IGLV3 21 | ENSG00000211662 | NCBI 28796

Details for: IGLV3 21

Gene ID: 28796

Symbol: IGLV3 21

Ensembl ID: ENSG00000211662

Description: immunoglobulin lambda variable 3-21

Associated with

Adaptive immune system
(R-HSA-1280218)
Anti-inflammatory response favouring leishmania parasite infection
(R-HSA-9662851)
Antigen activates b cell receptor (bcr) leading to generation of second messengers
(R-HSA-983695)
Binding and uptake of ligands by scavenger receptors
(R-HSA-2173782)
Cd22 mediated bcr regulation
(R-HSA-5690714)
Cell surface interactions at the vascular wall
(R-HSA-202733)
Classical antibody-mediated complement activation
(R-HSA-173623)
Complement cascade
(R-HSA-166658)
Creation of c4 and c2 activators
(R-HSA-166786)
Disease
(R-HSA-1643685)
Fc epsilon receptor (fceri) signaling
(R-HSA-2454202)
Fceri mediated ca+2 mobilization
(R-HSA-2871809)
Fceri mediated mapk activation
(R-HSA-2871796)
Fceri mediated nf-kb activation
(R-HSA-2871837)
Fcgamma receptor (fcgr) dependent phagocytosis
(R-HSA-2029480)
Fcgr3a-mediated il10 synthesis
(R-HSA-9664323)
Fcgr3a-mediated phagocytosis
(R-HSA-9664422)
Fcgr activation
(R-HSA-2029481)
Hemostasis
(R-HSA-109582)
Immune system
(R-HSA-168256)
Immunoregulatory interactions between a lymphoid and a non-lymphoid cell
(R-HSA-198933)
Infectious disease
(R-HSA-5663205)
Initial triggering of complement
(R-HSA-166663)
Innate immune system
(R-HSA-168249)
Leishmania infection
(R-HSA-9658195)
Leishmania parasite growth and survival
(R-HSA-9664433)
Leishmania phagocytosis
(R-HSA-9664417)
Parasite infection
(R-HSA-9664407)
Parasitic infection pathways
(R-HSA-9824443)
Potential therapeutics for sars
(R-HSA-9679191)
Regulation of actin dynamics for phagocytic cup formation
(R-HSA-2029482)
Regulation of complement cascade
(R-HSA-977606)
Role of lat2/ntal/lab on calcium mobilization
(R-HSA-2730905)
Role of phospholipids in phagocytosis
(R-HSA-2029485)
Sars-cov infections
(R-HSA-9679506)
Scavenging of heme from plasma
(R-HSA-2168880)
Signaling by the b cell receptor (bcr)
(R-HSA-983705)
Vesicle-mediated transport
(R-HSA-5653656)
Viral infection pathways
(R-HSA-9824446)
Adaptive immune response
(GO:0002250)
Antigen binding
(GO:0003823)
Blood microparticle
(GO:0072562)
Extracellular exosome
(GO:0070062)
Extracellular region
(GO:0005576)
Immune response
(GO:0006955)
Immunoglobulin complex
(GO:0019814)
Plasma membrane
(GO:0005886)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 7.9429
Cell Significance Index: -3.7500
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 1.0008
Cell Significance Index: 11.1900
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 0.6089
Cell Significance Index: 9.4200
Cell Name: naive regulatory T cell (CL0002677)
Fold Change: 0.4057
Cell Significance Index: 3.6500
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.3120
Cell Significance Index: 4.5300
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0010
Cell Significance Index: -0.1000
Cell Name: IgG plasmablast (CL0000982)
Fold Change: -0.0073
Cell Significance Index: -0.0600
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0564
Cell Significance Index: -4.3300
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0633
Cell Significance Index: -3.8800
Cell Name: lactocyte (CL0002325)
Fold Change: -0.0746
Cell Significance Index: -9.6400
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.0763
Cell Significance Index: -2.0400
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.0909
Cell Significance Index: -4.1200
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0948
Cell Significance Index: -16.1900
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.1118
Cell Significance Index: -3.0400
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.1304
Cell Significance Index: -9.7200
Cell Name: cytotoxic T cell (CL0000910)
Fold Change: -0.1386
Cell Significance Index: -2.0200
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1431
Cell Significance Index: -16.3900
Cell Name: Schwann cell (CL0002573)
Fold Change: -0.1515
Cell Significance Index: -1.7000
Cell Name: helper T cell (CL0000912)
Fold Change: -0.1528
Cell Significance Index: -2.1700
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.1632
Cell Significance Index: -4.1700
Cell Name: leukocyte (CL0000738)
Fold Change: -0.1672
Cell Significance Index: -2.8400
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.1731
Cell Significance Index: -8.0700
Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: -0.1779
Cell Significance Index: -3.0700
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.1835
Cell Significance Index: -4.4500
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: -0.1861
Cell Significance Index: -2.1900
Cell Name: plasma cell (CL0000786)
Fold Change: -0.1915
Cell Significance Index: -2.1400
Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: -0.2085
Cell Significance Index: -5.2000
Cell Name: proerythroblast (CL0000547)
Fold Change: -0.2114
Cell Significance Index: -3.0300
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: -0.2163
Cell Significance Index: -4.2300
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.2170
Cell Significance Index: -4.0100
Cell Name: lymphocyte (CL0000542)
Fold Change: -0.2268
Cell Significance Index: -3.0900
Cell Name: erythrocyte (CL0000232)
Fold Change: -0.2280
Cell Significance Index: -5.8100
Cell Name: preadipocyte (CL0002334)
Fold Change: -0.2310
Cell Significance Index: -4.5100
Cell Name: IgA plasma cell (CL0000987)
Fold Change: -0.2313
Cell Significance Index: -1.5400
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: -0.2466
Cell Significance Index: -3.0500
Cell Name: T-helper 17 cell (CL0000899)
Fold Change: -0.2477
Cell Significance Index: -1.8900
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: -0.2562
Cell Significance Index: -4.3800
Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -0.2622
Cell Significance Index: -3.8700
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -0.2683
Cell Significance Index: -4.5200
Cell Name: megakaryocyte (CL0000556)
Fold Change: -0.2698
Cell Significance Index: -4.3700
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.2792
Cell Significance Index: -10.2500
Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: -0.2860
Cell Significance Index: -3.7400
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: -0.2864
Cell Significance Index: -3.3900
Cell Name: blood cell (CL0000081)
Fold Change: -0.2880
Cell Significance Index: -2.4600
Cell Name: naive B cell (CL0000788)
Fold Change: -0.2887
Cell Significance Index: -3.0400
Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.2892
Cell Significance Index: -4.2700
Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: -0.2959
Cell Significance Index: -3.2300
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: -0.2983
Cell Significance Index: -3.7800
Cell Name: hepatocyte (CL0000182)
Fold Change: -0.2985
Cell Significance Index: -4.1400
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: -0.2987
Cell Significance Index: -4.2900
Cell Name: innate lymphoid cell (CL0001065)
Fold Change: -0.3028
Cell Significance Index: -3.8900
Cell Name: precursor B cell (CL0000817)
Fold Change: -0.3029
Cell Significance Index: -3.9200
Cell Name: B cell (CL0000236)
Fold Change: -0.3097
Cell Significance Index: -3.6600
Cell Name: memory B cell (CL0000787)
Fold Change: -0.3102
Cell Significance Index: -3.3000
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: -0.3165
Cell Significance Index: -4.3400
Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
Fold Change: -0.3198
Cell Significance Index: -3.8600
Cell Name: hepatic stellate cell (CL0000632)
Fold Change: -0.3204
Cell Significance Index: -3.3100
Cell Name: stromal cell (CL0000499)
Fold Change: -0.3210
Cell Significance Index: -3.2800
Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: -0.3217
Cell Significance Index: -3.3300
Cell Name: immature NK T cell (CL0000914)
Fold Change: -0.3262
Cell Significance Index: -4.1800
Cell Name: thymocyte (CL0000893)
Fold Change: -0.3304
Cell Significance Index: -4.1800
Cell Name: monocyte (CL0000576)
Fold Change: -0.3389
Cell Significance Index: -3.9000
Cell Name: double negative thymocyte (CL0002489)
Fold Change: -0.3470
Cell Significance Index: -4.1200
Cell Name: IgG plasma cell (CL0000985)
Fold Change: -0.3472
Cell Significance Index: -3.1800
Cell Name: Langerhans cell (CL0000453)
Fold Change: -0.3504
Cell Significance Index: -3.3400
Cell Name: primitive red blood cell (CL0002355)
Fold Change: -0.3520
Cell Significance Index: -3.9900
Cell Name: transit amplifying cell (CL0009010)
Fold Change: -0.3521
Cell Significance Index: -3.3800
Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
Fold Change: -0.3552
Cell Significance Index: -3.8300
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: -0.3556
Cell Significance Index: -3.8900
Cell Name: neutrophil (CL0000775)
Fold Change: -0.3586
Cell Significance Index: -4.4800
Cell Name: glial cell (CL0000125)
Fold Change: -0.3614
Cell Significance Index: -3.9600
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.3618
Cell Significance Index: -10.3700
Cell Name: plasmablast (CL0000980)
Fold Change: -0.3653
Cell Significance Index: -3.3900
Cell Name: acinar cell (CL0000622)
Fold Change: -0.3682
Cell Significance Index: -4.6300
Cell Name: myelocyte (CL0002193)
Fold Change: -0.3687
Cell Significance Index: -3.9400
Cell Name: conventional dendritic cell (CL0000990)
Fold Change: -0.3707
Cell Significance Index: -4.3800
Cell Name: intestinal crypt stem cell (CL0002250)
Fold Change: -0.3730
Cell Significance Index: -2.6300
Cell Name: cholangiocyte (CL1000488)
Fold Change: -0.3735
Cell Significance Index: -3.6900
Cell Name: plasmacytoid dendritic cell (CL0000784)
Fold Change: -0.3749
Cell Significance Index: -4.9200
Cell Name: type I NK T cell (CL0000921)
Fold Change: -0.3837
Cell Significance Index: -3.7400
Cell Name: osteoclast (CL0000092)
Fold Change: -0.3850
Cell Significance Index: -3.9300
Cell Name: myoepithelial cell (CL0000185)
Fold Change: -0.3852
Cell Significance Index: -4.3700
Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
Fold Change: -0.3903
Cell Significance Index: -3.7100
Cell Name: pericyte (CL0000669)
Fold Change: -0.3920
Cell Significance Index: -4.7000
Cell Name: T follicular helper cell (CL0002038)
Fold Change: -0.3933
Cell Significance Index: -4.1700
Cell Name: natural killer cell (CL0000623)
Fold Change: -0.3937
Cell Significance Index: -4.3600
Cell Name: non-classical monocyte (CL0000875)
Fold Change: -0.3938
Cell Significance Index: -4.3600
Cell Name: dendritic cell (CL0000451)
Fold Change: -0.3960
Cell Significance Index: -5.1700
Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
Fold Change: -0.3966
Cell Significance Index: -3.7100
Cell Name: regulatory T cell (CL0000815)
Fold Change: -0.3983
Cell Significance Index: -4.6200
Cell Name: immature B cell (CL0000816)
Fold Change: -0.3984
Cell Significance Index: -3.7700
Cell Name: class switched memory B cell (CL0000972)
Fold Change: -0.3991
Cell Significance Index: -3.5600
Cell Name: peg cell (CL4033014)
Fold Change: -0.4004
Cell Significance Index: -9.2500
Cell Name: keratinocyte (CL0000312)
Fold Change: -0.4024
Cell Significance Index: -10.0500
Cell Name: mast cell (CL0000097)
Fold Change: -0.4035
Cell Significance Index: -5.3100
Cell Name: pro-B cell (CL0000826)
Fold Change: -0.4046
Cell Significance Index: -4.3500
Cell Name: Kupffer cell (CL0000091)
Fold Change: -0.4076
Cell Significance Index: -3.7300
Cell Name: promyelocyte (CL0000836)
Fold Change: -0.4077
Cell Significance Index: -4.0300
Cell Name: vascular associated smooth muscle cell (CL0000359)
Fold Change: -0.4096
Cell Significance Index: -4.3500
Cell Name: erythroblast (CL0000765)
Fold Change: -0.4134
Cell Significance Index: -4.9300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Other Information

Description

**Key Characteristics** IGLV3-21 is a member of the immunoglobulin superfamily, which is involved in the recognition and binding of antigens. The lambda light chain, encoded by IGLV3-21, is a critical component of the B cell receptor (BCR) complex, which is essential for the activation of B cells in response to antigens. The lambda light chain also interacts with other molecules, such as Fc receptors and scavenger receptors, to facilitate phagocytosis and antigen presentation. **Pathways and Functions** IGLV3-21 is involved in various signaling pathways, including: 1. **Adaptive Immune Response**: IGLV3-21 plays a crucial role in the adaptive immune response by encoding the lambda light chain of immunoglobulins, which is essential for the recognition and binding of antigens. 2. **Antigen Recognition**: IGLV3-21 interacts with other molecules, such as Fc receptors and scavenger receptors, to facilitate the recognition and binding of antigens. 3. **Phagocytosis**: IGLV3-21 is involved in the regulation of phagocytosis, a process by which cells engulf and internalize pathogens and debris. 4. **Complement Cascade**: IGLV3-21 is involved in the regulation of the complement cascade, a series of reactions that help eliminate pathogens from the body. 5. **Innate Immune Response**: IGLV3-21 is also involved in the innate immune response, which provides the first line of defense against pathogens. **Clinical Significance** IGLV3-21 has significant clinical implications, particularly in the context of Leishmania parasite infection. The expression of IGLV3-21 is elevated in response to Leishmania parasite infection, suggesting a potential role in the immune response to this pathogen. Additionally, IGLV3-21 may play a role in other infectious diseases, such as SARS-CoV and Leishmania phagocytosis. Furthermore, IGLV3-21 may have therapeutic potential in the treatment of autoimmune diseases, such as rheumatoid arthritis, and other inflammatory conditions. The manipulation of IGLV3-21 expression may also provide insights into the development of novel immunotherapies for the treatment of cancer and other diseases. In conclusion, IGLV3-21 is a gene that plays a critical role in the adaptive immune response, antigen recognition, and phagocytosis. Its expression is significantly elevated in response to Leishmania parasite infection, suggesting a potential role in the immune response to this pathogen. Further research is needed to fully understand the functions and clinical significance of IGLV3-21.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.