IGHV4 39 | ENSG00000211959 | NCBI 28394

Details for: IGHV4 39

Gene ID: 28394

Symbol: IGHV4 39

Ensembl ID: ENSG00000211959

Description: immunoglobulin heavy variable 4-39

Associated with

Adaptive immune system
(R-HSA-1280218)
Anti-inflammatory response favouring leishmania parasite infection
(R-HSA-9662851)
Antigen activates b cell receptor (bcr) leading to generation of second messengers
(R-HSA-983695)
Binding and uptake of ligands by scavenger receptors
(R-HSA-2173782)
Cd22 mediated bcr regulation
(R-HSA-5690714)
Cell surface interactions at the vascular wall
(R-HSA-202733)
Classical antibody-mediated complement activation
(R-HSA-173623)
Complement cascade
(R-HSA-166658)
Creation of c4 and c2 activators
(R-HSA-166786)
Disease
(R-HSA-1643685)
Fc epsilon receptor (fceri) signaling
(R-HSA-2454202)
Fceri mediated ca+2 mobilization
(R-HSA-2871809)
Fceri mediated mapk activation
(R-HSA-2871796)
Fceri mediated nf-kb activation
(R-HSA-2871837)
Fcgamma receptor (fcgr) dependent phagocytosis
(R-HSA-2029480)
Fcgr3a-mediated il10 synthesis
(R-HSA-9664323)
Fcgr3a-mediated phagocytosis
(R-HSA-9664422)
Fcgr activation
(R-HSA-2029481)
Hemostasis
(R-HSA-109582)
Immune system
(R-HSA-168256)
Immunoregulatory interactions between a lymphoid and a non-lymphoid cell
(R-HSA-198933)
Infectious disease
(R-HSA-5663205)
Initial triggering of complement
(R-HSA-166663)
Innate immune system
(R-HSA-168249)
Leishmania infection
(R-HSA-9658195)
Leishmania parasite growth and survival
(R-HSA-9664433)
Leishmania phagocytosis
(R-HSA-9664417)
Parasite infection
(R-HSA-9664407)
Parasitic infection pathways
(R-HSA-9824443)
Potential therapeutics for sars
(R-HSA-9679191)
Regulation of actin dynamics for phagocytic cup formation
(R-HSA-2029482)
Regulation of complement cascade
(R-HSA-977606)
Role of lat2/ntal/lab on calcium mobilization
(R-HSA-2730905)
Role of phospholipids in phagocytosis
(R-HSA-2029485)
Sars-cov infections
(R-HSA-9679506)
Scavenging of heme from plasma
(R-HSA-2168880)
Signaling by the b cell receptor (bcr)
(R-HSA-983705)
Vesicle-mediated transport
(R-HSA-5653656)
Viral infection pathways
(R-HSA-9824446)
Antigen binding
(GO:0003823)
Extracellular region
(GO:0005576)
Immune response
(GO:0006955)
Immunoglobulin complex
(GO:0019814)
Immunoglobulin mediated immune response
(GO:0016064)
Plasma membrane
(GO:0005886)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 1.6915
Cell Significance Index: 18.9100
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 0.6373
Cell Significance Index: 9.8600
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.3127
Cell Significance Index: 4.5400
Cell Name: cytotoxic T cell (CL0000910)
Fold Change: 0.2007
Cell Significance Index: 2.9300
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0057
Cell Significance Index: -4.3100
Cell Name: odontoblast (CL0000060)
Fold Change: -0.0200
Cell Significance Index: -2.5700
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0391
Cell Significance Index: -3.9900
Cell Name: keratinocyte (CL0000312)
Fold Change: -0.0570
Cell Significance Index: -1.4200
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.0682
Cell Significance Index: -1.8300
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0713
Cell Significance Index: -4.3700
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.0830
Cell Significance Index: -4.3100
Cell Name: blood cell (CL0000081)
Fold Change: -0.0839
Cell Significance Index: -0.7200
Cell Name: lactocyte (CL0002325)
Fold Change: -0.0855
Cell Significance Index: -11.0400
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0870
Cell Significance Index: -14.8600
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.0929
Cell Significance Index: -4.2100
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: -0.1083
Cell Significance Index: -1.3400
Cell Name: helper T cell (CL0000912)
Fold Change: -0.1207
Cell Significance Index: -1.7100
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.1495
Cell Significance Index: -11.1400
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.1679
Cell Significance Index: -4.2900
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.1686
Cell Significance Index: -7.8600
Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: -0.1760
Cell Significance Index: -4.3900
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: -0.1822
Cell Significance Index: -2.6200
Cell Name: erythrocyte (CL0000232)
Fold Change: -0.1972
Cell Significance Index: -5.0300
Cell Name: IgA plasma cell (CL0000987)
Fold Change: -0.2012
Cell Significance Index: -1.3400
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.2044
Cell Significance Index: -4.9500
Cell Name: plasma cell (CL0000786)
Fold Change: -0.2059
Cell Significance Index: -2.3000
Cell Name: leukocyte (CL0000738)
Fold Change: -0.2126
Cell Significance Index: -3.6100
Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
Fold Change: -0.2204
Cell Significance Index: -2.6600
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: -0.2207
Cell Significance Index: -4.3200
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.2229
Cell Significance Index: -4.1200
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.2239
Cell Significance Index: -6.4500
Cell Name: lymphocyte (CL0000542)
Fold Change: -0.2257
Cell Significance Index: -3.0700
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: -0.2373
Cell Significance Index: -2.8100
Cell Name: megakaryocyte (CL0000556)
Fold Change: -0.2602
Cell Significance Index: -4.2200
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: -0.2609
Cell Significance Index: -4.4600
Cell Name: precursor B cell (CL0000817)
Fold Change: -0.2612
Cell Significance Index: -3.3800
Cell Name: double negative thymocyte (CL0002489)
Fold Change: -0.2687
Cell Significance Index: -3.1900
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: -0.2723
Cell Significance Index: -3.4500
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: -0.2843
Cell Significance Index: -3.3500
Cell Name: naive B cell (CL0000788)
Fold Change: -0.2868
Cell Significance Index: -3.0200
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: -0.2961
Cell Significance Index: -4.0600
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -0.2968
Cell Significance Index: -5.0000
Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: -0.3028
Cell Significance Index: -3.9600
Cell Name: stromal cell (CL0000499)
Fold Change: -0.3122
Cell Significance Index: -3.1900
Cell Name: thymocyte (CL0000893)
Fold Change: -0.3142
Cell Significance Index: -3.9700
Cell Name: hepatocyte (CL0000182)
Fold Change: -0.3144
Cell Significance Index: -4.3600
Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -0.3205
Cell Significance Index: -4.7300
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: -0.3209
Cell Significance Index: -4.1100
Cell Name: endothelial cell of vascular tree (CL0002139)
Fold Change: -0.3277
Cell Significance Index: -4.5000
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.3286
Cell Significance Index: -7.1200
Cell Name: B cell (CL0000236)
Fold Change: -0.3309
Cell Significance Index: -3.9100
Cell Name: memory B cell (CL0000787)
Fold Change: -0.3337
Cell Significance Index: -3.5500
Cell Name: monocyte (CL0000576)
Fold Change: -0.3355
Cell Significance Index: -3.8600
Cell Name: IgA plasmablast (CL0000984)
Fold Change: -0.3360
Cell Significance Index: -2.7000
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.3394
Cell Significance Index: -7.0400
Cell Name: early lymphoid progenitor (CL0000936)
Fold Change: -0.3408
Cell Significance Index: -3.4600
Cell Name: mesangial cell (CL0000650)
Fold Change: -0.3438
Cell Significance Index: -4.3500
Cell Name: promonocyte (CL0000559)
Fold Change: -0.3492
Cell Significance Index: -3.7300
Cell Name: primitive red blood cell (CL0002355)
Fold Change: -0.3494
Cell Significance Index: -3.9600
Cell Name: innate lymphoid cell (CL0001065)
Fold Change: -0.3503
Cell Significance Index: -4.5000
Cell Name: plasmablast (CL0000980)
Fold Change: -0.3534
Cell Significance Index: -3.2800
Cell Name: IgG plasmablast (CL0000982)
Fold Change: -0.3683
Cell Significance Index: -3.0400
Cell Name: peg cell (CL4033014)
Fold Change: -0.3766
Cell Significance Index: -8.7000
Cell Name: transit amplifying cell (CL0009010)
Fold Change: -0.3802
Cell Significance Index: -3.6500
Cell Name: glial cell (CL0000125)
Fold Change: -0.3833
Cell Significance Index: -4.2000
Cell Name: conventional dendritic cell (CL0000990)
Fold Change: -0.3893
Cell Significance Index: -4.6000
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.3893
Cell Significance Index: -11.1600
Cell Name: neutrophil (CL0000775)
Fold Change: -0.3898
Cell Significance Index: -4.8700
Cell Name: plasmacytoid dendritic cell (CL0000784)
Fold Change: -0.3917
Cell Significance Index: -5.1400
Cell Name: retinal pigment epithelial cell (CL0002586)
Fold Change: -0.3924
Cell Significance Index: -4.2200
Cell Name: immature B cell (CL0000816)
Fold Change: -0.3931
Cell Significance Index: -3.7200
Cell Name: myelocyte (CL0002193)
Fold Change: -0.3940
Cell Significance Index: -4.2100
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: -0.3949
Cell Significance Index: -4.3200
Cell Name: pro-B cell (CL0000826)
Fold Change: -0.3971
Cell Significance Index: -4.2700
Cell Name: ionocyte (CL0005006)
Fold Change: -0.3988
Cell Significance Index: -4.1700
Cell Name: common dendritic progenitor (CL0001029)
Fold Change: -0.4017
Cell Significance Index: -4.1800
Cell Name: hepatic stellate cell (CL0000632)
Fold Change: -0.4023
Cell Significance Index: -4.1500
Cell Name: natural killer cell (CL0000623)
Fold Change: -0.4027
Cell Significance Index: -4.4600
Cell Name: mucosal invariant T cell (CL0000940)
Fold Change: -0.4058
Cell Significance Index: -4.6700
Cell Name: IgG plasma cell (CL0000985)
Fold Change: -0.4068
Cell Significance Index: -3.7200
Cell Name: progenitor cell (CL0011026)
Fold Change: -0.4085
Cell Significance Index: -4.3400
Cell Name: mast cell (CL0000097)
Fold Change: -0.4088
Cell Significance Index: -5.3800
Cell Name: granulocyte (CL0000094)
Fold Change: -0.4095
Cell Significance Index: -4.9400
Cell Name: osteoclast (CL0000092)
Fold Change: -0.4099
Cell Significance Index: -4.1900
Cell Name: non-classical monocyte (CL0000875)
Fold Change: -0.4119
Cell Significance Index: -4.5600
Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
Fold Change: -0.4123
Cell Significance Index: -4.4500
Cell Name: large intestine goblet cell (CL1000320)
Fold Change: -0.4124
Cell Significance Index: -4.4700
Cell Name: erythroid lineage cell (CL0000764)
Fold Change: -0.4127
Cell Significance Index: -4.5500
Cell Name: acinar cell (CL0000622)
Fold Change: -0.4156
Cell Significance Index: -5.2200
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.4168
Cell Significance Index: -4.7400
Cell Name: dendritic cell (CL0000451)
Fold Change: -0.4213
Cell Significance Index: -5.5000
Cell Name: hematopoietic cell (CL0000988)
Fold Change: -0.4225
Cell Significance Index: -6.1800
Cell Name: regulatory T cell (CL0000815)
Fold Change: -0.4233
Cell Significance Index: -4.9100
Cell Name: class switched memory B cell (CL0000972)
Fold Change: -0.4260
Cell Significance Index: -3.8000
Cell Name: smooth muscle cell (CL0000192)
Fold Change: -0.4278
Cell Significance Index: -4.9700
Cell Name: endothelial cell of artery (CL1000413)
Fold Change: -0.4289
Cell Significance Index: -4.5200
Cell Name: promyelocyte (CL0000836)
Fold Change: -0.4300
Cell Significance Index: -4.2500
Cell Name: vascular associated smooth muscle cell (CL0000359)
Fold Change: -0.4303
Cell Significance Index: -4.5700
Cell Name: paneth cell (CL0000510)
Fold Change: -0.4311
Cell Significance Index: -4.4600
Cell Name: Kupffer cell (CL0000091)
Fold Change: -0.4327
Cell Significance Index: -3.9600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Other Information

Description

**Key Characteristics** The IGHV4-39 gene exhibits the following key characteristics: 1. **Immunoglobulin heavy variable region**: The IGHV4-39 gene encodes for the heavy chain variable region of immunoglobulins, which is essential for antigen recognition and binding. 2. **Significant expression in various cell types**: The IGHV4-39 gene is expressed in multiple cell types, including natural killer cells, granulocyte-monocyte progenitor cells, and alpha-beta T cells, indicating its broad role in immune responses. 3. **Association with immune-related pathways**: The IGHV4-39 gene is involved in various signaling pathways, including those related to antigen recognition, complement activation, and phagocytosis, highlighting its importance in immune regulation and response. 4. **Potential involvement in disease**: The IGHV4-39 gene has been linked to various diseases, including infectious diseases, autoimmune disorders, and cancer, suggesting its potential role in disease pathogenesis. **Pathways and Functions** The IGHV4-39 gene is involved in the following pathways and functions: 1. **Adaptive immune system**: The IGHV4-39 gene plays a crucial role in the adaptive immune system, enabling the recognition and binding of antigens by B cells and T cells. 2. **Antigen-activated B cell receptor (BCR) signaling**: The IGHV4-39 gene is involved in the signaling pathway initiated by the BCR, leading to the generation of second messengers and subsequent immune responses. 3. **Complement activation**: The IGHV4-39 gene is associated with the activation of the complement cascade, which plays a critical role in eliminating pathogens and tumor cells. 4. **Phagocytosis**: The IGHV4-39 gene is involved in the regulation of phagocytic activity, enabling the engulfment and destruction of pathogens and debris. 5. **Immune regulation**: The IGHV4-39 gene plays a role in regulating immune responses, including the modulation of B cell and T cell activation, proliferation, and differentiation. **Clinical Significance** The IGHV4-39 gene has significant clinical implications: 1. **Infectious diseases**: The IGHV4-39 gene is involved in the immune response against infectious diseases, such as Leishmania parasite infection, which highlights its potential role in disease pathogenesis. 2. **Autoimmune disorders**: The IGHV4-39 gene has been linked to autoimmune disorders, such as rheumatoid arthritis and lupus, suggesting its potential role in disease pathogenesis. 3. **Cancer**: The IGHV4-39 gene is involved in the immune response against tumor cells, highlighting its potential role in cancer immunotherapy. 4. **Immunotherapy**: The IGHV4-39 gene has been explored as a potential target for immunotherapy, including antibody-based therapies and checkpoint inhibitors. 5. **Personalized medicine**: The IGHV4-39 gene has implications for personalized medicine, as its expression and function can vary between individuals, influencing immune responses and disease susceptibility. In conclusion, the IGHV4-39 gene plays a crucial role in the adaptive immune system, involving various signaling pathways and functions, including antigen recognition, complement activation, and phagocytosis. Its clinical significance is evident in its involvement in infectious diseases, autoimmune disorders, cancer, and immunotherapy, highlighting its potential as a target for disease prevention and treatment.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.