H2AC18 | ENSG00000288825 | NCBI 8337

Details for: H2AC18

Gene ID: 8337

Symbol: H2AC18

Ensembl ID: ENSG00000288825

Description: H2A clustered histone 18

Associated with

Activation of anterior hox genes in hindbrain development during early embryogenesis
(R-HSA-5617472)
Activation of hox genes during differentiation
(R-HSA-5619507)
Amyloid fiber formation
(R-HSA-977225)
Assembly of the orc complex at the origin of replication
(R-HSA-68616)
Assembly of the pre-replicative complex
(R-HSA-68867)
B-wich complex positively regulates rrna expression
(R-HSA-5250924)
Base-excision repair, ap site formation
(R-HSA-73929)
Base excision repair
(R-HSA-73884)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular senescence
(R-HSA-2559583)
Chromatin modifications during the maternal to zygotic transition (mzt)
(R-HSA-9821002)
Chromatin modifying enzymes
(R-HSA-3247509)
Chromatin organization
(R-HSA-4839726)
Chromosome maintenance
(R-HSA-73886)
Cleavage of the damaged purine
(R-HSA-110331)
Cleavage of the damaged pyrimidine
(R-HSA-110329)
Condensation of prophase chromosomes
(R-HSA-2299718)
Defective pyroptosis
(R-HSA-9710421)
Deposition of new cenpa-containing nucleosomes at the centromere
(R-HSA-606279)
Depurination
(R-HSA-73927)
Depyrimidination
(R-HSA-73928)
Deubiquitination
(R-HSA-5688426)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of programmed cell death
(R-HSA-9645723)
Dna damage/telomere stress induced senescence
(R-HSA-2559586)
Dna methylation
(R-HSA-5334118)
Dna repair
(R-HSA-73894)
Dna replication
(R-HSA-69306)
Dna replication pre-initiation
(R-HSA-69002)
Epigenetic regulation by wdr5-containing histone modifying complexes
(R-HSA-9917777)
Epigenetic regulation of gene expression
(R-HSA-212165)
Epigenetic regulation of gene expression by mll3 and mll4 complexes
(R-HSA-9818564)
Ercc6 (csb) and ehmt2 (g9a) positively regulate rrna expression
(R-HSA-427389)
Esr-mediated signaling
(R-HSA-8939211)
Estrogen-dependent gene expression
(R-HSA-9018519)
Formation of the beta-catenin:tcf transactivating complex
(R-HSA-201722)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Gene silencing by rna
(R-HSA-211000)
Hats acetylate histones
(R-HSA-3214847)
Hcmv early events
(R-HSA-9609690)
Hcmv infection
(R-HSA-9609646)
Hdacs deacetylate histones
(R-HSA-3214815)
Infectious disease
(R-HSA-5663205)
Inhibition of dna recombination at telomere
(R-HSA-9670095)
Maternal to zygotic transition (mzt)
(R-HSA-9816359)
Meiosis
(R-HSA-1500620)
Meiotic recombination
(R-HSA-912446)
Meiotic synapsis
(R-HSA-1221632)
Metabolism of proteins
(R-HSA-392499)
Metalloprotease dubs
(R-HSA-5689901)
Mitotic prophase
(R-HSA-68875)
M phase
(R-HSA-68886)
Negative epigenetic regulation of rrna expression
(R-HSA-5250941)
Norc negatively regulates rrna expression
(R-HSA-427413)
Nucleosome assembly
(R-HSA-774815)
Oxidative stress induced senescence
(R-HSA-2559580)
Packaging of telomere ends
(R-HSA-171306)
Positive epigenetic regulation of rrna expression
(R-HSA-5250913)
Post-translational protein modification
(R-HSA-597592)
Prc2 methylates histones and dna
(R-HSA-212300)
Pre-notch expression and processing
(R-HSA-1912422)
Pre-notch transcription and translation
(R-HSA-1912408)
Recognition and association of dna glycosylase with site containing an affected purine
(R-HSA-110330)
Recognition and association of dna glycosylase with site containing an affected pyrimidine
(R-HSA-110328)
Regulation of endogenous retroelements
(R-HSA-9842860)
Regulation of endogenous retroelements by krab-zfp proteins
(R-HSA-9843940)
Regulation of endogenous retroelements by piwi-interacting rnas (pirnas)
(R-HSA-9845323)
Regulation of endogenous retroelements by the human silencing hub (hush) complex
(R-HSA-9843970)
Reproduction
(R-HSA-1474165)
Rho gtpase effectors
(R-HSA-195258)
Rho gtpases activate pkns
(R-HSA-5625740)
Rmts methylate histone arginines
(R-HSA-3214858)
Rna polymerase ii transcription
(R-HSA-73857)
Rna polymerase i promoter clearance
(R-HSA-73854)
Rna polymerase i promoter escape
(R-HSA-73772)
Rna polymerase i promoter opening
(R-HSA-73728)
Rna polymerase i transcription
(R-HSA-73864)
Runx1 regulates genes involved in megakaryocyte differentiation and platelet function
(R-HSA-8936459)
Runx1 regulates transcription of genes involved in differentiation of hscs
(R-HSA-8939236)
Senescence-associated secretory phenotype (sasp)
(R-HSA-2559582)
Signaling by notch
(R-HSA-157118)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signaling by wnt
(R-HSA-195721)
Signal transduction
(R-HSA-162582)
Sirt1 negatively regulates rrna expression
(R-HSA-427359)
Tcf dependent signaling in response to wnt
(R-HSA-201681)
Telomere maintenance
(R-HSA-157579)
Transcriptional regulation by runx1
(R-HSA-8878171)
Transcriptional regulation by small rnas
(R-HSA-5578749)
Transcriptional regulation of granulopoiesis
(R-HSA-9616222)
Ub-specific processing proteases
(R-HSA-5689880)
Uch proteinases
(R-HSA-5689603)
Viral infection pathways
(R-HSA-9824446)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: dendritic cell, human (CL0001056)
Fold Change: 20.5773
Cell Significance Index: 189.7800
Cell Name: pulmonary interstitial fibroblast (CL0002241)
Fold Change: 4.5096
Cell Significance Index: 27.9000
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 2.7306
Cell Significance Index: 123.7700
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 1.9080
Cell Significance Index: 116.9800
Cell Name: tracheobronchial smooth muscle cell (CL0019019)
Fold Change: 1.5527
Cell Significance Index: 15.9900
Cell Name: cell in vitro (CL0001034)
Fold Change: 1.4485
Cell Significance Index: 791.0400
Cell Name: pre-B-I cell (CL0000956)
Fold Change: 1.4348
Cell Significance Index: 6.7400
Cell Name: respiratory epithelial cell (CL0002368)
Fold Change: 1.1640
Cell Significance Index: 6.9800
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 1.0738
Cell Significance Index: 15.5900
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.9499
Cell Significance Index: 20.5800
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.8446
Cell Significance Index: 27.0500
Cell Name: tracheal goblet cell (CL1000329)
Fold Change: 0.6557
Cell Significance Index: 5.4200
Cell Name: lung neuroendocrine cell (CL1000223)
Fold Change: 0.5303
Cell Significance Index: 5.2600
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.4811
Cell Significance Index: 91.5600
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.4043
Cell Significance Index: 39.9900
Cell Name: B-1b B cell (CL0000821)
Fold Change: 0.3967
Cell Significance Index: 1.9900
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.3221
Cell Significance Index: 290.8300
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.1992
Cell Significance Index: 32.4000
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.1565
Cell Significance Index: 17.0200
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.0893
Cell Significance Index: 2.3900
Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: 0.0810
Cell Significance Index: 1.2200
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.0667
Cell Significance Index: 1.4200
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.0581
Cell Significance Index: 4.0200
Cell Name: basal cell of epithelium of trachea (CL1000348)
Fold Change: 0.0500
Cell Significance Index: 0.4300
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.0176
Cell Significance Index: 3.0100
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 0.0107
Cell Significance Index: 1.2300
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.0032
Cell Significance Index: 0.3800
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.0017
Cell Significance Index: 0.0500
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0013
Cell Significance Index: -0.9500
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0052
Cell Significance Index: -3.3300
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0053
Cell Significance Index: -3.9900
Cell Name: retinal blood vessel endothelial cell (CL0002585)
Fold Change: -0.0054
Cell Significance Index: -0.0700
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0062
Cell Significance Index: -0.8600
Cell Name: odontoblast (CL0000060)
Fold Change: -0.0062
Cell Significance Index: -0.7900
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0063
Cell Significance Index: -3.5300
Cell Name: hepatocyte (CL0000182)
Fold Change: -0.0065
Cell Significance Index: -0.0900
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0083
Cell Significance Index: -0.2900
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0098
Cell Significance Index: -2.0700
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0125
Cell Significance Index: -1.2800
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0161
Cell Significance Index: -2.9100
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.0176
Cell Significance Index: -0.4400
Cell Name: pancreatic stellate cell (CL0002410)
Fold Change: -0.0192
Cell Significance Index: -0.2400
Cell Name: lactocyte (CL0002325)
Fold Change: -0.0204
Cell Significance Index: -2.6300
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0229
Cell Significance Index: -3.3300
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0257
Cell Significance Index: -3.1600
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.0265
Cell Significance Index: -0.7200
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.0419
Cell Significance Index: -3.1200
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.0481
Cell Significance Index: -2.5000
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.0530
Cell Significance Index: -1.1000
Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.0543
Cell Significance Index: -3.5000
Cell Name: granulosa cell (CL0000501)
Fold Change: -0.0548
Cell Significance Index: -1.4400
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0593
Cell Significance Index: -2.7900
Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: -0.0614
Cell Significance Index: -0.3800
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.0646
Cell Significance Index: -2.3700
Cell Name: cytotoxic T cell (CL0000910)
Fold Change: -0.0672
Cell Significance Index: -0.9800
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0734
Cell Significance Index: -3.4200
Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: -0.0811
Cell Significance Index: -1.0600
Cell Name: primitive red blood cell (CL0002355)
Fold Change: -0.0897
Cell Significance Index: -1.0200
Cell Name: ciliated cell (CL0000064)
Fold Change: -0.0905
Cell Significance Index: -0.9800
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.0924
Cell Significance Index: -1.2600
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.0939
Cell Significance Index: -2.2800
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0962
Cell Significance Index: -2.5700
Cell Name: type G enteroendocrine cell (CL0000508)
Fold Change: -0.1001
Cell Significance Index: -1.0600
Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.1013
Cell Significance Index: -1.4500
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.1042
Cell Significance Index: -3.0700
Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: -0.1046
Cell Significance Index: -0.6600
Cell Name: erythrocyte (CL0000232)
Fold Change: -0.1060
Cell Significance Index: -2.7000
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.1071
Cell Significance Index: -3.7200
Cell Name: keratinocyte (CL0000312)
Fold Change: -0.1077
Cell Significance Index: -2.6900
Cell Name: prostate gland microvascular endothelial cell (CL2000059)
Fold Change: -0.1079
Cell Significance Index: -0.7800
Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
Fold Change: -0.1150
Cell Significance Index: -1.2700
Cell Name: duct epithelial cell (CL0000068)
Fold Change: -0.1164
Cell Significance Index: -1.6100
Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: -0.1164
Cell Significance Index: -1.2100
Cell Name: T follicular regulatory cell (CL0009113)
Fold Change: -0.1172
Cell Significance Index: -0.2900
Cell Name: Sertoli cell (CL0000216)
Fold Change: -0.1183
Cell Significance Index: -1.6600
Cell Name: P/D1 enteroendocrine cell (CL0002268)
Fold Change: -0.1198
Cell Significance Index: -1.3400
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.1200
Cell Significance Index: -3.4400
Cell Name: glandular cell of esophagus (CL0002657)
Fold Change: -0.1214
Cell Significance Index: -1.3000
Cell Name: smooth muscle cell of prostate (CL1000487)
Fold Change: -0.1227
Cell Significance Index: -1.4200
Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: -0.1228
Cell Significance Index: -1.3400
Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
Fold Change: -0.1239
Cell Significance Index: -2.4700
Cell Name: epithelial cell of uterus (CL0002149)
Fold Change: -0.1254
Cell Significance Index: -1.7400
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.1291
Cell Significance Index: -2.1600
Cell Name: megakaryocyte (CL0000556)
Fold Change: -0.1315
Cell Significance Index: -2.1300
Cell Name: neuroendocrine cell (CL0000165)
Fold Change: -0.1315
Cell Significance Index: -1.6700
Cell Name: keratocyte (CL0002363)
Fold Change: -0.1343
Cell Significance Index: -2.1300
Cell Name: natural T-regulatory cell (CL0000903)
Fold Change: -0.1440
Cell Significance Index: -1.4100
Cell Name: epithelial cell (CL0000066)
Fold Change: -0.1460
Cell Significance Index: -1.5400
Cell Name: uterine smooth muscle cell (CL0002601)
Fold Change: -0.1478
Cell Significance Index: -1.4200
Cell Name: naive T cell (CL0000898)
Fold Change: -0.1497
Cell Significance Index: -1.3600
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.1503
Cell Significance Index: -3.8400
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: -0.1563
Cell Significance Index: -1.9800
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: -0.1574
Cell Significance Index: -2.2400
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: -0.1588
Cell Significance Index: -1.3500
Cell Name: decidual cell (CL2000002)
Fold Change: -0.1646
Cell Significance Index: -2.6400
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: -0.1657
Cell Significance Index: -3.2400
Cell Name: myometrial cell (CL0002366)
Fold Change: -0.1667
Cell Significance Index: -1.9200
Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: -0.1672
Cell Significance Index: -1.1100
Cell Name: lung secretory cell (CL1000272)
Fold Change: -0.1694
Cell Significance Index: -1.2900
Cell Name: glutamatergic neuron (CL0000679)
Fold Change: -0.1735
Cell Significance Index: -1.8900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Other Information

Description

**Key Characteristics** 1. **Histone H2A family**: H2AC18 is a member of the histone H2A family, which consists of four subunits: H2A1, H2A2, H2A3, and H2A4. 2. **Clustered histone**: H2AC18 is a clustered histone, meaning it is associated with other histone subunits to form a complex. 3. **Expression in various cell types**: H2AC18 is significantly expressed in a range of cell types, including dendritic cells, pulmonary interstitial fibroblasts, enterocytes, and paneth cells. 4. **Chromatin organization**: H2AC18 plays a role in chromatin organization and assembly during various cellular processes. **Pathways and Functions** 1. **Activation of anterior hox genes in hindbrain development**: H2AC18 is involved in the activation of anterior hox genes during early embryogenesis, which is essential for hindbrain development. 2. **Amyloid fiber formation**: H2AC18 is involved in the formation of amyloid fibers, which are associated with neurodegenerative diseases such as Alzheimer's disease. 3. **Assembly of the orc complex at the origin of replication**: H2AC18 is involved in the assembly of the orc complex at the origin of replication, which is essential for DNA replication and repair. 4. **Base-excision repair**: H2AC18 is involved in base-excision repair, which is a pathway for repairing DNA damage caused by oxidative stress. 5. **Cell cycle regulation**: H2AC18 plays a role in regulating the cell cycle, particularly during the G2/M phase. 6. **Chromatin modifications**: H2AC18 is involved in various chromatin modifications, including acetylation and methylation, which regulate gene expression. 7. **DNA damage response**: H2AC18 is involved in the DNA damage response, particularly during the G2/M phase. **Clinical Significance** 1. **Neurodegenerative diseases**: H2AC18 is associated with neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and Huntington's disease. 2. **Cancer**: H2AC18 is involved in cancer development and progression, particularly in the context of DNA damage and chromatin modifications. 3. **Immune system disorders**: H2AC18 is involved in immune system disorders, particularly in the context of autoimmune diseases and immunodeficiency disorders. 4. **Epigenetic disorders**: H2AC18 is involved in epigenetic disorders, particularly in the context of DNA methylation and histone modifications. 5. **Telomere maintenance**: H2AC18 is involved in telomere maintenance, which is essential for maintaining genome stability. In conclusion, the H2AC18 gene plays a critical role in chromatin structure and function, and its dysregulation is associated with various diseases, including neurodegenerative diseases, cancer, immune system disorders, and epigenetic disorders. Further research is needed to fully understand the functions and clinical significance of H2AC18.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.