Details for: IGKV3 15

Gene ID: 28913

Symbol: IGKV3 15

Ensembl ID: ENSG00000244437

Description: immunoglobulin kappa variable 3-15

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 3.44
    Marker Score: 2,661
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 1.78
    Marker Score: 1,500
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 1.49
    Marker Score: 1,613
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 866
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7,690
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.07
    Marker Score: 2,666
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251,797
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 792
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,407
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.97
    Marker Score: 2,466
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5,314
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,740
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,294
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.86
    Marker Score: 399
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.81
    Marker Score: 1,315
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 707
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.73
    Marker Score: 417
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 177
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.65
    Marker Score: 7,506
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.58
    Marker Score: 461
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.55
    Marker Score: 147
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 0.51
    Marker Score: 493
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.51
    Marker Score: 677
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 0.44
    Marker Score: 918
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.43
    Marker Score: 238
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.39
    Marker Score: 162
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.39
    Marker Score: 203
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.38
    Marker Score: 746
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.36
    Marker Score: 209
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 0.36
    Marker Score: 208
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 0.35
    Marker Score: 302
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 0.33
    Marker Score: 115
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0.33
    Marker Score: 293
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 0.32
    Marker Score: 576
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 0.31
    Marker Score: 295
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.31
    Marker Score: 278
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.29
    Marker Score: 466
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 0.29
    Marker Score: 241
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.26
    Marker Score: 195
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 0.26
    Marker Score: 170
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 0.25
    Marker Score: 111
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.24
    Marker Score: 273
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.24
    Marker Score: 211
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.23
    Marker Score: 217
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 0.2
    Marker Score: 55
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: 0.19
    Marker Score: 49
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.18
    Marker Score: 235
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.16
    Marker Score: 36
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 0.16
    Marker Score: 35
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.15
    Marker Score: 82
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.15
    Marker Score: 340
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.15
    Marker Score: 245
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.15
    Marker Score: 147
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.14
    Marker Score: 63
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.14
    Marker Score: 91
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.14
    Marker Score: 92
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.14
    Marker Score: 233
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 0.13
    Marker Score: 110
  • Cell Name: pre-B-I cell (CL0000956)
    Fold Change: 0.13
    Marker Score: 34
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.13
    Marker Score: 99
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: 0.13
    Marker Score: 155
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 0.13
    Marker Score: 29
  • Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
    Fold Change: 0.12
    Marker Score: 33
  • Cell Name: B-1a B cell (CL0000820)
    Fold Change: 0.12
    Marker Score: 29
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 0.12
    Marker Score: 126
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.12
    Marker Score: 36
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.12
    Marker Score: 34
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.11
    Marker Score: 76
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.1
    Marker Score: 101
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 0.1
    Marker Score: 63
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.1
    Marker Score: 63
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.1
    Marker Score: 42
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 0.1
    Marker Score: 121
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.1
    Marker Score: 69
  • Cell Name: ILC1, human (CL0001077)
    Fold Change: 0.1
    Marker Score: 25
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.1
    Marker Score: 35
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.1
    Marker Score: 31
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.09
    Marker Score: 67
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.09
    Marker Score: 103
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.09
    Marker Score: 33
  • Cell Name: enucleated reticulocyte (CL0002422)
    Fold Change: 0.09
    Marker Score: 34
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.09
    Marker Score: 87
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.09
    Marker Score: 31
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.09
    Marker Score: 91
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 0.09
    Marker Score: 64
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 0.09
    Marker Score: 36
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.09
    Marker Score: 36
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 0.08
    Marker Score: 358
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.08
    Marker Score: 29
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.08
    Marker Score: 89
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.08
    Marker Score: 40
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 0.08
    Marker Score: 36
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.08
    Marker Score: 219
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.08
    Marker Score: 36
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 0.08
    Marker Score: 33
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.08
    Marker Score: 99
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0.08
    Marker Score: 238
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.07
    Marker Score: 65
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.07
    Marker Score: 42
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: 0.07
    Marker Score: 30

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IGKV3-15 is a member of the immunoglobulin superfamily, which is characterized by its ability to bind to specific ligands. The gene encodes a kappa light chain variable region, which is crucial for the specificity and affinity of the antibody. The expression of IGKV3-15 is restricted to a subset of cells, including natural killer cells, T cells, and monocytes, which highlights its role in the immune system. **Pathways and Functions:** IGKV3-15 is involved in multiple pathways and functions, including: 1. **Adaptive Immune Response:** IGKV3-15 plays a crucial role in the adaptive immune response, particularly in the activation of B cells and the regulation of immune system cells. 2. **Anti-inflammatory Response:** The gene is also involved in anti-inflammatory responses, favoring the survival of Leishmania parasites. 3. **Cell Surface Interactions:** IGKV3-15 is involved in cell surface interactions, including binding and uptake of ligands by scavenger receptors. 4. **Calcium Mobilization:** The gene regulates calcium mobilization, which is essential for various cellular processes, including phagocytosis and cell signaling. 5. **Actin Dynamics:** IGKV3-15 is involved in the regulation of actin dynamics, which is crucial for the formation of phagocytic cups. 6. **Vesicle-Mediated Transport:** The gene regulates vesicle-mediated transport, which is essential for the delivery of antigens and other molecules to target cells. **Clinical Significance:** The significance of IGKV3-15 extends beyond the immune system, as it is also implicated in various diseases and conditions, including: 1. **Leishmania Infection:** IGKV3-15 plays a crucial role in the survival and growth of Leishmania parasites. 2. **SARS-CoV Infections:** The gene is involved in the regulation of immune responses to SARS-CoV infections. 3. **Infectious Diseases:** IGKV3-15 is involved in the regulation of immune responses to various infectious diseases, including viral and bacterial infections. 4. **Autoimmune Diseases:** The gene may also play a role in the regulation of immune responses to autoimmune diseases. In conclusion, IGKV3-15 is a complex gene that plays a multifaceted role in the immune system and beyond. Its involvement in various pathways and functions highlights its significance in regulating immune responses and cellular processes. Further research is needed to fully understand the role of IGKV3-15 in disease and to explore its potential as a therapeutic target.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.