Details for: H2BC5

Gene ID: 3017

Symbol: H2BC5

Ensembl ID: ENSG00000158373

Description: H2B clustered histone 5

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 87.9487
    Cell Significance Index: -13.6800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 54.4465
    Cell Significance Index: -13.8100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 31.2118
    Cell Significance Index: -12.6800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 30.1331
    Cell Significance Index: -15.5000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 13.5010
    Cell Significance Index: -12.8900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 11.7847
    Cell Significance Index: -14.5300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.7747
    Cell Significance Index: -14.9000
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.9920
    Cell Significance Index: 12.2900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.4115
    Cell Significance Index: 21.1500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.3410
    Cell Significance Index: 36.5000
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 1.3168
    Cell Significance Index: 10.1500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.2672
    Cell Significance Index: 87.6400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.2606
    Cell Significance Index: 57.1400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.1654
    Cell Significance Index: 15.9000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 1.0537
    Cell Significance Index: 26.3400
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.0421
    Cell Significance Index: 9.2500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.9533
    Cell Significance Index: 61.5100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.8949
    Cell Significance Index: 46.4900
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.8716
    Cell Significance Index: 9.0200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.8236
    Cell Significance Index: 42.9000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.8089
    Cell Significance Index: 12.1900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.7321
    Cell Significance Index: 20.4600
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.7200
    Cell Significance Index: 7.6500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.6211
    Cell Significance Index: 17.9000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5776
    Cell Significance Index: 62.8300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5504
    Cell Significance Index: 33.0500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5442
    Cell Significance Index: 53.8300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5340
    Cell Significance Index: 11.5700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5282
    Cell Significance Index: 85.9100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5142
    Cell Significance Index: 97.8500
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.4640
    Cell Significance Index: 3.7100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2635
    Cell Significance Index: 143.9200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2633
    Cell Significance Index: 47.4700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.2229
    Cell Significance Index: 3.8200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.2166
    Cell Significance Index: 2.0000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.2073
    Cell Significance Index: 5.3000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2071
    Cell Significance Index: 41.1000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1608
    Cell Significance Index: 5.6500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1406
    Cell Significance Index: 17.2900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1348
    Cell Significance Index: 6.3400
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 0.1130
    Cell Significance Index: 1.1400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0784
    Cell Significance Index: 4.9400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0769
    Cell Significance Index: 10.5700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0678
    Cell Significance Index: 2.1700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0649
    Cell Significance Index: 7.4300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0644
    Cell Significance Index: 12.9100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0634
    Cell Significance Index: 8.1300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0614
    Cell Significance Index: 17.6800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0539
    Cell Significance Index: 6.9600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0515
    Cell Significance Index: 18.4900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0419
    Cell Significance Index: 2.3500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.0253
    Cell Significance Index: 0.5300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0230
    Cell Significance Index: 0.4900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0222
    Cell Significance Index: 20.0500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0208
    Cell Significance Index: 0.9700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0197
    Cell Significance Index: 8.6900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0037
    Cell Significance Index: -6.9200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0043
    Cell Significance Index: -0.3200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0062
    Cell Significance Index: -0.3100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0063
    Cell Significance Index: -0.4900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0085
    Cell Significance Index: -5.4100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0090
    Cell Significance Index: -0.2400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0092
    Cell Significance Index: -6.9600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0096
    Cell Significance Index: -17.7600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0109
    Cell Significance Index: -16.8200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0134
    Cell Significance Index: -18.2600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0144
    Cell Significance Index: -10.5700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0146
    Cell Significance Index: -10.8400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0167
    Cell Significance Index: -2.8500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0229
    Cell Significance Index: -12.9100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0232
    Cell Significance Index: -1.2200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0252
    Cell Significance Index: -11.4500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0277
    Cell Significance Index: -1.1400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0310
    Cell Significance Index: -19.3800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0353
    Cell Significance Index: -3.6100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0607
    Cell Significance Index: -8.8200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0765
    Cell Significance Index: -5.4100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0860
    Cell Significance Index: -2.3000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0897
    Cell Significance Index: -10.5800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0913
    Cell Significance Index: -19.2200
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.1011
    Cell Significance Index: -0.6000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1230
    Cell Significance Index: -12.8100
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.1282
    Cell Significance Index: -0.8100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1288
    Cell Significance Index: -2.1600
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: -0.1313
    Cell Significance Index: -1.4200
  • Cell Name: sebaceous gland cell (CL2000021)
    Fold Change: -0.1469
    Cell Significance Index: -0.1900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1650
    Cell Significance Index: -13.0700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1719
    Cell Significance Index: -1.7800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1760
    Cell Significance Index: -2.0000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1784
    Cell Significance Index: -6.2000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1848
    Cell Significance Index: -11.3300
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.2114
    Cell Significance Index: -1.3800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2306
    Cell Significance Index: -10.2000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2343
    Cell Significance Index: -6.9000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2362
    Cell Significance Index: -6.2100
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.2428
    Cell Significance Index: -1.9800
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.2539
    Cell Significance Index: -1.7200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2572
    Cell Significance Index: -6.6100
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2632
    Cell Significance Index: -6.0800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2725
    Cell Significance Index: -10.0100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** H2BC5 is a member of the histone H2B family, which forms a tetrameric complex with H3, H4, and H1 proteins to regulate chromatin structure and gene expression. H2BC5 is characterized by its ability to interact with other proteins and DNA, influencing chromatin organization and epigenetic regulation. **Pathways and Functions:** H2BC5 is involved in numerous cellular processes, including: 1. **Gene Expression and Regulation:** H2BC5 plays a critical role in regulating gene expression by influencing chromatin structure and epigenetic marks. 2. **DNA Replication and Repair:** H2BC5 is involved in the assembly of the pre-replicative complex and the repair of DNA double-strand breaks. 3. **Cell Cycle Regulation:** H2BC5 is required for the proper progression of the cell cycle, including mitosis and meiosis. 4. **Chromatin Assembly and Organization:** H2BC5 contributes to the assembly of nucleosomes and the regulation of chromatin structure. 5. **Epigenetic Regulation:** H2BC5 interacts with other epigenetic regulators, such as histone acetyltransferases and deacetylases, to influence gene expression. **Clinical Significance:** Dysregulation of H2BC5 has been implicated in various diseases, including: 1. **Cancer:** Alterations in H2BC5 expression have been observed in several types of cancer, including leukemia and lymphoma. 2. **Neurological Disorders:** H2BC5 has been linked to neurodegenerative diseases, such as Alzheimer's and Parkinson's, through its role in regulating gene expression and chromatin structure. 3. **Immunological Disorders:** H2BC5 plays a crucial role in the regulation of the immune response, and alterations in its expression have been observed in autoimmune diseases, such as multiple sclerosis. **Significantly Expressed Cells:** H2BC5 is expressed in various cell types, including: 1. **Thymocytes:** H2BC5 is essential for the proper development and function of thymocytes. 2. **Squamous Epithelial Cells:** H2BC5 is involved in the regulation of gene expression in squamous epithelial cells. 3. **Mononuclear Cells:** H2BC5 plays a role in the regulation of gene expression in mononuclear cells. **Proteins Associated with H2BC5:** H2BC5 interacts with various proteins, including: 1. **Histone H3.1:** H2BC5 forms a tetrameric complex with histone H3.1 to regulate chromatin structure. 2. **Histone H4:** H2BC5 interacts with histone H4 to influence chromatin organization. 3. **Histone H1:** H2BC5 interacts with histone H1 to regulate chromatin structure. In conclusion, H2BC5 is a multifaceted protein that plays a crucial role in regulating chromatin structure, gene expression, and cellular processes. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding its functions and significance in human health.

Genular Protein ID: 3317911138

Symbol: H2B1C_HUMAN

Name: Histone H2B type 1-C/E/F/G/I

UniProtKB Accession Codes:

P62807 P02278 Q3B872 Q4VB69 Q93078 Q93080

Database IDs:

ABCD 1 AGR 6 AlphaFoldDB 1 Antibodypedia 5 Bgee 1 BioGRID 6 BioGRID-ORCS 6 BioMuta 1 CCDS 5 CTD 6 ChiTaRS 3 DIP 1 DMDM 1 DNASU 1 DisGeNET 6 DrugBank 1 EMBL 22 EMDB 62 Ensembl 8 ExpressionAtlas 1 GO 15 Gene3D 1 GeneCards 5 GeneTree 1 GeneWiki 5 GlyCosmos 1 GlyGen 1 HGNC 5 HOGENOM 1 HPA 5 InParanoid 1 IntAct 1 InterPro 3 KEGG 6 MANE-Select 5 MIM 5 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 5 OrthoDB 1 PANTHER 2 PDB 52 PDBsum 52 PIR 2 PRIDE 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 Pumba 1 RNAct 1 Reactome 48 RefSeq 6 SASBDB 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 5 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1916825

Title: Isolation and characterization of two human H1 histone genes within clusters of core histone genes.

PubMed ID: 1916825

DOI: 10.1016/0888-7543(91)90183-f

PubMed ID: 9119399

Title: Human histone gene organization: nonregular arrangement within a large cluster.

PubMed ID: 9119399

DOI: 10.1006/geno.1996.4592

PubMed ID: 12408966

Title: The human and mouse replication-dependent histone genes.

PubMed ID: 12408966

DOI: 10.1016/s0888-7543(02)96850-3

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 422550

Title: Human spleen histone H2B. Isolation and amino acid sequence.

PubMed ID: 422550

DOI: 10.1093/oxfordjournals.jbchem.a132371

PubMed ID: 11859126

Title: Endotoxin-neutralizing antimicrobial proteins of the human placenta.

PubMed ID: 11859126

DOI: 10.4049/jimmunol.168.5.2356

PubMed ID: 8620898

Title: Biochemical and antibacterial analysis of human wound and blister fluid.

PubMed ID: 8620898

DOI: 10.1111/j.1432-1033.1996.0086n.x

PubMed ID: 12860195

Title: Antimicrobial peptides in the first line defence of human colon mucosa.

PubMed ID: 12860195

DOI: 10.1016/s0196-9781(03)00114-1

PubMed ID: 15019208

Title: Antimicrobial polypeptides of the human colonic epithelium.

PubMed ID: 15019208

DOI: 10.1016/j.peptides.2003.07.028

PubMed ID: 16627869

Title: Quantitative proteomic analysis of post-translational modifications of human histones.

PubMed ID: 16627869

DOI: 10.1074/mcp.m600007-mcp200

PubMed ID: 12757711

Title: Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase.

PubMed ID: 12757711

DOI: 10.1016/s0092-8674(03)00355-6

PubMed ID: 16307923

Title: Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation.

PubMed ID: 16307923

DOI: 10.1016/j.molcel.2005.09.025

PubMed ID: 16283522

Title: Inhibition of core histones acetylation by carcinogenic nickel(II).

PubMed ID: 16283522

DOI: 10.1007/s11010-005-8285-1

PubMed ID: 16713563

Title: Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II.

PubMed ID: 16713563

DOI: 10.1016/j.cell.2006.04.029

PubMed ID: 16457587

Title: Gene-specific characterization of human histone H2B by electron capture dissociation.

PubMed ID: 16457587

DOI: 10.1021/pr050268v

PubMed ID: 21726816

Title: The RING finger protein MSL2 in the MOF complex is an E3 ubiquitin ligase for H2B K34 and is involved in crosstalk with H3 K4 and K79 methylation.

PubMed ID: 21726816

DOI: 10.1016/j.molcel.2011.05.015

PubMed ID: 22121020

Title: GlcNAcylation of histone H2B facilitates its monoubiquitination.

PubMed ID: 22121020

DOI: 10.1038/nature10656

PubMed ID: 21925322

Title: Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification.

PubMed ID: 21925322

DOI: 10.1016/j.cell.2011.08.008

PubMed ID: 22389435

Title: Lysine succinylation and lysine malonylation in histones.

PubMed ID: 22389435

DOI: 10.1074/mcp.m111.015875

PubMed ID: 23824326

Title: USP49 deubiquitinates histone H2B and regulates cotranscriptional pre-mRNA splicing.

PubMed ID: 23824326

DOI: 10.1101/gad.211037.112

PubMed ID: 24681537

Title: Lysine 2-hydroxyisobutyrylation is a widely distributed active histone mark.

PubMed ID: 24681537

DOI: 10.1038/nchembio.1497

PubMed ID: 27105113

Title: Dynamic competing histone H4 K5K8 acetylation and butyrylation are hallmarks of highly active gene promoters.

PubMed ID: 27105113

DOI: 10.1016/j.molcel.2016.03.014

PubMed ID: 27105115

Title: Metabolic regulation of gene expression by histone lysine beta-hydroxybutyrylation.

PubMed ID: 27105115

DOI: 10.1016/j.molcel.2016.03.036

PubMed ID: 27530147

Title: PARP3 is a sensor of nicked nucleosomes and monoribosylates histone H2B(Glu2).

PubMed ID: 27530147

DOI: 10.1038/ncomms12404

PubMed ID: 31542297

Title: Glutarylation of histone H4 lysine 91 regulates chromatin dynamics.

PubMed ID: 31542297

DOI: 10.1016/j.molcel.2019.08.018

PubMed ID: 31645732

Title: Metabolic regulation of gene expression by histone lactylation.

PubMed ID: 31645732

DOI: 10.1038/s41586-019-1678-1

PubMed ID: 34874266

Title: Serine ADP-ribosylation marks nucleosomes for ALC1-dependent chromatin remodeling.

PubMed ID: 34874266

DOI: 10.7554/elife.71502

PubMed ID: 32911481

Title: The molecular basis of tight nuclear tethering and inactivation of cGAS.

PubMed ID: 32911481

DOI: 10.1038/s41586-020-2749-z

PubMed ID: 32911480

Title: Structural basis for sequestration and autoinhibition of cGAS by chromatin.

PubMed ID: 32911480

DOI: 10.1038/s41586-020-2748-0

PubMed ID: 32913000

Title: Structural basis of nucleosome-dependent cGAS inhibition.

PubMed ID: 32913000

DOI: 10.1126/science.abd0609

PubMed ID: 35390161

Title: Multivalent DNA and nucleosome acidic patch interactions specify VRK1 mitotic localization and activity.

PubMed ID: 35390161

DOI: 10.1093/nar/gkac198

Sequence Information:

  • Length: 126
  • Mass: 13906
  • Checksum: FAE1479F44BE703D
  • Sequence:
    • MPEPAKSAPA PKKGSKKAVT KAQKKDGKKR KRSRKESYSV YVYKVLKQVH PDTGISSKAM 
GIMNSFVNDI FERIAGEASR LAHYNKRSTI TSREIQTAVR LLLPGELAKH AVSEGTKAVT 
KYTSSK

Genular Protein ID: 2335913751

Symbol: H2B1D_HUMAN

Name: Histone H2B type 1-D

UniProtKB Accession Codes:

P58876

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 2 ExpressionAtlas 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRIDE 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 48 RefSeq 3 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9710638

Title: Core histones and HIRIP3, a novel histone-binding protein, directly interact with WD repeat protein HIRA.

PubMed ID: 9710638

DOI: 10.1128/mcb.18.9.5546

PubMed ID: 1916825

Title: Isolation and characterization of two human H1 histone genes within clusters of core histone genes.

PubMed ID: 1916825

DOI: 10.1016/0888-7543(91)90183-f

PubMed ID: 12408966

Title: The human and mouse replication-dependent histone genes.

PubMed ID: 12408966

DOI: 10.1016/s0888-7543(02)96850-3

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16627869

Title: Quantitative proteomic analysis of post-translational modifications of human histones.

PubMed ID: 16627869

DOI: 10.1074/mcp.m600007-mcp200

PubMed ID: 12757711

Title: Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase.

PubMed ID: 12757711

DOI: 10.1016/s0092-8674(03)00355-6

PubMed ID: 16307923

Title: Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation.

PubMed ID: 16307923

DOI: 10.1016/j.molcel.2005.09.025

PubMed ID: 16283522

Title: Inhibition of core histones acetylation by carcinogenic nickel(II).

PubMed ID: 16283522

DOI: 10.1007/s11010-005-8285-1

PubMed ID: 16713563

Title: Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II.

PubMed ID: 16713563

DOI: 10.1016/j.cell.2006.04.029

PubMed ID: 16457587

Title: Gene-specific characterization of human histone H2B by electron capture dissociation.

PubMed ID: 16457587

DOI: 10.1021/pr050268v

PubMed ID: 16319397

Title: Characterization of histones H2A and H2B variants and their post-translational modifications by mass spectrometry.

PubMed ID: 16319397

DOI: 10.1074/mcp.m500288-mcp200

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21925322

Title: Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification.

PubMed ID: 21925322

DOI: 10.1016/j.cell.2011.08.008

PubMed ID: 21726816

Title: The RING finger protein MSL2 in the MOF complex is an E3 ubiquitin ligase for H2B K34 and is involved in crosstalk with H3 K4 and K79 methylation.

PubMed ID: 21726816

DOI: 10.1016/j.molcel.2011.05.015

PubMed ID: 22389435

Title: Lysine succinylation and lysine malonylation in histones.

PubMed ID: 22389435

DOI: 10.1074/mcp.m111.015875

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23824326

Title: USP49 deubiquitinates histone H2B and regulates cotranscriptional pre-mRNA splicing.

PubMed ID: 23824326

DOI: 10.1101/gad.211037.112

PubMed ID: 24681537

Title: Lysine 2-hydroxyisobutyrylation is a widely distributed active histone mark.

PubMed ID: 24681537

DOI: 10.1038/nchembio.1497

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 27105113

Title: Dynamic competing histone H4 K5K8 acetylation and butyrylation are hallmarks of highly active gene promoters.

PubMed ID: 27105113

DOI: 10.1016/j.molcel.2016.03.014

PubMed ID: 27105115

Title: Metabolic regulation of gene expression by histone lysine beta-hydroxybutyrylation.

PubMed ID: 27105115

DOI: 10.1016/j.molcel.2016.03.036

PubMed ID: 27723750

Title: Serine is a new target residue for endogenous ADP-ribosylation on histones.

PubMed ID: 27723750

DOI: 10.1038/nchembio.2180

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 27530147

Title: PARP3 is a sensor of nicked nucleosomes and monoribosylates histone H2B(Glu2).

PubMed ID: 27530147

DOI: 10.1038/ncomms12404

PubMed ID: 31542297

Title: Glutarylation of histone H4 lysine 91 regulates chromatin dynamics.

PubMed ID: 31542297

DOI: 10.1016/j.molcel.2019.08.018

PubMed ID: 31645732

Title: Metabolic regulation of gene expression by histone lactylation.

PubMed ID: 31645732

DOI: 10.1038/s41586-019-1678-1

PubMed ID: 34874266

Title: Serine ADP-ribosylation marks nucleosomes for ALC1-dependent chromatin remodeling.

PubMed ID: 34874266

DOI: 10.7554/elife.71502

Sequence Information:

  • Length: 126
  • Mass: 13936
  • Checksum: FAE8378A44BE7028
  • Sequence:
    • MPEPTKSAPA PKKGSKKAVT KAQKKDGKKR KRSRKESYSV YVYKVLKQVH PDTGISSKAM 
GIMNSFVNDI FERIAGEASR LAHYNKRSTI TSREIQTAVR LLLPGELAKH AVSEGTKAVT 
KYTSSK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.