Gene TRGV9 - ENSG00000211695 | NCBI Gene ID: 6983

Details for: TRGV9

Gene ID: 6983

Symbol: TRGV9

Ensembl ID: ENSG00000211695

Description: T cell receptor gamma variable 9

Associated with

Adaptive immune response
(GO:0002250)
External side of plasma membrane
(GO:0009897)
Innate immune response
(GO:0045087)
Mhc protein binding
(GO:0042287)
Peptide antigen binding
(GO:0042605)
Plasma membrane
(GO:0005886)
T cell receptor complex
(GO:0042101)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: glutamatergic neuron (CL0000679)
Fold Change: 15.99
Marker Score: 162079
Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: 6.69
Marker Score: 8272
Cell Name: mature gamma-delta T cell (CL0000800)
Fold Change: 4.17
Marker Score: 13163
Cell Name: thymocyte (CL0000893)
Fold Change: 3.72
Marker Score: 3900
Cell Name: blood vessel endothelial cell (CL0000071)
Fold Change: 2.16
Marker Score: 2174.5
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 2
Marker Score: 1995
Cell Name: late pro-B cell (CL0002048)
Fold Change: 1.68
Marker Score: 1983
Cell Name: goblet cell (CL0000160)
Fold Change: 1.63
Marker Score: 10803
Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.61
Marker Score: 1170
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 1.26
Marker Score: 856
Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.25
Marker Score: 7568
Cell Name: abnormal cell (CL0001061)
Fold Change: 1.21
Marker Score: 3635
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 1.17
Marker Score: 487
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.15
Marker Score: 4815
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 1.09
Marker Score: 503
Cell Name: absorptive cell (CL0000212)
Fold Change: 1.06
Marker Score: 32720
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71827
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48052
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.99
Marker Score: 509
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.98
Marker Score: 462
Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
Fold Change: 0.97
Marker Score: 1422
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.94
Marker Score: 2385
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.93
Marker Score: 374
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.93
Marker Score: 5325
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.91
Marker Score: 326
Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
Fold Change: 0.81
Marker Score: 183
Cell Name: brush cell (CL0002204)
Fold Change: 0.8
Marker Score: 733
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.8
Marker Score: 609.5
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.77
Marker Score: 1255
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.77
Marker Score: 397
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.72
Marker Score: 462
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.7
Marker Score: 179
Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: 0.66
Marker Score: 1826
Cell Name: Unknown (CL0000548)
Fold Change: 0.58
Marker Score: 422
Cell Name: pro-T cell (CL0000827)
Fold Change: 0.55
Marker Score: 2259
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.55
Marker Score: 174
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.54
Marker Score: 434
Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
Fold Change: 0.53
Marker Score: 462
Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
Fold Change: 0.52
Marker Score: 115
Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
Fold Change: 0.52
Marker Score: 1269
Cell Name: mucosal invariant T cell (CL0000940)
Fold Change: 0.51
Marker Score: 455
Cell Name: ILC1, human (CL0001077)
Fold Change: 0.48
Marker Score: 121
Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
Fold Change: 0.43
Marker Score: 1256
Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
Fold Change: 0.42
Marker Score: 346
Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
Fold Change: 0.39
Marker Score: 557
Cell Name: fibroblast (CL0000057)
Fold Change: 0.39
Marker Score: 377
Cell Name: double negative T regulatory cell (CL0011024)
Fold Change: 0.38
Marker Score: 371
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 0.38
Marker Score: 378
Cell Name: small pre-B-II cell (CL0000954)
Fold Change: 0.35
Marker Score: 425
Cell Name: mast cell (CL0000097)
Fold Change: 0.35
Marker Score: 205
Cell Name: CD34-positive, CD56-positive, CD117-positive common innate lymphoid precursor, human (CL0001074)
Fold Change: 0.34
Marker Score: 95
Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
Fold Change: 0.33
Marker Score: 108
Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
Fold Change: 0.33
Marker Score: 200
Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
Fold Change: 0.32
Marker Score: 139
Cell Name: pro-B cell (CL0000826)
Fold Change: 0.32
Marker Score: 310
Cell Name: group 3 innate lymphoid cell (CL0001071)
Fold Change: 0.3
Marker Score: 124.5
Cell Name: hematopoietic cell (CL0000988)
Fold Change: 0.28
Marker Score: 183.5
Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: 0.27
Marker Score: 744
Cell Name: gamma-delta T cell (CL0000798)
Fold Change: 0.25
Marker Score: 167
Cell Name: natural killer cell (CL0000623)
Fold Change: 0.24
Marker Score: 313
Cell Name: megakaryocyte (CL0000556)
Fold Change: 0.23
Marker Score: 132
Cell Name: pre-B-I cell (CL0000956)
Fold Change: 0.23
Marker Score: 59
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.23
Marker Score: 61
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.23
Marker Score: 65
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.22
Marker Score: 74
Cell Name: blood cell (CL0000081)
Fold Change: 0.21
Marker Score: 2460
Cell Name: large pre-B-II cell (CL0000957)
Fold Change: 0.2
Marker Score: 541.5
Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
Fold Change: 0.2
Marker Score: 153
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.19
Marker Score: 116
Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
Fold Change: 0.19
Marker Score: 160
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.17
Marker Score: 43
Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
Fold Change: 0.17
Marker Score: 335
Cell Name: mature T cell (CL0002419)
Fold Change: 0.17
Marker Score: 1687
Cell Name: innate lymphoid cell (CL0001065)
Fold Change: 0.15
Marker Score: 53
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 0.15
Marker Score: 93
Cell Name: type I NK T cell (CL0000921)
Fold Change: 0.15
Marker Score: 115
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.15
Marker Score: 88
Cell Name: type II NK T cell (CL0000922)
Fold Change: 0.14
Marker Score: 44
Cell Name: leukocyte (CL0000738)
Fold Change: 0.14
Marker Score: 80
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.14
Marker Score: 92
Cell Name: platelet (CL0000233)
Fold Change: 0.14
Marker Score: 62
Cell Name: B cell (CL0000236)
Fold Change: 0.14
Marker Score: 129
Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
Fold Change: 0.14
Marker Score: 44
Cell Name: mature NK T cell (CL0000814)
Fold Change: 0.13
Marker Score: 62
Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
Fold Change: 0.13
Marker Score: 110
Cell Name: CD4-positive helper T cell (CL0000492)
Fold Change: 0.13
Marker Score: 140
Cell Name: early lymphoid progenitor (CL0000936)
Fold Change: 0.13
Marker Score: 63
Cell Name: group 2 innate lymphoid cell (CL0001069)
Fold Change: 0.13
Marker Score: 43
Cell Name: erythrocyte (CL0000232)
Fold Change: 0.13
Marker Score: 70
Cell Name: endothelial cell (CL0000115)
Fold Change: 0.13
Marker Score: 113
Cell Name: naive B cell (CL0000788)
Fold Change: 0.12
Marker Score: 104
Cell Name: T cell (CL0000084)
Fold Change: 0.11
Marker Score: 194
Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
Fold Change: 0.11
Marker Score: 198
Cell Name: hematopoietic precursor cell (CL0008001)
Fold Change: 0.1
Marker Score: 36
Cell Name: double negative thymocyte (CL0002489)
Fold Change: 0.1
Marker Score: 140
Cell Name: plasma cell (CL0000786)
Fold Change: 0.1
Marker Score: 108
Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: 0.1
Marker Score: 56
Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
Fold Change: 0.09
Marker Score: 20
Cell Name: IgA plasmablast (CL0000984)
Fold Change: 0.09
Marker Score: 23
Cell Name: lymphocyte (CL0000542)
Fold Change: 0.09
Marker Score: 44

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Other Information

Description

**Key characteristics:** * TRGV9 is a type I transmembrane protein. * It is expressed in high levels in gamma-delta T cells, which are a subset of cytotoxic T cells. * It is also expressed in other immune cells, including monocytes, macrophages, and dendritic cells. * TRGV9 is a member of the immunoglobulin superfamily, which is responsible for the recognition of peptide antigens. **Pathways and functions:** * TRGV9 is expressed on the surface of gamma-delta T cells, which are a subset of cytotoxic T cells. * It is involved in the recognition of peptide antigens presented by MHC class I molecules. * TRGV9 is also expressed on the surface of macrophages and dendritic cells, where it can interact with MHC class I molecules and activate these cells to produce cytokines that promote inflammation. * In addition, TRGV9 is expressed on the surface of intestinal epithelial cells, where it can interact with commensal bacteria. This interaction is important for maintaining intestinal homeostasis. **Clinical significance:** * Mutations in TRGV9 have been linked to several autoimmune diseases, including multiple sclerosis, rheumatoid arthritis, and inflammatory bowel disease. * These mutations can lead to the loss of TRGV9 expression on T cells, which can result in the inability of T cells to recognize peptide antigens and mount an immune response. * As a result, patients with TRGV9 mutations are more likely to develop autoimmune diseases. **Additional notes:** * TRGV9 is a highly conserved gene, with a similar gene found in mice and humans. * It is expressed in high levels in individuals of African descent. * TRGV9 is a promising target for the development of novel therapeutic strategies for autoimmune diseases.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.