activation. Its identification on dividing B cells in germinal centers further points to a specialized function during affinity maturation, a critical process for generating high-affinity antibodies [Link](https://doi.org/10.1074/jbc.m109.012807). The data suggests that [CLEC17A](/details-gene/388512) is not a general immune marker but rather a B cell-centric receptor. ## Pathways and Molecular Function [CLEC17A](/details-gene/388512) functions as a transmembrane protein, with its C-type lectin domain exposed on the [external side of plasma membrane](/details-go/GO:0009897). This location is consistent with its role in cell-cell or cell-pathogen interactions. Functionally, it is annotated with [pattern recognition receptor activity](/details-go/GO:0038187), enabling it to bind specific molecular patterns. Its C-type lectin domain confers the ability to recognize carbohydrate structures, specifically [D-mannose binding](/details-go/GO:0005537) and [fucose binding](/details-go/GO:0042806). This function is central to its role in the [immune response](/details-go/GO:0006955), likely by mediating recognition of glycosylated self-antigens or pathogen-associated molecular patterns. The annotation for [identical protein binding](/details-go/GO:0042802) suggests that [CLEC17A](/details-gene/388512) may form homodimers or oligomers on the cell surface, a common mechanism for enhancing ligand avidity and initiating downstream signaling cascades. ## Research Directions The specific expression of [CLEC17A](/details-gene/388512) on B cells, particularly in the dynamic environment of the germinal center, presents several avenues for future investigation into both normal immune function and pathology. **Testable Hypotheses:** 1. Given its expression on dividing germinal center B cells [Link](https://doi.org/10.1074/jbc.m109.012807) and its glycan-binding capabilities, [CLEC17A](/details-gene/388512) may function as a co-receptor that modulates B cell receptor (BCR) signaling during affinity maturation. Its binding to specific glycan ligands on follicular dendritic cells or T follicular helper cells could provide a survival or proliferative signal to B cells presenting high-affinity antibodies. 2. The high specificity for the B cell lineage suggests that aberrant [CLEC17A](/details-gene/388512) expression or signaling could be a contributing factor in the pathogenesis of B cell malignancies, such as germinal center-derived diffuse large B-cell lymphoma (DLBCL) or follicular lymphoma, by promoting uncontrolled cell division or resistance to apoptosis. **Proposed Experiment:** To test the second hypothesis regarding its role in B-cell malignancies, a multi-faceted approach could be employed. Initially, [CLEC17A](/details-gene/388512) expression should be profiled across a cohort of B-cell lymphoma patient biopsies using immunohistochemistry and RNA-seq to correlate its levels with disease subtype and clinical outcome. To establish a causal link, CRISPR-Cas9-mediated knockout of [CLEC17A](/details-gene/388512) could be performed in established germinal center-derived lymphoma cell lines. The functional consequences would be assessed by measuring changes in cell proliferation (e.g., via BrdU incorporation assays), apoptosis (e.g., via Annexin V/PI staining and caspase activity assays), and migration in vitro. **Therapeutic Potential:** The highly restricted expression of [CLEC17A](/details-gene/388512) on the surface of B cells makes it a compelling therapeutic target. Its specificity suggests that therapies targeting this receptor could achieve high efficacy against B cell-driven diseases while minimizing off-target effects on other tissues. For B-cell malignancies, [CLEC17A](/details-gene/388512) could serve as a target for antibody-drug conjugates (ADCs) designed to deliver a cytotoxic payload directly to cancerous B cells. Alternatively, it represents a promising target for chimeric antigen receptor (CAR)-T cell therapies. In either case, the therapeutic strategy would involve targeting the receptor for cell depletion or **inhibition** of its potential pro-survival functions.

Genular Protein ID: 1960581203

Symbol: CL17A_HUMAN

Name: C-type lectin domain family 17, member A

UniProtKB Accession Codes:

Q6ZS10 A8MX68 B2RTX0 B7ZMM4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 5 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 3 ExpressionAtlas 1 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 RefSeq 2 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 19419970

Title: Prolectin, a glycan-binding receptor on dividing B cells in germinal centers.

PubMed ID: 19419970

DOI: 10.1074/jbc.m109.012807

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 378
  • Mass: 42935
  • Checksum: A2F0747289DABB6E
  • Sequence:
    • MHNLYSITGY PDPPGTMEEE EEDDDYENST PPYKDLPPKP GTMEEEEEDD DYENSTPPYK 
DLPPKPGTME EEEEDDDYEN STPPYKDLPP KPGSSAPPRP PRAAKETEKP PLPCKPRNMT 
GLDLAAVTCP PPQLAVNLEP SPLQPSLAAT PVPWLNQRSG GPGCCQKRWM VYLCLLVVTS 
LFLGCLGLTV TLIKYQELME ELRMLSFQQM TWRTNMTGMA GLAGLKHDIA RVRADTNQSL 
VELWGLLDCR RITCPEGWLP FEGKCYYFSP STKSWDEARM FCQENYSHLV IINSFAEHNF 
VAKAHGSPRV YWLGLNDRAQ EGDWRWLDGS PVTLSFWEPE EPNNIHDEDC ATMNKGGTWN 
DLSCYKTTYW ICERKCSC