Details for: ZNF124

Gene ID: 7678

Symbol: ZNF124

Ensembl ID: ENSG00000196418

Description: zinc finger protein 124

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 132.8874
    Cell Significance Index: -20.6700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 74.0015
    Cell Significance Index: -18.7700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 42.7562
    Cell Significance Index: -17.3700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 18.2562
    Cell Significance Index: -17.4300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 16.8944
    Cell Significance Index: -20.8300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.5107
    Cell Significance Index: -20.1200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.8799
    Cell Significance Index: -10.6800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.4138
    Cell Significance Index: 280.5800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.3287
    Cell Significance Index: 216.1000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.9242
    Cell Significance Index: 51.8600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.7896
    Cell Significance Index: 48.5300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7413
    Cell Significance Index: 669.3300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.7043
    Cell Significance Index: 16.8900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6757
    Cell Significance Index: 73.5000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.6251
    Cell Significance Index: 125.4000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.5997
    Cell Significance Index: 14.9900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.4961
    Cell Significance Index: 57.8200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4640
    Cell Significance Index: 21.0300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4486
    Cell Significance Index: 12.9300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.3778
    Cell Significance Index: 24.3800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3354
    Cell Significance Index: 60.4700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.3261
    Cell Significance Index: 7.1400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3118
    Cell Significance Index: 21.5600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3046
    Cell Significance Index: 6.6000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2584
    Cell Significance Index: 92.6800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2399
    Cell Significance Index: 12.4600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2340
    Cell Significance Index: 28.7800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2261
    Cell Significance Index: 6.3200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2194
    Cell Significance Index: 13.8300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2116
    Cell Significance Index: 20.9300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1589
    Cell Significance Index: 30.2300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1189
    Cell Significance Index: 64.9300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0944
    Cell Significance Index: 65.2800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0937
    Cell Significance Index: 144.2300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0609
    Cell Significance Index: 4.6700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0506
    Cell Significance Index: 93.3300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0482
    Cell Significance Index: 21.3300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0375
    Cell Significance Index: 70.5600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0261
    Cell Significance Index: 35.4700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0259
    Cell Significance Index: 0.9100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0228
    Cell Significance Index: 0.3900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0124
    Cell Significance Index: 7.8900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0001
    Cell Significance Index: 0.0500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0079
    Cell Significance Index: -1.0900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0187
    Cell Significance Index: -13.7400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0214
    Cell Significance Index: -15.8300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0262
    Cell Significance Index: -19.8100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0288
    Cell Significance Index: -0.7700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0351
    Cell Significance Index: -19.8000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0356
    Cell Significance Index: -22.2000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0380
    Cell Significance Index: -6.4900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0479
    Cell Significance Index: -5.6500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0498
    Cell Significance Index: -1.2800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0511
    Cell Significance Index: -14.7100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0525
    Cell Significance Index: -7.6300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0587
    Cell Significance Index: -7.5300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0641
    Cell Significance Index: -1.3600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0722
    Cell Significance Index: -3.4000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0816
    Cell Significance Index: -5.4900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0899
    Cell Significance Index: -4.1900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0925
    Cell Significance Index: -9.4500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0962
    Cell Significance Index: -12.4300
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.0994
    Cell Significance Index: -1.0400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1020
    Cell Significance Index: -1.9900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1069
    Cell Significance Index: -4.7300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1074
    Cell Significance Index: -22.6200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1099
    Cell Significance Index: -2.3400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1121
    Cell Significance Index: -7.9300
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.1215
    Cell Significance Index: -1.7100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1216
    Cell Significance Index: -13.9300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1452
    Cell Significance Index: -4.6500
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.1605
    Cell Significance Index: -0.9700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1643
    Cell Significance Index: -5.7100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1730
    Cell Significance Index: -4.7100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1766
    Cell Significance Index: -9.2000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1828
    Cell Significance Index: -4.8900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1842
    Cell Significance Index: -19.1800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1902
    Cell Significance Index: -11.6600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1907
    Cell Significance Index: -3.7700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1915
    Cell Significance Index: -7.2500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1991
    Cell Significance Index: -14.8400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.2204
    Cell Significance Index: -2.0300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2261
    Cell Significance Index: -17.9100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2749
    Cell Significance Index: -9.0000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2857
    Cell Significance Index: -9.1000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2902
    Cell Significance Index: -8.2800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.3230
    Cell Significance Index: -4.6300
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.3356
    Cell Significance Index: -4.8200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3482
    Cell Significance Index: -18.2800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3521
    Cell Significance Index: -9.0000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.3706
    Cell Significance Index: -6.8500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.3925
    Cell Significance Index: -5.3600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4091
    Cell Significance Index: -14.3300
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.4254
    Cell Significance Index: -5.3100
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.4519
    Cell Significance Index: -6.5000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4522
    Cell Significance Index: -13.3200
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.4688
    Cell Significance Index: -3.0500
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.4738
    Cell Significance Index: -7.1400
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.4782
    Cell Significance Index: -4.9500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.4922
    Cell Significance Index: -10.2100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Transcription Factor Activity**: ZNF124 exhibits DNA-binding transcription factor activity, specifically targeting RNA polymerase II-specific sequences. This interaction is essential for regulating gene expression in various cell types. 2. **Cell-Specific Expression**: ZNF124 is expressed in specific cell types, including germ cells, mural cells, and neurons, highlighting its involvement in neuronal development and function. 3. **Metal Ion Binding**: ZNF124's ability to bind metal ions, such as zinc, is crucial for its transcriptional regulatory function. 4. **Protein Binding**: ZNF124 interacts with other proteins, including RNA polymerase II, to facilitate transcriptional regulation. **Pathways and Functions** 1. **Generic Transcription Pathway**: ZNF124 is involved in the regulation of transcription by RNA polymerase II, influencing the expression of genes involved in neuronal development and function. 2. **RNA Polymerase II Transcription Regulatory Region Sequence-Specific DNA Binding**: ZNF124's ability to bind to specific DNA sequences is critical for regulating gene expression in neurons. 3. **Metal Ion Binding Pathway**: ZNF124's interaction with metal ions, such as zinc, is essential for its transcriptional regulatory function. 4. **Regulation of Transcription by RNA Polymerase II**: ZNF124's involvement in regulating transcription by RNA polymerase II is critical for controlling gene expression in neurons. **Clinical Significance** 1. **Neurodevelopmental Disorders**: ZNF124's involvement in neuronal development and function highlights its potential role in neurodevelopmental disorders, such as autism spectrum disorder and schizophrenia. 2. **Neurodegenerative Diseases**: ZNF124's expression in specific neurons suggests its potential involvement in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 3. **Cancer Research**: ZNF124's role in regulating gene expression in neurons may also be relevant to cancer research, particularly in understanding the development and progression of certain types of cancer. 4. **Therapeutic Applications**: Further research on ZNF124's role in transcriptional regulation may lead to the development of novel therapeutic strategies for neurodevelopmental and neurodegenerative disorders. In conclusion, ZNF124's involvement in transcriptional regulation, particularly in neurons, highlights its potential role in various neurological and psychiatric disorders. Further research on this gene's function and clinical significance is essential for understanding its potential as a therapeutic target.

Genular Protein ID: 1573063453

Symbol: ZN124_HUMAN

Name: Zinc finger protein 124

UniProtKB Accession Codes:

Q15973 B3KNP3 J3KSE1 Q15974 Q4VAJ7 Q5T2V4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 Ensembl 3 ExpressionAtlas 1 GO 6 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 2 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 1 RefSeq 4 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7916577

Title: A novel zinc finger gene on human chromosome 1qter that is alternatively spliced in human tissues and cell lines.

PubMed ID: 7916577

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 351
  • Mass: 40217
  • Checksum: 9C6C2E4DC3B61FF2
  • Sequence:
    • MSGHPGSWEM NSVAFEDVAV NFTQEEWALL DPSQKNLYRD VMQETFRNLA SIGNKGEDQS 
IEDQYKNSSR NLRHIISHSG NNPYGCEECG KKPCTCKQCQ KTSLSVTRVH RDTVMHTGNG 
HYGCTICEKV FNIPSSFQIH QRNHTGEKPY ECMECGKALG FSRSLNRHKR IHTGEKRYEC 
KQCGKAFSRS SHLRDHERTH TGEKPYECKH CGKAFRYSNC LHYHERTHTG EKPYVCMECG 
KAFSCLSSLQ GHIKAHAGEE PYPCKQCGKA FRYASSLQKH EKTHIAQKPY VCNNCGKGFR 
CSSSLRDHER THTGEKPYEC QKCGKAFSRA STLWKHKKTH TGEKPYKCKK M

Genular Protein ID: 1309451367

Symbol: J3QKQ6_HUMAN

Name: N/A

UniProtKB Accession Codes:

J3QKQ6

Database IDs:

AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 1 Gene3D 1 GeneTree 1 HGNC 1 InterPro 3 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 2 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 1 SMART 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

Sequence Information:

  • Length: 77
  • Mass: 8760
  • Checksum: ACDAC95B69F7A7AF
  • Sequence:
    • MSGHPGSWEM NSVAFEDVAV NFTQEEWALL DPSQKNLYRD VMQETFRNLA SIGNKGEDQS 
IEDQYKNSSR NLRCTGS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.