Details for: P2RX5

Gene ID: 5026

Symbol: P2RX5

Ensembl ID: ENSG00000083454

Description: purinergic receptor P2X 5

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 23.6587
    Cell Significance Index: -3.6800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 13.7398
    Cell Significance Index: -3.4900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 5.9728
    Cell Significance Index: 191.3000
  • Cell Name: centroblast (CL0009112)
    Fold Change: 5.4435
    Cell Significance Index: 12.7000
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 4.5025
    Cell Significance Index: 20.1400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 4.5019
    Cell Significance Index: 112.5400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 4.4106
    Cell Significance Index: 95.5600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 3.1274
    Cell Significance Index: 201.7700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 3.0009
    Cell Significance Index: -3.7000
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 1.9074
    Cell Significance Index: 11.5200
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 1.5417
    Cell Significance Index: 4.1300
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.1333
    Cell Significance Index: 16.2400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.0493
    Cell Significance Index: 199.6900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 0.9686
    Cell Significance Index: -2.9800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.9593
    Cell Significance Index: 113.1300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.9435
    Cell Significance Index: 56.6400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.7306
    Cell Significance Index: 18.6700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.6976
    Cell Significance Index: 15.2800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5481
    Cell Significance Index: 59.6200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.5271
    Cell Significance Index: 11.2300
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.4484
    Cell Significance Index: 3.9400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.3135
    Cell Significance Index: 11.8700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3114
    Cell Significance Index: 62.4600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.3057
    Cell Significance Index: 13.5200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2665
    Cell Significance Index: 26.3600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2596
    Cell Significance Index: 17.9600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2344
    Cell Significance Index: 211.6200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.2204
    Cell Significance Index: 63.4300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2035
    Cell Significance Index: 15.6200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2004
    Cell Significance Index: 32.5900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1606
    Cell Significance Index: 8.4300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1545
    Cell Significance Index: 55.4000
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 0.1168
    Cell Significance Index: 0.3600
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 0.0820
    Cell Significance Index: 0.4100
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.0627
    Cell Significance Index: 0.6500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0142
    Cell Significance Index: 0.3800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.0070
    Cell Significance Index: 0.2100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0065
    Cell Significance Index: 0.4000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0062
    Cell Significance Index: 0.1800
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.0011
    Cell Significance Index: 0.0500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.0010
    Cell Significance Index: 0.0600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0006
    Cell Significance Index: -0.0200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0035
    Cell Significance Index: -1.8900
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0036
    Cell Significance Index: -0.0400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0051
    Cell Significance Index: -3.8600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0054
    Cell Significance Index: -4.0300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0057
    Cell Significance Index: -0.2600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0059
    Cell Significance Index: -3.7000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0063
    Cell Significance Index: -3.5500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0071
    Cell Significance Index: -5.1900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0103
    Cell Significance Index: -1.8600
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0153
    Cell Significance Index: -0.2300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0158
    Cell Significance Index: -0.8000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0175
    Cell Significance Index: -3.6800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0192
    Cell Significance Index: -3.2800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0198
    Cell Significance Index: -0.4100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0216
    Cell Significance Index: -2.7800
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0221
    Cell Significance Index: -0.9000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0236
    Cell Significance Index: -3.2500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0286
    Cell Significance Index: -3.3400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0313
    Cell Significance Index: -3.8500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0315
    Cell Significance Index: -3.6100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0358
    Cell Significance Index: -4.6200
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0423
    Cell Significance Index: -0.4500
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.0433
    Cell Significance Index: -0.4900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0474
    Cell Significance Index: -4.8400
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.0483
    Cell Significance Index: -0.4600
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0585
    Cell Significance Index: -1.2200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0609
    Cell Significance Index: -2.8400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0619
    Cell Significance Index: -3.9000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0619
    Cell Significance Index: -4.1600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0633
    Cell Significance Index: -3.5500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0647
    Cell Significance Index: -3.3600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0671
    Cell Significance Index: -3.1600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0684
    Cell Significance Index: -2.2400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0694
    Cell Significance Index: -5.1700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0713
    Cell Significance Index: -1.7100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0719
    Cell Significance Index: -1.0300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0744
    Cell Significance Index: -2.3700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0773
    Cell Significance Index: -1.6400
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0773
    Cell Significance Index: -1.0300
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0828
    Cell Significance Index: -1.7900
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0830
    Cell Significance Index: -1.4300
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0850
    Cell Significance Index: -1.0600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0851
    Cell Significance Index: -2.9800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0918
    Cell Significance Index: -2.3600
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0922
    Cell Significance Index: -2.3000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0956
    Cell Significance Index: -3.5100
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0988
    Cell Significance Index: -2.0100
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0989
    Cell Significance Index: -1.2500
  • Cell Name: intratelencephalic-projecting glutamatergic cortical neuron (CL4023008)
    Fold Change: -0.0992
    Cell Significance Index: -1.0200
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1017
    Cell Significance Index: -2.0100
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.1030
    Cell Significance Index: -1.3000
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.1036
    Cell Significance Index: -1.4100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1079
    Cell Significance Index: -2.8900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1081
    Cell Significance Index: -2.1700
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.1082
    Cell Significance Index: -2.6400
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1151
    Cell Significance Index: -2.4600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1171
    Cell Significance Index: -1.3300
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.1173
    Cell Significance Index: -1.7200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Purinergic Receptor**: P2X5 is a purinergic receptor that responds to extracellular ATP, a key regulator of cellular signaling. 2. **Calcium Ion Transport**: P2X5 regulates calcium ion transport into the cytosol, which is essential for various cellular processes, including signal transduction and gene expression. 3. **Immune Cell Regulation**: P2X5 is expressed in immune cells, including B cells, T cells, and dendritic cells, where it plays a crucial role in regulating immune responses. 4. **Extracellular ATP-Gated Channel**: P2X5 acts as an extracellular ATP-gated channel, allowing the passage of monatomic ions, including calcium, into the cell. **Pathways and Functions:** 1. **Calcium Signaling**: P2X5 regulates calcium ion transport into the cytosol, which activates various signaling pathways, including the MAPK/ERK pathway and the PI3K/Akt pathway. 2. **Immune Response**: P2X5 is involved in regulating immune responses, including B cell activation, T cell proliferation, and dendritic cell maturation. 3. **Hemostasis**: P2X5 regulates platelet calcium homeostasis, which is essential for platelet activation and aggregation. 4. **Neurotransmission**: P2X5 is also involved in regulating neurotransmission, including excitatory postsynaptic potential (EPSP) and inhibitory postsynaptic potential (IPSP). **Clinical Significance:** 1. **Autoimmune Disorders**: Dysregulation of P2X5 has been implicated in various autoimmune disorders, including rheumatoid arthritis, lupus, and multiple sclerosis. 2. **Inflammatory Conditions**: P2X5 is involved in regulating inflammatory responses, and its dysregulation has been linked to conditions such as asthma, chronic obstructive pulmonary disease (COPD), and inflammatory bowel disease. 3. **Cancer**: P2X5 has been implicated in the development and progression of various cancers, including breast cancer, lung cancer, and colon cancer. 4. **Neurological Disorders**: P2X5 is involved in regulating neurotransmission, and its dysregulation has been linked to conditions such as epilepsy, Parkinson's disease, and Alzheimer's disease. In conclusion, the P2RX5 gene plays a critical role in regulating calcium homeostasis and immune response, and its dysregulation has been implicated in various diseases, including autoimmune disorders, inflammatory conditions, and cancer. Further research is needed to fully understand the role of P2X5 in these diseases and to develop therapeutic strategies to modulate its activity.

Genular Protein ID: 3645852084

Symbol: P2RX5_HUMAN

Name: P2X purinoceptor 5

UniProtKB Accession Codes:

Q93086 A0A8V8TLD3 G5E981 O43450 O75540 Q308M5 Q59F38 Q8IXW4 Q93087 Q9NZV0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CTD 1 ChEBI 3 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 15 Ensembl 5 ExpressionAtlas 1 GO 18 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 RNAct 1 Reactome 2 RefSeq 4 Rhea 3 SMR 1 STRING 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9414125

Title: Primary structure and expression of a naturally truncated human P2X ATP receptor subunit from brain and immune system.

PubMed ID: 9414125

DOI: 10.1016/s0014-5793(97)01380-x

PubMed ID: 10673275

Title: The genomic region encompassing the nephropathic cystinosis gene (CTNS): complete sequencing of a 200-kb segment and discovery of a novel gene within the common cystinosis-causing deletion.

PubMed ID: 10673275

DOI: 10.1101/gr.10.2.165

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12761352

Title: Pharmacological and biophysical properties of the human P2X5 receptor.

PubMed ID: 12761352

DOI: 10.1124/mol.63.6.1407

PubMed ID: 17001079

Title: P2X5 subunit assembly requires scaffolding by the second transmembrane domain and a conserved aspartate.

PubMed ID: 17001079

DOI: 10.1074/jbc.m606113200

PubMed ID: 20223879

Title: Genetic and functional analysis of human P2X5 reveals a distinct pattern of exon 10 polymorphism with predominant expression of the nonfunctional receptor isoform.

PubMed ID: 20223879

DOI: 10.1124/mol.110.063636

Sequence Information:

  • Length: 444
  • Mass: 49303
  • Checksum: B7EF070C741C1B00
  • Sequence:
    • MGQAGCKGLC LSLFDYKTEK YVIAKNKKVG LLYRLLQASI LAYLVVWVFL IKKGYQDVDT 
SLQSAVITKV KGVAFTNTSD LGQRIWDVAD YVIPAQGENV FFVVTNLIVT PNQRQNVCAE 
NEGIPDGACS KDSDCHAGEA VTAGNGVKTG RCLRRENLAR GTCEIFAWCP LETSSRPEEP 
FLKEAEDFTI FIKNHIRFPK FNFSKSNVMD VKDRSFLKSC HFGPKNHYCP IFRLGSVIRW 
AGSDFQDIAL EGGVIGINIE WNCDLDKAAS ECHPHYSFSR LDNKLSKSVS SGYNFRFARY 
YRDAAGVEFR TLMKAYGIRF DVMVNGKAGK FSIIPTIINV GSGVALMGAG AFFCDLVLIY 
LIKKREFYRD KKYEEVRGLE DSSQEAEDEA SGLGLSEQLT SGPGLLGMPE QQELQEPPEA 
KRGSSSQKGN GSVCPQLLEP HRST

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.