IGHV3 7 | ENSG00000211938 | NCBI 28452

Details for: IGHV3 7

Gene ID: 28452

Symbol: IGHV3 7

Ensembl ID: ENSG00000211938

Description: immunoglobulin heavy variable 3-7

Associated with

Adaptive immune system
(R-HSA-1280218)
Anti-inflammatory response favouring leishmania parasite infection
(R-HSA-9662851)
Antigen activates b cell receptor (bcr) leading to generation of second messengers
(R-HSA-983695)
Binding and uptake of ligands by scavenger receptors
(R-HSA-2173782)
Cd22 mediated bcr regulation
(R-HSA-5690714)
Cell surface interactions at the vascular wall
(R-HSA-202733)
Classical antibody-mediated complement activation
(R-HSA-173623)
Complement cascade
(R-HSA-166658)
Creation of c4 and c2 activators
(R-HSA-166786)
Disease
(R-HSA-1643685)
Fc epsilon receptor (fceri) signaling
(R-HSA-2454202)
Fceri mediated ca+2 mobilization
(R-HSA-2871809)
Fceri mediated mapk activation
(R-HSA-2871796)
Fceri mediated nf-kb activation
(R-HSA-2871837)
Fcgamma receptor (fcgr) dependent phagocytosis
(R-HSA-2029480)
Fcgr3a-mediated il10 synthesis
(R-HSA-9664323)
Fcgr3a-mediated phagocytosis
(R-HSA-9664422)
Fcgr activation
(R-HSA-2029481)
Hemostasis
(R-HSA-109582)
Immune system
(R-HSA-168256)
Immunoregulatory interactions between a lymphoid and a non-lymphoid cell
(R-HSA-198933)
Infectious disease
(R-HSA-5663205)
Initial triggering of complement
(R-HSA-166663)
Innate immune system
(R-HSA-168249)
Leishmania infection
(R-HSA-9658195)
Leishmania parasite growth and survival
(R-HSA-9664433)
Leishmania phagocytosis
(R-HSA-9664417)
Parasite infection
(R-HSA-9664407)
Parasitic infection pathways
(R-HSA-9824443)
Potential therapeutics for sars
(R-HSA-9679191)
Regulation of actin dynamics for phagocytic cup formation
(R-HSA-2029482)
Regulation of complement cascade
(R-HSA-977606)
Role of lat2/ntal/lab on calcium mobilization
(R-HSA-2730905)
Role of phospholipids in phagocytosis
(R-HSA-2029485)
Sars-cov infections
(R-HSA-9679506)
Scavenging of heme from plasma
(R-HSA-2168880)
Signaling by the b cell receptor (bcr)
(R-HSA-983705)
Vesicle-mediated transport
(R-HSA-5653656)
Viral infection pathways
(R-HSA-9824446)
Antigen binding
(GO:0003823)
Blood microparticle
(GO:0072562)
Extracellular exosome
(GO:0070062)
Extracellular region
(GO:0005576)
Immune response
(GO:0006955)
Immunoglobulin complex
(GO:0019814)
Immunoglobulin mediated immune response
(GO:0016064)
Plasma membrane
(GO:0005886)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 12.4291
Cell Significance Index: 257.8300
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 5.6883
Cell Significance Index: 199.8800
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 3.9714
Cell Significance Index: 99.2800
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 3.7946
Cell Significance Index: 82.2100
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 3.3446
Cell Significance Index: 96.3700
Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: 3.3180
Cell Significance Index: 50.0000
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 1.7971
Cell Significance Index: 20.0900
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.9368
Cell Significance Index: 178.2800
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.8064
Cell Significance Index: 36.5500
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.7531
Cell Significance Index: 45.2100
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.5879
Cell Significance Index: 12.5200
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.4609
Cell Significance Index: 50.1300
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.4053
Cell Significance Index: 5.8900
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.2984
Cell Significance Index: 29.5200
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.2514
Cell Significance Index: 226.9700
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.2333
Cell Significance Index: 16.1400
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.2024
Cell Significance Index: 32.9200
Cell Name: odontoblast (CL0000060)
Fold Change: 0.0112
Cell Significance Index: 1.4400
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: -0.0006
Cell Significance Index: -0.0100
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0052
Cell Significance Index: -3.9200
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0077
Cell Significance Index: -0.4700
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.0206
Cell Significance Index: -0.6600
Cell Name: keratinocyte (CL0000312)
Fold Change: -0.0248
Cell Significance Index: -0.6200
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0446
Cell Significance Index: -4.5600
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0463
Cell Significance Index: -2.1600
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.0473
Cell Significance Index: -1.2700
Cell Name: lactocyte (CL0002325)
Fold Change: -0.0501
Cell Significance Index: -6.4700
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.0785
Cell Significance Index: -4.0800
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.0879
Cell Significance Index: -6.5500
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.0940
Cell Significance Index: -2.5600
Cell Name: squamous epithelial cell (CL0000076)
Fold Change: -0.1480
Cell Significance Index: -1.8000
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.1509
Cell Significance Index: -7.0900
Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: -0.1580
Cell Significance Index: -3.9400
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.1607
Cell Significance Index: -4.1100
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.1880
Cell Significance Index: -6.9000
Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: -0.1931
Cell Significance Index: -2.5300
Cell Name: lymphocyte (CL0000542)
Fold Change: -0.2014
Cell Significance Index: -2.7400
Cell Name: plasma cell (CL0000786)
Fold Change: -0.2068
Cell Significance Index: -2.3100
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: -0.2191
Cell Significance Index: -2.5900
Cell Name: thymocyte (CL0000893)
Fold Change: -0.2200
Cell Significance Index: -2.7800
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.2254
Cell Significance Index: -2.5600
Cell Name: erythrocyte (CL0000232)
Fold Change: -0.2351
Cell Significance Index: -5.9900
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: -0.2429
Cell Significance Index: -2.8600
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.2466
Cell Significance Index: -7.0700
Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: -0.2476
Cell Significance Index: -2.0800
Cell Name: common dendritic progenitor (CL0001029)
Fold Change: -0.2508
Cell Significance Index: -2.6100
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.2531
Cell Significance Index: -6.1300
Cell Name: hematopoietic cell (CL0000988)
Fold Change: -0.2543
Cell Significance Index: -3.7200
Cell Name: ionocyte (CL0005006)
Fold Change: -0.2554
Cell Significance Index: -2.6700
Cell Name: precursor B cell (CL0000817)
Fold Change: -0.2612
Cell Significance Index: -3.3800
Cell Name: naive regulatory T cell (CL0002677)
Fold Change: -0.2634
Cell Significance Index: -2.3700
Cell Name: megakaryocyte (CL0000556)
Fold Change: -0.2692
Cell Significance Index: -4.3600
Cell Name: IgA plasma cell (CL0000987)
Fold Change: -0.2778
Cell Significance Index: -1.8500
Cell Name: hepatocyte (CL0000182)
Fold Change: -0.2866
Cell Significance Index: -3.9800
Cell Name: peg cell (CL4033014)
Fold Change: -0.2870
Cell Significance Index: -6.6300
Cell Name: common lymphoid progenitor (CL0000051)
Fold Change: -0.2886
Cell Significance Index: -2.9300
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: -0.2918
Cell Significance Index: -3.6100
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: -0.3019
Cell Significance Index: -4.1400
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: -0.3066
Cell Significance Index: -6.0000
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -0.3140
Cell Significance Index: -5.2900
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.3198
Cell Significance Index: -5.9100
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: -0.3212
Cell Significance Index: -4.0700
Cell Name: leukocyte (CL0000738)
Fold Change: -0.3282
Cell Significance Index: -5.5800
Cell Name: primitive red blood cell (CL0002355)
Fold Change: -0.3335
Cell Significance Index: -3.7800
Cell Name: progenitor cell (CL0011026)
Fold Change: -0.3370
Cell Significance Index: -3.5800
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: -0.3416
Cell Significance Index: -5.8400
Cell Name: plasmablast (CL0000980)
Fold Change: -0.3416
Cell Significance Index: -3.1700
Cell Name: stromal cell (CL0000499)
Fold Change: -0.3475
Cell Significance Index: -3.5500
Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -0.3489
Cell Significance Index: -5.1500
Cell Name: double negative thymocyte (CL0002489)
Fold Change: -0.3504
Cell Significance Index: -4.1600
Cell Name: IgG plasmablast (CL0000982)
Fold Change: -0.3622
Cell Significance Index: -2.9900
Cell Name: naive B cell (CL0000788)
Fold Change: -0.3695
Cell Significance Index: -3.8900
Cell Name: transit amplifying cell (CL0009010)
Fold Change: -0.3698
Cell Significance Index: -3.5500
Cell Name: neutrophil (CL0000775)
Fold Change: -0.3698
Cell Significance Index: -4.6200
Cell Name: promonocyte (CL0000559)
Fold Change: -0.3698
Cell Significance Index: -3.9500
Cell Name: Hofbauer cell (CL3000001)
Fold Change: -0.3754
Cell Significance Index: -3.0600
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: -0.3767
Cell Significance Index: -4.1200
Cell Name: IgG plasma cell (CL0000985)
Fold Change: -0.3838
Cell Significance Index: -3.5100
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: -0.3865
Cell Significance Index: -6.8300
Cell Name: B cell (CL0000236)
Fold Change: -0.3969
Cell Significance Index: -4.6900
Cell Name: osteoclast (CL0000092)
Fold Change: -0.3997
Cell Significance Index: -4.0800
Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: -0.4020
Cell Significance Index: -2.4900
Cell Name: endothelial stalk cell (CL0002671)
Fold Change: -0.4025
Cell Significance Index: -4.5100
Cell Name: IgA plasmablast (CL0000984)
Fold Change: -0.4081
Cell Significance Index: -3.2800
Cell Name: acinar cell (CL0000622)
Fold Change: -0.4164
Cell Significance Index: -5.2300
Cell Name: muscle cell (CL0000187)
Fold Change: -0.4171
Cell Significance Index: -3.9900
Cell Name: monocyte (CL0000576)
Fold Change: -0.4215
Cell Significance Index: -4.8500
Cell Name: vascular associated smooth muscle cell (CL0000359)
Fold Change: -0.4266
Cell Significance Index: -4.5300
Cell Name: club cell (CL0000158)
Fold Change: -0.4268
Cell Significance Index: -4.6500
Cell Name: memory B cell (CL0000787)
Fold Change: -0.4277
Cell Significance Index: -4.5500
Cell Name: immature B cell (CL0000816)
Fold Change: -0.4280
Cell Significance Index: -4.0500
Cell Name: ciliated cell (CL0000064)
Fold Change: -0.4350
Cell Significance Index: -4.7100
Cell Name: smooth muscle cell (CL0000192)
Fold Change: -0.4407
Cell Significance Index: -5.1200
Cell Name: basophil mast progenitor cell (CL0002028)
Fold Change: -0.4491
Cell Significance Index: -3.7900
Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
Fold Change: -0.4515
Cell Significance Index: -4.8800
Cell Name: T-helper 17 cell (CL0000899)
Fold Change: -0.4548
Cell Significance Index: -3.4700
Cell Name: cholangiocyte (CL1000488)
Fold Change: -0.4566
Cell Significance Index: -4.5100
Cell Name: early lymphoid progenitor (CL0000936)
Fold Change: -0.4600
Cell Significance Index: -4.6700
Cell Name: serous secreting cell of bronchus submucosal gland (CL4033005)
Fold Change: -0.4617
Cell Significance Index: -4.6200
Cell Name: fibroblast of lung (CL0002553)
Fold Change: -0.4619
Cell Significance Index: -5.4900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Other Information

Description

**Key Characteristics:** 1. **Immunoglobulin heavy chain**: The IGHV3-7 gene encodes for a variable region of the immunoglobulin heavy chain, which is essential for the recognition and binding of antigens. 2. **Adaptive immune system**: The IGHV3-7 gene is involved in the adaptive immune response, which is a specific and highly effective defense mechanism against pathogens. 3. **B cell receptor (BCR) signaling**: The IGHV3-7 gene is activated by the BCR, leading to the generation of second messengers and subsequent immune responses. 4. **Complement cascade regulation**: The IGHV3-7 gene plays a role in regulating the complement cascade, which is a critical component of the innate immune response. **Pathways and Functions:** The IGHV3-7 gene is involved in various immune pathways, including: 1. **Antigen binding and uptake**: The IGHV3-7 gene is involved in the binding and uptake of antigens by immune cells, such as B cells and macrophages. 2. **B cell activation**: The IGHV3-7 gene is activated by the BCR, leading to the activation of B cells and the production of antibodies. 3. **Complement cascade regulation**: The IGHV3-7 gene plays a role in regulating the complement cascade, which is a critical component of the innate immune response. 4. **Immune response modulation**: The IGHV3-7 gene is involved in modulating the immune response, including the regulation of inflammation and the production of cytokines. 5. **Scavenging of pathogens**: The IGHV3-7 gene is involved in the scavenging of pathogens, including Leishmania parasites, through the activation of phagocytic cells. **Clinical Significance:** The IGHV3-7 gene has significant clinical implications in various diseases, including: 1. **Leishmaniasis**: The IGHV3-7 gene is involved in the pathogenesis of Leishmaniasis, a disease caused by Leishmania parasites. 2. **Autoimmune diseases**: The IGHV3-7 gene may be involved in the pathogenesis of autoimmune diseases, such as rheumatoid arthritis and lupus, due to its role in regulating the immune response. 3. **Cancer**: The IGHV3-7 gene may be involved in the development of cancer, as it is involved in the regulation of immune responses and the activation of immune cells. 4. **Infectious diseases**: The IGHV3-7 gene is involved in the regulation of immune responses to infectious diseases, including viral and bacterial infections. 5. **Vaccine development**: The IGHV3-7 gene may be a target for vaccine development, as it is involved in the regulation of immune responses and the activation of immune cells. In conclusion, the IGHV3-7 gene plays a critical role in the adaptive immune system, and its dysregulation may contribute to various diseases. Further research is needed to fully understand the clinical significance of this gene and its potential applications in immunotherapy and vaccine development.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.