IGHV3 7 | ENSG00000211938 | NCBI 28452

Details for: IGHV3 7

Gene ID: 28452

Symbol: IGHV3 7

Ensembl ID: ENSG00000211938

Description: immunoglobulin heavy variable 3-7

Associated with

Adaptive immune system
(R-HSA-1280218)
Anti-inflammatory response favouring leishmania parasite infection
(R-HSA-9662851)
Antigen activates b cell receptor (bcr) leading to generation of second messengers
(R-HSA-983695)
Binding and uptake of ligands by scavenger receptors
(R-HSA-2173782)
Cd22 mediated bcr regulation
(R-HSA-5690714)
Cell surface interactions at the vascular wall
(R-HSA-202733)
Classical antibody-mediated complement activation
(R-HSA-173623)
Complement cascade
(R-HSA-166658)
Creation of c4 and c2 activators
(R-HSA-166786)
Disease
(R-HSA-1643685)
Fc epsilon receptor (fceri) signaling
(R-HSA-2454202)
Fceri mediated ca+2 mobilization
(R-HSA-2871809)
Fceri mediated mapk activation
(R-HSA-2871796)
Fceri mediated nf-kb activation
(R-HSA-2871837)
Fcgamma receptor (fcgr) dependent phagocytosis
(R-HSA-2029480)
Fcgr3a-mediated il10 synthesis
(R-HSA-9664323)
Fcgr3a-mediated phagocytosis
(R-HSA-9664422)
Fcgr activation
(R-HSA-2029481)
Hemostasis
(R-HSA-109582)
Immune system
(R-HSA-168256)
Immunoregulatory interactions between a lymphoid and a non-lymphoid cell
(R-HSA-198933)
Infectious disease
(R-HSA-5663205)
Initial triggering of complement
(R-HSA-166663)
Innate immune system
(R-HSA-168249)
Leishmania infection
(R-HSA-9658195)
Leishmania parasite growth and survival
(R-HSA-9664433)
Leishmania phagocytosis
(R-HSA-9664417)
Parasite infection
(R-HSA-9664407)
Parasitic infection pathways
(R-HSA-9824443)
Potential therapeutics for sars
(R-HSA-9679191)
Regulation of actin dynamics for phagocytic cup formation
(R-HSA-2029482)
Regulation of complement cascade
(R-HSA-977606)
Role of lat2/ntal/lab on calcium mobilization
(R-HSA-2730905)
Role of phospholipids in phagocytosis
(R-HSA-2029485)
Sars-cov infections
(R-HSA-9679506)
Scavenging of heme from plasma
(R-HSA-2168880)
Signaling by the b cell receptor (bcr)
(R-HSA-983705)
Vesicle-mediated transport
(R-HSA-5653656)
Viral infection pathways
(R-HSA-9824446)
Antigen binding
(GO:0003823)
Blood microparticle
(GO:0072562)
Extracellular exosome
(GO:0070062)
Extracellular region
(GO:0005576)
Immune response
(GO:0006955)
Immunoglobulin complex
(GO:0019814)
Immunoglobulin mediated immune response
(GO:0016064)
Plasma membrane
(GO:0005886)

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: glutamatergic neuron (CL0000679)
Fold Change: 15.99
Marker Score: 162,071
Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: 6.68
Marker Score: 8,265
Cell Name: microglial cell (CL0000129)
Fold Change: 3.75
Marker Score: 6,831
Cell Name: blood vessel endothelial cell (CL0000071)
Fold Change: 2.21
Marker Score: 2,229
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 2
Marker Score: 1,990
Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.6
Marker Score: 1,165
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 1.36
Marker Score: 865
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 1.26
Marker Score: 850
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 1.16
Marker Score: 483
Cell Name: goblet cell (CL0000160)
Fold Change: 1.15
Marker Score: 7,644
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.15
Marker Score: 4,808
Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
Fold Change: 1.12
Marker Score: 870
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 1.04
Marker Score: 251,802
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 1.04
Marker Score: 791
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71,820
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48,045
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30,407
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.98
Marker Score: 505
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.97
Marker Score: 458
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2,412
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.93
Marker Score: 5,323
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.92
Marker Score: 370
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2,740
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.9
Marker Score: 323
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5,294
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.87
Marker Score: 400
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.83
Marker Score: 1,343
Cell Name: brush cell (CL0002204)
Fold Change: 0.77
Marker Score: 707
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.76
Marker Score: 393
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.72
Marker Score: 458
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.69
Marker Score: 177
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.56
Marker Score: 444
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.55
Marker Score: 146
Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
Fold Change: 0.52
Marker Score: 563
Cell Name: IgG plasmablast (CL0000982)
Fold Change: 0.49
Marker Score: 135
Cell Name: IgA plasmablast (CL0000984)
Fold Change: 0.48
Marker Score: 126
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.46
Marker Score: 275
Cell Name: megakaryocyte (CL0000556)
Fold Change: 0.45
Marker Score: 253
Cell Name: IgA plasma cell (CL0000987)
Fold Change: 0.44
Marker Score: 375
Cell Name: double negative thymocyte (CL0002489)
Fold Change: 0.39
Marker Score: 535
Cell Name: plasmablast (CL0000980)
Fold Change: 0.35
Marker Score: 463
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.32
Marker Score: 100
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 0.31
Marker Score: 784
Cell Name: unswitched memory B cell (CL0000970)
Fold Change: 0.3
Marker Score: 176
Cell Name: IgG plasma cell (CL0000985)
Fold Change: 0.29
Marker Score: 127
Cell Name: blood cell (CL0000081)
Fold Change: 0.26
Marker Score: 3,038
Cell Name: IgM plasma cell (CL0000986)
Fold Change: 0.26
Marker Score: 89
Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
Fold Change: 0.25
Marker Score: 214
Cell Name: class switched memory B cell (CL0000972)
Fold Change: 0.25
Marker Score: 231
Cell Name: B cell (CL0000236)
Fold Change: 0.23
Marker Score: 220
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.22
Marker Score: 63
Cell Name: small pre-B-II cell (CL0000954)
Fold Change: 0.22
Marker Score: 260
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.22
Marker Score: 73
Cell Name: endothelial cell (CL0000115)
Fold Change: 0.22
Marker Score: 193
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.21
Marker Score: 137
Cell Name: glial cell (CL0000125)
Fold Change: 0.2
Marker Score: 223
Cell Name: mucosal invariant T cell (CL0000940)
Fold Change: 0.2
Marker Score: 179
Cell Name: erythrocyte (CL0000232)
Fold Change: 0.2
Marker Score: 109
Cell Name: CD38-negative naive B cell (CL0002102)
Fold Change: 0.19
Marker Score: 407
Cell Name: mast cell (CL0000097)
Fold Change: 0.18
Marker Score: 105
Cell Name: myeloid cell (CL0000763)
Fold Change: 0.18
Marker Score: 288
Cell Name: immature B cell (CL0000816)
Fold Change: 0.18
Marker Score: 119
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.17
Marker Score: 42
Cell Name: double negative T regulatory cell (CL0011024)
Fold Change: 0.16
Marker Score: 159
Cell Name: plasma cell (CL0000786)
Fold Change: 0.16
Marker Score: 179
Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
Fold Change: 0.16
Marker Score: 138
Cell Name: follicular B cell (CL0000843)
Fold Change: 0.15
Marker Score: 161
Cell Name: T follicular helper cell (CL0002038)
Fold Change: 0.15
Marker Score: 122
Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
Fold Change: 0.14
Marker Score: 234
Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
Fold Change: 0.14
Marker Score: 320
Cell Name: mature NK T cell (CL0000814)
Fold Change: 0.14
Marker Score: 65
Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
Fold Change: 0.14
Marker Score: 271
Cell Name: memory B cell (CL0000787)
Fold Change: 0.14
Marker Score: 104
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 0.14
Marker Score: 138
Cell Name: pre-B-I cell (CL0000956)
Fold Change: 0.14
Marker Score: 35
Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
Fold Change: 0.13
Marker Score: 28
Cell Name: platelet (CL0000233)
Fold Change: 0.13
Marker Score: 57
Cell Name: B-1 B cell (CL0000819)
Fold Change: 0.13
Marker Score: 219
Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
Fold Change: 0.12
Marker Score: 28
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.12
Marker Score: 52
Cell Name: B-2 B cell (CL0000822)
Fold Change: 0.12
Marker Score: 153
Cell Name: B-1b B cell (CL0000821)
Fold Change: 0.12
Marker Score: 27
Cell Name: naive B cell (CL0000788)
Fold Change: 0.11
Marker Score: 102
Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
Fold Change: 0.11
Marker Score: 31
Cell Name: plasmacytoid dendritic cell, human (CL0001058)
Fold Change: 0.11
Marker Score: 29
Cell Name: thymocyte (CL0000893)
Fold Change: 0.11
Marker Score: 114
Cell Name: epithelial fate stem cell (CL0000036)
Fold Change: 0.11
Marker Score: 31
Cell Name: large pre-B-II cell (CL0000957)
Fold Change: 0.11
Marker Score: 292
Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
Fold Change: 0.11
Marker Score: 31
Cell Name: ILC1, human (CL0001077)
Fold Change: 0.11
Marker Score: 27
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 0.11
Marker Score: 56
Cell Name: hematopoietic cell (CL0000988)
Fold Change: 0.11
Marker Score: 70
Cell Name: dendritic cell (CL0000451)
Fold Change: 0.1
Marker Score: 72
Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
Fold Change: 0.1
Marker Score: 84
Cell Name: retinal pigment epithelial cell (CL0002586)
Fold Change: 0.1
Marker Score: 30
Cell Name: inflammatory macrophage (CL0000863)
Fold Change: 0.1
Marker Score: 31
Cell Name: M cell of gut (CL0000682)
Fold Change: 0.1
Marker Score: 25
Cell Name: mature B cell (CL0000785)
Fold Change: 0.1
Marker Score: 70
Cell Name: gamma-delta T cell (CL0000798)
Fold Change: 0.09
Marker Score: 63
Cell Name: T-helper 17 cell (CL0000899)
Fold Change: 0.09
Marker Score: 60

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

Description

**Key Characteristics:** 1. **Immunoglobulin heavy chain**: The IGHV3-7 gene encodes for a variable region of the immunoglobulin heavy chain, which is essential for the recognition and binding of antigens. 2. **Adaptive immune system**: The IGHV3-7 gene is involved in the adaptive immune response, which is a specific and highly effective defense mechanism against pathogens. 3. **B cell receptor (BCR) signaling**: The IGHV3-7 gene is activated by the BCR, leading to the generation of second messengers and subsequent immune responses. 4. **Complement cascade regulation**: The IGHV3-7 gene plays a role in regulating the complement cascade, which is a critical component of the innate immune response. **Pathways and Functions:** The IGHV3-7 gene is involved in various immune pathways, including: 1. **Antigen binding and uptake**: The IGHV3-7 gene is involved in the binding and uptake of antigens by immune cells, such as B cells and macrophages. 2. **B cell activation**: The IGHV3-7 gene is activated by the BCR, leading to the activation of B cells and the production of antibodies. 3. **Complement cascade regulation**: The IGHV3-7 gene plays a role in regulating the complement cascade, which is a critical component of the innate immune response. 4. **Immune response modulation**: The IGHV3-7 gene is involved in modulating the immune response, including the regulation of inflammation and the production of cytokines. 5. **Scavenging of pathogens**: The IGHV3-7 gene is involved in the scavenging of pathogens, including Leishmania parasites, through the activation of phagocytic cells. **Clinical Significance:** The IGHV3-7 gene has significant clinical implications in various diseases, including: 1. **Leishmaniasis**: The IGHV3-7 gene is involved in the pathogenesis of Leishmaniasis, a disease caused by Leishmania parasites. 2. **Autoimmune diseases**: The IGHV3-7 gene may be involved in the pathogenesis of autoimmune diseases, such as rheumatoid arthritis and lupus, due to its role in regulating the immune response. 3. **Cancer**: The IGHV3-7 gene may be involved in the development of cancer, as it is involved in the regulation of immune responses and the activation of immune cells. 4. **Infectious diseases**: The IGHV3-7 gene is involved in the regulation of immune responses to infectious diseases, including viral and bacterial infections. 5. **Vaccine development**: The IGHV3-7 gene may be a target for vaccine development, as it is involved in the regulation of immune responses and the activation of immune cells. In conclusion, the IGHV3-7 gene plays a critical role in the adaptive immune system, and its dysregulation may contribute to various diseases. Further research is needed to fully understand the clinical significance of this gene and its potential applications in immunotherapy and vaccine development.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.