Details for: EGFL7

Gene ID: 51162

Symbol: EGFL7

Ensembl ID: ENSG00000172889

Description: EGF like domain multiple 7

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 166.8325
    Cell Significance Index: -25.9500
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 72.9826
    Cell Significance Index: -30.0700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 63.1127
    Cell Significance Index: -25.6400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 58.5359
    Cell Significance Index: -30.1100
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 41.8615
    Cell Significance Index: -28.0900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 27.3372
    Cell Significance Index: -26.1000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 21.7283
    Cell Significance Index: -26.7900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 15.1571
    Cell Significance Index: 789.5100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 11.3818
    Cell Significance Index: -24.9100
  • Cell Name: glomerular capillary endothelial cell (CL1001005)
    Fold Change: 8.2668
    Cell Significance Index: 30.8100
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 7.4547
    Cell Significance Index: 45.0400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.9715
    Cell Significance Index: -27.5100
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 6.8270
    Cell Significance Index: 98.1900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 5.0262
    Cell Significance Index: 57.1000
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 4.8152
    Cell Significance Index: 30.1500
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 4.6451
    Cell Significance Index: 16.1600
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 3.4434
    Cell Significance Index: 20.3300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 3.3617
    Cell Significance Index: 59.4100
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 2.9589
    Cell Significance Index: 23.3600
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 2.7690
    Cell Significance Index: 28.6800
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 2.1132
    Cell Significance Index: 31.6700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.5964
    Cell Significance Index: 51.1300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.4871
    Cell Significance Index: 95.9400
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 1.2460
    Cell Significance Index: 11.8500
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.2270
    Cell Significance Index: 9.2700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.8320
    Cell Significance Index: 158.3400
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.7321
    Cell Significance Index: 5.9700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.5626
    Cell Significance Index: 15.0500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.5250
    Cell Significance Index: 24.4800
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: 0.4272
    Cell Significance Index: 5.8500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4242
    Cell Significance Index: 383.0100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3953
    Cell Significance Index: 79.3000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3724
    Cell Significance Index: 47.7400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3188
    Cell Significance Index: 31.5400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.3124
    Cell Significance Index: 6.5400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2730
    Cell Significance Index: 149.1100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2158
    Cell Significance Index: 35.1000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0945
    Cell Significance Index: 10.2800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0756
    Cell Significance Index: 27.1200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0005
    Cell Significance Index: -0.3900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0010
    Cell Significance Index: -0.0500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0090
    Cell Significance Index: -0.2300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0105
    Cell Significance Index: -19.7300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0184
    Cell Significance Index: -33.8800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0219
    Cell Significance Index: -0.6300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0219
    Cell Significance Index: -33.7300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0229
    Cell Significance Index: -16.9400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0258
    Cell Significance Index: -35.1000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0334
    Cell Significance Index: -14.7700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0341
    Cell Significance Index: -25.0000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0350
    Cell Significance Index: -0.8800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0368
    Cell Significance Index: -6.6400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0385
    Cell Significance Index: -2.6700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0397
    Cell Significance Index: -25.1900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0417
    Cell Significance Index: -23.5300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0499
    Cell Significance Index: -31.1300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0586
    Cell Significance Index: -11.6300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0601
    Cell Significance Index: -17.2800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0657
    Cell Significance Index: -29.8000
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0730
    Cell Significance Index: -1.1300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0741
    Cell Significance Index: -3.3600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1066
    Cell Significance Index: -2.3100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.1074
    Cell Significance Index: -6.4500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1084
    Cell Significance Index: -12.6300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1139
    Cell Significance Index: -15.6400
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1179
    Cell Significance Index: -1.2200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1318
    Cell Significance Index: -16.2100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1324
    Cell Significance Index: -22.6100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1380
    Cell Significance Index: -2.3100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1399
    Cell Significance Index: -14.2900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1419
    Cell Significance Index: -4.9300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1444
    Cell Significance Index: -30.4100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1447
    Cell Significance Index: -8.8700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1521
    Cell Significance Index: -4.0600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1685
    Cell Significance Index: -19.3100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1937
    Cell Significance Index: -28.1500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2190
    Cell Significance Index: -16.8100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2217
    Cell Significance Index: -28.6400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2614
    Cell Significance Index: -30.8300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2624
    Cell Significance Index: -27.3200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.3410
    Cell Significance Index: -24.1200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3582
    Cell Significance Index: -26.7000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3596
    Cell Significance Index: -24.1800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3622
    Cell Significance Index: -28.6900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.3895
    Cell Significance Index: -8.0800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3908
    Cell Significance Index: -11.5100
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.4214
    Cell Significance Index: -5.1800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.4549
    Cell Significance Index: -27.9600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4622
    Cell Significance Index: -29.1300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.4862
    Cell Significance Index: -22.8500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.4920
    Cell Significance Index: -14.0400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.5003
    Cell Significance Index: -25.9900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.5163
    Cell Significance Index: -28.9700
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.5556
    Cell Significance Index: -7.6300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.6080
    Cell Significance Index: -21.3000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.6425
    Cell Significance Index: -28.4200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.6462
    Cell Significance Index: -21.1600
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: -0.6494
    Cell Significance Index: -4.4600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.6716
    Cell Significance Index: -21.3900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.6787
    Cell Significance Index: -14.4600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cellular expression:** EGFL7 is highly expressed in various cell types, including polychromatophilic erythroblast, embryonic stem cells, mucosal type mast cells, and lung endothelial cells. 2. **Protein structure:** The EGFL7 protein is a member of the EGF-like domain family, consisting of a single EGF-like domain and a transmembrane domain. 3. **Function:** EGFL7 is involved in the regulation of endothelial cell proliferation, vasculogenesis, and angiogenesis. 4. **Signaling pathways:** EGFL7 interacts with various signaling pathways, including the Notch signaling pathway, and is involved in the regulation of immune cell function. **Pathways and Functions:** 1. **Angiogenesis:** EGFL7 is involved in the regulation of endothelial cell proliferation and vasculogenesis, promoting angiogenesis and blood vessel development. 2. **Cell adhesion:** EGFL7 interacts with cell surface receptors, regulating cell adhesion and migration. 3. **Negative regulation of Notch signaling pathway:** EGFL7 inhibits the Notch signaling pathway, which is involved in cell differentiation and proliferation. 4. **Positive regulation of endothelial cell proliferation:** EGFL7 promotes endothelial cell proliferation, contributing to angiogenesis and vasculogenesis. 5. **Protein binding:** EGFL7 interacts with various proteins, including cell surface receptors and signaling molecules. **Clinical Significance:** 1. **Cancer:** EGFL7 has been implicated in various cancers, including breast cancer and lung cancer, where it is involved in tumor angiogenesis and metastasis. 2. **Inflammatory diseases:** EGFL7 is also involved in inflammatory diseases, such as asthma and allergic reactions, where it regulates mast cell and T cell function. 3. **Vascular disorders:** EGFL7 has been implicated in vascular disorders, including atherosclerosis and hypertension, where it is involved in endothelial cell function and angiogenesis. 4. **Immunological disorders:** EGFL7 is also involved in immunological disorders, including autoimmune diseases, where it regulates immune cell function and inflammation. In conclusion, EGFL7 is a multifunctional gene that plays a crucial role in various biological processes, including angiogenesis, cell adhesion, and immune regulation. Further research is needed to fully understand the functions and clinical significance of EGFL7 in different diseases.

Genular Protein ID: 960302186

Symbol: EGFL7_HUMAN

Name: Epidermal growth factor-like protein 7

UniProtKB Accession Codes:

Q9UHF1 B3KRP0 M9VTX9 Q5M7Y5 Q5VUD5 Q96EG0

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 11 Ensembl 4 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 6 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 5 SIGNOR 1 SMART 2 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 23386126

Title: EGFL7 ligates alphavbeta3 integrin to enhance vessel formation.

PubMed ID: 23386126

DOI: 10.1182/blood-2011-11-394882

PubMed ID: 23639441

Title: CASZ1 promotes vascular assembly and morphogenesis through the direct regulation of an EGFL7/RhoA-mediated pathway.

PubMed ID: 23639441

DOI: 10.1016/j.devcel.2013.03.003

Sequence Information:

  • Length: 273
  • Mass: 29618
  • Checksum: 5740BB845ED5A988
  • Sequence:
    • MRGSQEVLLM WLLVLAVGGT EHAYRPGRRV CAVRAHGDPV SESFVQRVYQ PFLTTCDGHR 
ACSTYRTIYR TAYRRSPGLA PARPRYACCP GWKRTSGLPG ACGAAICQPP CRNGGSCVQP 
GRCRCPAGWR GDTCQSDVDE CSARRGGCPQ RCVNTAGSYW CQCWEGHSLS ADGTLCVPKG 
GPPRVAPNPT GVDSAMKEEV QRLQSRVDLL EEKLQLVLAP LHSLASQALE HGLPDPGSLL 
VHSFQQLGRI DSLSEQISFL EEQLGSCSCK KDS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.