H2BC15 | ENSG00000233822 | NCBI 8341

Details for: H2BC15

Gene ID: 8341

Symbol: H2BC15

Ensembl ID: ENSG00000233822

Description: H2B clustered histone 15

Associated with

Activation of anterior hox genes in hindbrain development during early embryogenesis
(R-HSA-5617472)
Activation of hox genes during differentiation
(R-HSA-5619507)
Amyloid fiber formation
(R-HSA-977225)
Assembly of the orc complex at the origin of replication
(R-HSA-68616)
Assembly of the pre-replicative complex
(R-HSA-68867)
B-wich complex positively regulates rrna expression
(R-HSA-5250924)
Base-excision repair, ap site formation
(R-HSA-73929)
Base excision repair
(R-HSA-73884)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cell cycle checkpoints
(R-HSA-69620)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular senescence
(R-HSA-2559583)
Chromatin modifications during the maternal to zygotic transition (mzt)
(R-HSA-9821002)
Chromatin modifying enzymes
(R-HSA-3247509)
Chromatin organization
(R-HSA-4839726)
Chromosome maintenance
(R-HSA-73886)
Defective pyroptosis
(R-HSA-9710421)
Deposition of new cenpa-containing nucleosomes at the centromere
(R-HSA-606279)
Depurination
(R-HSA-73927)
Depyrimidination
(R-HSA-73928)
Deubiquitination
(R-HSA-5688426)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of programmed cell death
(R-HSA-9645723)
Dna damage/telomere stress induced senescence
(R-HSA-2559586)
Dna double-strand break repair
(R-HSA-5693532)
Dna double strand break response
(R-HSA-5693606)
Dna methylation
(R-HSA-5334118)
Dna repair
(R-HSA-73894)
Dna replication
(R-HSA-69306)
Dna replication pre-initiation
(R-HSA-69002)
E3 ubiquitin ligases ubiquitinate target proteins
(R-HSA-8866654)
Epigenetic regulation by wdr5-containing histone modifying complexes
(R-HSA-9917777)
Epigenetic regulation of gene expression
(R-HSA-212165)
Epigenetic regulation of gene expression by mll3 and mll4 complexes
(R-HSA-9818564)
Ercc6 (csb) and ehmt2 (g9a) positively regulate rrna expression
(R-HSA-427389)
Esr-mediated signaling
(R-HSA-8939211)
Estrogen-dependent gene expression
(R-HSA-9018519)
Formation of the beta-catenin:tcf transactivating complex
(R-HSA-201722)
G2/m checkpoints
(R-HSA-69481)
G2/m dna damage checkpoint
(R-HSA-69473)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Gene silencing by rna
(R-HSA-211000)
Hats acetylate histones
(R-HSA-3214847)
Hcmv infection
(R-HSA-9609646)
Hdacs deacetylate histones
(R-HSA-3214815)
Hdr through homologous recombination (hrr) or single strand annealing (ssa)
(R-HSA-5693567)
Homology directed repair
(R-HSA-5693538)
Infectious disease
(R-HSA-5663205)
Inhibition of dna recombination at telomere
(R-HSA-9670095)
Maternal to zygotic transition (mzt)
(R-HSA-9816359)
Meiosis
(R-HSA-1500620)
Meiotic recombination
(R-HSA-912446)
Meiotic synapsis
(R-HSA-1221632)
Metabolism of proteins
(R-HSA-392499)
Mitotic prophase
(R-HSA-68875)
M phase
(R-HSA-68886)
Negative epigenetic regulation of rrna expression
(R-HSA-5250941)
Nonhomologous end-joining (nhej)
(R-HSA-5693571)
Norc negatively regulates rrna expression
(R-HSA-427413)
Nucleosome assembly
(R-HSA-774815)
Oxidative stress induced senescence
(R-HSA-2559580)
Packaging of telomere ends
(R-HSA-171306)
Positive epigenetic regulation of rrna expression
(R-HSA-5250913)
Post-translational protein modification
(R-HSA-597592)
Prc2 methylates histones and dna
(R-HSA-212300)
Pre-notch expression and processing
(R-HSA-1912422)
Pre-notch transcription and translation
(R-HSA-1912408)
Protein ubiquitination
(R-HSA-8852135)
Recruitment and atm-mediated phosphorylation of repair and signaling proteins at dna double strand breaks
(R-HSA-5693565)
Regulation of endogenous retroelements
(R-HSA-9842860)
Regulation of endogenous retroelements by krab-zfp proteins
(R-HSA-9843940)
Regulation of endogenous retroelements by the human silencing hub (hush) complex
(R-HSA-9843970)
Replacement of protamines by nucleosomes in the male pronucleus
(R-HSA-9821993)
Reproduction
(R-HSA-1474165)
Respiratory syncytial virus infection pathway
(R-HSA-9820952)
Rho gtpase effectors
(R-HSA-195258)
Rna polymerase ii transcription
(R-HSA-73857)
Rna polymerase i promoter clearance
(R-HSA-73854)
Rna polymerase i promoter escape
(R-HSA-73772)
Rna polymerase i promoter opening
(R-HSA-73728)
Rna polymerase i transcription
(R-HSA-73864)
Senescence-associated secretory phenotype (sasp)
(R-HSA-2559582)
Signaling by notch
(R-HSA-157118)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signaling by wnt
(R-HSA-195721)
Signal transduction
(R-HSA-162582)
Sirt1 negatively regulates rrna expression
(R-HSA-427359)
Tcf dependent signaling in response to wnt
(R-HSA-201681)
Telomere maintenance
(R-HSA-157579)
Transcriptional regulation by runx1
(R-HSA-8878171)
Transcriptional regulation by small rnas
(R-HSA-5578749)
Transcriptional regulation of granulopoiesis
(R-HSA-9616222)
Ub-specific processing proteases
(R-HSA-5689880)
Viral infection pathways
(R-HSA-9824446)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 49.3104
Cell Significance Index: -7.6700
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 32.1317
Cell Significance Index: -8.1500
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 7.4293
Cell Significance Index: -9.1600
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 2.3593
Cell Significance Index: -9.3100
Cell Name: early pro-B cell (CL0002046)
Fold Change: 1.8757
Cell Significance Index: 121.0100
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 1.8135
Cell Significance Index: -5.5700
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 1.4541
Cell Significance Index: 276.7200
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.3663
Cell Significance Index: 61.9300
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.9606
Cell Significance Index: 66.4300
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.8951
Cell Significance Index: 25.7900
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.7015
Cell Significance Index: 633.3900
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.6599
Cell Significance Index: 39.6200
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.6512
Cell Significance Index: 70.8300
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.6437
Cell Significance Index: 63.6800
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.5327
Cell Significance Index: 86.6400
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.5313
Cell Significance Index: 11.5100
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.4598
Cell Significance Index: 24.1400
Cell Name: epithelial cell of uterus (CL0002149)
Fold Change: 0.3798
Cell Significance Index: 5.2700
Cell Name: paneth cell of colon (CL0009009)
Fold Change: 0.3784
Cell Significance Index: 5.6700
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.3480
Cell Significance Index: 18.0800
Cell Name: pro-T cell (CL0000827)
Fold Change: 0.3139
Cell Significance Index: 8.0200
Cell Name: retinal rod cell (CL0000604)
Fold Change: 0.2680
Cell Significance Index: 3.2000
Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: 0.2349
Cell Significance Index: 3.5400
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.2290
Cell Significance Index: 6.1300
Cell Name: large intestine goblet cell (CL1000320)
Fold Change: 0.2261
Cell Significance Index: 2.4500
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.1892
Cell Significance Index: 34.1000
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.1879
Cell Significance Index: 37.2900
Cell Name: odontoblast (CL0000060)
Fold Change: 0.1697
Cell Significance Index: 21.7600
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.1631
Cell Significance Index: 5.7300
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 0.1589
Cell Significance Index: 5.5200
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 0.1433
Cell Significance Index: 1.3200
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.1403
Cell Significance Index: 3.9200
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.1248
Cell Significance Index: 14.7200
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.1140
Cell Significance Index: 15.6600
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.1058
Cell Significance Index: 1.7700
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.1044
Cell Significance Index: 57.0400
Cell Name: DN3 thymocyte (CL0000807)
Fold Change: 0.0888
Cell Significance Index: 0.8900
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 0.0810
Cell Significance Index: 23.3200
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.0784
Cell Significance Index: 2.5100
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.0693
Cell Significance Index: 8.5200
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.0672
Cell Significance Index: 3.1600
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0545
Cell Significance Index: 24.0800
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.0498
Cell Significance Index: 3.8300
Cell Name: cone retinal bipolar cell (CL0000752)
Fold Change: 0.0441
Cell Significance Index: 0.3400
Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: 0.0419
Cell Significance Index: 0.6000
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 0.0416
Cell Significance Index: 0.8700
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.0373
Cell Significance Index: 1.7400
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.0320
Cell Significance Index: 2.0200
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.0302
Cell Significance Index: 10.8500
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 0.0289
Cell Significance Index: 0.3700
Cell Name: lactocyte (CL0002325)
Fold Change: 0.0276
Cell Significance Index: 3.5700
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 0.0204
Cell Significance Index: 2.9700
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0194
Cell Significance Index: 12.3200
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0055
Cell Significance Index: 10.2700
Cell Name: granulosa cell (CL0000501)
Fold Change: 0.0053
Cell Significance Index: 0.1400
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.0045
Cell Significance Index: 0.7800
Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0033
Cell Significance Index: 6.0900
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 0.0026
Cell Significance Index: 0.1200
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 0.0017
Cell Significance Index: 0.0500
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0004
Cell Significance Index: -0.6700
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0018
Cell Significance Index: -0.3700
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0037
Cell Significance Index: -0.1000
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.0047
Cell Significance Index: -0.1000
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0049
Cell Significance Index: -3.7400
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.0053
Cell Significance Index: -0.2000
Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.0053
Cell Significance Index: -0.3800
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0054
Cell Significance Index: -7.2900
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0092
Cell Significance Index: -0.9400
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0095
Cell Significance Index: -7.0500
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0113
Cell Significance Index: -8.2600
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0134
Cell Significance Index: -6.0900
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0135
Cell Significance Index: -7.6000
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.0183
Cell Significance Index: -0.9300
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.0245
Cell Significance Index: -0.4200
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0310
Cell Significance Index: -1.7400
Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: -0.0477
Cell Significance Index: -0.2600
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.0484
Cell Significance Index: -1.2100
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0495
Cell Significance Index: -10.4200
Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.0561
Cell Significance Index: -2.3000
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0581
Cell Significance Index: -6.6600
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.0594
Cell Significance Index: -4.4300
Cell Name: Hofbauer cell (CL3000001)
Fold Change: -0.0625
Cell Significance Index: -0.5100
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0785
Cell Significance Index: -4.8100
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.0846
Cell Significance Index: -8.8100
Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
Fold Change: -0.0919
Cell Significance Index: -1.2900
Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.1002
Cell Significance Index: -1.4800
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.1041
Cell Significance Index: -2.9900
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.1141
Cell Significance Index: -9.0400
Cell Name: radial glial cell (CL0000681)
Fold Change: -0.1281
Cell Significance Index: -0.7600
Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
Fold Change: -0.1509
Cell Significance Index: -0.7900
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -0.1531
Cell Significance Index: -1.5900
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.1558
Cell Significance Index: -4.0100
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.1561
Cell Significance Index: -4.2500
Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: -0.1623
Cell Significance Index: -1.1000
Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.1886
Cell Significance Index: -4.1300
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: -0.1895
Cell Significance Index: -2.0600
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.1954
Cell Significance Index: -2.2200
Cell Name: pulmonary interstitial fibroblast (CL0002241)
Fold Change: -0.2053
Cell Significance Index: -1.2700
Cell Name: myometrial cell (CL0002366)
Fold Change: -0.2053
Cell Significance Index: -2.3700
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.2078
Cell Significance Index: -4.3100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics:** H2BC15 is a histone protein that is post-translationally modified at lysine 15 (H2B1N) and is enriched in chromatin modifications. It is a component of the nucleosome core and plays a central role in chromatin organization and gene regulation. H2BC15 is also involved in various cellular processes, including cell cycle regulation, DNA repair, and epigenetic regulation of gene expression. **Pathways and Functions:** H2BC15 is involved in several key pathways, including: 1. **Activation of anterior hox genes in hindbrain development during early embryogenesis**: H2BC15 is required for the proper expression of anterior hox genes, which are essential for hindbrain development. 2. **Assembly of the orc complex at the origin of replication**: H2BC15 is involved in the assembly of the orc complex, which is required for DNA replication and repair. 3. **Base-excision repair**: H2BC15 plays a role in base-excision repair, a mechanism for repairing damaged DNA. 4. **Cell cycle regulation**: H2BC15 is involved in the regulation of the cell cycle, including the G2/M checkpoint. 5. **Epigenetic regulation of gene expression**: H2BC15 is involved in the regulation of gene expression through chromatin modifications and histone acetylation. **Clinical Significance:** Dysregulation of H2BC15 has been implicated in various diseases, including: 1. **Cancer**: Altered expression of H2BC15 has been observed in several types of cancer, including breast, lung, and colon cancer. 2. **Neurological disorders**: H2BC15 has been implicated in neurological disorders, including Alzheimer's disease and schizophrenia. 3. **Immune system disorders**: H2BC15 is involved in the regulation of the immune system and has been implicated in autoimmune disorders, such as rheumatoid arthritis. In conclusion, H2BC15 is a histone protein that plays a crucial role in chromatin organization and gene regulation. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the mechanisms of H2BC15 and its role in human disease. **Future Directions:** Further research is needed to fully understand the mechanisms of H2BC15 and its role in human disease. Potential areas of investigation include: 1. **Mechanistic studies**: Investigating the mechanisms by which H2BC15 regulates chromatin and gene expression. 2. **Clinical studies**: Investigating the clinical significance of H2BC15 in various diseases. 3. **Therapeutic targeting**: Developing therapies that target H2BC15 or its regulatory pathways. By understanding the role of H2BC15 in chromatin organization and gene regulation, we can gain insights into the mechanisms of various diseases and develop novel therapeutic strategies.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Histone H2B type 1-N

Genular Protein ID: 3613600013

Symbol: H2B1N_HUMAN

Name: Histone H2B type 1-N

UniProtKB Accession Codes:

Q99877 B2R5L4 Q494S8 Q96FB7

Database IDs:

Citations:

PubMed ID: 9439656

Title: The human histone gene cluster at the D6S105 locus.

PubMed ID: 9439656

DOI: 10.1007/s004390050630

PubMed ID: 12408966

Title: The human and mouse replication-dependent histone genes.

PubMed ID: 12408966

DOI: 10.1016/s0888-7543(02)96850-3

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16627869

Title: Quantitative proteomic analysis of post-translational modifications of human histones.

PubMed ID: 16627869

DOI: 10.1074/mcp.m600007-mcp200

PubMed ID: 12757711

Title: Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase.

PubMed ID: 12757711

DOI: 10.1016/s0092-8674(03)00355-6

PubMed ID: 16307923

Title: Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation.

PubMed ID: 16307923

DOI: 10.1016/j.molcel.2005.09.025

PubMed ID: 16283522

Title: Inhibition of core histones acetylation by carcinogenic nickel(II).

PubMed ID: 16283522

DOI: 10.1007/s11010-005-8285-1

PubMed ID: 16713563

Title: Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II.

PubMed ID: 16713563

DOI: 10.1016/j.cell.2006.04.029

PubMed ID: 16319397

Title: Characterization of histones H2A and H2B variants and their post-translational modifications by mass spectrometry.

PubMed ID: 16319397

DOI: 10.1074/mcp.m500288-mcp200

PubMed ID: 21925322

Title: Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification.

PubMed ID: 21925322

DOI: 10.1016/j.cell.2011.08.008

PubMed ID: 21726816

Title: The RING finger protein MSL2 in the MOF complex is an E3 ubiquitin ligase for H2B K34 and is involved in crosstalk with H3 K4 and K79 methylation.

PubMed ID: 21726816

DOI: 10.1016/j.molcel.2011.05.015

PubMed ID: 22389435

Title: Lysine succinylation and lysine malonylation in histones.

PubMed ID: 22389435

DOI: 10.1074/mcp.m111.015875

PubMed ID: 23824326

Title: USP49 deubiquitinates histone H2B and regulates cotranscriptional pre-mRNA splicing.

PubMed ID: 23824326

DOI: 10.1101/gad.211037.112

PubMed ID: 24681537

Title: Lysine 2-hydroxyisobutyrylation is a widely distributed active histone mark.

PubMed ID: 24681537

DOI: 10.1038/nchembio.1497

PubMed ID: 27105113

Title: Dynamic competing histone H4 K5K8 acetylation and butyrylation are hallmarks of highly active gene promoters.

PubMed ID: 27105113

DOI: 10.1016/j.molcel.2016.03.014

PubMed ID: 27105115

Title: Metabolic regulation of gene expression by histone lysine beta-hydroxybutyrylation.

PubMed ID: 27105115

DOI: 10.1016/j.molcel.2016.03.036

PubMed ID: 27530147

Title: PARP3 is a sensor of nicked nucleosomes and monoribosylates histone H2B(Glu2).

PubMed ID: 27530147

DOI: 10.1038/ncomms12404

PubMed ID: 31542297

Title: Glutarylation of histone H4 lysine 91 regulates chromatin dynamics.

PubMed ID: 31542297

DOI: 10.1016/j.molcel.2019.08.018

PubMed ID: 31645732

Title: Metabolic regulation of gene expression by histone lactylation.

PubMed ID: 31645732

DOI: 10.1038/s41586-019-1678-1

PubMed ID: 34874266

Title: Serine ADP-ribosylation marks nucleosomes for ALC1-dependent chromatin remodeling.

PubMed ID: 34874266

DOI: 10.7554/elife.71502

Sequence Information:

Length: 126
Mass: 13922
Checksum: FAEB278D44BE702F
Sequence:

MPEPSKSAPA PKKGSKKAVT KAQKKDGKKR KRSRKESYSV YVYKVLKQVH PDTGISSKAM 
GIMNSFVNDI FERIAGEASR LAHYNKRSTI TSREIQTAVR LLLPGELAKH AVSEGTKAVT 
KYTSSK

Database document:

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Details for: H2BC15

Associated with

Cells (max top 100)

Other Information

The human histone gene cluster at the D6S105 locus. PubMed ID: 9439656

The human and mouse replication-dependent histone genes. PubMed ID: 12408966

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and analysis of human chromosome 6. PubMed ID: 14574404

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Quantitative proteomic analysis of post-translational modifications of human histones. PubMed ID: 16627869

Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase. PubMed ID: 12757711

Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation. PubMed ID: 16307923

Inhibition of core histones acetylation by carcinogenic nickel(II). PubMed ID: 16283522

Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II. PubMed ID: 16713563

Characterization of histones H2A and H2B variants and their post-translational modifications by mass spectrometry. PubMed ID: 16319397

Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification. PubMed ID: 21925322

The RING finger protein MSL2 in the MOF complex is an E3 ubiquitin ligase for H2B K34 and is involved in crosstalk with H3 K4 and K79 methylation. PubMed ID: 21726816

Lysine succinylation and lysine malonylation in histones. PubMed ID: 22389435

USP49 deubiquitinates histone H2B and regulates cotranscriptional pre-mRNA splicing. PubMed ID: 23824326

Lysine 2-hydroxyisobutyrylation is a widely distributed active histone mark. PubMed ID: 24681537

Dynamic competing histone H4 K5K8 acetylation and butyrylation are hallmarks of highly active gene promoters. PubMed ID: 27105113

Metabolic regulation of gene expression by histone lysine beta-hydroxybutyrylation. PubMed ID: 27105115

PARP3 is a sensor of nicked nucleosomes and monoribosylates histone H2B(Glu2). PubMed ID: 27530147

Glutarylation of histone H4 lysine 91 regulates chromatin dynamics. PubMed ID: 31542297

Metabolic regulation of gene expression by histone lactylation. PubMed ID: 31645732

Serine ADP-ribosylation marks nucleosomes for ALC1-dependent chromatin remodeling. PubMed ID: 34874266