Details for: GPR18

Gene ID: 2841

Symbol: GPR18

Ensembl ID: ENSG00000125245

Description: G protein-coupled receptor 18

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 25.4588
    Cell Significance Index: -3.9600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 15.8490
    Cell Significance Index: -4.0200
  • Cell Name: centroblast (CL0009112)
    Fold Change: 7.8309
    Cell Significance Index: 18.2700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 3.2199
    Cell Significance Index: -3.9700
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 2.4880
    Cell Significance Index: 6.6700
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 2.1502
    Cell Significance Index: 21.5600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.5275
    Cell Significance Index: 180.1400
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 1.4271
    Cell Significance Index: 4.4000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.8615
    Cell Significance Index: 85.2300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 0.8205
    Cell Significance Index: -2.5200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7727
    Cell Significance Index: 697.6500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4483
    Cell Significance Index: 72.9200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4054
    Cell Significance Index: 44.0900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.3184
    Cell Significance Index: 6.7800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2327
    Cell Significance Index: 16.0900
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 0.2091
    Cell Significance Index: 0.9400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2041
    Cell Significance Index: 5.8800
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 0.1939
    Cell Significance Index: 0.9700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1939
    Cell Significance Index: 11.6400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.1928
    Cell Significance Index: 4.0000
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.1653
    Cell Significance Index: 2.4400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1182
    Cell Significance Index: 7.6300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1127
    Cell Significance Index: 21.4500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0694
    Cell Significance Index: 13.7700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0494
    Cell Significance Index: 3.7900
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.0351
    Cell Significance Index: 0.6100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0317
    Cell Significance Index: 6.3700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0305
    Cell Significance Index: 1.0700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0266
    Cell Significance Index: 1.4900
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.0133
    Cell Significance Index: 0.2000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0112
    Cell Significance Index: 0.2800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0078
    Cell Significance Index: 2.8100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0071
    Cell Significance Index: 10.8800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0068
    Cell Significance Index: 12.5100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0061
    Cell Significance Index: 11.4500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0059
    Cell Significance Index: 8.0300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0027
    Cell Significance Index: 0.4900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0009
    Cell Significance Index: 0.0500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0022
    Cell Significance Index: -0.3200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0031
    Cell Significance Index: -1.7200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0044
    Cell Significance Index: -3.2500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0051
    Cell Significance Index: -3.8900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0054
    Cell Significance Index: -3.4200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0062
    Cell Significance Index: -2.8200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0065
    Cell Significance Index: -3.6600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0069
    Cell Significance Index: -0.1500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0101
    Cell Significance Index: -0.6200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0106
    Cell Significance Index: -0.4800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0155
    Cell Significance Index: -4.4500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0191
    Cell Significance Index: -4.0200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0197
    Cell Significance Index: -1.2100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0217
    Cell Significance Index: -3.7100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0237
    Cell Significance Index: -2.9100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0249
    Cell Significance Index: -2.9100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0275
    Cell Significance Index: -3.7800
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.0280
    Cell Significance Index: -0.2900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0298
    Cell Significance Index: -1.8800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0333
    Cell Significance Index: -3.8200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0343
    Cell Significance Index: -3.5700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0344
    Cell Significance Index: -0.4100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0350
    Cell Significance Index: -0.6000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0375
    Cell Significance Index: -1.5400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0396
    Cell Significance Index: -1.0600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0397
    Cell Significance Index: -5.1300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0410
    Cell Significance Index: -4.1900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0425
    Cell Significance Index: -0.8300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0446
    Cell Significance Index: -2.0800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0449
    Cell Significance Index: -3.0200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0470
    Cell Significance Index: -2.0800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0478
    Cell Significance Index: -1.8100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0483
    Cell Significance Index: -1.2900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0514
    Cell Significance Index: -1.5100
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0516
    Cell Significance Index: -1.2600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0525
    Cell Significance Index: -1.6800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0617
    Cell Significance Index: -2.9000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0671
    Cell Significance Index: -3.4900
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0678
    Cell Significance Index: -0.8700
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.0697
    Cell Significance Index: -0.3800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0700
    Cell Significance Index: -5.2200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0755
    Cell Significance Index: -1.9300
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0793
    Cell Significance Index: -1.1600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0806
    Cell Significance Index: -2.1600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0823
    Cell Significance Index: -2.3000
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0833
    Cell Significance Index: -1.2300
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0844
    Cell Significance Index: -2.6700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0845
    Cell Significance Index: -2.9600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0870
    Cell Significance Index: -2.7700
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0879
    Cell Significance Index: -3.8200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0910
    Cell Significance Index: -2.9800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0976
    Cell Significance Index: -2.5100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0985
    Cell Significance Index: -2.6800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1022
    Cell Significance Index: -2.4500
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.1027
    Cell Significance Index: -1.7500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1035
    Cell Significance Index: -3.8000
  • Cell Name: mature T cell (CL0002419)
    Fold Change: -0.1112
    Cell Significance Index: -0.8000
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.1123
    Cell Significance Index: -1.4000
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.1139
    Cell Significance Index: -1.5500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1180
    Cell Significance Index: -2.5500
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.1235
    Cell Significance Index: -1.9100
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.1280
    Cell Significance Index: -1.6200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** GPR18 is a GPCR that belongs to the class A/1 (rhodopsin-like receptors) and exhibits a high degree of sequence similarity to other GPCRs. It is characterized by its ability to bind to N-arachidonyl glycine (NAG) and other endogenous ligands, which triggers a signaling cascade that modulates various cellular processes. GPR18 is highly expressed in retinal cells, immune cells, and stem cells, suggesting its involvement in multiple physiological and pathological processes. **Pathways and Functions:** GPR18 is implicated in several signaling pathways that modulate immune responses, cellular differentiation, and signal transduction. Some of the key pathways associated with GPR18 include: 1. **Cd8-positive, alpha-beta intraepithelial T cell differentiation:** GPR18 regulates the differentiation of alpha-beta intraepithelial T cells, which are crucial for maintaining immune homeostasis. 2. **Cd8-positive, gamma-delta intraepithelial T cell differentiation:** GPR18 also modulates the differentiation of gamma-delta intraepithelial T cells, which play a key role in mucosal immunity. 3. **G alpha (i) signaling events:** GPR18 triggers G alpha i signaling events, which inhibit adenylate cyclase activity and reduce cAMP levels, leading to a decrease in immune cell activation. 4. **Negative regulation of leukocyte chemotaxis:** GPR18 inhibits leukocyte chemotaxis, which is essential for preventing excessive immune responses and tissue damage. 5. **Negative regulation of tumor necrosis factor production:** GPR18 also suppresses tumor necrosis factor production, which is a pro-inflammatory cytokine that promotes inflammation and tissue damage. **Clinical Significance:** GPR18 has been implicated in various diseases, including: 1. **Autoimmune disorders:** GPR18 has been shown to regulate immune responses in autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 2. **Inflammatory bowel disease:** GPR18 has been implicated in the pathogenesis of inflammatory bowel disease (IBD), where it regulates immune cell activation and inflammation. 3. **Cancer:** GPR18 has been shown to modulate immune responses in cancer, where it can either suppress or promote tumor growth and metastasis. 4. **Neurological disorders:** GPR18 has been implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease, where it regulates immune responses and inflammation. In conclusion, GPR18 is a complex GPCR that plays a crucial role in modulating immune responses, cellular differentiation, and signal transduction pathways. Further research is needed to fully understand the mechanisms of GPR18 and its clinical implications in various diseases.

Genular Protein ID: 1112507970

Symbol: GPR18_HUMAN

Name: N-arachidonyl glycine receptor

UniProtKB Accession Codes:

Q14330 Q6GTM3 Q96HI6 Q9H2L2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 4 DrugCentral 1 EMBL 7 Ensembl 4 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 3 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9205118

Title: Cloning and chromosomal localization of a gene (GPR18) encoding a novel seven transmembrane receptor highly expressed in spleen and testis.

PubMed ID: 9205118

DOI: 10.1006/geno.1997.4752

PubMed ID: 16844083

Title: Identification of N-arachidonylglycine as the endogenous ligand for orphan G-protein-coupled receptor GPR18.

PubMed ID: 16844083

DOI: 10.1016/j.bbrc.2006.06.175

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 24762058

Title: Activation of GPR18 by cannabinoid compounds: a tale of biased agonism.

PubMed ID: 24762058

DOI: 10.1111/bph.12746

PubMed ID: 27018161

Title: GPR18 undergoes a high degree of constitutive trafficking but is unresponsive to N-Arachidonoyl Glycine.

PubMed ID: 27018161

DOI: 10.7717/peerj.1835

PubMed ID: 27572937

Title: Characterization of non-olfactory GPCRs in human sperm with a focus on GPR18.

PubMed ID: 27572937

DOI: 10.1038/srep32255

Sequence Information:

  • Length: 331
  • Mass: 38134
  • Checksum: 5B0B755A74FBBB36
  • Sequence:
    • MITLNNQDQP VPFNSSHPDE YKIAALVFYS CIFIIGLFVN ITALWVFSCT TKKRTTVTIY 
MMNVALVDLI FIMTLPFRMF YYAKDEWPFG EYFCQILGAL TVFYPSIALW LLAFISADRY 
MAIVQPKYAK ELKNTCKAVL ACVGVWIMTL TTTTPLLLLY KDPDKDSTPA TCLKISDIIY 
LKAVNVLNLT RLTFFFLIPL FIMIGCYLVI IHNLLHGRTS KLKPKVKEKS IRIIITLLVQ 
VLVCFMPFHI CFAFLMLGTG ENSYNPWGAF TTFLMNLSTC LDVILYYIVS KQFQARVISV 
MLYRNYLRSM RRKSFRSGSL RSLSNINSEM L

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.