Details for: WASHC2A

Gene ID: 387680

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: WASHC2A

Ensembl ID: ENSG00000099290

Description: WASH complex subunit 2A

Cell Significance Landscape

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • CD14-positive monocyte CL0001054
    CSI 5.38
    rCSI 6.7%
    PRS 95.68
  • central memory CD4-positive, alpha-beta T cell CL0000904
    CSI 5.26
    rCSI 3.1%
    PRS 98.54
  • CD4-positive, alpha-beta memory T cell CL0000897
    CSI 5.13
    rCSI 3.68%
    PRS 97.77
  • unswitched memory B cell CL0000970
    CSI 4.45
    rCSI 3.74%
    PRS 97.18
  • dendritic cell, human CL0001056
    CSI 4.07
    rCSI 6.24%
    PRS 95.47
  • melanocyte CL0000148
    CSI 3.77
    rCSI 2.79%
    PRS 87.13
  • kidney connecting tubule epithelial cell CL1000768
    CSI 3.65
    rCSI 9.25%
    PRS 84.64
  • double negative thymocyte CL0002489
    CSI 3.52
    rCSI 2.44%
    PRS 97.35
  • secretory cell CL0000151
    CSI 3.41
    rCSI 3.56%
    PRS 89.63
  • T follicular helper cell CL0002038
    CSI 3.29
    rCSI 2.46%
    PRS 97.01
  • Kupffer cell CL0000091
    CSI 2.99
    rCSI 6.83%
    PRS 91.63
  • CD4-positive helper T cell CL0000492
    CSI 2.86
    rCSI 2.16%
    PRS 96.87
  • intestine goblet cell CL0019031
    CSI 2.78
    rCSI 2.47%
    PRS 88.28
  • alternatively activated macrophage CL0000890
    CSI 2.66
    rCSI 3.34%
    PRS 95.48
  • activated type II NK T cell CL0000931
    CSI 2.56
    rCSI 2.88%
    PRS 97.02
  • renal alpha-intercalated cell CL0005011
    CSI 2.54
    rCSI 3.4%
    PRS 93.74
  • early lymphoid progenitor CL0000936
    CSI 2.44
    rCSI 2.14%
    PRS 93.36
  • CD14-low, CD16-positive monocyte CL0002396
    CSI 2.41
    rCSI 1.85%
    PRS 93.44
  • pulmonary capillary endothelial cell CL4028001
    CSI 2.39
    rCSI 4.56%
    PRS 95.66
  • myeloid leukocyte CL0000766
    CSI 2.31
    rCSI 2.14%
    PRS 91.69
  • group 3 innate lymphoid cell CL0001071
    CSI 2.27
    rCSI 1.71%
    PRS 93.73
  • elicited macrophage CL0000861
    CSI 2.23
    rCSI 2.05%
    PRS 94.72
  • double-positive, alpha-beta thymocyte CL0000809
    CSI 2.16
    rCSI 2.2%
    PRS 95.23
  • retinal blood vessel endothelial cell CL0002585
    CSI 2.11
    rCSI 3.38%
    PRS 92.79
  • retinal pigment epithelial cell CL0002586
    CSI 2.1
    rCSI 4.18%
    PRS 87.33
  • lung ciliated cell CL1000271
    CSI 2.06
    rCSI 2.38%
    PRS 85.4
  • colon epithelial cell CL0011108
    CSI 2.06
    rCSI 2.16%
    PRS 88.47
  • effector memory CD8-positive, alpha-beta T cell, terminally differentiated CL0001062
    CSI 2.03
    rCSI 10.21%
    PRS 97.08
  • basal cell of epidermis CL0002187
    CSI 1.94
    rCSI 3.43%
    PRS 62.3
  • ciliated cell CL0000064
    CSI 1.9
    rCSI 3.08%
    PRS 85.14
  • alveolar macrophage CL0000583
    CSI 1.83
    rCSI 3.01%
    PRS 92.31
  • CD8-positive, alpha-beta cytotoxic T cell CL0000794
    CSI 1.81
    rCSI 2.17%
    PRS 97.72
  • astrocyte of the cerebral cortex CL0002605
    CSI 1.67
    rCSI 3.74%
    PRS 78.41
  • squamous epithelial cell CL0000076
    CSI 1.65
    rCSI 3.92%
    PRS 88.04
  • intermediate monocyte CL0002393
    CSI 1.65
    rCSI 2.49%
    PRS 94.29
  • cardiac endothelial cell CL0010008
    CSI 1.61
    rCSI 6.48%
    PRS 91.13
  • myeloid dendritic cell CL0000782
    CSI 1.5
    rCSI 2.17%
    PRS 97.18
  • regular atrial cardiac myocyte CL0002129
    CSI 1.4
    rCSI 4.49%
    PRS 87.28
  • glial cell CL0000125
    CSI 1.22
    rCSI 4.64%
    PRS 84.3
  • cardiac muscle cell CL0000746
    CSI 1.19
    rCSI 1.71%
    PRS 83.04
  • retinal ganglion cell CL0000740
    CSI 1.02
    rCSI 2.25%
    PRS 80.36
  • lung macrophage CL1001603
    CSI 0.97
    rCSI 2.16%
    PRS 94.64
  • ciliated columnar cell of tracheobronchial tree CL0002145
    CSI 0.88
    rCSI 2%
    PRS 84.03

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Comma-separated if multiple.
Comma-separated if multiple.
Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

Loading network (please wait)...

Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [WASHC2A](/details-gene/387680) (WASH complex subunit 2A) is a protein-coding gene located on chromosome 10q11.23. It encodes a key component of the WASH (Wiskott-Aldrich syndrome protein and SCAR homolog) complex, a crucial regulator of actin nucleation on the surface of endosomes. Functionally, [WASHC2A](/details-gene/387680) is integral to processes involving [endosomal transport](/details-go/GO:0016197), [retrograde transport from endosome to Golgi](/details-go/GO:0042147), and the regulation of the Arp2/3 complex. Its expression profile indicates a significant role in cells with high endocytic and trafficking activity, particularly within the immune system. **Overall**, it is most significant in myeloid cells like [CD14-positive monocyte](/details-cell/CL0001054) and [dendritic cell, human](/details-cell/CL0001056), as well as in various lymphocyte populations including [central memory CD4-positive, alpha-beta T cell](/details-cell/CL0000904) and [unswitched memory B cell](/details-cell/CL0000970), suggesting a fundamental role in vesicle trafficking essential for immune cell function. ## Cellular Roles and Expression Landscape The expression pattern of [WASHC2A](/details-gene/387680) underscores its importance as a core component of cellular trafficking machinery, particularly within the hematopoietic system. **Overall**, the gene shows its highest significance in professional antigen-presenting cells and lymphocytes. It is a top marker in [CD14-positive monocyte](/details-cell/CL0001054) (CSI: 5.38), the precursors to macrophages and dendritic cells, and also in mature [dendritic cell, human](/details-cell/CL0001056) (CSI: 4.07) and liver-resident [Kupffer cell](/details-cell/CL0000091) (CSI: 2.99). This is consistent with the high demand for endosomal sorting and vesicle transport required for pathogen uptake, processing, and antigen presentation in these cells. Within the lymphoid lineage, [WASHC2A](/details-gene/387680) is highly significant in long-lived memory populations, such as [central memory CD4-positive, alpha-beta T cell](/details-cell/CL0000904) (CSI: 5.26), [CD4-positive, alpha-beta memory T cell](/details-cell/CL0000897) (CSI: 5.13), and [unswitched memory B cell](/details-cell/CL0000970) (CSI: 4.45). This suggests a role in maintaining cellular homeostasis and receptor recycling necessary for the surveillance functions of these cells. Its significance extends to other specialized T cell subsets like [T follicular helper cell](/details-cell/CL0002038) (CSI: 3.29) and developing [double negative thymocyte](/details-cell/CL0002489) (CSI: 3.52), highlighting its broad importance across T cell development and function. Beyond the immune system, notable significance in [melanocyte](/details-cell/CL0000148) (CSI: 3.77) and [secretory cell](/details-cell/CL0000151) (CSI: 3.41) may point to its involvement in melanosome transport and general protein secretion pathways, respectively, further cementing its role as a fundamental regulator of intracellular trafficking. ## Pathways and Molecular Function The functional annotations for [WASHC2A](/details-gene/387680) align precisely with its role as a member of the WASH complex. Its primary biological process is associated with [endosomal transport](/details-go/GO:0016197), including [protein localization to endosome](/details-go/GO:0036010) and [retrograde transport, endosome to golgi](/details-go/GO:0042147). This function is critical for sorting cargo proteins and recycling receptors from endosomes back to the Golgi apparatus or plasma membrane, a process essential for cellular signaling and homeostasis. Research has directly implicated the WASH complex in the endosomal trafficking of key transporters like the copper transporter ATP7A ([Link](https://doi.org/10.1091/mbc.e14-06-1073)). At the molecular level, [WASHC2A](/details-gene/387680) is involved in [regulation of arp2/3 complex-mediated actin nucleation](/details-go/GO:0034315). By recruiting the Arp2/3 complex to endosomal membranes, the WASH complex generates localized actin patches that provide the mechanical force for vesicle scission and motility. Its molecular functions include [phosphatidylinositol phosphate binding](/details-go/GO:1901981) and [protein binding](/details-go/GO:0005515), which are essential for its recruitment to specific membrane domains on early endosomes and its interaction with other trafficking components, such as the retromer complex ([Link](https://doi.org/10.1038/ncb3610)). As expected, it is a core component of the [WASH complex](/details-go/GO:0071203) and is localized to the [early endosome](/details-go/GO:0005769) and its membrane, as well as being found in the [cytosol](/details-go/GO:0005829). ## Research Directions Given the fundamental role of [WASHC2A](/details-gene/387680) in endosomal trafficking and its high significance in immune cells, future research should focus on its specific contributions to immunological processes and its potential involvement in disease. **Proposed Hypotheses:** 1. **Hypothesis:** The high significance of [WASHC2A](/details-gene/387680) in [dendritic cell, human](/details-cell/CL0001056) and [CD14-positive monocyte](/details-cell/CL0001054) suggests that its function is critical for efficient MHC class II antigen presentation. Deficiencies in [WASHC2A](/details-gene/387680) may impair the formation of peptide-MHC II complexes in late endosomes/lysosomes, leading to a diminished T cell-activating capacity. 2. **Hypothesis:** In [central memory CD4-positive, alpha-beta T cell](/details-cell/CL0000904), [WASHC2A](/details-gene/387680)-mediated trafficking is essential for the long-term maintenance of surface receptors, such as the T cell receptor (TCR) and cytokine receptors (e.g., IL-7R), which are vital for the survival and homeostatic proliferation of memory cells. **Key Experimental Approach:** To test the first hypothesis regarding antigen presentation, a robust experimental plan could be implemented. One could use a CRISPR-Cas9 or shRNA-based approach to specifically knock down [WASHC2A](/details-gene/387680) in primary human monocyte-derived dendritic cells. These knockdown cells, alongside control cells, would be pulsed with a model protein antigen (e.g., ovalbumin). The efficiency of antigen presentation could be quantified by: * **Biochemical Analysis:** Assessing the surface levels of peptide-loaded MHC class II molecules using flow cytometry with specific antibodies. * **Functional Co-culture Assay:** Co-culturing the dendritic cells with antigen-specific CD4+ T cells and measuring T cell activation through proliferation assays (e.g., CellTrace Violet dilution) or by quantifying cytokine production (e.g., IFN-γ, IL-2) via ELISA or intracellular cytokine staining. A significant reduction in T cell activation in the knockdown condition would confirm the critical role of [WASHC2A](/details-gene/387680) in this pathway. **Therapeutic Potential:** As an intracellular component of a ubiquitous and essential protein complex, [WASHC2A](/details-gene/387680) presents a challenging therapeutic target. Direct inhibition would likely lead to significant off-target effects and cellular toxicity due to the disruption of fundamental trafficking processes in healthy cells. However, in specific pathological contexts, such as certain autoimmune diseases or cancers where dysregulated endosomal trafficking contributes to the disease phenotype, indirect modulation of the WASH complex pathway could be considered. Therapeutic strategies would likely require highly specific delivery mechanisms or focus on targeting downstream effectors unique to the diseased cell type, rather than direct inhibition of [WASHC2A](/details-gene/387680) itself.

Genular Protein ID: 289571048

Symbol: WAC2A_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q641Q2 A2A3S2 A2A3U6 Q5SNT6 Q6DHY0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 5 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 2 ExpressionAtlas 1 GO 14 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 RefSeq 2 SMR 1 STRING 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25355947

Title: COMMD1 is linked to the WASH complex and regulates endosomal trafficking of the copper transporter ATP7A.

PubMed ID: 25355947

DOI: 10.1091/mbc.e14-06-1073

PubMed ID: 28892079

Title: Retriever is a multiprotein complex for retromer-independent endosomal cargo recycling.

PubMed ID: 28892079

DOI: 10.1038/ncb3610

PubMed ID: 29084197

Title: TBC1D23 is a bridging factor for endosomal vesicle capture by golgins at the trans-Golgi.

PubMed ID: 29084197

DOI: 10.1038/ncb3627

Sequence Information:

  • Length: 1341
  • Mass: 147184
  • Checksum: 8F0F755EB1493EA7
  • Sequence:
    • MMNRTTPDQE LAPASEPVWE RPWSVEEIRR SSQSWSLAAD AGLLQFLQEF SQQTISRTHE 
IKKQVDGLIR ETKATDCRLH NVFNDFLMLS NTQFIENRVY DEEVEEPVLK AEAEKTEQEK 
TREQKEVDLI PKVQEAVNYG LQVLDSAFEQ LDIKAGNSDS EEDDANGRVE LILEPKDLYI 
DRPLPYLIGS KLFMEQEDVG LGELSSEEGS VGSDRGSIVD TEEEKEEEES DEDFAHHSDN 
EQNRHTTQMS DEEEDDDGCD LFADSEKEEE DIEDIEENTR PKRSRPTSFA DELAARIKGD 
AVGRVDEEPT TLPSGEAKPR KTLKEKKERR TPSDDEEDNL FAPPKLTDED FSPFGSGGGL 
FSGGKGLFDD EDEESDLFTE APQDRQAGAS VKEESSSSKP GKKIPAGAVS VFLGDTDVFG 
AASVPSMKEP QKPEQPTPRK SPYGPPPTGL FDDDDGDDDD DFFSAPHSKP SKTGKVQSTA 
DIFGDEEGDL FKEKAVASPE ATVSQTDENK ARAEKKVTLS SSKNLKPSSE TKTQKGLFSD 
EEDSEDLFSS QSASKLKGAS LLPGKLPTLV SLFDDEDEED NLFGGTAAKK QTLCLQAQRE 
EKAKASELSK KKASALLFSS DEEDQWNIPA SQTHLASDSR SKGEPRDSGT LQSQEAKAVK 
KTSLFEEDEE DDLFAIAKDS QKKTQRVSLL FEDDVDSGGS LFGSPPTSVP PATKKKETVS 
EAPPLLFSDE EEKEAQLGVK SVDKKVESAK ESLKFGRTDV AESEKEGLLT RSAQETVKHS 
DLFSSSSPWD KGTKPRTKTV LSLFDEEEDK MEDQNIIQAP QKEVGKGRDP DAHPKSTGVF 
QDEELLFSHK LQKDNDPDVD LFAGTKKTKL LEPSVGSLFG DDEDDDLFSS AKSQPLVQEK 
KRVVKKDHSV DSFKNQKHPE SIQGSKEKGI WKPETPQDSS GLAPFKTKEP STRIGKIQAN 
LAINPAALLP TAASQISEVK PVLPELAFPS SEHRRSHGLE SVPVLPGSGE AGVSFDLPAQ 
ADTLHSANKS RVKMRGKRRP QTRAARRLAA QESSETEDMS VPRGPIAQWA DGAISPNGHR 
PQLRAASGED STEEALAAAA APWEGGPVPG VDRSPFAKSL GHSRGEADLF DSGDIFSTGT 
GSQSVERTKP KAKIAENPAN PPVGGKAKSP MFPALGEASS DDDLFQSAKP KPAKKTNPFP 
LLEDEDDLFT DQKVKKNETK SNSQQDVILT TQDIFEDDIF ATEAIKPSQK TREKEKTLES 
NLFDDNIDIF ADLTVKPKEK SKKKVEAKSI FDDDMDDIFS SGIQAKTTKP KSRSAQAAPE 
PRFEHKVSNI FDDPLNAFGG Q

Genular Protein ID: 3717454664

Symbol: E7ESD2_HUMAN

Name: N/A

UniProtKB Accession Codes:

E7ESD2

Database IDs:

ARBA 6 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 2 ExpressionAtlas 1 GO 5 GeneTree 1 HGNC 1 InterPro 1 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 2 Pfam 2 Proteomes 2 ProteomicsDB 2 RefSeq 1 SAM 1 SMR 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 1279
  • Mass: 140173
  • Checksum: E27CE22CCCF120D6
  • Sequence:
    • MMNRTTPDQE LAPASEPVWE RPWSVEEIRR SSQSWSLAAD AGLLQFLQEF SQQTISRTHE 
IKKQVDGLIR ETKATDCRLH NVFNDFLMLS NTQFIENRVY DEEVEEPVLK AEAEKTEQEK 
TREQKEVDLI PKVQEAVNYG LQVLDSAFEQ LDIKAGNSDS EEDDANGRVE LILEPKDLYI 
DRPLPYLIGS KLFMEQEDVG LGELSSEEGS VGSDRGSIVD TEEEKEEEES DEDFAHHSDN 
EQNRHTTQMS DEEEDDDGCD LFADSEKEEE DIEDIEENTR PKRSRPTSFA DELAARIKGD 
AVGRVDEEPT TLPSGEAKPR KTLKEKKERR TPSDDEEDNL FAPPKLTDED FSPFGSGGGL 
FSGGKGLFDD EDEESDLFTE APQDRQAGAS VKEESSSSKP GKKIPAGAVS VFLGDTDVFG 
AASVPSMKEP QKPEQPTPRK SPYGPPPTGL FDDDDGDDDD DFFSAPHSKP SKTGKVQSTA 
DIFGDEEGDL FKEKAVASPE ATVSQTDENK ARAEKKVTLS SSKNLKPSSE TKTQKGLFSD 
EEDSEDLFSS QSASKLKGAS LLPGKLPTLV SLFDDEDEED NLFGGTAAKK QTLCLQAQRE 
EKAKASELSK KKASALLFSS DEEDQWNIPA SQTHLASDSR SKGEPRDSGT LQSQEAKAVK 
KTSLFEEDEE DDLFAIAKDS QKKTQRVSLL FEDDVDSGGS LFGSPPTSVP PATKKKETVS 
EAPPLLFSDE EEKEAQLGVK SVDKKVESAK ESLKFGRTDV AESEKEGLLT RSAQETVKHS 
DLFSSSSPWD KGTKPRTKTV LSLFDEEEDK MEDQNIIQAP QKEVGKGRDP DAHPKSTGVF 
QDEELLFSHK LQKDNDPDVD LFAGTKKTKL LEPSVGSLFG DDEDDDLFSS AKSQPLANLA 
INPAALLPTA ASQISEVKPV LPELAFPSSE HRRSHGLESV PVLPGSGEAG VSFDLPAQAD 
TLHSANKSRV KMRGKRRPQT RAARRLAAQE SSETEDMSVP RGPIAQWADG AISPNGHRPQ 
LRAASGEDST EEALAAAAAP WEGGPVPGVD RSPFAKSLGH SRGEADLFDS GDIFSTGTGS 
QSVERTKPKA KIAENPANPP VGGKAKSPMF PALGEASSDD DLFQSAKPKP AKKTNPFPLL 
EDEDDLFTDQ KVKKNETKSN SQQDVILTTQ DIFEDDIFAT EAIKPSQKTR EKEKTLESNL 
FDDNIDIFAD LTVKPKEKSK KKVEAKSIFD DDMDDIFSSG IQAKTTKPKS RSAQAAPEPR 
FEHKVSNIFD DPLNAFGGQ

Genular Protein ID: 1485895134

Symbol: A0A087WYF6_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A087WYF6

Database IDs:

ARBA 6 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 2 ExpressionAtlas 1 GO 5 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 1 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 2 Pfam 2 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 1 SMR 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 1245
  • Mass: 136571
  • Checksum: 25E1532A3FC9B133
  • Sequence:
    • MMNRTTPDQE LAPASEPVWE RPWSVEEIRR SSQSWSLAAD AGLLQFLQEF SQQTISRTHE 
IKKQVDGLIR ETKATDCRLH NVFNDFLMLS NTQFIENRVY DEEVEEPVLK AEAEKTEQEK 
TREQKEVDLI PKVQEAVNYG LQVLDSAFEQ LDIKAGNSDS EEDDANGRVE LILEPKDLYI 
DRPLPYLIGS KLFMEQEDVG LGELSSEEGS VGSDRGSIVD TEEEKEEEES DEDFAHHSDN 
EQNRHTTQMS DEEEDDDGCD LFADSEKEEE DIEDIEENTR PKRSRPTSFA DELAARIKGD 
AVGRVDEEPT NEEDNLFAPP KLTDEDFSPF GSGGGLFSGG KGLFDDEDEE SDLFTEAPQD 
RQAGASVKEE SSSSKPGKKI PAGAVSVFLG DTDVFGAASV PSMKEPQKPE QPTPRKSPYG 
PPPTGLFDDD DGDDDDDFFS APHSKPSKTG KVQSTADIFG DEEGDLFKEK AVASPEATVS 
QTDENKARAE KKVTLSSSKN LKPSSETKTQ KGLFSDEEDS EDLFSSQSAS KLKGASLLPG 
KLPTLVSLFD DEDEEDNLFG GTAAKKQTLC LQAQREEKAK ASELSKKKAS ALLFSSDEED 
QWNIPASQTH LASDSRSKGE PRDSGTLQSQ EAKAVKKTSL FEEDEEDDLF AIAKDSQKKT 
QRVSLLFEDD VDSGGSLFGS PPTSVPPATK EGLLTRSAQE TVKHSDLFSS SSPWDKGTKP 
RTKTVLSLFD EEEDKMEDQN IIQAPQKEVG KGRDPDAHPK STGVFQDEEL LFSHKLQKDN 
DPDVDLFAGT KKTKLLEPSV GSLFGDDEDD DLFSSAKSQP LVQEKKRVVK KDHSVDSFKN 
QKHPESIQGS KEKGIWKPET PQANLAINPA ALLPTAASQI SEVKPVLPEL AFPSSEHRRS 
HGLESVPVLP GSGEAGVSFD LPAQADTLHS ANKSRVKMRG KRRPQTRAAR RLAAQESSET 
EDMSVPRGPI AQWADGAISP NGHRPQLRAA SGEDSTEEAL AAAAAPWEGG PVPGVDRSPF 
AKSLGHSRGE ADLFDSGDIF STGTGSQSVE RTKPKAKIAE NPANPPVGGK AKSPMFPALG 
EASSDDDLFQ SAKPKPAKKT NPFPLLEDED DLFTDQKVKK NETKSNSQQD VILTTQDIFE 
DDIFATEAIK PSQKTREKEK TLESNLFDDN IDIFADLTVK PKEKSKKKVE AKSIFDDDMD 
DIFSSGIQAK TTKPKSRSAQ AAPEPRFEHK VSNIFDDPLN AFGGQ

Genular Protein ID: 1648159493

Symbol: Q6P0Q7_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q6P0Q7

Database IDs:

ARBA 2 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 1 IntAct 1 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 PharmGKB 1 RefSeq 3 SAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 126
  • Mass: 14213
  • Checksum: 65BD671F684C3616
  • Sequence:
    • KNETKSNSQQ DVILTTQDIF EDDIFATEAI KPSQKTREKE KTLESNLFDD NIDIFADLTV 
KPKEKSKKKV EAKSIFDDDM DDIFSSGIQA KTTKPKSRSA QAAPEPRFEH KVSNIFDDPL 
NAFGGQ