Details for: KCNN4

Gene ID: 3783

Symbol: KCNN4

Ensembl ID: ENSG00000104783

Description: potassium calcium-activated channel subfamily N member 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 20.2335
    Cell Significance Index: -8.2200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 17.9386
    Cell Significance Index: -4.5500
  • Cell Name: epithelial cell of sweat gland (CL1000448)
    Fold Change: 16.0635
    Cell Significance Index: 11.4800
  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 5.8504
    Cell Significance Index: -0.9100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 5.7626
    Cell Significance Index: -7.1100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 4.8676
    Cell Significance Index: 226.9500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 3.4996
    Cell Significance Index: -9.3800
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: 3.2317
    Cell Significance Index: 67.4000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.9528
    Cell Significance Index: 153.3900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.4729
    Cell Significance Index: 33.7400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.0983
    Cell Significance Index: -8.2800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.0970
    Cell Significance Index: 57.0800
  • Cell Name: salivary gland glandular cell (CL1001596)
    Fold Change: 2.0930
    Cell Significance Index: 11.6500
  • Cell Name: serous secreting cell of bronchus submucosal gland (CL4033005)
    Fold Change: 2.0665
    Cell Significance Index: 20.6800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.7889
    Cell Significance Index: 340.4300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.7212
    Cell Significance Index: 37.2900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.5572
    Cell Significance Index: 41.5800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 1.4846
    Cell Significance Index: -4.5600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.4742
    Cell Significance Index: 69.2900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.3634
    Cell Significance Index: 20.4300
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.2853
    Cell Significance Index: 7.9300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.0536
    Cell Significance Index: 136.1200
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.9497
    Cell Significance Index: 13.6100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.8410
    Cell Significance Index: 24.7000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.8348
    Cell Significance Index: 90.8000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7946
    Cell Significance Index: 129.2400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7764
    Cell Significance Index: 46.6100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.7296
    Cell Significance Index: 85.0300
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.5416
    Cell Significance Index: 5.6100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4746
    Cell Significance Index: 85.5600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4656
    Cell Significance Index: 420.3800
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.4622
    Cell Significance Index: 6.5800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4139
    Cell Significance Index: 28.6200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4055
    Cell Significance Index: 18.3800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.3676
    Cell Significance Index: 3.3900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3523
    Cell Significance Index: 10.1500
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.3110
    Cell Significance Index: 1.9300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.3103
    Cell Significance Index: 9.9400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2998
    Cell Significance Index: 35.3500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2378
    Cell Significance Index: 29.2400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.2161
    Cell Significance Index: 5.7800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.2147
    Cell Significance Index: 5.5200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1725
    Cell Significance Index: 17.0600
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.1681
    Cell Significance Index: 2.6000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1647
    Cell Significance Index: 89.9300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1113
    Cell Significance Index: 3.9100
  • Cell Name: mucus secreting cell of tracheobronchial tree submucosal gland (CL4033037)
    Fold Change: 0.1003
    Cell Significance Index: 0.6700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0896
    Cell Significance Index: 11.4900
  • Cell Name: trophoblast giant cell (CL0002488)
    Fold Change: 0.0465
    Cell Significance Index: 0.3300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0445
    Cell Significance Index: 0.9500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0424
    Cell Significance Index: 8.5100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0217
    Cell Significance Index: 7.7700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0154
    Cell Significance Index: 4.4500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0063
    Cell Significance Index: 0.1300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0032
    Cell Significance Index: -5.9500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0041
    Cell Significance Index: -0.0700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0044
    Cell Significance Index: -0.1100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0062
    Cell Significance Index: -11.3500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0064
    Cell Significance Index: -4.8100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0074
    Cell Significance Index: -11.4000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0088
    Cell Significance Index: -11.9600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0096
    Cell Significance Index: -4.2400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0123
    Cell Significance Index: -9.0100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0130
    Cell Significance Index: -9.6300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0140
    Cell Significance Index: -8.8900
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.0168
    Cell Significance Index: -0.1600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0178
    Cell Significance Index: -10.0500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0205
    Cell Significance Index: -1.0300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0212
    Cell Significance Index: -9.6000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0264
    Cell Significance Index: -1.7000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0274
    Cell Significance Index: -0.7000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0337
    Cell Significance Index: -6.7000
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.0361
    Cell Significance Index: -0.4200
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0465
    Cell Significance Index: -0.7000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0479
    Cell Significance Index: -1.3400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0499
    Cell Significance Index: -3.7200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0540
    Cell Significance Index: -5.5200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0543
    Cell Significance Index: -9.2800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0569
    Cell Significance Index: -8.2700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0596
    Cell Significance Index: -2.4400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0630
    Cell Significance Index: -8.6500
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.0675
    Cell Significance Index: -0.4400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0691
    Cell Significance Index: -3.6000
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.0699
    Cell Significance Index: -0.9700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0764
    Cell Significance Index: -7.9500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0833
    Cell Significance Index: -9.5400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0899
    Cell Significance Index: -5.5100
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0916
    Cell Significance Index: -1.5400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1139
    Cell Significance Index: -8.7400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1185
    Cell Significance Index: -4.3500
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: -0.1242
    Cell Significance Index: -0.2800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1260
    Cell Significance Index: -8.4800
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.1288
    Cell Significance Index: -2.2200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1356
    Cell Significance Index: -1.5400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1400
    Cell Significance Index: -4.4600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1521
    Cell Significance Index: -5.3300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1555
    Cell Significance Index: -6.8800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1599
    Cell Significance Index: -8.9700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1604
    Cell Significance Index: -5.2500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1674
    Cell Significance Index: -10.2900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IKCa channels are characterized by their ability to activate in response to an increase in intracellular calcium levels, leading to the efflux of potassium ions from the cell. This results in hyperpolarization of the cell membrane, which can modulate various cellular processes, including neuronal excitability, muscle contraction, and cell signaling. The KCNN4 gene is distinct from other SK channel genes due to its intermediate conductance and unique subunit composition. **Pathways and Functions:** IKCa channels are involved in a range of physiological processes, including: 1. **Cell Volume Homeostasis:** IKCa channels help regulate cell swelling and shrinkage by controlling potassium ion flux. 2. **Neuronal Excitability:** IKCa channels modulate neuronal excitability, which is crucial for maintaining proper neuronal function and preventing excessive neuronal activity. 3. **Immune Response:** IKCa channels are expressed on T cells, where they modulate T cell receptor signaling and cytokine production. 4. **Vesicle Trafficking:** IKCa channels regulate the release of vesicles, which is essential for cellular communication and signaling. 5. **Calcium Ion Transport:** IKCa channels contribute to the regulation of calcium ion transport across the plasma membrane. **Clinical Significance:** Dysregulation of KCNN4 has been implicated in various diseases, including: 1. **Neurological Disorders:** Mutations in KCNN4 have been associated with neurological disorders, such as epilepsy and neuropathic pain. 2. **Immune System Dysregulation:** Abnormalities in IKCa channel function have been linked to immune system disorders, including autoimmune diseases and cancer. 3. **Metabolic Disorders:** KCNN4 has been implicated in metabolic disorders, such as obesity and diabetes, where it regulates glucose and lipid metabolism. 4. **Cancer:** IKCa channels have been shown to regulate cancer cell growth, invasion, and metastasis. In conclusion, KCNN4 plays a vital role in maintaining cellular homeostasis and regulating immune function. Further research is necessary to fully elucidate the mechanisms of KCNN4 in various diseases and to explore its potential as a therapeutic target.

Genular Protein ID: 465697

Symbol: KCNN4_HUMAN

Name: IKCa1

UniProtKB Accession Codes:

O15554 Q53XR4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 1 ChEMBL 1 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 DrugBank 9 DrugCentral 1 EMBL 14 EMDB 3 Ensembl 1 ExpressionAtlas 1 GO 30 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9380751

Title: hSK4, a member of a novel subfamily of calcium-activated potassium channels.

PubMed ID: 9380751

DOI: 10.1073/pnas.94.20.11013

PubMed ID: 9326665

Title: A human intermediate conductance calcium-activated potassium channel.

PubMed ID: 9326665

DOI: 10.1073/pnas.94.21.11651

PubMed ID: 9407042

Title: A novel gene, hKCa4, encodes the calcium-activated potassium channel in human T lymphocytes.

PubMed ID: 9407042

DOI: 10.1074/jbc.272.52.32723

PubMed ID: 9693050

Title: Human calcium-activated potassium channel gene KCNN4 maps to chromosome 19q13.2 in the region deleted in diamond-blackfan anemia.

PubMed ID: 9693050

DOI: 10.1006/geno.1998.5333

PubMed ID: 10961988

Title: Up-regulation of the IKCa1 potassium channel during T-cell activation. Molecular mechanism and functional consequences.

PubMed ID: 10961988

DOI: 10.1074/jbc.m003941200

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10026195

Title: Calmodulin mediates calcium-dependent activation of the intermediate conductance KCa channel, IKCa1.

PubMed ID: 10026195

DOI: 10.1074/jbc.274.9.5746

PubMed ID: 11425865

Title: Delineation of the clotrimazole/TRAM-34 binding site on the intermediate conductance calcium-activated potassium channel, IKCa1.

PubMed ID: 11425865

DOI: 10.1074/jbc.m105231200

PubMed ID: 15831468

Title: The phosphatidylinositol 3-phosphate phosphatase myotubularin-related protein 6 (MTMR6) is a negative regulator of the Ca2+-activated K+ channel KCa3.1.

PubMed ID: 15831468

DOI: 10.1128/mcb.25.9.3630-3638.2005

PubMed ID: 17157250

Title: Histidine phosphorylation of the potassium channel KCa3.1 by nucleoside diphosphate kinase B is required for activation of KCa3.1 and CD4 T cells.

PubMed ID: 17157250

DOI: 10.1016/j.molcel.2006.11.012

PubMed ID: 18796614

Title: Protein histidine phosphatase 1 negatively regulates CD4 T cells by inhibiting the K+ channel KCa3.1.

PubMed ID: 18796614

DOI: 10.1073/pnas.0803678105

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24591580

Title: Sequential breakdown of 3-phosphorylated phosphoinositides is essential for the completion of macropinocytosis.

PubMed ID: 24591580

DOI: 10.1073/pnas.1311029111

PubMed ID: 26418693

Title: KCa3.1-Dependent Hyperpolarization Enhances Intracellular Ca2+ Signaling Induced by fMLF in Differentiated U937 Cells.

PubMed ID: 26418693

DOI: 10.1371/journal.pone.0139243

PubMed ID: 29953543

Title: Crystal structure of the C-terminal four-helix bundle of the potassium channel KCa3.1.

PubMed ID: 29953543

DOI: 10.1371/journal.pone.0199942

PubMed ID: 29724949

Title: Activation mechanism of a human SK-calmodulin channel complex elucidated by cryo-EM structures.

PubMed ID: 29724949

DOI: 10.1126/science.aas9466

PubMed ID: 26178367

Title: Novel Gardos channel mutations linked to dehydrated hereditary stomatocytosis (xerocytosis).

PubMed ID: 26178367

DOI: 10.1002/ajh.24117

PubMed ID: 26148990

Title: A mutation in the Gardos channel is associated with hereditary xerocytosis.

PubMed ID: 26148990

DOI: 10.1182/blood-2015-04-642496

PubMed ID: 26198474

Title: Mutations in the Gardos channel (KCNN4) are associated with hereditary xerocytosis.

PubMed ID: 26198474

DOI: 10.1182/blood-2015-07-657957

Sequence Information:

  • Length: 427
  • Mass: 47696
  • Checksum: 23F9AF66609B410F
  • Sequence:
    • MGGDLVLGLG ALRRRKRLLE QEKSLAGWAL VLAGTGIGLM VLHAEMLWFG GCSWALYLFL 
VKCTISISTF LLLCLIVAFH AKEVQLFMTD NGLRDWRVAL TGRQAAQIVL ELVVCGLHPA 
PVRGPPCVQD LGAPLTSPQP WPGFLGQGEA LLSLAMLLRL YLVPRAVLLR SGVLLNASYR 
SIGALNQVRF RHWFVAKLYM NTHPGRLLLG LTLGLWLTTA WVLSVAERQA VNATGHLSDT 
LWLIPITFLT IGYGDVVPGT MWGKIVCLCT GVMGVCCTAL LVAVVARKLE FNKAEKHVHN 
FMMDIQYTKE MKESAARVLQ EAWMFYKHTR RKESHAARRH QRKLLAAINA FRQVRLKHRK 
LREQVNSMVD ISKMHMILYD LQQNLSSSHR ALEKQIDTLA GKLDALTELL STALGPRQLP 
EPSQQSK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.