H2BC4 | ENSG00000180596 | NCBI 8347

Details for: H2BC4

Gene ID: 8347

Symbol: H2BC4

Ensembl ID: ENSG00000180596

Description: H2B clustered histone 4

Associated with

Activation of anterior hox genes in hindbrain development during early embryogenesis
(R-HSA-5617472)
Activation of hox genes during differentiation
(R-HSA-5619507)
Amyloid fiber formation
(R-HSA-977225)
Assembly of the orc complex at the origin of replication
(R-HSA-68616)
Assembly of the pre-replicative complex
(R-HSA-68867)
B-wich complex positively regulates rrna expression
(R-HSA-5250924)
Base-excision repair, ap site formation
(R-HSA-73929)
Base excision repair
(R-HSA-73884)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cell cycle checkpoints
(R-HSA-69620)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular senescence
(R-HSA-2559583)
Chromatin modifications during the maternal to zygotic transition (mzt)
(R-HSA-9821002)
Chromatin modifying enzymes
(R-HSA-3247509)
Chromatin organization
(R-HSA-4839726)
Chromosome maintenance
(R-HSA-73886)
Defective pyroptosis
(R-HSA-9710421)
Deposition of new cenpa-containing nucleosomes at the centromere
(R-HSA-606279)
Depurination
(R-HSA-73927)
Depyrimidination
(R-HSA-73928)
Deubiquitination
(R-HSA-5688426)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of programmed cell death
(R-HSA-9645723)
Dna damage/telomere stress induced senescence
(R-HSA-2559586)
Dna double-strand break repair
(R-HSA-5693532)
Dna double strand break response
(R-HSA-5693606)
Dna methylation
(R-HSA-5334118)
Dna repair
(R-HSA-73894)
Dna replication
(R-HSA-69306)
Dna replication pre-initiation
(R-HSA-69002)
E3 ubiquitin ligases ubiquitinate target proteins
(R-HSA-8866654)
Epigenetic regulation by wdr5-containing histone modifying complexes
(R-HSA-9917777)
Epigenetic regulation of gene expression
(R-HSA-212165)
Epigenetic regulation of gene expression by mll3 and mll4 complexes
(R-HSA-9818564)
Ercc6 (csb) and ehmt2 (g9a) positively regulate rrna expression
(R-HSA-427389)
Esr-mediated signaling
(R-HSA-8939211)
Estrogen-dependent gene expression
(R-HSA-9018519)
Formation of the beta-catenin:tcf transactivating complex
(R-HSA-201722)
G2/m checkpoints
(R-HSA-69481)
G2/m dna damage checkpoint
(R-HSA-69473)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Gene silencing by rna
(R-HSA-211000)
Hats acetylate histones
(R-HSA-3214847)
Hcmv infection
(R-HSA-9609646)
Hdacs deacetylate histones
(R-HSA-3214815)
Hdr through homologous recombination (hrr) or single strand annealing (ssa)
(R-HSA-5693567)
Homology directed repair
(R-HSA-5693538)
Infectious disease
(R-HSA-5663205)
Inhibition of dna recombination at telomere
(R-HSA-9670095)
Maternal to zygotic transition (mzt)
(R-HSA-9816359)
Meiosis
(R-HSA-1500620)
Meiotic recombination
(R-HSA-912446)
Meiotic synapsis
(R-HSA-1221632)
Metabolism of proteins
(R-HSA-392499)
Mitotic prophase
(R-HSA-68875)
M phase
(R-HSA-68886)
Negative epigenetic regulation of rrna expression
(R-HSA-5250941)
Nonhomologous end-joining (nhej)
(R-HSA-5693571)
Norc negatively regulates rrna expression
(R-HSA-427413)
Nucleosome assembly
(R-HSA-774815)
Oxidative stress induced senescence
(R-HSA-2559580)
Packaging of telomere ends
(R-HSA-171306)
Positive epigenetic regulation of rrna expression
(R-HSA-5250913)
Post-translational protein modification
(R-HSA-597592)
Prc2 methylates histones and dna
(R-HSA-212300)
Pre-notch expression and processing
(R-HSA-1912422)
Pre-notch transcription and translation
(R-HSA-1912408)
Protein ubiquitination
(R-HSA-8852135)
Recruitment and atm-mediated phosphorylation of repair and signaling proteins at dna double strand breaks
(R-HSA-5693565)
Regulation of endogenous retroelements
(R-HSA-9842860)
Regulation of endogenous retroelements by krab-zfp proteins
(R-HSA-9843940)
Regulation of endogenous retroelements by piwi-interacting rnas (pirnas)
(R-HSA-9845323)
Regulation of endogenous retroelements by the human silencing hub (hush) complex
(R-HSA-9843970)
Replacement of protamines by nucleosomes in the male pronucleus
(R-HSA-9821993)
Reproduction
(R-HSA-1474165)
Rho gtpase effectors
(R-HSA-195258)
Rna polymerase ii transcription
(R-HSA-73857)
Rna polymerase i promoter clearance
(R-HSA-73854)
Rna polymerase i promoter escape
(R-HSA-73772)
Rna polymerase i promoter opening
(R-HSA-73728)
Rna polymerase i transcription
(R-HSA-73864)
Senescence-associated secretory phenotype (sasp)
(R-HSA-2559582)
Signaling by notch
(R-HSA-157118)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signaling by wnt
(R-HSA-195721)
Signal transduction
(R-HSA-162582)
Sirt1 negatively regulates rrna expression
(R-HSA-427359)
Tcf dependent signaling in response to wnt
(R-HSA-201681)
Telomere maintenance
(R-HSA-157579)
Transcriptional regulation by runx1
(R-HSA-8878171)
Transcriptional regulation by small rnas
(R-HSA-5578749)
Transcriptional regulation of granulopoiesis
(R-HSA-9616222)
Ub-specific processing proteases
(R-HSA-5689880)
Viral infection pathways
(R-HSA-9824446)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 42.1099
Cell Significance Index: -6.5500
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 31.1461
Cell Significance Index: -7.9000
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 6.8616
Cell Significance Index: -8.4600
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 2.1895
Cell Significance Index: -8.6400
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.0804
Cell Significance Index: 14.7400
Cell Name: early pro-B cell (CL0002046)
Fold Change: 1.0175
Cell Significance Index: 65.6500
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.7437
Cell Significance Index: 671.5200
Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 0.7272
Cell Significance Index: 7.5300
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.6893
Cell Significance Index: 74.9700
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.6575
Cell Significance Index: 18.9500
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.6435
Cell Significance Index: 38.6300
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.6071
Cell Significance Index: 98.7400
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.5966
Cell Significance Index: 27.0400
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.5260
Cell Significance Index: 100.1000
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.4949
Cell Significance Index: 48.9600
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.4848
Cell Significance Index: 22.7900
Cell Name: DN3 thymocyte (CL0000807)
Fold Change: 0.4638
Cell Significance Index: 4.6500
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.4632
Cell Significance Index: 10.0400
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.4518
Cell Significance Index: 23.4700
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.3770
Cell Significance Index: 44.4600
Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: 0.3630
Cell Significance Index: 5.4700
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.3577
Cell Significance Index: 24.7400
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.3264
Cell Significance Index: 8.8900
Cell Name: germ cell (CL0000586)
Fold Change: 0.2371
Cell Significance Index: 1.7900
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.2192
Cell Significance Index: 119.7200
Cell Name: lactocyte (CL0002325)
Fold Change: 0.2079
Cell Significance Index: 26.8700
Cell Name: epithelial cell of uterus (CL0002149)
Fold Change: 0.1834
Cell Significance Index: 2.5500
Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: 0.1812
Cell Significance Index: 1.1200
Cell Name: lens fiber cell (CL0011004)
Fold Change: 0.1439
Cell Significance Index: 4.5500
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.1424
Cell Significance Index: 5.0100
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.1422
Cell Significance Index: 6.6300
Cell Name: thyroid follicular cell (CL0002258)
Fold Change: 0.1365
Cell Significance Index: 1.4500
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.1125
Cell Significance Index: 22.3300
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.0977
Cell Significance Index: 2.0800
Cell Name: Sertoli cell (CL0000216)
Fold Change: 0.0884
Cell Significance Index: 1.2400
Cell Name: primordial germ cell (CL0000670)
Fold Change: 0.0875
Cell Significance Index: 0.5400
Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
Fold Change: 0.0727
Cell Significance Index: 1.0200
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 0.0708
Cell Significance Index: 8.1100
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.0553
Cell Significance Index: 1.7700
Cell Name: odontoblast (CL0000060)
Fold Change: 0.0381
Cell Significance Index: 4.8900
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.0351
Cell Significance Index: 4.3100
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 0.0346
Cell Significance Index: 0.6400
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0336
Cell Significance Index: 14.8700
Cell Name: Hofbauer cell (CL3000001)
Fold Change: 0.0208
Cell Significance Index: 0.1700
Cell Name: tuft cell of small intestine (CL0009080)
Fold Change: 0.0198
Cell Significance Index: 0.2000
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0197
Cell Significance Index: 26.7500
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 0.0117
Cell Significance Index: 0.1500
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.0092
Cell Significance Index: 0.1900
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 0.0050
Cell Significance Index: 1.4400
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 0.0047
Cell Significance Index: 0.6900
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.0047
Cell Significance Index: 0.1300
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.0012
Cell Significance Index: 0.1700
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.0000
Cell Significance Index: 0.0000
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0015
Cell Significance Index: -0.2800
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0019
Cell Significance Index: -3.6200
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0035
Cell Significance Index: -2.5700
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0042
Cell Significance Index: -2.6500
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0044
Cell Significance Index: -6.7900
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0046
Cell Significance Index: -8.4500
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0053
Cell Significance Index: -0.4100
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0056
Cell Significance Index: -0.5700
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0080
Cell Significance Index: -6.0500
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.0091
Cell Significance Index: -0.6800
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0095
Cell Significance Index: -6.9600
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0097
Cell Significance Index: -5.4800
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.0099
Cell Significance Index: -0.5000
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0100
Cell Significance Index: -1.7000
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0156
Cell Significance Index: -5.5900
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0158
Cell Significance Index: -7.1600
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.0232
Cell Significance Index: -0.5800
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0300
Cell Significance Index: -6.0200
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.0356
Cell Significance Index: -0.9100
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0394
Cell Significance Index: -8.3000
Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.0395
Cell Significance Index: -1.6200
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.0439
Cell Significance Index: -1.2900
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -0.0532
Cell Significance Index: -0.4900
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.0537
Cell Significance Index: -1.3800
Cell Name: granulosa cell (CL0000501)
Fold Change: -0.0593
Cell Significance Index: -1.5600
Cell Name: paneth cell of colon (CL0009009)
Fold Change: -0.0681
Cell Significance Index: -1.0200
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0753
Cell Significance Index: -4.2300
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.0770
Cell Significance Index: -4.8500
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.0778
Cell Significance Index: -8.1000
Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.0826
Cell Significance Index: -5.8400
Cell Name: peg cell (CL4033014)
Fold Change: -0.0918
Cell Significance Index: -2.1200
Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
Fold Change: -0.0959
Cell Significance Index: -1.0200
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.0992
Cell Significance Index: -7.8600
Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: -0.1075
Cell Significance Index: -0.6700
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.1093
Cell Significance Index: -6.7000
Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.1222
Cell Significance Index: -1.7500
Cell Name: syncytiotrophoblast cell (CL0000525)
Fold Change: -0.1284
Cell Significance Index: -1.2200
Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: -0.1357
Cell Significance Index: -0.7400
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.1366
Cell Significance Index: -7.1700
Cell Name: oral mucosa squamous cell (CL1001576)
Fold Change: -0.1385
Cell Significance Index: -1.1900
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -0.1497
Cell Significance Index: -1.5500
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.1652
Cell Significance Index: -2.7700
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.1760
Cell Significance Index: -2.0000
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.1768
Cell Significance Index: -3.7000
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.1811
Cell Significance Index: -8.0100
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.1820
Cell Significance Index: -6.6800
Cell Name: type I muscle cell (CL0002211)
Fold Change: -0.1832
Cell Significance Index: -4.4700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Other Information

Description

**Key Characteristics** H2BC4 is a member of the histone H2B family, which is the most abundant protein component of chromatin. It is composed of 111 amino acids and is characterized by its ability to interact with other histone proteins and DNA-binding factors. H2BC4 is highly conserved across species, suggesting its essential role in maintaining genome stability. Its expression is tightly regulated during cell cycle progression, with high levels of expression during the S phase of the cell cycle. **Pathways and Functions** H2BC4 is involved in various cellular processes, including: 1. **DNA Replication**: H2BC4 is required for the assembly of the pre-replicative complex, which is essential for DNA replication. 2. **Chromatin Modifications**: H2BC4 is involved in chromatin modifications during the maternal-to-zygotic transition, which is critical for the regulation of gene expression in early development. 3. **RNA Expression**: H2BC4 regulates RNA expression by interacting with RNA polymerase II and other transcription factors. 4. **DNA Repair**: H2BC4 is involved in the repair of DNA double-strand breaks, which is essential for maintaining genome stability. 5. **Cell Cycle Regulation**: H2BC4 is required for the regulation of cell cycle progression, with high levels of expression during the S phase of the cell cycle. **Clinical Significance** Dysregulation of H2BC4 has been implicated in various diseases, including: 1. **Cancer**: H2BC4 is overexpressed in several types of cancer, including breast, lung, and colon cancer. 2. **Neuronal Disorders**: H2BC4 is involved in the regulation of gene expression in neuronal cells, and its dysregulation has been implicated in neurodegenerative diseases, such as Alzheimer's and Parkinson's disease. 3. **Immune Responses**: H2BC4 is involved in the regulation of immune responses, and its dysregulation has been implicated in autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. In conclusion, H2BC4 is a critical protein that plays a central role in various cellular processes, including DNA replication, transcription, and repair. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding its function and regulation.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.