Details for: TERF2

Gene ID: 7014

Symbol: TERF2

Ensembl ID: ENSG00000132604

Description: telomeric repeat binding factor 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 144.2024
    Cell Significance Index: -22.4300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 86.8542
    Cell Significance Index: -22.0300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 51.6603
    Cell Significance Index: -24.3900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 51.0760
    Cell Significance Index: -20.7500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 21.7755
    Cell Significance Index: -20.7900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 18.8815
    Cell Significance Index: -23.2800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 8.8881
    Cell Significance Index: -23.8100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 6.8274
    Cell Significance Index: -20.9700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.9452
    Cell Significance Index: -23.4600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.9478
    Cell Significance Index: -8.6400
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 3.1313
    Cell Significance Index: 51.6000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.0221
    Cell Significance Index: 922.8800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.0188
    Cell Significance Index: 13.9000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.8921
    Cell Significance Index: 178.9500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.8624
    Cell Significance Index: 93.8100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.8527
    Cell Significance Index: 55.0100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.8172
    Cell Significance Index: 96.3700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.7604
    Cell Significance Index: 150.9000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6988
    Cell Significance Index: 113.6500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.5112
    Cell Significance Index: 183.3500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4769
    Cell Significance Index: 13.7400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4108
    Cell Significance Index: 28.4100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.3960
    Cell Significance Index: 10.6100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3770
    Cell Significance Index: 17.0900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3385
    Cell Significance Index: 234.0900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.3345
    Cell Significance Index: 21.0800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2853
    Cell Significance Index: 39.1800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2820
    Cell Significance Index: 14.6500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2766
    Cell Significance Index: 34.0100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2760
    Cell Significance Index: 6.9000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2759
    Cell Significance Index: 49.7400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2715
    Cell Significance Index: 20.8400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2594
    Cell Significance Index: 5.6200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2459
    Cell Significance Index: 134.2700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.2452
    Cell Significance Index: 13.7600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2276
    Cell Significance Index: 43.3200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2196
    Cell Significance Index: 21.7200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1748
    Cell Significance Index: 77.2900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1362
    Cell Significance Index: 8.3700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1216
    Cell Significance Index: 5.6700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1124
    Cell Significance Index: 3.0600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0766
    Cell Significance Index: 3.3900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0673
    Cell Significance Index: 1.8800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0613
    Cell Significance Index: 2.3200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.0575
    Cell Significance Index: 1.2300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0487
    Cell Significance Index: 1.7100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0467
    Cell Significance Index: 7.9700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0412
    Cell Significance Index: 77.4900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0190
    Cell Significance Index: 0.3700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0168
    Cell Significance Index: 10.6700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0164
    Cell Significance Index: 0.8600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0137
    Cell Significance Index: 25.2800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0111
    Cell Significance Index: 17.0900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0015
    Cell Significance Index: 0.0400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0017
    Cell Significance Index: -2.3300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0028
    Cell Significance Index: -1.2700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0077
    Cell Significance Index: -4.8000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0093
    Cell Significance Index: -6.9100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0129
    Cell Significance Index: -9.4600
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.0195
    Cell Significance Index: -0.1500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0205
    Cell Significance Index: -11.5600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0262
    Cell Significance Index: -19.8200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0303
    Cell Significance Index: -4.4100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0349
    Cell Significance Index: -4.4700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0607
    Cell Significance Index: -12.7800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0665
    Cell Significance Index: -1.1400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0711
    Cell Significance Index: -20.4500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0725
    Cell Significance Index: -1.5500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0844
    Cell Significance Index: -5.9700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0854
    Cell Significance Index: -5.7400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0865
    Cell Significance Index: -8.8400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0907
    Cell Significance Index: -10.5700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0968
    Cell Significance Index: -4.5500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1091
    Cell Significance Index: -12.5000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1098
    Cell Significance Index: -14.1800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1135
    Cell Significance Index: -12.9600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1357
    Cell Significance Index: -3.8900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1458
    Cell Significance Index: -7.6000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1539
    Cell Significance Index: -3.3700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1712
    Cell Significance Index: -4.4000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1881
    Cell Significance Index: -14.0200
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.1887
    Cell Significance Index: -1.1400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1914
    Cell Significance Index: -4.5900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1949
    Cell Significance Index: -9.8500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1984
    Cell Significance Index: -20.6600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1995
    Cell Significance Index: -6.3900
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2329
    Cell Significance Index: -5.3800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2412
    Cell Significance Index: -19.1000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2507
    Cell Significance Index: -5.2000
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.2735
    Cell Significance Index: -2.2300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.2899
    Cell Significance Index: -4.2800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3339
    Cell Significance Index: -20.4700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3851
    Cell Significance Index: -6.4500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4181
    Cell Significance Index: -10.6800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.4283
    Cell Significance Index: -9.0900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4472
    Cell Significance Index: -15.5400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.4472
    Cell Significance Index: -11.7600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4540
    Cell Significance Index: -14.4600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.4570
    Cell Significance Index: -13.0400
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.4768
    Cell Significance Index: -7.6500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TERF2 is a highly conserved protein that belongs to the telomeric repeat-binding factor (TRF) family. It is characterized by its ability to bind to G-rich telomeric DNA sequences and regulate telomere length through its interaction with telomerase and other telomere-associated proteins. TERF2 is predominantly expressed in somatic cells, including neurons, B cells, and other cell types involved in immune responses. **Pathways and Functions:** TERF2 is involved in several cellular processes, including: 1. **Telomere maintenance:** TERF2 regulates telomere length by inhibiting telomerase activity and preventing excessive telomere lengthening. 2. **DNA repair:** TERF2 interacts with DNA glycosylases to recognize and repair damaged bases, thereby maintaining genomic integrity. 3. **Cellular senescence:** TERF2 promotes cellular senescence by regulating the expression of genes involved in this process. 4. **Axonal transport:** TERF2 is involved in the regulation of axonal transport, ensuring the proper transport of proteins and RNAs along axons. 5. **Cellular responses to stimuli:** TERF2 regulates cellular responses to various stimuli, including DNA damage and oxidative stress. **Clinical Significance:** Dysregulation of TERF2 has been implicated in various diseases, including: 1. **Cancer:** TERF2 mutations have been linked to an increased risk of certain cancers, such as breast and ovarian cancer. 2. **Neurodegenerative diseases:** TERF2 dysregulation has been implicated in neurodegenerative diseases, such as Alzheimer's and Parkinson's disease. 3. **Telomere-related disorders:** TERF2 mutations can cause telomere-related disorders, such as premature aging and telomere shortening syndromes. In conclusion, TERF2 is a critical protein involved in maintaining telomere integrity and regulating cellular homeostasis. Its dysregulation has significant clinical implications, highlighting the importance of further research into the role of TERF2 in human disease. **Future Directions:** 1. **Investigating the molecular mechanisms of TERF2 regulation:** Further studies are needed to elucidate the molecular mechanisms underlying TERF2 regulation and its interactions with other proteins. 2. **Developing therapeutic strategies:** Targeting TERF2 or its regulatory pathways may provide a novel therapeutic approach for treating diseases associated with dysregulated TERF2 activity. 3. **Understanding the clinical implications of TERF2 mutations:** Further research is necessary to fully understand the clinical implications of TERF2 mutations and their role in human disease.

Genular Protein ID: 694837204

Symbol: TERF2_HUMAN

Name: Telomeric repeat-binding factor 2

UniProtKB Accession Codes:

Q15554

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 3 CORUM 1 CPTAC 3 CPTC 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 2 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 5 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 42 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 15 PDBsum 15 PIR 1 PIRSF 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 14 RefSeq 1 SASBDB 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9326950

Title: Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2.

PubMed ID: 9326950

DOI: 10.1038/ng1097-231

PubMed ID: 9326951

Title: Telomeric localization of TRF2, a novel human telobox protein.

PubMed ID: 9326951

DOI: 10.1038/ng1097-236

PubMed ID: 8614633

Title: The telobox, a Myb-related telomeric DNA binding motif found in proteins from yeast, plants and human.

PubMed ID: 8614633

DOI: 10.1093/nar/24.7.1294

PubMed ID: 9476899

Title: TRF2 protects human telomeres from end-to-end fusions.

PubMed ID: 9476899

DOI: 10.1016/s0092-8674(00)80932-0

PubMed ID: 10888888

Title: Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres.

PubMed ID: 10888888

DOI: 10.1038/77139

PubMed ID: 15316005

Title: TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres.

PubMed ID: 15316005

DOI: 10.1074/jbc.m409047200

PubMed ID: 15383534

Title: Telosome, a mammalian telomere-associated complex formed by multiple telomeric proteins.

PubMed ID: 15383534

DOI: 10.1074/jbc.m409293200

PubMed ID: 16166375

Title: Shelterin: the protein complex that shapes and safeguards human telomeres.

PubMed ID: 16166375

DOI: 10.1101/gad.1346005

PubMed ID: 16223874

Title: DNA damage-induced phosphorylation of the human telomere-associated protein TRF2.

PubMed ID: 16223874

DOI: 10.1073/pnas.0507915102

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16730176

Title: Apollo, an Artemis-related nuclease, interacts with TRF2 and protects human telomeres in S phase.

PubMed ID: 16730176

DOI: 10.1016/j.cub.2006.05.022

PubMed ID: 16730175

Title: The Apollo 5' exonuclease functions together with TRF2 to protect telomeres from DNA repair.

PubMed ID: 16730175

DOI: 10.1016/j.cub.2006.05.021

PubMed ID: 16606622

Title: hSnm1B is a novel telomere-associated protein.

PubMed ID: 16606622

DOI: 10.1074/jbc.c600038200

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 18468965

Title: Endogenous hSNM1B/Apollo interacts with TRF2 and stimulates ATM in response to ionizing radiation.

PubMed ID: 18468965

DOI: 10.1016/j.dnarep.2008.03.020

PubMed ID: 18593705

Title: The protein hSnm1B is stabilized when bound to the telomere-binding protein TRF2.

PubMed ID: 18593705

DOI: 10.1074/jbc.m800388200

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19596235

Title: Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair.

PubMed ID: 19596235

DOI: 10.1016/j.cell.2009.06.030

PubMed ID: 19596784

Title: Arginine methylation regulates telomere length and stability.

PubMed ID: 19596784

DOI: 10.1128/mcb.00009-09

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20655466

Title: TRF2 and Apollo cooperate with topoisomerase 2alpha to protect human telomeres from replicative damage.

PubMed ID: 20655466

DOI: 10.1016/j.cell.2010.05.032

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 11545737

Title: Structure of the TRFH dimerization domain of the human telomeric proteins TRF1 and TRF2.

PubMed ID: 11545737

DOI: 10.1016/s1097-2765(01)00321-5

PubMed ID: 15608617

Title: How the human telomeric proteins TRF1 and TRF2 recognize telomeric DNA: a view from high-resolution crystal structures.

PubMed ID: 15608617

DOI: 10.1038/sj.embor.7400314

PubMed ID: 18202258

Title: A shared docking motif in TRF1 and TRF2 used for differential recruitment of telomeric proteins.

PubMed ID: 18202258

DOI: 10.1126/science.1151804

PubMed ID: 28216226

Title: NBS1 phosphorylation status dictates repair choice of dysfunctional telomeres.

PubMed ID: 28216226

DOI: 10.1016/j.molcel.2017.01.016

Sequence Information:

  • Length: 542
  • Mass: 59594
  • Checksum: 3A278AC6B594C43A
  • Sequence:
    • MAAGAGTAGP ASGPGVVRDP AASQPRKRPG REGGEGARRS DTMAGGGGSS DGSGRAAGRR 
ASRSSGRARR GRHEPGLGGP AERGAGEARL EEAVNRWVLK FYFHEALRAF RGSRYGDFRQ 
IRDIMQALLV RPLGKEHTVS RLLRVMQCLS RIEEGENLDC SFDMEAELTP LESAINVLEM 
IKTEFTLTEA VVESSRKLVK EAAVIICIKN KEFEKASKIL KKHMSKDPTT QKLRNDLLNI 
IREKNLAHPV IQNFSYETFQ QKMLRFLESH LDDAEPYLLT MAKKALKSES AASSTGKEDK 
QPAPGPVEKP PREPARQLRN PPTTIGMMTL KAAFKTLSGA QDSEAAFAKL DQKDLVLPTQ 
ALPASPALKN KRPRKDENES SAPADGEGGS ELQPKNKRMT ISRLVLEEDS QSTEPSAGLN 
SSQEAASAPP SKPTVLNQPL PGEKNPKVPK GKWNSSNGVE EKETWVEEDE LFQVQAAPDE 
DSTTNITKKQ KWTVEESEWV KAGVQKYGEG NWAAISKNYP FVNRTAVMIK DRWRTMKRLG 
MN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.