Details for: H2BC21
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 93.6062
Cell Significance Index: -14.5600 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 45.6547
Cell Significance Index: -11.5800 - Cell Name: embryonic stem cell (CL0002322)
Fold Change: 35.5142
Cell Significance Index: -14.6300 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 29.2485
Cell Significance Index: -15.0500 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 12.5146
Cell Significance Index: -15.4300 - Cell Name: sebaceous gland cell (CL2000021)
Fold Change: 8.1465
Cell Significance Index: 10.5400 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 3.9559
Cell Significance Index: -15.6100 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 3.8125
Cell Significance Index: -11.7100 - Cell Name: kidney cell (CL1000497)
Fold Change: 2.7817
Cell Significance Index: 22.2100 - Cell Name: epithelial cell of prostate (CL0002231)
Fold Change: 1.7570
Cell Significance Index: 10.8400 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 1.3557
Cell Significance Index: 71.1800 - Cell Name: thyroid follicular cell (CL0002258)
Fold Change: 1.2885
Cell Significance Index: 13.6900 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 1.2561
Cell Significance Index: 81.0400 - Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 1.2060
Cell Significance Index: 12.4800 - Cell Name: cone retinal bipolar cell (CL0000752)
Fold Change: 1.0898
Cell Significance Index: 8.4000 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 1.0011
Cell Significance Index: 27.2500 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 0.9732
Cell Significance Index: 20.3700 - Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: 0.9688
Cell Significance Index: 8.6000 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.9289
Cell Significance Index: 25.9600 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.8407
Cell Significance Index: 52.9900 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.7266
Cell Significance Index: 71.8800 - Cell Name: retinal rod cell (CL0000604)
Fold Change: 0.6761
Cell Significance Index: 8.0600 - Cell Name: lactocyte (CL0002325)
Fold Change: 0.6591
Cell Significance Index: 85.1500 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.6445
Cell Significance Index: 70.1100 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.6187
Cell Significance Index: 100.6300 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.6182
Cell Significance Index: 32.1200 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.5498
Cell Significance Index: 15.8400 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.4857
Cell Significance Index: 29.1600 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 0.4837
Cell Significance Index: 16.8100 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.4635
Cell Significance Index: 21.0100 - Cell Name: OFF-bipolar cell (CL0000750)
Fold Change: 0.3939
Cell Significance Index: 3.4700 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.3597
Cell Significance Index: 24.8800 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.3332
Cell Significance Index: 63.4100 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.2897
Cell Significance Index: 52.2200 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.1966
Cell Significance Index: 4.2600 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.1927
Cell Significance Index: 24.7000 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: 0.1902
Cell Significance Index: 2.8500 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 0.1873
Cell Significance Index: 21.4600 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.1868
Cell Significance Index: 22.9700 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.1746
Cell Significance Index: 13.0100 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.1667
Cell Significance Index: 7.8400 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.1449
Cell Significance Index: 79.1600 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.0883
Cell Significance Index: 12.1200 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0794
Cell Significance Index: 35.0900 - Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 0.0644
Cell Significance Index: 0.7000 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.0438
Cell Significance Index: 2.0400 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.0388
Cell Significance Index: 2.9800 - Cell Name: enteric neuron (CL0007011)
Fold Change: 0.0345
Cell Significance Index: 0.2500 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: 0.0305
Cell Significance Index: 0.4600 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.0294
Cell Significance Index: 0.6100 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.0249
Cell Significance Index: 0.6700 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.0090
Cell Significance Index: 1.5300 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.0062
Cell Significance Index: 0.2000 - Cell Name: granulosa cell (CL0000501)
Fold Change: 0.0019
Cell Significance Index: 0.0500 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.0017
Cell Significance Index: 1.2700 - Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.0026
Cell Significance Index: -0.5100 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0052
Cell Significance Index: -3.8200 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0071
Cell Significance Index: -13.2800 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.0079
Cell Significance Index: -0.4000 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0097
Cell Significance Index: -0.2600 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0103
Cell Significance Index: -14.0400 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0104
Cell Significance Index: -19.1400 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0120
Cell Significance Index: -18.5000 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0127
Cell Significance Index: -9.3400 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0142
Cell Significance Index: -5.1100 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.0142
Cell Significance Index: -0.5800 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0155
Cell Significance Index: -9.8400 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0171
Cell Significance Index: -9.6400 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0173
Cell Significance Index: -0.2900 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0242
Cell Significance Index: -11.0000 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.0249
Cell Significance Index: -0.5300 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0303
Cell Significance Index: -3.1000 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0304
Cell Significance Index: -19.0000 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0403
Cell Significance Index: -8.0900 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.0431
Cell Significance Index: -5.0800 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.0554
Cell Significance Index: -3.9200 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0699
Cell Significance Index: -10.1700 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0747
Cell Significance Index: -15.7300 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.0799
Cell Significance Index: -1.0900 - Cell Name: ON-bipolar cell (CL0000749)
Fold Change: -0.0814
Cell Significance Index: -0.9200 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.0849
Cell Significance Index: -2.1700 - Cell Name: Hofbauer cell (CL3000001)
Fold Change: -0.0932
Cell Significance Index: -0.7600 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0950
Cell Significance Index: -5.3300 - Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: -0.0951
Cell Significance Index: -1.2200 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.1100
Cell Significance Index: -1.2500 - Cell Name: melanocyte of skin (CL1000458)
Fold Change: -0.1184
Cell Significance Index: -1.6600 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1342
Cell Significance Index: -13.9700 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -0.1459
Cell Significance Index: -1.5100 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.1466
Cell Significance Index: -2.7100 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -0.1640
Cell Significance Index: -1.5100 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.1662
Cell Significance Index: -13.1600 - Cell Name: Sertoli cell (CL0000216)
Fold Change: -0.1761
Cell Significance Index: -2.4700 - Cell Name: epidermal cell (CL0000362)
Fold Change: -0.1774
Cell Significance Index: -0.4000 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.1992
Cell Significance Index: -12.2100 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.2374
Cell Significance Index: -3.5100 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.2381
Cell Significance Index: -4.0800 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.2537
Cell Significance Index: -6.5200 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.2606
Cell Significance Index: -7.4700 - Cell Name: syncytiotrophoblast cell (CL0000525)
Fold Change: -0.2769
Cell Significance Index: -2.6300 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.2891
Cell Significance Index: -10.1600
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 2182216233
Symbol: H2B2E_HUMAN
Name: Histone H2B type 2-E
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 1469070
Title: A human histone H2B.1 variant gene, located on chromosome 1, utilizes alternative 3' end processing.
PubMed ID: 1469070
PubMed ID: 12408966
Title: The human and mouse replication-dependent histone genes.
PubMed ID: 12408966
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 11859126
Title: Endotoxin-neutralizing antimicrobial proteins of the human placenta.
PubMed ID: 11859126
PubMed ID: 8620898
Title: Biochemical and antibacterial analysis of human wound and blister fluid.
PubMed ID: 8620898
PubMed ID: 12860195
Title: Antimicrobial peptides in the first line defence of human colon mucosa.
PubMed ID: 12860195
PubMed ID: 15019208
Title: Antimicrobial polypeptides of the human colonic epithelium.
PubMed ID: 15019208
PubMed ID: 16627869
Title: Quantitative proteomic analysis of post-translational modifications of human histones.
PubMed ID: 16627869
PubMed ID: 1993178
Title: Isolation and characterization of a cDNA from a human histone H2B gene which is reciprocally expressed in relation to replication-dependent H2B histone genes during HL60 cell differentiation.
PubMed ID: 1993178
DOI: 10.1021/bi00220a024
PubMed ID: 12757711
Title: Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase.
PubMed ID: 12757711
PubMed ID: 16307923
Title: Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation.
PubMed ID: 16307923
PubMed ID: 16283522
Title: Inhibition of core histones acetylation by carcinogenic nickel(II).
PubMed ID: 16283522
PubMed ID: 16713563
Title: Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II.
PubMed ID: 16713563
PubMed ID: 16457587
Title: Gene-specific characterization of human histone H2B by electron capture dissociation.
PubMed ID: 16457587
DOI: 10.1021/pr050268v
PubMed ID: 21925322
Title: Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification.
PubMed ID: 21925322
PubMed ID: 21726816
Title: The RING finger protein MSL2 in the MOF complex is an E3 ubiquitin ligase for H2B K34 and is involved in crosstalk with H3 K4 and K79 methylation.
PubMed ID: 21726816
PubMed ID: 22389435
Title: Lysine succinylation and lysine malonylation in histones.
PubMed ID: 22389435
PubMed ID: 23824326
Title: USP49 deubiquitinates histone H2B and regulates cotranscriptional pre-mRNA splicing.
PubMed ID: 23824326
PubMed ID: 24681537
Title: Lysine 2-hydroxyisobutyrylation is a widely distributed active histone mark.
PubMed ID: 24681537
PubMed ID: 27105113
Title: Dynamic competing histone H4 K5K8 acetylation and butyrylation are hallmarks of highly active gene promoters.
PubMed ID: 27105113
PubMed ID: 27105115
Title: Metabolic regulation of gene expression by histone lysine beta-hydroxybutyrylation.
PubMed ID: 27105115
PubMed ID: 27530147
Title: PARP3 is a sensor of nicked nucleosomes and monoribosylates histone H2B(Glu2).
PubMed ID: 27530147
DOI: 10.1038/ncomms12404
PubMed ID: 31542297
Title: Glutarylation of histone H4 lysine 91 regulates chromatin dynamics.
PubMed ID: 31542297
PubMed ID: 31645732
Title: Metabolic regulation of gene expression by histone lactylation.
PubMed ID: 31645732
PubMed ID: 34874266
Title: Serine ADP-ribosylation marks nucleosomes for ALC1-dependent chromatin remodeling.
PubMed ID: 34874266
DOI: 10.7554/elife.71502
Sequence Information:
- Length: 126
- Mass: 13920
- Checksum: 0410A881ABBE6647
- Sequence:
MPEPAKSAPA PKKGSKKAVT KAQKKDGKKR KRSRKESYSI YVYKVLKQVH PDTGISSKAM GIMNSFVNDI FERIAGEASR LAHYNKRSTI TSREIQTAVR LLLPGELAKH AVSEGTKAVT KYTSSK
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.