Details for: TRGV9

Gene ID: 6983

Symbol: TRGV9

Ensembl ID: ENSG00000211695

Description: T cell receptor gamma variable 9

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 12.4940
    Cell Significance Index: 439.0200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 5.7030
    Cell Significance Index: 142.5600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 5.5790
    Cell Significance Index: 342.0500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 5.0113
    Cell Significance Index: 144.3900
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 4.2032
    Cell Significance Index: 11.2600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 3.6133
    Cell Significance Index: 74.9600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.0611
    Cell Significance Index: 93.4300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.5906
    Cell Significance Index: 34.4600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.4149
    Cell Significance Index: 269.2600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.2248
    Cell Significance Index: 39.2300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.1696
    Cell Significance Index: 115.7000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.9528
    Cell Significance Index: 24.3400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9288
    Cell Significance Index: 838.6200
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.7034
    Cell Significance Index: 10.6000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.6111
    Cell Significance Index: 13.0200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5047
    Cell Significance Index: 82.0800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4968
    Cell Significance Index: 54.0400
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.4619
    Cell Significance Index: 4.9200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2769
    Cell Significance Index: 19.1500
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0.1371
    Cell Significance Index: 1.1300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1358
    Cell Significance Index: 8.1500
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.1357
    Cell Significance Index: 0.7400
  • Cell Name: activated type II NK T cell (CL0000931)
    Fold Change: 0.1211
    Cell Significance Index: 0.3100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0594
    Cell Significance Index: 2.7900
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0015
    Cell Significance Index: -2.7200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0018
    Cell Significance Index: -2.7900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0022
    Cell Significance Index: -0.0600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0031
    Cell Significance Index: -0.0700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0039
    Cell Significance Index: -2.9300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0108
    Cell Significance Index: -0.6800
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0129
    Cell Significance Index: -0.1800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0151
    Cell Significance Index: -3.0300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0157
    Cell Significance Index: -3.1100
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0168
    Cell Significance Index: -0.2500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0204
    Cell Significance Index: -2.8100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0242
    Cell Significance Index: -3.1100
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0294
    Cell Significance Index: -0.5000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0317
    Cell Significance Index: -3.9000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0343
    Cell Significance Index: -2.2100
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.0348
    Cell Significance Index: -0.3100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0404
    Cell Significance Index: -4.1300
  • Cell Name: mature T cell (CL0002419)
    Fold Change: -0.0493
    Cell Significance Index: -0.3600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0549
    Cell Significance Index: -3.0800
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0599
    Cell Significance Index: -0.8400
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0617
    Cell Significance Index: -0.7800
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0638
    Cell Significance Index: -0.6600
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.0641
    Cell Significance Index: -1.0300
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.0731
    Cell Significance Index: -0.7300
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0794
    Cell Significance Index: -1.6200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0853
    Cell Significance Index: -3.1300
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0856
    Cell Significance Index: -1.3000
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0903
    Cell Significance Index: -1.0000
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0923
    Cell Significance Index: -1.0900
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0935
    Cell Significance Index: -0.9700
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.0955
    Cell Significance Index: -0.9900
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: -0.0960
    Cell Significance Index: -0.9400
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: -0.0963
    Cell Significance Index: -0.7700
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: -0.0972
    Cell Significance Index: -1.0300
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.0984
    Cell Significance Index: -0.8300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0999
    Cell Significance Index: -2.8500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1004
    Cell Significance Index: -2.6900
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.1094
    Cell Significance Index: -1.1100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1110
    Cell Significance Index: -2.9200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1139
    Cell Significance Index: -3.0400
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1197
    Cell Significance Index: -2.9900
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: -0.1200
    Cell Significance Index: -1.4500
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: -0.1216
    Cell Significance Index: -1.2600
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.1227
    Cell Significance Index: -1.4500
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.1234
    Cell Significance Index: -1.1700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1277
    Cell Significance Index: -3.7600
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1280
    Cell Significance Index: -3.2600
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.1304
    Cell Significance Index: -1.6800
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1337
    Cell Significance Index: -3.0900
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.1350
    Cell Significance Index: -1.0500
  • Cell Name: brain vascular cell (CL4023072)
    Fold Change: -0.1361
    Cell Significance Index: -1.5600
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.1393
    Cell Significance Index: -1.5700
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.1407
    Cell Significance Index: -2.4300
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.1417
    Cell Significance Index: -2.0300
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.1468
    Cell Significance Index: -1.8600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1501
    Cell Significance Index: -2.9300
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.1508
    Cell Significance Index: -2.4200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1520
    Cell Significance Index: -3.2300
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.1628
    Cell Significance Index: -1.4800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1637
    Cell Significance Index: -3.9700
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.1673
    Cell Significance Index: -2.0700
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.1674
    Cell Significance Index: -2.8200
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1707
    Cell Significance Index: -2.5200
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.1724
    Cell Significance Index: -2.4800
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1729
    Cell Significance Index: -3.3800
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.1764
    Cell Significance Index: -1.1500
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.1778
    Cell Significance Index: -1.4400
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.1808
    Cell Significance Index: -1.5400
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: -0.1822
    Cell Significance Index: -1.7200
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.1846
    Cell Significance Index: -2.9900
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.1853
    Cell Significance Index: -2.1800
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.1883
    Cell Significance Index: -2.5100
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.1893
    Cell Significance Index: -2.6900
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.1909
    Cell Significance Index: -2.4700
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.1924
    Cell Significance Index: -2.1500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TRGV9 is a member of the TCRβ family, which is responsible for recognizing peptide antigens presented by MHC molecules. The gamma-delta T cell receptor (γδ TCR) is distinct from the alpha-beta TCR, and its unique structure allows for the recognition of a broader range of antigens. TRGV9 is specifically involved in the recognition of endogenous and exogenous antigens, and its expression is tightly regulated to ensure proper immune function. One of the key characteristics of TRGV9 is its ability to bind to MHC class I molecules, which is essential for the activation of gamma-delta T cells. This binding also enables the recognition of peptide antigens presented by MHC class I molecules, allowing for the activation of immune responses against viral infections and tumor cells. **Pathways and Functions:** TRGV9 is involved in several key pathways, including the adaptive immune response, innate immune response, and peptide antigen binding. The adaptive immune response is a highly specific response to pathogens, and TRGV9 plays a crucial role in the recognition and elimination of these pathogens. The gamma-delta T cells expressing TRGV9 can recognize a wide range of antigens, including viral peptides, tumor antigens, and bacterial antigens. TRGV9 is also involved in the regulation of the innate immune response, which provides the first line of defense against pathogens. The gamma-delta T cells expressing TRGV9 can recognize endogenous ligands, such as lipid antigens, and activate immune responses against these antigens. In addition to its role in the adaptive and innate immune responses, TRGV9 is also involved in the regulation of cell signaling pathways, including the PI3K/AKT and MAPK/ERK pathways. These pathways are critical for the activation and proliferation of gamma-delta T cells. **Clinical Significance:** The clinical significance of TRGV9 is multifaceted. The gamma-delta T cells expressing TRGV9 have been implicated in the protection against viral infections, including HIV and hepatitis B. These cells have also been shown to recognize tumor antigens, making them potential therapeutic targets for cancer immunotherapy. Furthermore, the expression of TRGV9 in various other cell types, including neurons and endothelial cells, suggests a broader role for gamma-delta T cells in the regulation of tissue homeostasis and immune responses. The dysregulation of TRGV9 expression has been implicated in several diseases, including autoimmune disorders and inflammatory bowel disease. In conclusion, TRGV9 is a multifaceted gene that plays a critical role in the adaptive and innate immune responses, as well as in the regulation of cell signaling pathways. Its clinical significance extends beyond the traditional role of gamma-delta T cells in immunity, and suggests a broader range of functions for these cells in the regulation of tissue homeostasis and immune responses. Further research is needed to fully elucidate the role of TRGV9 in human disease and to explore its potential as a therapeutic target.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.