Details for: GPR18

Gene ID: 2841

Symbol: GPR18

Ensembl ID: ENSG00000125245

Description: G protein-coupled receptor 18

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 5.22
    Marker Score: 6504
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 4.79
    Marker Score: 13978
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 4.21
    Marker Score: 4039.5
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 4.1
    Marker Score: 12163.5
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 3.14
    Marker Score: 9013
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 2.2
    Marker Score: 6264
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.59
    Marker Score: 1156
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.5
    Marker Score: 4455
  • Cell Name: centroblast (CL0009112)
    Fold Change: 1.26
    Marker Score: 621
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.25
    Marker Score: 843
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.17
    Marker Score: 2041
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.15
    Marker Score: 477
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.14
    Marker Score: 4796
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 1.11
    Marker Score: 1339
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 1.1
    Marker Score: 667
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.06
    Marker Score: 636
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.05
    Marker Score: 16492
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 1.04
    Marker Score: 248
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1
    Marker Score: 2041
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71807
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48032
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 0.97
    Marker Score: 223
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 498
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.96
    Marker Score: 1828.5
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 453
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2411
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 0.94
    Marker Score: 1014
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.93
    Marker Score: 2533
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 0.92
    Marker Score: 1017
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2738
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.91
    Marker Score: 366
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.9
    Marker Score: 5117
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.89
    Marker Score: 799
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 318
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.87
    Marker Score: 437
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5279
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.8
    Marker Score: 369
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1249
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 388
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.73
    Marker Score: 670
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.71
    Marker Score: 452
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.71
    Marker Score: 539
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.68
    Marker Score: 242
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 174
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 0.64
    Marker Score: 628
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.62
    Marker Score: 468
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 0.57
    Marker Score: 1186
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 0.56
    Marker Score: 335
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 443
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.53
    Marker Score: 167
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 0.52
    Marker Score: 169
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.51
    Marker Score: 487
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.5
    Marker Score: 6691
  • Cell Name: pre-B-I cell (CL0000956)
    Fold Change: 0.48
    Marker Score: 123
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.47
    Marker Score: 345
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.46
    Marker Score: 351
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.46
    Marker Score: 1277
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.44
    Marker Score: 447
  • Cell Name: B-1a B cell (CL0000820)
    Fold Change: 0.42
    Marker Score: 101
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 0.41
    Marker Score: 271
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.4
    Marker Score: 228
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.4
    Marker Score: 125
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 0.38
    Marker Score: 1056
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.37
    Marker Score: 183
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.36
    Marker Score: 3586
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 0.36
    Marker Score: 229
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.35
    Marker Score: 203
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.35
    Marker Score: 339
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.35
    Marker Score: 93
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 0.35
    Marker Score: 204
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 0.34
    Marker Score: 245
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 0.32
    Marker Score: 580
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.32
    Marker Score: 213
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.32
    Marker Score: 250
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 0.32
    Marker Score: 162
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.31
    Marker Score: 433
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.3
    Marker Score: 153
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 0.3
    Marker Score: 250
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.3
    Marker Score: 143.5
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.3
    Marker Score: 105
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.3
    Marker Score: 325
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.29
    Marker Score: 133
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 0.29
    Marker Score: 90
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 0.29
    Marker Score: 846
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 0.29
    Marker Score: 269
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.28
    Marker Score: 283
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.28
    Marker Score: 14738.5
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.28
    Marker Score: 182
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.28
    Marker Score: 235
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.27
    Marker Score: 84
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.27
    Marker Score: 344
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.26
    Marker Score: 538
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.26
    Marker Score: 155
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.26
    Marker Score: 105
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 0.25
    Marker Score: 109
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.25
    Marker Score: 212
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.25
    Marker Score: 104
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.25
    Marker Score: 181
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.24
    Marker Score: 244

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Other Information

**Key characteristics:** * GPR18 is a transmembrane protein that is expressed as a single-pass transmembrane protein. * It is a member of the GPCR superfamily, which is a large family of cell surface receptors that are expressed in a variety of tissues. * GPR18 is a ligand-gated channel that is expressed in the plasma membrane of endothelial cells. * It is a negative regulator of leukocyte chemotaxis, tumor necrosis factor production, and plasma membrane signaling. **Pathways and functions:** * GPR18 is involved in the regulation of inflammation and immune responses. * It is expressed in retinal ganglion cells, which are responsible for the detection of visual stimuli. * GPR18 is also expressed in other cell types that are involved in inflammation, such as ON-bipolar cells, retina horizontal cells, and OFF-bipolar cells. * It is thought to play a role in the regulation of the inflammatory response to visual stimuli. **Clinical significance:** * Mutations in GPR18 have been linked to a number of eye diseases, including retinal dystrophy, diabetic retinopathy, and macular degeneration. * Inhibitors of GPR18 have been shown to be effective in reducing inflammation and damage in animal models of eye diseases. * Therefore, GPR18 is a potential target for the treatment of eye diseases.

Genular Protein ID: 1112507970

Symbol: GPR18_HUMAN

Name: N-arachidonyl glycine receptor

UniProtKB Accession Codes:

Q14330 Q6GTM3 Q96HI6 Q9H2L2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 4 DrugCentral 1 EMBL 7 Ensembl 4 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 3 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9205118

Title: Cloning and chromosomal localization of a gene (GPR18) encoding a novel seven transmembrane receptor highly expressed in spleen and testis.

PubMed ID: 9205118

DOI: 10.1006/geno.1997.4752

PubMed ID: 16844083

Title: Identification of N-arachidonylglycine as the endogenous ligand for orphan G-protein-coupled receptor GPR18.

PubMed ID: 16844083

DOI: 10.1016/j.bbrc.2006.06.175

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 24762058

Title: Activation of GPR18 by cannabinoid compounds: a tale of biased agonism.

PubMed ID: 24762058

DOI: 10.1111/bph.12746

PubMed ID: 27018161

Title: GPR18 undergoes a high degree of constitutive trafficking but is unresponsive to N-Arachidonoyl Glycine.

PubMed ID: 27018161

DOI: 10.7717/peerj.1835

PubMed ID: 27572937

Title: Characterization of non-olfactory GPCRs in human sperm with a focus on GPR18.

PubMed ID: 27572937

DOI: 10.1038/srep32255

Sequence Information:

  • Length: 331
  • Mass: 38134
  • Checksum: 5B0B755A74FBBB36
  • Sequence:
    • MITLNNQDQP VPFNSSHPDE YKIAALVFYS CIFIIGLFVN ITALWVFSCT TKKRTTVTIY 
MMNVALVDLI FIMTLPFRMF YYAKDEWPFG EYFCQILGAL TVFYPSIALW LLAFISADRY 
MAIVQPKYAK ELKNTCKAVL ACVGVWIMTL TTTTPLLLLY KDPDKDSTPA TCLKISDIIY 
LKAVNVLNLT RLTFFFLIPL FIMIGCYLVI IHNLLHGRTS KLKPKVKEKS IRIIITLLVQ 
VLVCFMPFHI CFAFLMLGTG ENSYNPWGAF TTFLMNLSTC LDVILYYIVS KQFQARVISV 
MLYRNYLRSM RRKSFRSGSL RSLSNINSEM L

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.