IGHV3 30 | ENSG00000270550 | NCBI 28439

Details for: IGHV3 30

Gene ID: 28439

Symbol: IGHV3 30

Ensembl ID: ENSG00000270550

Description: immunoglobulin heavy variable 3-30

Associated with

Adaptive immune system
(R-HSA-1280218)
Anti-inflammatory response favouring leishmania parasite infection
(R-HSA-9662851)
Antigen activates b cell receptor (bcr) leading to generation of second messengers
(R-HSA-983695)
Binding and uptake of ligands by scavenger receptors
(R-HSA-2173782)
Cd22 mediated bcr regulation
(R-HSA-5690714)
Cell surface interactions at the vascular wall
(R-HSA-202733)
Classical antibody-mediated complement activation
(R-HSA-173623)
Complement cascade
(R-HSA-166658)
Creation of c4 and c2 activators
(R-HSA-166786)
Disease
(R-HSA-1643685)
Fc epsilon receptor (fceri) signaling
(R-HSA-2454202)
Fceri mediated ca+2 mobilization
(R-HSA-2871809)
Fceri mediated mapk activation
(R-HSA-2871796)
Fceri mediated nf-kb activation
(R-HSA-2871837)
Fcgamma receptor (fcgr) dependent phagocytosis
(R-HSA-2029480)
Fcgr3a-mediated il10 synthesis
(R-HSA-9664323)
Fcgr3a-mediated phagocytosis
(R-HSA-9664422)
Fcgr activation
(R-HSA-2029481)
Hemostasis
(R-HSA-109582)
Immune system
(R-HSA-168256)
Immunoregulatory interactions between a lymphoid and a non-lymphoid cell
(R-HSA-198933)
Infectious disease
(R-HSA-5663205)
Initial triggering of complement
(R-HSA-166663)
Innate immune system
(R-HSA-168249)
Leishmania infection
(R-HSA-9658195)
Leishmania parasite growth and survival
(R-HSA-9664433)
Leishmania phagocytosis
(R-HSA-9664417)
Parasite infection
(R-HSA-9664407)
Parasitic infection pathways
(R-HSA-9824443)
Potential therapeutics for sars
(R-HSA-9679191)
Regulation of actin dynamics for phagocytic cup formation
(R-HSA-2029482)
Regulation of complement cascade
(R-HSA-977606)
Role of lat2/ntal/lab on calcium mobilization
(R-HSA-2730905)
Role of phospholipids in phagocytosis
(R-HSA-2029485)
Sars-cov infections
(R-HSA-9679506)
Scavenging of heme from plasma
(R-HSA-2168880)
Signaling by the b cell receptor (bcr)
(R-HSA-983705)
Vesicle-mediated transport
(R-HSA-5653656)
Viral infection pathways
(R-HSA-9824446)
Antigen binding
(GO:0003823)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Immune response
(GO:0006955)
Immunoglobulin complex
(GO:0019814)
Immunoglobulin mediated immune response
(GO:0016064)
Plasma membrane
(GO:0005886)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 4.8066
Cell Significance Index: 53.7200
Cell Name: double negative thymocyte (CL0002489)
Fold Change: 0.7038
Cell Significance Index: 8.3600
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 0.6108
Cell Significance Index: 9.4500
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.5390
Cell Significance Index: 6.8300
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.1262
Cell Significance Index: 3.3800
Cell Name: adipocyte (CL0000136)
Fold Change: 0.0015
Cell Significance Index: 0.0200
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0051
Cell Significance Index: -3.8900
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0558
Cell Significance Index: -5.7000
Cell Name: keratinocyte (CL0000312)
Fold Change: -0.0718
Cell Significance Index: -1.7900
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.0755
Cell Significance Index: -3.9200
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.0801
Cell Significance Index: -1.9400
Cell Name: collagen secreting cell (CL0000667)
Fold Change: -0.0838
Cell Significance Index: -0.4700
Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.1059
Cell Significance Index: -6.8300
Cell Name: lactocyte (CL0002325)
Fold Change: -0.1132
Cell Significance Index: -14.6200
Cell Name: granulosa cell (CL0000501)
Fold Change: -0.1424
Cell Significance Index: -3.7500
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.1480
Cell Significance Index: -3.7800
Cell Name: early T lineage precursor (CL0002425)
Fold Change: -0.1495
Cell Significance Index: -2.1700
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: -0.1504
Cell Significance Index: -1.8600
Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: -0.1624
Cell Significance Index: -4.0500
Cell Name: leukocyte (CL0000738)
Fold Change: -0.1672
Cell Significance Index: -2.8400
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.1884
Cell Significance Index: -2.1400
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: -0.1895
Cell Significance Index: -2.2300
Cell Name: lymphocyte (CL0000542)
Fold Change: -0.1944
Cell Significance Index: -2.6500
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.1966
Cell Significance Index: -14.6500
Cell Name: thymocyte (CL0000893)
Fold Change: -0.2058
Cell Significance Index: -2.6000
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.2062
Cell Significance Index: -7.5700
Cell Name: plasma cell (CL0000786)
Fold Change: -0.2220
Cell Significance Index: -2.4800
Cell Name: precursor B cell (CL0000817)
Fold Change: -0.2411
Cell Significance Index: -3.1200
Cell Name: erythrocyte (CL0000232)
Fold Change: -0.2414
Cell Significance Index: -6.1500
Cell Name: IgA plasma cell (CL0000987)
Fold Change: -0.2448
Cell Significance Index: -1.6300
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.2580
Cell Significance Index: -7.0200
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.2665
Cell Significance Index: -4.4600
Cell Name: megakaryocyte (CL0000556)
Fold Change: -0.2667
Cell Significance Index: -4.3200
Cell Name: mononuclear cell (CL0000842)
Fold Change: -0.2811
Cell Significance Index: -1.1700
Cell Name: stromal cell (CL0000499)
Fold Change: -0.2917
Cell Significance Index: -2.9800
Cell Name: naive B cell (CL0000788)
Fold Change: -0.2944
Cell Significance Index: -3.1000
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: -0.2945
Cell Significance Index: -3.4800
Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: -0.2990
Cell Significance Index: -3.9100
Cell Name: IgG plasma cell (CL0000985)
Fold Change: -0.3029
Cell Significance Index: -2.7700
Cell Name: hematopoietic cell (CL0000988)
Fold Change: -0.3084
Cell Significance Index: -4.5100
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: -0.3286
Cell Significance Index: -6.4300
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.3311
Cell Significance Index: -6.1200
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: -0.3340
Cell Significance Index: -4.5800
Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: -0.3384
Cell Significance Index: -3.9300
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: -0.3396
Cell Significance Index: -5.8100
Cell Name: monocyte (CL0000576)
Fold Change: -0.3463
Cell Significance Index: -3.9900
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.3479
Cell Significance Index: -16.2200
Cell Name: B cell (CL0000236)
Fold Change: -0.3508
Cell Significance Index: -4.1500
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: -0.3538
Cell Significance Index: -3.8700
Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
Fold Change: -0.3562
Cell Significance Index: -4.3000
Cell Name: primitive red blood cell (CL0002355)
Fold Change: -0.3569
Cell Significance Index: -4.0400
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.3571
Cell Significance Index: -10.2900
Cell Name: blood cell (CL0000081)
Fold Change: -0.3625
Cell Significance Index: -3.0900
Cell Name: retinal pigment epithelial cell (CL0002586)
Fold Change: -0.3673
Cell Significance Index: -3.9500
Cell Name: B-1b B cell (CL0000821)
Fold Change: -0.3728
Cell Significance Index: -1.8700
Cell Name: osteoclast (CL0000092)
Fold Change: -0.3967
Cell Significance Index: -4.0500
Cell Name: erythroblast (CL0000765)
Fold Change: -0.3985
Cell Significance Index: -4.7500
Cell Name: cholangiocyte (CL1000488)
Fold Change: -0.4054
Cell Significance Index: -4.0000
Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: -0.4073
Cell Significance Index: -4.2800
Cell Name: promyelocyte (CL0000836)
Fold Change: -0.4138
Cell Significance Index: -4.0900
Cell Name: lung ciliated cell (CL1000271)
Fold Change: -0.4170
Cell Significance Index: -4.0800
Cell Name: muscle cell (CL0000187)
Fold Change: -0.4234
Cell Significance Index: -4.0500
Cell Name: hepatocyte (CL0000182)
Fold Change: -0.4276
Cell Significance Index: -5.9300
Cell Name: immature B cell (CL0000816)
Fold Change: -0.4291
Cell Significance Index: -4.0600
Cell Name: B-2 B cell (CL0000822)
Fold Change: -0.4310
Cell Significance Index: -3.8200
Cell Name: nasal mucosa goblet cell (CL0002480)
Fold Change: -0.4353
Cell Significance Index: -4.4400
Cell Name: memory B cell (CL0000787)
Fold Change: -0.4390
Cell Significance Index: -4.6700
Cell Name: common lymphoid progenitor (CL0000051)
Fold Change: -0.4393
Cell Significance Index: -4.4600
Cell Name: plasmablast (CL0000980)
Fold Change: -0.4402
Cell Significance Index: -4.0900
Cell Name: early lymphoid progenitor (CL0000936)
Fold Change: -0.4403
Cell Significance Index: -4.4700
Cell Name: serous secreting cell (CL0000313)
Fold Change: -0.4466
Cell Significance Index: -3.9300
Cell Name: neutrophil (CL0000775)
Fold Change: -0.4531
Cell Significance Index: -5.6600
Cell Name: B-1a B cell (CL0000820)
Fold Change: -0.4536
Cell Significance Index: -2.4100
Cell Name: kidney collecting duct intercalated cell (CL1001432)
Fold Change: -0.4673
Cell Significance Index: -4.4500
Cell Name: blood vessel smooth muscle cell (CL0019018)
Fold Change: -0.4676
Cell Significance Index: -4.4200
Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
Fold Change: -0.4757
Cell Significance Index: -4.0100
Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
Fold Change: -0.4803
Cell Significance Index: -4.1300
Cell Name: progenitor cell (CL0011026)
Fold Change: -0.4886
Cell Significance Index: -5.1900
Cell Name: DN4 thymocyte (CL0000808)
Fold Change: -0.4951
Cell Significance Index: -3.7300
Cell Name: squamous epithelial cell (CL0000076)
Fold Change: -0.4966
Cell Significance Index: -6.0400
Cell Name: inflammatory macrophage (CL0000863)
Fold Change: -0.5030
Cell Significance Index: -3.8700
Cell Name: glial cell (CL0000125)
Fold Change: -0.5038
Cell Significance Index: -5.5200
Cell Name: M cell of gut (CL0000682)
Fold Change: -0.5041
Cell Significance Index: -4.2000
Cell Name: promonocyte (CL0000559)
Fold Change: -0.5051
Cell Significance Index: -5.4000
Cell Name: mast cell (CL0000097)
Fold Change: -0.5099
Cell Significance Index: -6.7100
Cell Name: transit amplifying cell (CL0009010)
Fold Change: -0.5105
Cell Significance Index: -4.9000
Cell Name: vascular associated smooth muscle cell (CL0000359)
Fold Change: -0.5108
Cell Significance Index: -5.4300
Cell Name: mature B cell (CL0000785)
Fold Change: -0.5116
Cell Significance Index: -3.3300
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.5135
Cell Significance Index: -14.7200
Cell Name: mesothelial cell (CL0000077)
Fold Change: -0.5199
Cell Significance Index: -6.3200
Cell Name: pro-B cell (CL0000826)
Fold Change: -0.5245
Cell Significance Index: -5.6400
Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
Fold Change: -0.5305
Cell Significance Index: -5.7200
Cell Name: capillary endothelial cell (CL0002144)
Fold Change: -0.5343
Cell Significance Index: -6.0700
Cell Name: non-classical monocyte (CL0000875)
Fold Change: -0.5347
Cell Significance Index: -5.9200
Cell Name: lung resident memory CD8-positive, alpha-beta T cell (CL4033039)
Fold Change: -0.5369
Cell Significance Index: -4.7500
Cell Name: smooth muscle cell (CL0000192)
Fold Change: -0.5380
Cell Significance Index: -6.2500
Cell Name: erythroid lineage cell (CL0000764)
Fold Change: -0.5387
Cell Significance Index: -5.9400
Cell Name: alveolar adventitial fibroblast (CL4028006)
Fold Change: -0.5393
Cell Significance Index: -5.9900
Cell Name: epithelial cell of thymus (CL0002293)
Fold Change: -0.5397
Cell Significance Index: -4.1500
Cell Name: acinar cell (CL0000622)
Fold Change: -0.5406
Cell Significance Index: -6.7900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Other Information

Description

**Key Characteristics:** 1. **Gene Location and Structure:** The IGHV3-30 gene is located on chromosome 14q32.33 and is part of the immunoglobulin heavy chain locus. It is a single copy gene that codes for the heavy chain variable region of immunoglobulin molecules. 2. **Expression Patterns:** The IGHV3-30 gene is expressed in a wide range of cell types, including CD16-positive natural killer cells, CD56-dim natural killer cells, double-negative thymocytes, granulocyte-monocyte progenitor cells, goblet cells, and effector CD8-positive alpha-beta T cells. 3. **Function:** The IGHV3-30 gene plays a crucial role in the production of antibodies against Leishmania parasites and other pathogens. It is involved in antigen binding, signaling, and regulation of the complement cascade. **Pathways and Functions:** 1. **Adaptive Immune Response:** The IGHV3-30 gene is involved in the adaptive immune response, including the production of antibodies against Leishmania parasites and other pathogens. 2. **Antigen Binding:** The IGHV3-30 gene is responsible for the binding of antigens to the B cell receptor (BCR), leading to the activation of B cells and the production of antibodies. 3. **Complement Cascade:** The IGHV3-30 gene is involved in the regulation of the complement cascade, including the creation of C4 and C2 activators. 4. **Cell Surface Interactions:** The IGHV3-30 gene is involved in cell surface interactions at the vascular wall, including the binding and uptake of ligands by scavenger receptors. 5. **Immune Response Regulation:** The IGHV3-30 gene is involved in the regulation of immune responses, including the production of cytokines and the activation of immune cells. **Clinical Significance:** 1. **Infectious Diseases:** The IGHV3-30 gene has been implicated in the pathogenesis of infectious diseases, including Leishmania infections. 2. **Autoimmune Disorders:** The IGHV3-30 gene has been linked to autoimmune disorders, including autoimmune hemolytic anemia and rheumatoid arthritis. 3. **Cancer:** The IGHV3-30 gene has been implicated in the development of cancer, including lymphoma and leukemia. 4. **Viral Infections:** The IGHV3-30 gene has been involved in the pathogenesis of viral infections, including SARS-CoV and Leishmania infections. 5. **Potential Therapeutics:** The IGHV3-30 gene has potential therapeutic applications, including the development of vaccines and antibody-based therapies against Leishmania parasites and other pathogens. In conclusion, the IGHV3-30 gene is a crucial component of the adaptive immune system, playing a significant role in the production of antibodies against various pathogens. Its dysregulation has been implicated in various diseases, including infectious diseases, autoimmune disorders, and cancer. Further research is needed to fully understand the complexities of this gene and its role in human disease.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.