Details for: KCNN4

Gene ID: 3783

Symbol: KCNN4

Ensembl ID: ENSG00000104783

Description: potassium calcium-activated channel subfamily N member 4

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 3.29
    Marker Score: 9431
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.05
    Marker Score: 8071
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 1.98
    Marker Score: 791
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.53
    Marker Score: 3461
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.49
    Marker Score: 2197
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.44
    Marker Score: 3270
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 1.4
    Marker Score: 1250.5
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 1.35
    Marker Score: 428
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.11
    Marker Score: 7088
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 1.07
    Marker Score: 380
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251768
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.01
    Marker Score: 792
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71786
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48010
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30404
  • Cell Name: tracheobronchial serous cell (CL0019001)
    Fold Change: 0.96
    Marker Score: 349
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.95
    Marker Score: 492
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2408
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 447
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5303
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2733
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.91
    Marker Score: 747
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.9
    Marker Score: 524
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.87
    Marker Score: 313
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5268
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.86
    Marker Score: 1753
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.85
    Marker Score: 944
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 0.84
    Marker Score: 271
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.82
    Marker Score: 1959
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.82
    Marker Score: 5223
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.78
    Marker Score: 780.5
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.78
    Marker Score: 594
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1260
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.75
    Marker Score: 511
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.75
    Marker Score: 1837
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.75
    Marker Score: 186
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.74
    Marker Score: 298
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.74
    Marker Score: 383
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.74
    Marker Score: 511
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.73
    Marker Score: 545.5
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.71
    Marker Score: 2897
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7
    Marker Score: 450
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 0.7
    Marker Score: 422
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.7
    Marker Score: 639
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.7
    Marker Score: 1239
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.68
    Marker Score: 1769
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.68
    Marker Score: 318
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.68
    Marker Score: 711
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.67
    Marker Score: 2814
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 171
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.65
    Marker Score: 492
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.62
    Marker Score: 326
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.61
    Marker Score: 124
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.61
    Marker Score: 3725
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.61
    Marker Score: 808
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.6
    Marker Score: 209
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 0.59
    Marker Score: 552
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 0.56
    Marker Score: 407
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 443
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.55
    Marker Score: 352
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.55
    Marker Score: 1722
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.53
    Marker Score: 544
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.52
    Marker Score: 990
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.52
    Marker Score: 138
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.51
    Marker Score: 181
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.51
    Marker Score: 254
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.5
    Marker Score: 391
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 0.5
    Marker Score: 359
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.49
    Marker Score: 185
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.48
    Marker Score: 1437
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.48
    Marker Score: 622
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.47
    Marker Score: 307
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.45
    Marker Score: 209
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.45
    Marker Score: 7068
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.45
    Marker Score: 267
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.44
    Marker Score: 186
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.44
    Marker Score: 713
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 0.44
    Marker Score: 104
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.43
    Marker Score: 257
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: 0.43
    Marker Score: 212
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.42
    Marker Score: 442
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.41
    Marker Score: 747
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 0.4
    Marker Score: 705
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 0.39
    Marker Score: 94
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.38
    Marker Score: 5142
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 0.38
    Marker Score: 220
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.37
    Marker Score: 427
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.36
    Marker Score: 571
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.36
    Marker Score: 222
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.35
    Marker Score: 122
  • Cell Name: B-1a B cell (CL0000820)
    Fold Change: 0.35
    Marker Score: 84
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.35
    Marker Score: 113
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 0.35
    Marker Score: 146
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.35
    Marker Score: 105
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.35
    Marker Score: 100
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.35
    Marker Score: 452
  • Cell Name: centroblast (CL0009112)
    Fold Change: 0.35
    Marker Score: 170
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.34
    Marker Score: 152
  • Cell Name: promonocyte (CL0000559)
    Fold Change: 0.33
    Marker Score: 212
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.33
    Marker Score: 3818

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Other Information

## Summary The KCNN4 gene encodes a protein that is a member of the potassium calcium-activated channel subfamily N (KCNN) protein family. KCNNs are a large family of ion channels that are expressed in a variety of cell types. They are involved in a variety of cellular processes, including calcium signaling, cell volume homeostasis, and immune responses. ## Key characteristics * KCNN4 is a transmembrane protein that is expressed in various cell types. * It is a member of the KCNN family of potassium channels. * It is a ligand-gated channel, meaning that its activity is modulated by the binding of a specific ligand. * KCNN4 is expressed in high levels in cells that are exposed to calcium, such as retinal cone cells and placental villous trophoblast cells. * It is also expressed in cells that are involved in immune responses, such as serous secreting cells and macrophages. ## Pathways and functions * KCNN4 is a key regulator of calcium signaling in many cell types. * It is involved in the regulation of cell volume homeostasis, by controlling the opening and closing of potassium channels in the cell membrane. * It is also involved in the regulation of immune responses, by controlling the opening and closing of potassium channels in immune cells. * KCNN4 is a key regulator of the epithelial-mesenchymal transition, a process by which epithelial cells lose their epithelial characteristics and become mesenchymal cells. ## Clinical significance Mutations in KCNN4 have been linked to a number of human diseases, including glaucoma, epilepsy, and asthma. These diseases are characterized by abnormal calcium signaling and cell volume homeostasis. KCNN4 is a promising target for the treatment of these diseases. ## Other important points * KCNN4 is a highly conserved protein, with a similar sequence in mammals, birds, and reptiles. * It is a member of therodotoxin superfamily of potassium channels. * It is a relatively new protein, with the first sequence being identified in 2003.

Genular Protein ID: 465697

Symbol: KCNN4_HUMAN

Name: Intermediate conductance calcium-activated potassium channel protein 4

UniProtKB Accession Codes:

O15554 Q53XR4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 ChEMBL 1 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 DrugBank 9 DrugCentral 1 EMBL 14 EMDB 3 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 25 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 4 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9380751

Title: hSK4, a member of a novel subfamily of calcium-activated potassium channels.

PubMed ID: 9380751

DOI: 10.1073/pnas.94.20.11013

PubMed ID: 9326665

Title: A human intermediate conductance calcium-activated potassium channel.

PubMed ID: 9326665

DOI: 10.1073/pnas.94.21.11651

PubMed ID: 9407042

Title: A novel gene, hKCa4, encodes the calcium-activated potassium channel in human T lymphocytes.

PubMed ID: 9407042

DOI: 10.1074/jbc.272.52.32723

PubMed ID: 9693050

Title: Human calcium-activated potassium channel gene KCNN4 maps to chromosome 19q13.2 in the region deleted in diamond-blackfan anemia.

PubMed ID: 9693050

DOI: 10.1006/geno.1998.5333

PubMed ID: 10961988

Title: Up-regulation of the IKCa1 potassium channel during T-cell activation. Molecular mechanism and functional consequences.

PubMed ID: 10961988

DOI: 10.1074/jbc.m003941200

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10026195

Title: Calmodulin mediates calcium-dependent activation of the intermediate conductance KCa channel, IKCa1.

PubMed ID: 10026195

DOI: 10.1074/jbc.274.9.5746

PubMed ID: 11425865

Title: Delineation of the clotrimazole/TRAM-34 binding site on the intermediate conductance calcium-activated potassium channel, IKCa1.

PubMed ID: 11425865

DOI: 10.1074/jbc.m105231200

PubMed ID: 15831468

Title: The phosphatidylinositol 3-phosphate phosphatase myotubularin-related protein 6 (MTMR6) is a negative regulator of the Ca2+-activated K+ channel KCa3.1.

PubMed ID: 15831468

DOI: 10.1128/mcb.25.9.3630-3638.2005

PubMed ID: 17157250

Title: Histidine phosphorylation of the potassium channel KCa3.1 by nucleoside diphosphate kinase B is required for activation of KCa3.1 and CD4 T cells.

PubMed ID: 17157250

DOI: 10.1016/j.molcel.2006.11.012

PubMed ID: 18796614

Title: Protein histidine phosphatase 1 negatively regulates CD4 T cells by inhibiting the K+ channel KCa3.1.

PubMed ID: 18796614

DOI: 10.1073/pnas.0803678105

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24591580

Title: Sequential breakdown of 3-phosphorylated phosphoinositides is essential for the completion of macropinocytosis.

PubMed ID: 24591580

DOI: 10.1073/pnas.1311029111

PubMed ID: 26178367

Title: Novel Gardos channel mutations linked to dehydrated hereditary stomatocytosis (xerocytosis).

PubMed ID: 26178367

DOI: 10.1002/ajh.24117

PubMed ID: 26148990

Title: A mutation in the Gardos channel is associated with hereditary xerocytosis.

PubMed ID: 26148990

DOI: 10.1182/blood-2015-04-642496

PubMed ID: 26198474

Title: Mutations in the Gardos channel (KCNN4) are associated with hereditary xerocytosis.

PubMed ID: 26198474

DOI: 10.1182/blood-2015-07-657957

Sequence Information:

  • Length: 427
  • Mass: 47696
  • Checksum: 23F9AF66609B410F
  • Sequence:
    • MGGDLVLGLG ALRRRKRLLE QEKSLAGWAL VLAGTGIGLM VLHAEMLWFG GCSWALYLFL 
VKCTISISTF LLLCLIVAFH AKEVQLFMTD NGLRDWRVAL TGRQAAQIVL ELVVCGLHPA 
PVRGPPCVQD LGAPLTSPQP WPGFLGQGEA LLSLAMLLRL YLVPRAVLLR SGVLLNASYR 
SIGALNQVRF RHWFVAKLYM NTHPGRLLLG LTLGLWLTTA WVLSVAERQA VNATGHLSDT 
LWLIPITFLT IGYGDVVPGT MWGKIVCLCT GVMGVCCTAL LVAVVARKLE FNKAEKHVHN 
FMMDIQYTKE MKESAARVLQ EAWMFYKHTR RKESHAARRH QRKLLAAINA FRQVRLKHRK 
LREQVNSMVD ISKMHMILYD LQQNLSSSHR ALEKQIDTLA GKLDALTELL STALGPRQLP 
EPSQQSK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.