Details for: USF1

Gene ID: 7391

Symbol: USF1

Ensembl ID: ENSG00000158773

Description: upstream transcription factor 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 76.5694
    Cell Significance Index: -11.9100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 47.7048
    Cell Significance Index: -12.1000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 28.3810
    Cell Significance Index: -11.5300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 12.1184
    Cell Significance Index: -11.5700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 9.9922
    Cell Significance Index: -12.3200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.5168
    Cell Significance Index: -12.1000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.1475
    Cell Significance Index: -12.4200
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 2.5630
    Cell Significance Index: 42.2400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 2.3800
    Cell Significance Index: -7.3100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.1951
    Cell Significance Index: 194.3800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7411
    Cell Significance Index: 80.6100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.7351
    Cell Significance Index: 10.0300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.7331
    Cell Significance Index: 13.5500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6541
    Cell Significance Index: 39.2700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4508
    Cell Significance Index: 81.2700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4084
    Cell Significance Index: 28.2400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3967
    Cell Significance Index: 11.4300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3813
    Cell Significance Index: 8.2600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3481
    Cell Significance Index: 314.2900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3100
    Cell Significance Index: 14.0500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.2820
    Cell Significance Index: 14.6900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2589
    Cell Significance Index: 30.5300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2189
    Cell Significance Index: 14.1300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2162
    Cell Significance Index: 149.5100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2142
    Cell Significance Index: 21.1900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1899
    Cell Significance Index: 23.3500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1704
    Cell Significance Index: 8.8500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1518
    Cell Significance Index: 30.4500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1372
    Cell Significance Index: 3.4300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1369
    Cell Significance Index: 27.1700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1038
    Cell Significance Index: 2.9000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0963
    Cell Significance Index: 3.3900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0949
    Cell Significance Index: 51.8500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0728
    Cell Significance Index: 10.0000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0699
    Cell Significance Index: 25.0800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0657
    Cell Significance Index: 4.1400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0551
    Cell Significance Index: 24.3500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0078
    Cell Significance Index: 14.6400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0016
    Cell Significance Index: 2.3900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0003
    Cell Significance Index: 0.6300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0042
    Cell Significance Index: -2.6700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0058
    Cell Significance Index: -7.8400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0094
    Cell Significance Index: -0.4400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0140
    Cell Significance Index: -10.2800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0158
    Cell Significance Index: -11.9400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0169
    Cell Significance Index: -12.5100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0181
    Cell Significance Index: -8.2000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0188
    Cell Significance Index: -0.4000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0194
    Cell Significance Index: -1.4900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0202
    Cell Significance Index: -2.5900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0220
    Cell Significance Index: -1.3500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0221
    Cell Significance Index: -3.2100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0231
    Cell Significance Index: -13.0500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0231
    Cell Significance Index: -14.4500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0238
    Cell Significance Index: -6.8600
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.0306
    Cell Significance Index: -0.6500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0393
    Cell Significance Index: -4.0200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0419
    Cell Significance Index: -1.2300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0433
    Cell Significance Index: -3.0600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0448
    Cell Significance Index: -2.5200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0506
    Cell Significance Index: -1.3500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0513
    Cell Significance Index: -5.9800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0558
    Cell Significance Index: -9.5300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0648
    Cell Significance Index: -1.1100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0679
    Cell Significance Index: -14.3100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0715
    Cell Significance Index: -8.1900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0750
    Cell Significance Index: -2.1500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0755
    Cell Significance Index: -0.7000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0787
    Cell Significance Index: -3.7000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0905
    Cell Significance Index: -11.6900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1111
    Cell Significance Index: -11.5700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1313
    Cell Significance Index: -8.0500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1340
    Cell Significance Index: -9.9900
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.1377
    Cell Significance Index: -1.1700
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.1394
    Cell Significance Index: -4.4100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1415
    Cell Significance Index: -9.5200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1510
    Cell Significance Index: -4.0400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1525
    Cell Significance Index: -12.0800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1582
    Cell Significance Index: -4.1600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1583
    Cell Significance Index: -4.0700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1644
    Cell Significance Index: -7.2700
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.1709
    Cell Significance Index: -2.6000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1844
    Cell Significance Index: -9.6800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1870
    Cell Significance Index: -5.9900
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.2033
    Cell Significance Index: -2.8500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2081
    Cell Significance Index: -7.8800
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2137
    Cell Significance Index: -3.2200
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.2146
    Cell Significance Index: -3.2100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2166
    Cell Significance Index: -3.6300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2179
    Cell Significance Index: -5.9300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2202
    Cell Significance Index: -4.6100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2586
    Cell Significance Index: -6.9300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2629
    Cell Significance Index: -9.2100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2694
    Cell Significance Index: -8.5800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2710
    Cell Significance Index: -5.2900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2740
    Cell Significance Index: -8.9700
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.2789
    Cell Significance Index: -1.8900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2926
    Cell Significance Index: -4.1900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2937
    Cell Significance Index: -10.7800
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.2941
    Cell Significance Index: -2.4700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** USF1 is a transcription factor that belongs to the basic helix-loop-helix (bHLH) family. It is characterized by its ability to bind to specific DNA sequences, known as USF1-binding sites, which are typically located upstream of target gene promoters. USF1's binding activity is regulated by post-translational modifications, such as phosphorylation and acetylation, which modulate its interaction with other proteins and transcriptional machinery. The protein is also capable of heterodimerizing with other transcription factors, including estrogen receptor (ER) and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), thereby expanding its transcriptional regulatory repertoire. **Pathways and Functions** USF1 is involved in various signaling pathways that regulate cellular responses to environmental stimuli, including: 1. **Glucose homeostasis**: USF1 modulates the expression of genes involved in glucose metabolism, such as glycolysis and gluconeogenesis, thereby influencing insulin sensitivity and glucose tolerance. 2. **Lipid metabolism**: USF1 regulates the expression of genes involved in lipid synthesis and degradation, including those involved in cholesterol and fatty acid metabolism. 3. **Cell growth and differentiation**: USF1 is involved in regulating cell growth and differentiation, particularly in neural progenitor cells and epithelial cells, where it modulates the expression of genes involved in cell proliferation and differentiation. 4. **Immune response**: USF1 is expressed in immune cells, such as classical monocytes and macrophages, where it regulates the expression of genes involved in immune response, including those involved in cytokine production and antigen presentation. **Clinical Significance** USF1 has been implicated in various diseases, including: 1. **Type 2 diabetes**: USF1 has been shown to play a role in regulating glucose homeostasis and insulin sensitivity, making it a potential therapeutic target for the treatment of type 2 diabetes. 2. **Obesity**: USF1 has been implicated in regulating lipid metabolism and energy balance, making it a potential therapeutic target for the treatment of obesity. 3. **Neurological disorders**: USF1 has been shown to play a role in regulating neural progenitor cell proliferation and differentiation, making it a potential therapeutic target for the treatment of neurological disorders, such as Alzheimer's disease and Parkinson's disease. 4. **Cancer**: USF1 has been implicated in regulating cell growth and differentiation, making it a potential therapeutic target for the treatment of certain types of cancer. In conclusion, USF1 is a multifunctional transcription factor that plays a crucial role in regulating various cellular processes, including transcription, metabolism, and cell growth. Its dysregulation has been implicated in various diseases, making it a potential therapeutic target for the treatment of these conditions.

Genular Protein ID: 1770217218

Symbol: USF1_HUMAN

Name: Upstream stimulatory factor 1

UniProtKB Accession Codes:

P22415 B2RBZ4 Q5SY46 Q7Z5Y1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 2 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 32 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 3 SASBDB 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2249772

Title: The adenovirus major late transcription factor USF is a member of the helix-loop-helix group of regulatory proteins and binds to DNA as a dimer.

PubMed ID: 2249772

DOI: 10.1101/gad.4.10.1730

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14573800

Title: Transcription factor USF, expressed during the entire phase of Varicella-zoster virus infection, interacts physically with the major viral transactivator IE62 and plays a significant role in virus replication.

PubMed ID: 14573800

DOI: 10.1099/vir.0.19335-0

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 8306960

Title: Structure and function of the b/HLH/Z domain of USF.

PubMed ID: 8306960

DOI: 10.1002/j.1460-2075.1994.tb06247.x

PubMed ID: 14991056

Title: Familial combined hyperlipidemia is associated with upstream transcription factor 1 (USF1).

PubMed ID: 14991056

DOI: 10.1038/ng1320

Sequence Information:

  • Length: 310
  • Mass: 33538
  • Checksum: BFDA91519B4B80AE
  • Sequence:
    • MKGQQKTAET EEGTVQIQEG AVATGEDPTS VAIASIQSAA TFPDPNVKYV FRTENGGQVM 
YRVIQVSEGQ LDGQTEGTGA ISGYPATQSM TQAVIQGAFT SDDAVDTEGT AAETHYTYFP 
STAVGDGAGG TTSGSTAAVV TTQGSEALLG QATPPGTGQF FVMMSPQEVL QGGSQRSIAP 
RTHPYSPKSE APRTTRDEKR RAQHNEVERR RRDKINNWIV QLSKIIPDCS MESTKSGQSK 
GGILSKACDY IQELRQSNHR LSEELQGLDQ LQLDNDVLRQ QVEDLKNKNL LLRAQLRHHG 
LEVVIKNDSN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.