IGKV3 15 | ENSG00000244437 | NCBI 28913

Details for: IGKV3 15

Gene ID: 28913

Symbol: IGKV3 15

Ensembl ID: ENSG00000244437

Description: immunoglobulin kappa variable 3-15

Associated with

Adaptive immune system
(R-HSA-1280218)
Anti-inflammatory response favouring leishmania parasite infection
(R-HSA-9662851)
Antigen activates b cell receptor (bcr) leading to generation of second messengers
(R-HSA-983695)
Binding and uptake of ligands by scavenger receptors
(R-HSA-2173782)
Cd22 mediated bcr regulation
(R-HSA-5690714)
Cell surface interactions at the vascular wall
(R-HSA-202733)
Classical antibody-mediated complement activation
(R-HSA-173623)
Complement cascade
(R-HSA-166658)
Creation of c4 and c2 activators
(R-HSA-166786)
Disease
(R-HSA-1643685)
Fc epsilon receptor (fceri) signaling
(R-HSA-2454202)
Fceri mediated ca+2 mobilization
(R-HSA-2871809)
Fceri mediated mapk activation
(R-HSA-2871796)
Fceri mediated nf-kb activation
(R-HSA-2871837)
Fcgamma receptor (fcgr) dependent phagocytosis
(R-HSA-2029480)
Fcgr3a-mediated il10 synthesis
(R-HSA-9664323)
Fcgr3a-mediated phagocytosis
(R-HSA-9664422)
Fcgr activation
(R-HSA-2029481)
Hemostasis
(R-HSA-109582)
Immune system
(R-HSA-168256)
Immunoregulatory interactions between a lymphoid and a non-lymphoid cell
(R-HSA-198933)
Infectious disease
(R-HSA-5663205)
Initial triggering of complement
(R-HSA-166663)
Innate immune system
(R-HSA-168249)
Leishmania infection
(R-HSA-9658195)
Leishmania parasite growth and survival
(R-HSA-9664433)
Leishmania phagocytosis
(R-HSA-9664417)
Parasite infection
(R-HSA-9664407)
Parasitic infection pathways
(R-HSA-9824443)
Potential therapeutics for sars
(R-HSA-9679191)
Regulation of actin dynamics for phagocytic cup formation
(R-HSA-2029482)
Regulation of complement cascade
(R-HSA-977606)
Role of lat2/ntal/lab on calcium mobilization
(R-HSA-2730905)
Role of phospholipids in phagocytosis
(R-HSA-2029485)
Sars-cov infections
(R-HSA-9679506)
Scavenging of heme from plasma
(R-HSA-2168880)
Signaling by the b cell receptor (bcr)
(R-HSA-983705)
Vesicle-mediated transport
(R-HSA-5653656)
Viral infection pathways
(R-HSA-9824446)
Adaptive immune response
(GO:0002250)
Antigen binding
(GO:0003823)
Blood microparticle
(GO:0072562)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Immune response
(GO:0006955)
Immunoglobulin complex
(GO:0019814)
Immunoglobulin production
(GO:0002377)
Plasma membrane
(GO:0005886)

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
Fold Change: 3.44
Marker Score: 2,661
Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
Fold Change: 1.78
Marker Score: 1,500
Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
Fold Change: 1.49
Marker Score: 1,613
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 1.37
Marker Score: 866
Cell Name: goblet cell (CL0000160)
Fold Change: 1.16
Marker Score: 7,690
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 1.07
Marker Score: 2,666
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 1.04
Marker Score: 251,797
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 1.04
Marker Score: 792
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30,407
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.97
Marker Score: 2,466
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.93
Marker Score: 5,314
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2,740
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5,294
Cell Name: mature NK T cell (CL0000814)
Fold Change: 0.86
Marker Score: 399
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.81
Marker Score: 1,315
Cell Name: brush cell (CL0002204)
Fold Change: 0.77
Marker Score: 707
Cell Name: megakaryocyte (CL0000556)
Fold Change: 0.73
Marker Score: 417
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.69
Marker Score: 177
Cell Name: blood cell (CL0000081)
Fold Change: 0.65
Marker Score: 7,506
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.58
Marker Score: 461
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.55
Marker Score: 147
Cell Name: double negative T regulatory cell (CL0011024)
Fold Change: 0.51
Marker Score: 493
Cell Name: plasmablast (CL0000980)
Fold Change: 0.51
Marker Score: 677
Cell Name: CD38-negative naive B cell (CL0002102)
Fold Change: 0.44
Marker Score: 918
Cell Name: erythrocyte (CL0000232)
Fold Change: 0.43
Marker Score: 238
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.39
Marker Score: 162
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 0.39
Marker Score: 203
Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
Fold Change: 0.38
Marker Score: 746
Cell Name: mast cell (CL0000097)
Fold Change: 0.36
Marker Score: 209
Cell Name: unswitched memory B cell (CL0000970)
Fold Change: 0.36
Marker Score: 208
Cell Name: IgA plasma cell (CL0000987)
Fold Change: 0.35
Marker Score: 302
Cell Name: IgM plasma cell (CL0000986)
Fold Change: 0.33
Marker Score: 115
Cell Name: mucosal invariant T cell (CL0000940)
Fold Change: 0.33
Marker Score: 293
Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
Fold Change: 0.32
Marker Score: 576
Cell Name: class switched memory B cell (CL0000972)
Fold Change: 0.31
Marker Score: 295
Cell Name: endothelial cell (CL0000115)
Fold Change: 0.31
Marker Score: 278
Cell Name: myeloid cell (CL0000763)
Fold Change: 0.29
Marker Score: 466
Cell Name: T follicular helper cell (CL0002038)
Fold Change: 0.29
Marker Score: 241
Cell Name: memory B cell (CL0000787)
Fold Change: 0.26
Marker Score: 195
Cell Name: immature B cell (CL0000816)
Fold Change: 0.26
Marker Score: 170
Cell Name: IgG plasma cell (CL0000985)
Fold Change: 0.25
Marker Score: 111
Cell Name: plasma cell (CL0000786)
Fold Change: 0.24
Marker Score: 273
Cell Name: naive B cell (CL0000788)
Fold Change: 0.24
Marker Score: 211
Cell Name: B cell (CL0000236)
Fold Change: 0.23
Marker Score: 217
Cell Name: IgG plasmablast (CL0000982)
Fold Change: 0.2
Marker Score: 55
Cell Name: IgA plasmablast (CL0000984)
Fold Change: 0.19
Marker Score: 49
Cell Name: natural killer cell (CL0000623)
Fold Change: 0.18
Marker Score: 235
Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
Fold Change: 0.16
Marker Score: 36
Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
Fold Change: 0.16
Marker Score: 35
Cell Name: plasmacytoid dendritic cell (CL0000784)
Fold Change: 0.15
Marker Score: 82
Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
Fold Change: 0.15
Marker Score: 340
Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
Fold Change: 0.15
Marker Score: 245
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 0.15
Marker Score: 147
Cell Name: platelet (CL0000233)
Fold Change: 0.14
Marker Score: 63
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.14
Marker Score: 91
Cell Name: gamma-delta T cell (CL0000798)
Fold Change: 0.14
Marker Score: 92
Cell Name: T cell (CL0000084)
Fold Change: 0.14
Marker Score: 233
Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
Fold Change: 0.13
Marker Score: 110
Cell Name: pre-B-I cell (CL0000956)
Fold Change: 0.13
Marker Score: 34
Cell Name: type I NK T cell (CL0000921)
Fold Change: 0.13
Marker Score: 99
Cell Name: B-2 B cell (CL0000822)
Fold Change: 0.13
Marker Score: 155
Cell Name: B-1b B cell (CL0000821)
Fold Change: 0.13
Marker Score: 29
Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
Fold Change: 0.12
Marker Score: 33
Cell Name: B-1a B cell (CL0000820)
Fold Change: 0.12
Marker Score: 29
Cell Name: follicular B cell (CL0000843)
Fold Change: 0.12
Marker Score: 126
Cell Name: inflammatory macrophage (CL0000863)
Fold Change: 0.12
Marker Score: 36
Cell Name: tracheobronchial smooth muscle cell (CL0019019)
Fold Change: 0.12
Marker Score: 34
Cell Name: dendritic cell (CL0000451)
Fold Change: 0.11
Marker Score: 76
Cell Name: pro-B cell (CL0000826)
Fold Change: 0.1
Marker Score: 101
Cell Name: myeloid dendritic cell (CL0000782)
Fold Change: 0.1
Marker Score: 63
Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
Fold Change: 0.1
Marker Score: 63
Cell Name: endothelial cell of artery (CL1000413)
Fold Change: 0.1
Marker Score: 42
Cell Name: small pre-B-II cell (CL0000954)
Fold Change: 0.1
Marker Score: 121
Cell Name: conventional dendritic cell (CL0000990)
Fold Change: 0.1
Marker Score: 69
Cell Name: ILC1, human (CL0001077)
Fold Change: 0.1
Marker Score: 25
Cell Name: hematopoietic precursor cell (CL0008001)
Fold Change: 0.1
Marker Score: 35
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.1
Marker Score: 31
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: 0.09
Marker Score: 67
Cell Name: glial cell (CL0000125)
Fold Change: 0.09
Marker Score: 103
Cell Name: transitional stage B cell (CL0000818)
Fold Change: 0.09
Marker Score: 33
Cell Name: enucleated reticulocyte (CL0002422)
Fold Change: 0.09
Marker Score: 34
Cell Name: fibroblast (CL0000057)
Fold Change: 0.09
Marker Score: 87
Cell Name: intermediate monocyte (CL0002393)
Fold Change: 0.09
Marker Score: 31
Cell Name: dendritic cell, human (CL0001056)
Fold Change: 0.09
Marker Score: 91
Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
Fold Change: 0.09
Marker Score: 64
Cell Name: alternatively activated macrophage (CL0000890)
Fold Change: 0.09
Marker Score: 36
Cell Name: peptic cell (CL0000155)
Fold Change: 0.09
Marker Score: 36
Cell Name: T-helper 22 cell (CL0001042)
Fold Change: 0.08
Marker Score: 358
Cell Name: innate lymphoid cell (CL0001065)
Fold Change: 0.08
Marker Score: 29
Cell Name: macrophage (CL0000235)
Fold Change: 0.08
Marker Score: 89
Cell Name: lymphocyte (CL0000542)
Fold Change: 0.08
Marker Score: 40
Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
Fold Change: 0.08
Marker Score: 36
Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: 0.08
Marker Score: 219
Cell Name: duct epithelial cell (CL0000068)
Fold Change: 0.08
Marker Score: 36
Cell Name: memory T cell (CL0000813)
Fold Change: 0.08
Marker Score: 33
Cell Name: monocyte (CL0000576)
Fold Change: 0.08
Marker Score: 99
Cell Name: mature gamma-delta T cell (CL0000800)
Fold Change: 0.08
Marker Score: 238
Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
Fold Change: 0.07
Marker Score: 65
Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: 0.07
Marker Score: 42
Cell Name: group 3 innate lymphoid cell (CL0001071)
Fold Change: 0.07
Marker Score: 30

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

Description

**Key Characteristics:** IGKV3-15 is a member of the immunoglobulin superfamily, which is characterized by its ability to bind to specific ligands. The gene encodes a kappa light chain variable region, which is crucial for the specificity and affinity of the antibody. The expression of IGKV3-15 is restricted to a subset of cells, including natural killer cells, T cells, and monocytes, which highlights its role in the immune system. **Pathways and Functions:** IGKV3-15 is involved in multiple pathways and functions, including: 1. **Adaptive Immune Response:** IGKV3-15 plays a crucial role in the adaptive immune response, particularly in the activation of B cells and the regulation of immune system cells. 2. **Anti-inflammatory Response:** The gene is also involved in anti-inflammatory responses, favoring the survival of Leishmania parasites. 3. **Cell Surface Interactions:** IGKV3-15 is involved in cell surface interactions, including binding and uptake of ligands by scavenger receptors. 4. **Calcium Mobilization:** The gene regulates calcium mobilization, which is essential for various cellular processes, including phagocytosis and cell signaling. 5. **Actin Dynamics:** IGKV3-15 is involved in the regulation of actin dynamics, which is crucial for the formation of phagocytic cups. 6. **Vesicle-Mediated Transport:** The gene regulates vesicle-mediated transport, which is essential for the delivery of antigens and other molecules to target cells. **Clinical Significance:** The significance of IGKV3-15 extends beyond the immune system, as it is also implicated in various diseases and conditions, including: 1. **Leishmania Infection:** IGKV3-15 plays a crucial role in the survival and growth of Leishmania parasites. 2. **SARS-CoV Infections:** The gene is involved in the regulation of immune responses to SARS-CoV infections. 3. **Infectious Diseases:** IGKV3-15 is involved in the regulation of immune responses to various infectious diseases, including viral and bacterial infections. 4. **Autoimmune Diseases:** The gene may also play a role in the regulation of immune responses to autoimmune diseases. In conclusion, IGKV3-15 is a complex gene that plays a multifaceted role in the immune system and beyond. Its involvement in various pathways and functions highlights its significance in regulating immune responses and cellular processes. Further research is needed to fully understand the role of IGKV3-15 in disease and to explore its potential as a therapeutic target.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.