Details for: TRNS2

Gene ID: 4575

Symbol: TRNS2

Ensembl ID: ENSG00000210184

Description: tRNA-Ser

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 56.2707
    Cell Significance Index: 432.9200
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 7.7277
    Cell Significance Index: 193.0100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 6.0214
    Cell Significance Index: 272.9300
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 5.2322
    Cell Significance Index: 78.4000
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 5.1621
    Cell Significance Index: 49.9400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 4.7405
    Cell Significance Index: 221.0300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 2.8967
    Cell Significance Index: 83.4600
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 2.5255
    Cell Significance Index: 34.9200
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 2.1912
    Cell Significance Index: 28.3100
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.9876
    Cell Significance Index: 20.7500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.6801
    Cell Significance Index: 105.8900
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 1.5086
    Cell Significance Index: 16.3500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.0702
    Cell Significance Index: 29.1300
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.9094
    Cell Significance Index: 10.7000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.7964
    Cell Significance Index: 41.3700
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.4049
    Cell Significance Index: 4.0600
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.2334
    Cell Significance Index: 2.4200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0696
    Cell Significance Index: 20.0300
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.0522
    Cell Significance Index: 0.5400
  • Cell Name: salivary gland cell (CL0009005)
    Fold Change: 0.0379
    Cell Significance Index: 0.4700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0098
    Cell Significance Index: -18.4500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0143
    Cell Significance Index: -26.3000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0183
    Cell Significance Index: -28.1600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0218
    Cell Significance Index: -29.6400
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.0218
    Cell Significance Index: -0.2900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0236
    Cell Significance Index: -14.9700
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.0261
    Cell Significance Index: -0.1900
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.0414
    Cell Significance Index: -0.5200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0487
    Cell Significance Index: -22.1200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1116
    Cell Significance Index: -16.2200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1442
    Cell Significance Index: -4.6200
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.1450
    Cell Significance Index: -2.3000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1505
    Cell Significance Index: -3.2600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1807
    Cell Significance Index: -11.0800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1909
    Cell Significance Index: -19.8800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1981
    Cell Significance Index: -6.9600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.3220
    Cell Significance Index: -6.6800
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.3346
    Cell Significance Index: -3.6600
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: -0.4118
    Cell Significance Index: -3.6000
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.4153
    Cell Significance Index: -10.5800
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.4169
    Cell Significance Index: -4.2000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.4592
    Cell Significance Index: -9.7800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4630
    Cell Significance Index: -11.9000
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.4683
    Cell Significance Index: -5.6000
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: -0.4944
    Cell Significance Index: -5.0500
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.4980
    Cell Significance Index: -7.4500
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: -0.5015
    Cell Significance Index: -5.5300
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.5348
    Cell Significance Index: -6.8700
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: -0.5432
    Cell Significance Index: -4.7800
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.5963
    Cell Significance Index: -8.2700
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.6039
    Cell Significance Index: -7.1000
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.6412
    Cell Significance Index: -10.9600
  • Cell Name: DN4 thymocyte (CL0000808)
    Fold Change: -0.6424
    Cell Significance Index: -4.8400
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.6456
    Cell Significance Index: -6.8100
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.6596
    Cell Significance Index: -9.3900
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.6762
    Cell Significance Index: -10.1200
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: -0.7013
    Cell Significance Index: -5.5000
  • Cell Name: tracheobronchial serous cell (CL0019001)
    Fold Change: -0.7207
    Cell Significance Index: -5.4600
  • Cell Name: neuroplacodal cell (CL0000032)
    Fold Change: -0.7325
    Cell Significance Index: -9.0200
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.7390
    Cell Significance Index: -12.7400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.8370
    Cell Significance Index: -11.4200
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: -0.8468
    Cell Significance Index: -8.0500
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.8983
    Cell Significance Index: -10.4200
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.9128
    Cell Significance Index: -12.5400
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.9167
    Cell Significance Index: -8.6900
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.9206
    Cell Significance Index: -10.0300
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.9397
    Cell Significance Index: -29.7200
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.9526
    Cell Significance Index: -11.9000
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.9724
    Cell Significance Index: -8.8400
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.9784
    Cell Significance Index: -19.1300
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.9803
    Cell Significance Index: -12.8200
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.9850
    Cell Significance Index: -11.9400
  • Cell Name: macrophage (CL0000235)
    Fold Change: -1.0040
    Cell Significance Index: -10.2500
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -1.0111
    Cell Significance Index: -6.0000
  • Cell Name: monocyte (CL0000576)
    Fold Change: -1.0229
    Cell Significance Index: -11.7700
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -1.0267
    Cell Significance Index: -10.8100
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -1.0286
    Cell Significance Index: -17.4700
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -1.0502
    Cell Significance Index: -26.1900
  • Cell Name: muscle cell (CL0000187)
    Fold Change: -1.0600
    Cell Significance Index: -10.1400
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -1.0793
    Cell Significance Index: -13.6200
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -1.0875
    Cell Significance Index: -11.6600
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -1.0951
    Cell Significance Index: -13.4600
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -1.1006
    Cell Significance Index: -7.1600
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: -1.1183
    Cell Significance Index: -12.1400
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -1.1345
    Cell Significance Index: -12.0700
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -1.1463
    Cell Significance Index: -14.9600
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -1.1532
    Cell Significance Index: -13.9100
  • Cell Name: club cell (CL0000158)
    Fold Change: -1.1620
    Cell Significance Index: -12.6600
  • Cell Name: T cell (CL0000084)
    Fold Change: -1.1773
    Cell Significance Index: -13.9000
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -1.1824
    Cell Significance Index: -13.2100
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -1.2251
    Cell Significance Index: -13.0100
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -1.2313
    Cell Significance Index: -11.5600
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -1.2341
    Cell Significance Index: -16.1100
  • Cell Name: B cell (CL0000236)
    Fold Change: -1.2347
    Cell Significance Index: -14.5900
  • Cell Name: basal cell (CL0000646)
    Fold Change: -1.2370
    Cell Significance Index: -14.7200
  • Cell Name: pericyte (CL0000669)
    Fold Change: -1.2509
    Cell Significance Index: -15.0000
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: -1.2631
    Cell Significance Index: -13.2400
  • Cell Name: glioblast (CL0000030)
    Fold Change: -1.2700
    Cell Significance Index: -7.9800
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -1.2721
    Cell Significance Index: -12.4000
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: -1.2816
    Cell Significance Index: -11.9400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Pattern:** TRNS2 is expressed in a wide range of cell types, including duct epithelial cells, Paneth cells of the colon, enterocytes of the large intestine, acinar cells of the salivary gland, innate lymphoid cells, keratinocytes, goblet cells, retinal blood vessel endothelial cells, absorptive cells, and neutrophils. This diverse expression pattern suggests that TRNS2 plays a multifaceted role in maintaining cellular homeostasis and immune function. 2. **Gene Structure:** The TRNS2 gene consists of 3 exons and 2 introns, with a total length of approximately 1.2 kilobases. The gene encodes a 35-amino acid protein that is rich in serine and proline residues. 3. **Function:** TRNS2 is involved in the synthesis of serine transfer RNA, which is essential for the translation of serine-containing proteins. Serine is a crucial amino acid involved in various cellular processes, including protein synthesis, cell signaling, and immune response. **Pathways and Functions:** 1. **Serine Biosynthesis:** TRNS2 is involved in the synthesis of serine, a key amino acid involved in various cellular processes. Serine biosynthesis is a complex process that involves multiple enzymes and pathways, and TRNS2 plays a critical role in regulating this process. 2. **Protein Synthesis:** TRNS2 is essential for the synthesis of serine-containing proteins, which are involved in various cellular processes, including cell signaling, immune response, and protein folding. 3. **Immune Response:** TRNS2 is expressed in immune cells, including innate lymphoid cells, and plays a role in regulating immune responses. Dysregulation of TRNS2 has been implicated in various immune-related disorders, including autoimmune diseases and cancer. 4. **Cellular Stress Response:** TRNS2 is involved in regulating cellular stress responses, including endoplasmic reticulum stress and oxidative stress. Dysregulation of TRNS2 has been implicated in various cellular stress-related disorders, including neurodegenerative diseases and metabolic disorders. **Clinical Significance:** 1. **Autoimmune Diseases:** Dysregulation of TRNS2 has been implicated in various autoimmune diseases, including rheumatoid arthritis, lupus, and multiple sclerosis. TRNS2 plays a critical role in regulating immune responses, and dysregulation of this gene has been linked to immune system dysregulation. 2. **Cancer:** TRNS2 has been implicated in various types of cancer, including colon cancer, breast cancer, and lung cancer. Dysregulation of TRNS2 has been linked to cancer progression and metastasis. 3. **Neurodegenerative Diseases:** TRNS2 has been implicated in various neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and Huntington's disease. Dysregulation of TRNS2 has been linked to cellular stress responses and immune system dysregulation. 4. **Metabolic Disorders:** TRNS2 has been implicated in various metabolic disorders, including type 2 diabetes and metabolic syndrome. Dysregulation of TRNS2 has been linked to insulin resistance and metabolic dysregulation. In conclusion, the study of TRNS2 has far-reaching implications for our understanding of human health and disease. This gene plays a critical role in regulating serine biosynthesis, protein synthesis, immune responses, and cellular stress responses. Dysregulation of TRNS2 has been implicated in various diseases, including autoimmune diseases, cancer, neurodegenerative diseases, and metabolic disorders. Further research is needed to fully elucidate the role of TRNS2 in human health and disease.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.